Ongoing

3

810

Europe

Bleomycin, Prednisone, Vincristine, Doxorubicin, Cyclophosphamide, Dacarbazine, Etoposide, Procarbazine, Vinblastine, Powder for solution for injection, Tablet, Solution for injection, Powder for solution for infusion, Solution for infusion, Capsule*

CHU de Dijon

Hodgkin Lymphoma not previously treated

 

 

Active, not recruiting

3

615

Europe, RoW

bleomycin sulfate, doxorubicin hydrochloride, mechlorethamine hydrochloride, prednisone, procarbazine hydrochloride, vinblastine sulfate, vincristine sulfate, low-LET cobalt-60 gamma ray therapy, low-LET photon therapy, radiation therapy

European Organisation for Research and Treatment of Cancer - EORTC

Lymphoma

05/00

 

Completed

3

1202

Europe

bleomycin sulfate, filgrastim, pegfilgrastim, cyclophosphamide, dacarbazine, doxorubicin hydrochloride, etoposide, prednisolone, procarbazine hydrochloride, vinblastine sulfate, vincristine sulfate

University College, London, Cancer Research UK, Cancer Research UK & UCL Cancer Trials Centre

Lymphoma

01/16

05/24

Not yet recruiting

3

310

Europe

Rituximab, Methotrexate, Cytarabine, Thiotepa, Busulfan, Procarbazine, Concentrate for solution for infusion, Solution for infusion, Powder for concentrate for solution for infusion, Capsule, hard

Medical Center - University of Freiburg, BMBF Federal Ministry of Education and Research

Primary diffuse large B-cell lymphoma of the central nervous system(PCNSL) is a rare lymphoma affecting only the central nervous systemcompartment. PCNSL patients are typically 60 years or older and havepoor prognoses. Considering the poor prognosis of this patientpopulation, this randomised phase III trial proposal is of great clinicalimportance to provide patients optimal treatment. Das primäre diffuse großzellige B-Zell-Lymphom des zentralenNervensystems (PCNSL) ist ein seltenes Lymphom, das nur das zentraleNervensystem betrifft. PCNSL-Patienten sind in der Regel 60 Jahre oderälter. In Anbetracht der schlechten Prognose dieser Patientengruppe istdiese randomisierte Phase-III-Studie von großer klinischer Bedeutung,um den Patienten eine optimale Behandlung zu bieten., The primary lymphoma of the central nervous system is a rare disease,which occurs only in the central nervous system and more often amongelderly patient, who have a poor prognosis. Das primäres Lymphom des zentralen Nervensystems ist ein seltenesLymphom, das nur das zentrale Nervensystem betrifft und bei Patientenab 60 Jahren öfter auftritt und eine schlechte Prognose hat., Diseases [C] - Blood and lymphatic diseases [C15]

 

 

Active, not recruiting

3

305

Europe, Canada, US

concomitant temozolomide (TMZ), radiotherapy, procarbazine, adjuvant temozolomide (TMZ), CCNU, vincristine

Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI), European Organisation for Research and Treatment Center (EORTC), Canadian Cancer Trials Group

