loratadine / Generic mfg. 
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  • ||||||||||  vancomycin / Generic mfg.
    Review, Journal:  Oral vancomycin induced flushing syndrome in a multiple myeloma patient: A case report and review of the literature. (Pubmed Central) -  Jan 15, 2025   
    However, this is just speculation and there are insufficient data, particularly in vivo data, to draw any conclusions. For patients with risk factors such as gastrointestinal pathology and renal insufficiency, monitoring of vancomycin serum concentration, mast cell degranulation, histamine release, and MRGPRX2 levels is recommended to avoid vancomycin flushing Syndrome, and vancomycin can still be used under supervision.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Impact of HPMCAS Grade on the Release of Weakly Basic Drugs from Amorphous Solid Dispersions. (Pubmed Central) -  Jan 6, 2025   
    Herein, insoluble complex formation between the lipophilic weakly basic drugs, cinnarizine or loratadine, and the enteric polymer, hydroxypropyl methylcellulose acetate succinate (HPMCAS), was studied and used to better understand drug and polymer release from their corresponding amorphous solid dispersions (ASDs)...These observations provide a baseline to understand the role of drug-polymer electrostatic interactions on release from ASDs formulated with HPMCAS. Future studies should focus on adding complexity to media conditions by employing simulated intestinal fluids with solubilizing components.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Insight into the Structure of the Neutral Amino Acid Transporter B0AT2 Enabled the Discovery of Tiagabine as an Inhibitor. (Pubmed Central) -  Dec 27, 2024   
    The results showed that tiagabine appears to have a higher affinity to the transporter than loratadine, which is the most potent inhibitor to date. Our findings support the development of new B0AT2 inhibitors that could be useful for investigating their therapeutic relevance, while the identification of tiagabine as a novel SLC6A15 inhibitor adds a new dimension to the pharmacological complexity of this drug.
  • ||||||||||  loratadine / Generic mfg.
    Preclinical, Journal:  Effect of acupuncture combined with bloodletting therapy on mast cell degranulation in urticaria rats (Pubmed Central) -  Nov 14, 2024   
    Acupuncture combined with bloodletting effectively suppress mast cell degranulation in the sensitized skin tissue on the back of urticaria rats, and ameliorate the histopathological morphology. Its effect mechanism may be related to inhibiting the differentiation and proliferation of helper T cells 2 and regulating the humoral immune response.
  • ||||||||||  Aphexda (motixafortide) / BioLineRx, Ayrmid
    Comparative Analysis of Dexamethasone-Enhanced Pre-Medication in Motixafortide-Induced Hematopoietic Stem Cell Mobilization for Multiple Myeloma: A Retrospective Study (Halls G-H (San Diego Convention Center)) -  Nov 6, 2024 - Abstract #ASH2024ASH_3715;    
    Patients also received loratadine 10 mg daily beginning on the day of G-CSF initiation, 3 days prior to motixafortide...Subsequently, 16 patients were started on MF-DEX, which consisted of starting famotidine 20 mg, montelukast 10 mg on the day of growth factor administration and continuing until 1 day after collection (5 days total), along with IV dexamethasone 8 mg added onto the standard premedications listed previously...Although patients who received the standard premedications had no grade 4 events and all AEs were manageable with supportive care, it was a clear burden to our patients and nursing staff. After adoption of MF-DEX our center has seen less hypersensitivity reactions and patient outcomes have improved.
  • ||||||||||  loratadine / Generic mfg.
    Cost-Effectiveness of Spleen Aminopeptide Oral Solution in the Treatment of Adenoid Hypertrophy in Children () -  Nov 4, 2024 - Abstract #ISPOREU2024ISPOR_EU_1094;    
    P4
    After adoption of MF-DEX our center has seen less hypersensitivity reactions and patient outcomes have improved. From a societal perspective, for afflicted child with AH, loratadine in combination with spleen aminopeptide oral solution has an economic advantage over loratadine monotherapy when the Willing to Pay (WTP) value is 1 time of GDP per capita.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Novel anti-virulence compounds disrupt exotoxin expression in MRSA. (Pubmed Central) -  Oct 21, 2024   
    This report delves further into our two lead compounds, loratadine and a structurally related brominated carbazole, and their effects on hemolysin production in methicillin-resistant S. aureus (MRSA)...Specifically, this work sheds light on novel compounds that decrease MRSA's ability to lyse host red blood cells. Importantly, it also highlights the importance of examining strain-specific differences in response to therapeutic interventions that could ultimately affect clinical outcomes.
