| Resolor (prucalopride) / J&J, Takeda |
2010-023996-25: The effect of fluoxetine and 5-HT4 serotonin receptor agonists on cerebral axonal energy metabolism and glutamate levels in multiple sclerosis. |
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| Ongoing | 4 | 32 | Europe | fluoxetine, Cisapride, Prucalopride, Coated tablet | | Multiple sclerosis (both relapsing remitting and progressive forms) | | | | |
2012-004367-44: A STUDY TO COMPARE THE EFFECT OF A STIMULANT LAXATIVE (SODIUM PICOSULFATE) AND OF A PROKINETIC DRUG (PRUCALOPRIDE) ON SENSITIVITY AND MOTILITY OF THE LEFT COLON IN HEALTHY SUBJECTS |
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| Ongoing | 4 | 10 | Europe | SODIUM PICOSULFATE, PRUCALOPRIDE, Tablet, Coated tablet, GUTTALAX, RESOLOR | KU LEUVEN, KULEUVEN | SENSORY AND MOTOR RESPONSE OF DESCENDING COLON TO DISTENSION WILL BE STUDIED IN HEALTHY SUBJECTS, HEALTHY SUBJECTS, Body processes [G] - Physiological processes [G07] | | | | |
2013-002705-65: The effect of Prucalopride (Resolor) on the stomach motor function and the stomach sensitivity |
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| Ongoing | 4 | 20 | Europe | Resolor | TARGID, TARGID, KULeuven | Functional dyspepsia, Functional dyspepsia is a medical condition characterized by chronic or recurrent pain in the upper abdomen, upper abdominal fullness and feeling full earlier than expected when eating., Diseases [C] - Digestive System Diseases [C06] | | | | |
2014-000361-52: Pilot study: Anti-inflammatory effect of stimulation of the intestinal nervous system: a potential new therapy to accelerate gastric emptying |
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| Ongoing | 4 | 30 | Europe | Resolor, M0001, Film-coated tablet, Resolor | KULeuven, KULeuven | Patients undergoing pancreaduodenectomy due to benign or malignant tumor drug will be studied for prokinetic or anti-inflammatory effects, because they are known to influence gastrointestinal motility, Patients undergoing partial or full resection of the pancreas due to benign or malignant tumor, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
2013-000821-30: CLINICAL RESPONSE TO 5HT4 RECEPTORS AGONIST (PRUCALOPRIDE): GASTROCOLIC REFLEX ESTUDIO DEL REFLEJO GASTROCOLICO: INFLUENCIA DE PRUCALOPRIDA |
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| Ongoing | 4 | 10 | Europe | Resolor, Resolor | Enrique Rey Díaz-Rubio, fundacion investigación biomedica hospital clinico san carlos | chronic constipation estreñimiento cronico | | | | |
2012-005348-92: PROGASS PRucalopride On the GAstreonteric transit in Systemic Sclerosis PROGASS Studio per valutare l’effetto gastroenterico della Prucalopride in pazienti affetti da sclerosi sistemica |
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| Ongoing | 4 | 40 | Europe | RESOLOR*28CPR RIV 2MG, RESOLOR*28CPR RIV 2MG | FONDAZIONE IRCCS CA\' GRANDA OSPEDALE MAGGIORE POLICLINICO DI MILANO, Shire Italia S.p.A | Sysemic sclerosis with gastroenteric involvement (constipation) Sclerosi sistemica con interessamento gastroenterico (stipsi) | | | | |
2017-004175-31: A study to investigate the efficacy of prucalopride to treat typical reflux symptoms in patients with gastro-esophageal reflux disease Een studie om de efficaciteit van prucalopride in de behandeling van reflux symptomen in patiënten met gastro-oesofageale reflux ziekte. |
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| Ongoing | 4 | 60 | Europe | Resolor, Coated tablet, Resolor 2mg | TARGID, KU Leuven, TARGID, KU Leuven | refractory gastro-esophageal reflux disease refractaire gastro-oesofagale reflux ziekte, refractory gastro-oesophageal reflux disease refractaire gastro-oesofagale reflux ziekte, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
NCT04985669: Study of Comparative Effectiveness of Prucalopride and Lubiprostone in Constipation Predominant Irritable Bowel Syndrome |
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| Recruiting | 4 | 140 | RoW | Prucalopride 2mg, calopride | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Patient Satisfaction | 02/22 | 03/22 | | |
NCT02425774: Anti-inflammatory Effect of Pre-operative Stimulation of the Cholinergic Anti-Inflammatory Pathway |
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| Recruiting | 4 | 30 | Europe | Vagus stimulation, Sham stimulation, Prucalopride, Placebo | KU Leuven, Universitaire Ziekenhuizen KU Leuven | Postoperative Ileus | 12/25 | 12/25 | | |
NCT05455359: Gastrointestinal Dysmotility on Aspiration Risk |
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| Not yet recruiting | 4 | 120 | NA | Prucalopride, Famotidine | Boston Children's Hospital | Esophageal Motility Disorders, Gastric Motor Dysfunction, Aspiration Pneumonia, Gastro Esophageal Reflux | 07/27 | 07/27 | | |
NCT05726097: Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure |
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| Completed | 3 | 147 | Europe | polyethylene glycol, Laxabon, sodium phosphate, Phosphoral, polyethylene glycol + ascorbic acid, Plenvu, gastrografin, magnesiumoxid + sodium picosulfate, Picoprep, prucalopride, Resolol | Region Skane, Lund University, Odense University Hospital | Colon Cancer, Inflammatory Bowel Diseases, Gastrointestinal Bleed, Colon Polyp | 10/23 | 10/23 | | |
2022-003221-22: A study to determine how safe and effective different doses of prucalopride are in children and teenagers with functional constipation |