Brain and Central Nervous System Tumors

10/25

10/25

Recruiting

3

1875

Canada, US

Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bleomycin Sulfate, Blanoxan, BleMomycine, Blenoxane, Bleo-cell, Bleo-S, Bleocin, Bleolem, Bleomycin Sulfas, Bleomycin Sulphate, Bleomycini Sulfas, Blexane, Oil Bleo, Brentuximab Vedotin, ADC SGN-35, Adcetris, Anti-CD30 Antibody-Drug Conjugate SGN-35, Anti-CD30 Monoclonal Antibody-MMAE SGN-35, Anti-CD30 Monoclonal Antibody-Monomethylauristatin E SGN-35, cAC10-vcMMAE, SGN 35, SGN-35, SGN35, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Dacarbazine, 4-(Dimethyltriazeno)imidazole-5-carboxamide, 5-(Dimethyltriazeno)imidazole-4-carboxamide, Asercit, Biocarbazine, Dacarbazina, Dacarbazina Almirall, Dacarbazine - DTIC, Dacatic, Dakarbazin, Deticene, Detimedac, DIC, Dimethyl (triazeno) imidazolecarboxamide, Dimethyl Triazeno Imidazol Carboxamide, Dimethyl Triazeno Imidazole Carboxamide, dimethyl-triazeno-imidazole carboxamide, Dimethyl-triazeno-imidazole-carboximide, DTIC, DTIC-Dome, Fauldetic, Imidazole Carboxamide, Imidazole Carboxamide Dimethyltriazeno, WR-139007, Doxorubicin Hydrochloride, 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI), ADM, Adriacin, Adriamycin, Adriamycin Hydrochloride, Adriamycin PFS, Adriamycin RDF, ADRIAMYCIN, HYDROCHLORIDE, Adriamycine, Adriblastina, Adriblastine, Adrimedac, Chloridrato de Doxorrubicina, DOX, DOXO-CELL, Doxolem, Doxorubicin HCl, Doxorubicin.HCl, Doxorubin, Farmiblastina, FI 106, FI-106, FI106, hydroxydaunorubicin, Rubex, Etoposide, Demethyl Epipodophyllotoxin Ethylidine Glucoside, EPEG, Lastet, Toposar, Vepesid, VP 16, VP 16-213, VP 16213, VP-16, VP-16-213, VP-16213, VP16, VP16213, Etoposide Phosphate, Etopophos, Fludeoxyglucose F-18, 18FDG, FDG, Fludeoxyglucose (18F), fludeoxyglucose F 18, Fludeoxyglucose F18, Fluorine-18 2-Fluoro-2-deoxy-D-Glucose, Fluorodeoxyglucose F18, Involved-site Radiation Therapy, ISRT, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, PT, Prednisolone, (11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione, .delta.1-Hydrocortisone, Adnisolone, Aprednislon, Capsoid, Cortalone, Cortisolone, Dacortin H, Decaprednil, Decortin H, Delta(1)Hydrocortisone, Delta- Cortef, Delta-Cortef, Delta-Diona, Delta-F, Delta-Phoricol, Delta1-dehydro-hydrocortisone, Deltacortril, Deltahydrocortisone, Deltasolone, Deltidrosol, Dhasolone, Di-Adreson-F, Dontisolon D, Estilsona, Fisopred, Frisolona, Gupisone, Hostacortin H, Hydeltra, Hydeltrasol, Klismacort, Kuhlprednon, Lenisolone, Lepi-Cortinolo, Linola-H N, Linola-H-Fett N, Longiprednil, Metacortandralone, Meti Derm, Meticortelone, Opredsone, Panafcortelone, Precortisyl, Pred-Clysma, Predeltilone, Predni-Coelin, Predni-Helvacort, Prednicortelone, Prednisolonum, Prelone, Prenilone, Sterane, Prednisone, .delta.1-Cortisone, 1, 2-Dehydrocortisone, Adasone, Cortancyl, Dacortin, DeCortin, Decortisyl, Decorton, Delta 1-Cortisone, Delta-Dome, Deltacortene, Deltacortisone, Deltadehydrocortisone, Deltasone, Deltison, Deltra, Econosone, Lisacort, Meprosona-F, Metacortandracin, Meticorten, Ofisolona, Orasone, Panafcort, Panasol-S, Paracort, Perrigo Prednisone, PRED, Predicor, Predicorten, Prednicen-M, Prednicort, Prednidib, Prednilonga, Predniment, Prednisone Intensol, Prednisonum, Prednitone, Promifen, Rayos, Servisone, SK-Prednisone, Procarbazine Hydrochloride, Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI), Ibenzmethyzine hydrochloride, Matulane, MIH hydrochloride, Natulan, Natulanar, Natunalar, NCI C01810, NCI-C01810, NCIC01810, p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride, p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI), PCB, PCB Hydrochloride, PCZ, Ro 4 6467/1, Ro 4-6467/1, Questionnaire Administration, Vinblastine Sulfate, 29060 LE, 29060-LE, Exal, Velban, Velbe, Velsar, VINCALEUKOBLASTINE, Vincristine Sulfate, Kyocristine, Leurocristine Sulfate, Leurocristine, sulfate, Oncovin, Vincasar, Vincosid, Vincrex, Vincristine, sulfate

