loratadine / Generic mfg. 
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  • ||||||||||  loratadine / Generic mfg., levocetirizine / Generic mfg., desloratadine / Generic mfg.
    Profile of H1-antihistamine prescriptions for chronic urticaria among Spanish allergists () -  Apr 30, 2022 - Abstract #EAACI2022EAACI_1186;    
    In refractory cases of chronic urticaria, the most frequent attitude was to increase the dose of the same 2GH1AH and not to use mixed 2GH1AH/1GH1AH regimens. A high proportion believed that 4-times the authorized 2GH1AH dose was sufficiently safe, but the maximum dose achieved differed among H1AHs.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Anti-Inflammatory Activities of an Anti-Histamine Drug, Loratadine, by Suppressing TAK1 in AP-1 Pathway. (Pubmed Central) -  Apr 19, 2022   
    In addition, Loratadine was able to reduce gastric bleeding in acute gastritis-induced mice; Western blotting using the stomach samples showed reduced p-c-Fos protein levels. Loratadine was shown to effectively suppress inflammation by specifically targeting TAK1 and suppressing consequent AP-1 signaling pathway activation and inflammatory cytokine production.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Loratadine. (Pubmed Central) -  Apr 17, 2022   
    The chapter also includes methods of analysis of the drug such as compendial, titrimetric, electrochemical, spectroscopic, chromatographic and capillary electrophoretic methods. The chapter also covers clinical applications of the drug such as its uses, doses, ADME profiles and mechanism of action.
  • ||||||||||  famotidine / Generic mfg., loratadine / Generic mfg.
    Enrollment change, Trial termination:  ATEE: Antihistamines in Eosinophilic Esophagitis (clinicaltrials.gov) -  Apr 6, 2022   
    P2,  N=1, Terminated, 
    The chapter also covers clinical applications of the drug such as its uses, doses, ADME profiles and mechanism of action. N=50 --> 1 | Recruiting --> Terminated; low enrollment
  • ||||||||||  temozolomide / Generic mfg.
    Journal:  Descriptors for some Compounds with Pharmacological Activity; Calculation of Properties. (Pubmed Central) -  Mar 23, 2022   
    Abraham model solute descriptors have been determined for nisoldipine, nizatidine, loratadine, zonisamide, oxaprozin, rebamipide, domperidone, temozolomide, 'florfenicol', florfenicol A, dapsone, chrysin, benorilate, β-lapachone, and Ipriflavone based on published partition coefficients, molar solubilities and gas chromatographic retention indices. The calculated solute descriptors, combined with our previously published Abraham model correlations, are used to predict several important physicochemical and biological properties, such as air-water, air-blood, air-lung, air-fat, air-skin, water-lipid, water-membrane and water-skin partition coefficients, as well as permeation from water through skin.
  • ||||||||||  Alesion (epinastine) / Boehringer Ingelheim
    Clinical, Review, Journal:  Antihistamine use during breastfeeding with focus on breast milk transfer and safety in humans - a systematic literature review. (Pubmed Central) -  Mar 17, 2022   
    In addition, one study investigated the impact of chlorpheniramine or promethazine on prolactin levels among 17 women, and one study investigated possible adverse drug reactions in 85 breastfed infants exposed to various antihistamines...Most product labels of the ten antihistamines with available information in both EU and the US, reported lack of evidence and recommended to avoid use during breastfeeding. The knowledge gap on antihistamines and lactation is extensive, and further human studies are warranted to ensure optimal treatment of breastfeeding women with allergy.
  • ||||||||||  loratadine / Generic mfg., olopatadine / Generic mfg.
    New P4 trial:  A Study Comparing the Efficacy of Pataday (clinicaltrials.gov) -  Mar 4, 2022   
    P4,  N=60, Recruiting, 
  • ||||||||||  A Shock to the Heart: Atypical Presentation of Covid-19 Induced Fulminant Perimyocarditis (Area J, Hall F (North Building, Exhibition Level), Moscone Center) -  Feb 19, 2022 - Abstract #ATS2022ATS_1258;    
    Per infectious disease, the patient was started on our institutional covid regimen: oral dexamethasone 6 mg qd, zinc, vitamins C and D, famotidine, loratadine, lovenox, and remdesivir...Colchicine was initiated for pericarditis treatment...Patients who successfully recovered from this disease were reported to have been treated earlier with higher dose steroids - methylprednisolone 200mg/day- in conjunction with immunoglobulin therapy to suppress inflammatory mediated processes. As new variants of coronavirus continue to rise, it is imperative for clinicians to have early suspicion and work up for cardiac related disease as this could potentially be lifesaving with prompt initiation of aggressive immunomodulating and anti-inflammatory agents.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Cocrystal formation of loratadine-succinic acid and its improved solubility. (Pubmed Central) -  Feb 15, 2022   
    Cocrystal of loratadine and succinic acid is formed by stoichiometry of 1:1 via C=O and H-O interaction. Cocrystal phase shows different physicochemical properties and responding to those properties, it shows improved loratadine solubility as well.
  • ||||||||||  lovastatin / Generic mfg.
    Journal:  Function and Expression of Bile Salt Export Pump in Suspension Human Hepatocytes. (Pubmed Central) -  Feb 10, 2022   
    Interestingly, cyclosporine A, troglitazone, itraconazole, loratadine, and lovastatin inhibited G-CA efflux more potently than G-CDCA efflux (3- to 5-fold)...The study also illustrated the major role of BSEP relative to basolateral MRP3 and MRP4 in transport of bile salts in SHH. Understanding of BSEP function in SHH may bolster the utility of this platform in mechanistic understanding of bile salt disposition and potentially in the assessment of drugs for BSEP inhibition.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Chemical Constituents of the Deep-Sea-Derived Penicillium solitum. (Pubmed Central) -  Feb 4, 2022   
    Viridicatol (13) displayed moderate anti-tumor activities against PANC-1, Hela, and A549 cells with IC values of around 20 μM. Moreover, 13 displayed potent in vitro anti-food allergic activity with an IC value of 13 μM, compared to that of 92 μM for the positive control, loratadine, while indole-3-acetic acid methyl ester (9) and penicopeptide A (10) showed moderate effects (IC = 50 and 58 μM, respectively).
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Loratadine inhibits Staphylococcus aureus virulence and biofilm formation. (Pubmed Central) -  Feb 1, 2022   
    Regarding mechanism, loratadine exposure reduced RNA levels of virulence-related S. aureus genes, and loratadine-induced mutations in MgrA reduced loratadine-MgrA binding. Overexpression of mutated mgrA in wild-type S. aureus decreased the biofilm formation inhibition effect of loratadine.
  • ||||||||||  NOTHING TO SNEEZE AT: A CASE OF EOSINOPHILIA-ASSOCIATED CORONARY VASOSPASM (eAbstract site) -  Jan 28, 2022 - Abstract #ACC2022ACC_5160;    
    It is important to consider coronary vasospasm as a cause of anginal chest pain, especially in young patients without risk factors for atherosclerotic disease. Though calcium channel blockers and nitroglycerin are the main-stay of treatment, recognition and treatment of eosinophilia-associated coronary vasospasm in patients with AERD is critical to improving patient outcomes.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Anti-food allergic alkaloids from the lotus seed pot. (Pubmed Central) -  Jan 14, 2022   
    Their structures were established by detailed analysis of the 1D-, 2D-NMR, and HRESIMS data. N-Nornuciferine ( 9 ) and lirinidine ( 10 ) showed potent in vitro anti-food allergic activity with IC50 values of 40.0 and 55.4 μM, respectively, compared to 91.4 μM for loratadine, the positive control.