loratadine / Generic mfg. 
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  • ||||||||||  Entyvio (vedolizumab) / Takeda
    Eosinophilic Cystitis in a Pediatric Patient with X-linked Chronic Granulomatous Disease (Exhibit Hall (Upper Concourse); Monitor 06) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_951;    
    His colitis was well-controlled with vedolizumab when he presented for evaluation of new onset dysuria and intermittent scrotal pain that improved with voiding...He was started on intravesical dexamethasone 10mg, to minimize complications from systemic steroid use, and oral loratadine 5mg on intravesical treatment days...Discussion Reported cases of pediatric eosinophilic cystitis are mostly in young children, only requiring a short course of intravesical steroids and oral antihistamine, unlike our patient2,3 . More research is needed to elucidate the history, optimal diagnosis and guide appropriate management of eosinophilic cystitis in pediatric X-CGD patients.
  • ||||||||||  loratadine / Generic mfg., aspirin / Generic mfg., paracetamol / Generic mfg.
    A Rare Cause of Urticaria In An NSAID Tolerant Patient (Exhibit Hall (Upper Concourse); Monitor 01) -  Oct 10, 2022 - Abstract #ACAAI2022ACAAI_809;    
    He also noted urticaria with Excedrin migraine, which contains acetaminophen, aspirin, and caffeine...He was treated with 20mg of loratadine...If a patient is NSAID tolerant and develops symptoms with acetaminophen, it is more likely to be IgE-mediated. Acetaminophen challenge should be done with caution and avoided if positive.
  • ||||||||||  Comirnaty (tozinameran) / Pfizer, Fosun Pharma, BioNTech
    NOT THE VACCINE, BUT ANAPHYLAXIS TO THE COVID-19 VIRUS ITSELF (Convention Center Exhibit Hall: Poster Area) -  Aug 16, 2022 - Abstract #CHEST2022CHEST_1990;    
    SARS-CoV-2 has clinically presented itself in a multitude of ways across many disciplines. In a patient with a history of urticaria, prolonged anaphylactic symptoms can be triggered by the virus itself.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Milk Oral Lyophilizates with Loratadine: Screening for New Excipients for Pediatric Use. (Pubmed Central) -  Jul 29, 2022   
    Finally, three formulations were prepared to confront the predictions of the DoE and further studied to thoroughly understand the observed effects. The experimental results showed the potential of milk in the development of oral lyophilizates loaded with different doses of suspended API.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Loratadine, an antihistaminic drug, suppresses the proliferation of endometrial stromal cells by inhibition of TRPV2. (Pubmed Central) -  Jul 15, 2022   
    Taken together, our study revealed that the antihistaminic drugs loratadine, astemizole and clemizole target TRPV2 in a concentration-dependent manner. The identification of these antihistaminic drugs as blockers of TRPV2 may form a new starting point for the synthesis of more potent and selective TRPV2 antagonists, which could further lead to the unravelling of the physiological role of the channel.
  • ||||||||||  cetirizine oral / Generic mfg., loratadine / Generic mfg.
    Review, Journal:  Medical management of rhinitis in pregnancy. (Pubmed Central) -  Jul 13, 2022   
    The management of rhinitis in pregnancy can therefore be complex. This review aims to evaluate the current medical management options for rhinitis in pregnancy.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Clinical Efficacy of Tuomin Zhiti Decoction in Allergic Rhinitis. (Pubmed Central) -  Jul 2, 2022   
    One hundred patients with AR treated in the Department of Otolaryngology of our hospital from January 2019 to December 2020 were recruited and assigned via a random number table method (1 : 1) to receive either oral loratadine and mometasone nasal spray (control group) or the Tuomin Zhiti decoction plus oral loratadine and mometasone nasal spray (study group)...Significantly lower post-treatment peripheral blood eosinophil count (EOS) and eosinophil cationic protein (ECP) levels were observed in the study group in contrast to those of the control group. The Tuomin Zhiti decoction for the treatment of AR patients alleviates their clinical symptoms, reduces the inflammatory responses, enhances the immune function of patients by regulating IL-4 and IFN-γ, and lowers the long-term recurrence rate.