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| Not yet recruiting | 3 | 175 | US | Prucalopride, TAK-555, Film-coated tablet, Oral solution | Takeda Development Center Americas, Inc., Takeda Development Center Americas, Inc. | Constipation, Constipation, Diseases [C] - Digestive System Diseases [C06] | | | | |
NCT04759833: A Study of Prucalopride For Functional Constipation in Children and Teenagers |
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| Terminated | 3 | 175 | US | Prucalopride, TAK-555, Prucalopride succinate, Placebo | Takeda, Takeda Development Center Americas, Inc. | Constipation | 11/23 | 11/23 | | |
NCT04757493: The Effects of Prucalopride in Patients With Constipation Predominant Irritable Bowel Syndrome |
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| Recruiting | 2/3 | 160 | RoW | Prucalopride 2mg, Placebo | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | Irritable Bowel Syndrome | 10/21 | 11/21 | | |
2011-000308-16: Prucalopride versus placebo in patients with significantly delayed gastric emptying of idiopathic and diabetic nature |
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| Ongoing | 2 | 60 | Europe | Film-coated tablet, Resolor | UZ Leuven, Shire | Patients with delayed gastric emptying (t1/2 for solids ≥ 109 min) either from idiopathic or diabetic origin, delayed gastric emptying (when it takes ≥ 109 minutes before half of a standard solid meal has left the stomach) either from idiopathic or diabetic origin, Diseases [C] - Digestive System Diseases [C06] | | | | |
2018-002192-18: Characterization of a macrophage population under the control of nerves in the gastrointestinal tract Karakterisatie van de macrofaagpopulatie die onder de controle is van zenuwcellen in het maagdarmstelsel |
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| Ongoing | 2 | 10 | Europe | Resolor, Film-coated tablet, Resolor | KU Leuven, KU Leuven | Patients undergoing colorectal surgery due to benign or malignant carcinoma, diverticulitis or constipationdrug will be used to differentiate between macrophages that are modulated by enteric neurons and those that are not, Patients undergoing partial or full resection of the colon or rectum, Body processes [G] - Digestive System and Oral Physiological Phenomena [G10] | | | | |
NCT05001763: Prucalopride for Postoperative Ileus in Patients Undergoing Robot-assisted Laparoscopic Radical Cystectomy |
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| Not yet recruiting | 2 | 160 | NA | Prucalopride, Resolor, Placebo | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Postoperative Ileus, Bladder Cancer | 09/23 | 10/23 | | |
ChiCTR1800016158: Role of prucalopride and its effectiveness in bowel preparation for colonoscopy |
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| Completed | N/A | 189 | | Prucalopride ;Fleet | Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation; Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation | People who receive colonoscopy | | | | |
ChiCTR-IPR-17011999: The Application of Lactulose and Prucalopride in Intestine Preparation in Chronic Constipation Patients before Colonoscopy |
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| Not yet recruiting | N/A | 100 | | Polyethylene glycol ;Polyethylene glycol + Lactulose | Jingjiang People Hospital; None, Independent Project | the cleansing of bowel | | | | |
| Not yet recruiting | N/A | 100 | | ZhiShi 10g, BaiZhu 30g ;ZhiShi 10g, BaiZhu 50g ;ZhiShi 10g, BaiZhu 70g ;Prucalopride Succinate Tablets | The Affiliated Hospital of Nanjing University of Chinese Medicine; The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Provincial Commission of Health and Family Planning | Constipation | | | | |
| Completed | N/A | 50 | Europe | Prucalopride, Resolor, Montegrity, Axunio, Placebo | University of Oxford | Depression in Remission | 11/23 | 11/23 | | |
NCT05966246: The Effect of Prucalopride Succinate on Gastrointestinal Motility After Laparoscopic Gastrectomy : Prospective Double Blind Case-control Study |
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| Completed | N/A | 106 | RoW | Arm I : Experimental (Prucalopride succinate group), Arm II : Control (Mosapride citrate group) | Gangnam Severance Hospital | Gastric Cancer | 06/23 | 06/23 | | |
NCT06474286: Prucalopride for Cognitive Functioning in Schizophrenia |
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| Not yet recruiting | N/A | 34 | RoW | Prucalopride 1 MG, 5HT4 receptor agonist | University of Pittsburgh, Fogarty International Center of the National Institute of Health, K S Hegde Medical Academy | Schizophrenia | 10/25 | 12/25 | | |
NCT04961840: A Study to Assess Maternal and Fetal Outcomes After Taking Prucalopride During Pregnancy |
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| Active, not recruiting | N/A | 100 | US | No Intervention | Takeda | Constipation, Pregnancy | 12/25 | 12/25 | | |
NCT04869280: Post-Marketing Study of Prucalopride Safety In Pregnancy |
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| Recruiting | N/A | 616 | US | No Intervention | Takeda, The Organization of Teratology Information Specialists | Chronic Idiopathic Constipation (CIC) | 05/26 | 05/26 | | |
NCT04838522: A Study of Prucalopride in Breastfeeding Women With Constipation |
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| Recruiting | N/A | 12 | US | No Intervention | Takeda, UC San Diego Human Milk Research Biorepository | Chronic Idiopathic Constipation (CIC) | 12/26 | 12/26 | | |