  • ||||||||||  loratadine / Generic mfg., lisinopril / Generic mfg.
    Recurrent Exertional Rhabdomyolysis () -  Oct 12, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_5336;    
    Importantly, it also highlights the importance of examining strain-specific differences in response to therapeutic interventions that could ultimately affect clinical outcomes. No family history.Meds: lisinopril 2.5mg, loratadine 10mg, omeprozole 20mg dailyAM labs after the morning run:UA: dark brown color, protein 100mg/dL, Heme >1.0 mg/dL, RBC <1/hpf.Renal panel: Na 135, K 4.2, Cr 1.0.Myoglobin-Urine 3574 H Ng/Ml (ref 0 - 13)Myoglobin-Serum 72 Ng/Ml (ref 28 - 72)CK 484 H U/L (ref 46
  • ||||||||||  URTICARIA PIGMENTOSA PRESENTING AS A BULLOUS RASH IN A 4-MONTH-OLD (Monitor 15; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_673;    
    The patient was discharged with loratadine, diphenhydramine, saline washes and topical antibiotics for flares...The pediatric AI team started montelukast and oral prednisolone with significant improvement...Bullous Lesions on 4-month old patient Bullous lesions on scalp and in neck folds during initial hospitalization. Abstracts: Medically Challenging Case Abstracts / Ann Allergy Asthma Immunol 00 (2024) 1?110 101
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Behind the Counter Danger: Pseudoephedrine-Induced Seizure in an Elderly Patient. (Pubmed Central) -  Sep 20, 2024   
    The report presents the case of an 83-year-old man with a medical history of diabetes, hypertension, and dyslipidemia who experienced a generalized tonic-clonic seizure after taking an over-the-counter medication containing loratadine and pseudoephedrine...The case highlights the importance of comprehensive neurological assessment and diagnostic testing in patients with seizures to identify the underlying cause and guide appropriate management. Additional research is necessary to better understand the potential risks and benefits of using pseudoephedrine in elderly patients and explore alternative options for treating nasal congestion.
  • ||||||||||  chlorpheniramine / Generic mfg., loratadine / Generic mfg.
    Preclinical, Journal:  Unravelling Microarray Patch Performance: The Role of In Vitro Release Medium and Biorelevant Testing. (Pubmed Central) -  Aug 28, 2024   
    Our findings highlight the effect of the in vitro release medium composition on both LOR and CPM release rate and their penetration through the skin. Furthermore, we identified the importance of considering the interplay between the physicochemical attributes of the drug molecules, the design of the MAP formulation, and the structural properties of the skin when designing IVRT and IVPT protocols.
  • ||||||||||  Uncommon Presentation of Esophageal Foreign Body Impaction in an Elderly Patient (Exhibit Hall E) -  Aug 20, 2024 - Abstract #ACG2024ACG_2739;    
    Among adults, genuine foreign body ingestion is rare and usually seen in those with psychiatric disorders, alcohol intoxication, neglected elderly patients, and incarcerated individuals seeking secondary gain through release to a medical facility. This case report highlights the importance of maintaining a high index of suspicion for foreign body ingestion in patients presenting with dysphagia, particularly in elderly individuals, to facilitate timely diagnosis and management, thereby minimizing the risk of life-threatening complications.
  • ||||||||||  Favourable Response of Telangiectasia Macularis Eruptiva Perstans to 595 nm Pulsed Dye Laser (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_2819;    
    Other treatment modalities including other antihistamines (cetirizine, loratadine, hydroxyzine) , montelukast and sodium cromoglycate - were all ineffective in relieving his itch... In conclusion, we present a case of TMEP with clinically favorable response to PDL, adding to the armamentarium of treatment options for this condition.