  • ||||||||||  fexofenadine / Generic mfg., cetirizine oral / Generic mfg., loratadine / Generic mfg.
    Journal:  Analysis of degradation and pathways of three common antihistamine drugs by NaClO, UV, and UV-NaClO methods. (Pubmed Central) -  Jun 22, 2022   
    There were 9, 8, and 10 chloride oxidation products of loratadine, fexofenadine, and cetirizine, respectively, and 8 photolysis products of cetirizine were identified. For cetirizine, it was found that there were three identical intermediates produced by photodegradation and NaClO oxidation.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Network Pharmacology Study to Elucidate the Key Targets of Underlying Antihistamines against COVID-19. (Pubmed Central) -  Jun 22, 2022   
    Our results showed that Loratadine might exert as an antagonist on GRIN2B via the neuroactive ligand-receptor interaction pathway. To sum up, we elucidated the most potential antihistamine, a key target, and a key pharmacological pathway as alleviating components against COVID-19, supporting scientific evidence for further research.
  • ||||||||||  loratadine / Generic mfg.
    Trial completion date, Trial primary completion date:  Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization (clinicaltrials.gov) -  May 26, 2022   
    P1,  N=70, Not yet recruiting, 
    The obtained results illustrate the potential of plant-based expression systems for exploiting the enzymatic activities of eukaryotic CYPs with broad substrate specificities. Trial completion date: Jun 2021 --> Jun 2025 | Trial primary completion date: Jun 2021 --> Jun 2023
  • ||||||||||  remdesivir / Generic mfg.
    Preclinical, Journal:  Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice. (Pubmed Central) -  May 10, 2022   
    Specifically, SARS-CoV-2 spike protein-induced MC degranulation resulted in alveolar-capillary injury, while pretreatment of pulmonary microvascular endothelial cells with antihistamines prevented adhesion junction disruption; predictably, the combination of antiviral drug remdesivir with the antihistamine loratadine, a histamine receptor 1 (HR1) antagonist, dampened viral replication and inflammation, thereby greatly reducing lung injury. Our findings emphasize the crucial role of MCs in SARS-CoV-2-induced inflammation and lung injury and provide a feasible combination antiviral and anti-inflammatory therapy for COVID-19 treatment.
  • ||||||||||  Onon dry syrup (pranlukast) / Ono Pharma
    Journal:  The Effects of Combined Therapeutic Protocol on Allergic Rhinitis Symptoms and Molecular Determinants. (Pubmed Central) -  May 8, 2022   
    Allergic symptoms (nasal rubbing and sneezing), serum Igs (IgG1, total and OVA-specific IgE), eicosanoids (LTB4 and LTC4), histamine, TSLP, and IL-4 as well as gene expressions of MUC5a, Caspase-1, NLR3, HRH1, and CysLT1R were reduced in the animals receiving each of the therapeutic regimens; however, more pronounced effects were seen in the group treated with the triple combined protocol (loratadine + fluticasone + pranlukast). The combination of the loratadine, fluticasone, and pranlukast can effectively control the symptoms of AR probably via modulating several related mechanisms at early and late phases of allergic responses.
  • ||||||||||  loratadine / Generic mfg., olopatadine / Generic mfg.
    Trial completion:  A Study Comparing the Efficacy of Pataday (clinicaltrials.gov) -  May 3, 2022   
    P4,  N=58, Completed, 
    The combination of the loratadine, fluticasone, and pranlukast can effectively control the symptoms of AR probably via modulating several related mechanisms at early and late phases of allergic responses. Recruiting --> Completed
  • ||||||||||  loratadine / Generic mfg.
    Non immediate hypersensitivity reaction to antihistamines in pollen allergy: a case report () -  Apr 30, 2022 - Abstract #EAACI2022EAACI_1312;    
    Since loratadine and ebastine belong to the piperdine chemical group, it was decided not to undergo an oral challenge to Ebastine. Conclusion The patient was diagnosed with non-immediate hypersensitivity reaction to antihistamines verified by oral controlled exposure to cetirizine (belonging to the second generation of piperazines) and loratadine (belonging to the second generation of piperidines) with good tolerance to dexchlorpheniramine (first generation of alkylamines).