National Cancer Institute (NCI)

Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

04/31

04/31

Not yet recruiting

2

128

Europe

Ibrutinib 140 mg, Rituximab, Methotrexate, Procarbazine, Vincristine, Prednisone, Capsule, hard, Solution for infusion, Capsule, Tablet, Revlimid 5 mg, Revlimid 10 mg, Imbruvica 140 mg

Institut Curie, PHRC-K 2018 Public Health Grant, CELGENE SAS, JANSSEN-CILAG, KEOCYT SAS

Primary Central Nervous System Lymphoma (PCNSL) in patients aged 18 to 60, in first-line treatment Lymphome primitif du système nerveux central chez des patients âgés de 18 à 60 ans, en traitement de première ligne, Primary Central Nervous System Lymphoma in patients aged 18 to 60, first treatment Lymphome primitif du système nerveux central chez des patients âgés de 18 à 60 ans, 1er traitement, Diseases [C] - Cancer [C04]

 

 

Completed

2

33

US

Rituximab, Methotrexate, Vincristine, Procarbazine, PBPCs collection, Busulfan, Thiotepa, and Cyclophosphamide, During each cycle, you will receive Rituximab typically as an outpatient on day 1 and then be, admitted on day 2 to receive the other chemotherapy. You will be in the hospital for about 5 days and will be re-admitted to the hospital about 9 days, later to start the next cycle. After each cycle of chemotherapy you will take a medicine called G-CSF to protect you against, infection. PBPCs will be collected when determined by your doctor and may occur with cycle 1 or cycle 2., You will be admitted again for the high-dose chemotherapy and will receive supportive, medications to help avoid complications, including antibiotics and blood transfusions. Three, drugs, Busulfan, Thiotepa, and Cyclophosphamide will be given to you over 8 days. After a, rest period of approximately 1-2 days, we will give your PBPCs (or bone marrow) back to you, by vein. You will be in the hospital for at least 3 weeks.

Memorial Sloan Kettering Cancer Center

CNS Lymphoma, CNS Brain Cancer, Non-Hodgkin's Lymphoma

02/23

02/23

Completed

2

146

Europe, Canada, US, RoW

Pembrolizumab, MK-3475, SCH 900475, KEYTRUDA®, Doxorubicin, Adriamycin, DOXIL®, Rubex®, Vinblastine, Alkaban-AQ®, Velban®, Dacarbazine, Dtic-Dome®, Bleomycin, Blenoxane®, Etoposide, Toposar®, VePesid®, Etopophos®, VP-16, Etoposide phosphate, Cyclophosphamide, Neosar®, Cytoxan®, Vincristine, Oncovin®, Vincasar PFS®, Procarbazine, Matulane®, Prednisone, Liquid Pred®, Meticorten®, Orasone®, Deltasone®

Merck Sharp & Dohme LLC, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co.,Inc

Classical Hodgkin Lymphoma

10/23

05/24

Not yet recruiting

2

65

Europe, US

Rituximab, Methotrexate, Procarbazine, Temozolomide, Liso-cel, JCAR017, Breyanzi, Fludarabine, Cyclophosphamide, Calcium folinate, Leucovorin

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Lymphoma

01/28

01/29

Active, not recruiting

1/2

118

Europe

Lenalidomide, Revlimid, Ibrutinib, Imbruvica

Institut Curie, National Cancer Institute, France

Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Primary

08/25

08/35

Active, not recruiting

1

20

Japan

ONO-4059, Tirabrutinib Hydrochloride, Rituximab, Methotrexate, Procarbazine, Vincristine

Ono Pharmaceutical Co. Ltd

Primary Central Nervous System Lymphoma

04/28

08/28