  • ||||||||||  loratadine / Generic mfg.
    Polymorphic Maculopapular Mastocytosis in a Filipino Infant: A Case Report (Poster Area) -  Aug 5, 2024 - Abstract #EADV2024EADV_2041;    
    Treatment primarily focuses on relieving symptoms and avoiding factors that can exacerbate the condition. While it can be challenging for both the patient and their family, most cases have a good prognosis.
  • ||||||||||  Journal:  6-Carboxycellulose Acetate Butyrate: Effectiveness as an Amorphous Solid Dispersion Polymer. (Pubmed Central) -  Aug 1, 2024   
    Furthermore, CCAB ASDs with both loratadine and ibuprofen could be improved by the addition of the water-soluble polymer poly(vinylpyrrolidone) (PVP), with which CCAB shows good miscibility. CCAB provided solubility enhancement in some cases, and the slower drug release exhibited by CCAB, especially in the stomach, could be especially beneficial, for example, in formulations containing known stomach irritants like ibuprofen.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Loratadine Derivative Lo-7: A Weapon against Drug-Resistant Enterococcus and Streptococcal Infections. (Pubmed Central) -  Jul 28, 2024   
    Mechanistically, exposure to the loratadine derivative Lo-7 resulted in membrane depolarization without affecting membrane permeability in S. agalactiae. The potential targeting of the SecG subunit of the SecYEG membrane-embedded channel by the loratadine derivative Lo-7 in S. agalactiae was identified through quantitative proteomics, a drug affinity responsive target stability assay, and molecular docking.
  • ||||||||||  loratadine / Generic mfg., prednisone / Generic mfg., pregabalin / Generic mfg.
    Journal:  A case report on acquired reactive perforating collagenosis. (Pubmed Central) -  Jul 19, 2024   
    The model, coupled with immune profiling, offers insights into the molecular and immunological landscape of LUAD, presenting implications for personalized medicine and targeted therapies. This case report demonstrates that clinical dermoscopy can improve the diagnosis rate of ARPC, and pregabalin capsules can significantly relieve itching symptoms.
  • ||||||||||  loratadine / Generic mfg.
    Journal:  Clinical Effect Analysis of Fire-needle Acupuncture at Neiyingxiang Treating Persistent Allergic Rhinitis. (Pubmed Central) -  Jun 6, 2024   
    Here, we report a patient with RPC who was resistant to topical corticosteroids, oral loratadine, and thalidomide, and responded well to dupilumab without significant side effects. Fire-needle acupuncture at Neiyingxiang (ExHN 9) is effective for improving nasal allergy symptoms and quality of life in patients with moderate and severe persistent AR, and the duration of its effects is long.
  • ||||||||||  loratadine / Generic mfg.
    Probiotics combined with prebiotics alleviated seasonal allergic rhinitis by altering the intestinal microbiota (PS-15; Poster board no. 17) -  May 31, 2024 - Abstract #ERS2024ERS_1386;    
    Outcome measures included total nasal symptom score (TNSS), visual analog scale, rhinitis quality of life questionnaire, fractional exhaled nitric oxide, and the rate and intensity of Loratadine use... Probiotics combined with prebiotics significantly relieved symptoms of seasonal AR patients, which may related to fluctuations in the composition and metabolic function of the intestinal microbiota and further ameliorating host immunity.
  • ||||||||||  loratadine / Generic mfg., ebastine / Generic mfg.
    Journal:  Mast cell degranulation-triggered by SARS-CoV-2 induces tracheal-bronchial epithelial inflammation and injury. (Pubmed Central) -  Apr 28, 2024   
    Taken together, our findings confirm the essential role of MC degranulation in SARS-CoV-2-induced hyper-inflammation and the subsequent tissue lesions. Furthermore, our results support the use of ebastine or loratadine to inhibit SARS-CoV-2-triggered degranulation, thereby preventing tissue damage caused by hyper-inflammation.