- |||||||||| Ryanodex (dantrolene) / Eagle Pharma
Preclinical, Journal: Evidence of Functional Ryanodine Receptors in Rat Mesenteric Collecting Lymphatic Vessels. (Pubmed Central) - Mar 24, 2020
Responses to SP were characterized in lymphatic vessels in the absence or presence of pretreatment with nifedipine to block L-type Ca channels, caffeine to block normal release and uptake of Ca from the sarcoplasmic reticulum, ryanodine to block all RyR isoforms, or dantrolene to more selectively block RyR1 and RyR3...RyR2 and RyR3 protein are found predominantly in the collecting lymphatic smooth muscle layer. Collectively, the data suggest that SP-induced tonic contraction requires both extracellular Ca plus Ca release from internal stores, and that RyRs play a role in the normal contractions and responsiveness to SP of rat mesenteric collecting lymphatics.
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma, Invokana (canagliflozin) / J&J, Daiichi Sankyo, Mitsubishi Tanabe
Journal: Carbazole based Electron Donor Acceptor (EDA) catalysis for the synthesis of biaryl and aryl-heteroaryl compounds. (Pubmed Central) - Mar 21, 2020
The in situ generated EDA complex even in a catalytic amount is found to be efficient for the Single Electron Transfer (SET) process without any photoactivation. Biaryl compounds, 2-phenylfuran, 2-phenylthiophene, and 2-phenylpyrrole and bioactive compounds such as dantrolene and canagliflozin have been synthesized in moderate to excellent yields.
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma, Azulfidine (sulfasalazine) / Generic mfg., warfarin / Generic mfg.
Mesalamine Induced Eosinophilic Pleural Effusion (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_7798;
Multiple medications have been associated with the development of EPE, including mesalamine, warfarin, dantrolene, and valproic acid. In cases of EPE with unclear etiology despite extensive workup, patient’s medications list should be reviewed to rule out medications induced EPE.
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma, lorazepam / Generic mfg.
2,4 DNP, A Lethal Slimming Pill (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area G) - Mar 15, 2020 - Abstract #ATS2020ATS_5415;
Within a few minutes of arrival to ER, the patient became extremely agitated and had to be given 8 mg of lorazepam in 2 doses and was later intubated...Fever and diaphoresis should be promptly treated with active cooling measures such as cooling blankets, IV Tylenol and Dantrolene can be considered if first line cooling measures fail...Because of extremely high mortality, an intensive approach should be adopted early in symptomatic patients who present after taking a potentially fatal dose. These patients should be managed in ICU with early intubation and mechanical ventilation and physicians should be aware that deterioration can be rapidly fatal.
- |||||||||| baclofen / Generic mfg.
Syndrome of Trephined following Intrathecal Baclofen Pump Placement () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1635;
However, an unintended and potential complication in a patient with a craniectomy and intrathecal pump implantation may an increase sinking of the craniectomy site. Therefore, it is important to determine the timing of ITBP placement in a patient with a craniectomy who has not yet undergone cranioplasty.Conclusions : Intrathecal baclofen pumps should be considered in patients with refractory paroxysmal sympathetic hyperactivity however, an unintended and under-reported complication may be increased sinking of the craniectomy site.
- |||||||||| baclofen / Generic mfg., bromocriptine / Generic mfg.
Emergence from Vegetative State Following Intrathecal Baclofen Pump Placement () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_888;
Additionally, three weeks after placement, the patient emerged from a vegetative state. Placement of an intrathecal baclofen pump allows the patient to be weaned off of sedating medications and reduce autonomic instability promoting emergence.Conclusions : Implantation of an intrathecal baclofen pump reduces autonomic storming, dystonic posturing, and may help with emergence from a vegetative state.
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma
A unique presentation of spastic paraplegia following non-paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis: A case report. () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_414;
She progressed functionally and cognitively; however, suffered from persistent spasticity in bilateral hip and knee flexion and ankle plantar-flexion, requiring dantrolene and ankle splinting...Conclusions : Our patient exhibits the first described case, to our knowledge , of spastic paraplegia following anti-NMDA receptor encephalitis. As more information is accrued regarding anti-NMDA receptor encephalitis, it is important to make physicians caring for this population aware of this possible clinical presentation.
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma
Journal: Time-dependent effects of dantrolene on motor evoked potentials in experimental spinal cord injuries. (Pubmed Central) - Jan 29, 2020
The electrophysiological efficacy of our model of trauma as SCI has been complemented with the significant differences between the control group and the SCI group. This creates a need for electrophysiological studies to be conducted in the future because effects, even at a minimum level, may play an important role in finding an applicable medicine for SCI.
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma
ESSENTIAL ROLE OF CALCIUM SIGNALING IN THE MODULATION OF CAMP-MEDIATED INTESTINAL ANION SECRETION () - Jan 28, 2020 - Abstract #DDW2020DDW_2694;
It may trigger SOC via PKA phosphrylation of ryanodine receptor to deplete the ER Ca2+ store and cause Ca2+ entry via STIM1/Orai1, which plays a critical role in cAMP-mediated intestinal ion secretion. Our findings provide a new insight to a cross-talk mechanism of cAMP and Ca2+ signaling in epithelial ion secretion
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma
Preclinical, Journal: Determination and tissue distribution studies of dantrolene sodium with hydroxypropyl-β-cyclodextrin in rat tissue by HPLC/MS/MS. (Pubmed Central) - Jan 23, 2020
The results showed that Da was rapidly and widely distributed in tissues and reach the C (maximum concentrations) within 0.5h in all tissues after oral administration of Da-HP-β-CD (DHC) ,and then metabolized by liver and finally excreted from kidney,which indicated DHC inclusion complex has better absorption and higher oral bioavailability than Da. And the results provided evidence for the safety and effectiveness of drug clinical application.
- |||||||||| Ryanodex (dantrolene) / Eagle Pharma
Journal: Succinylcholine Use and Dantrolene Availability: Reply. (Pubmed Central) - Jan 21, 2020
We need to better understand the wide spectrum of clinical phenotypes of COL4A1 mutations and potential complications in order to better manage surgery of patients with schizencephaly. No abstract available
- |||||||||| Case Report of Treatment of Neuroleptic Malignant Syndrome in Child Adolescent (Spadolini - Ground Floor) - Jan 17, 2020 - Abstract #SIRS2020SIRS_287;
In cases of NMS in patients who cannot terminate use of neuroleptics due to underlying mental disorders, ECT is an effective method to treat both NMS and mental disorders. Safety and efficacy of ECT have been already proven, and it is highly recommended when needed.
- |||||||||| dantrolene / Generic mfg.
Clinical, Journal: Malignant Hyperthermia: A Case Report in a Trauma Patient. (Pubmed Central) - Jan 10, 2020
A full 70 minutes elapsed before initial signs of hypermetabolism were noted, namely a rise in end-tidal carbon dioxide level. The patient received dantrolene sodium approximately 120 minutes after induction of anesthesia...Intraoperative vigilance in the monitoring of vital signs cannot be overemphasized. An increase in end-tidal carbon dioxide values, in addition to other clinical signs that cannot be easily attributed to other causes, should increase the clinical index of suspicion for a diagnosis.
- |||||||||| dantrolene / Generic mfg.
Journal: Role of dantrolene in dinitrophenol (DNP) overdose: A continuing question? (Pubmed Central) - Jan 10, 2020
Our cases demonstrate the hyperthermia reducing effects of dantrolene in DNP toxicity and contribute to the existing literature on this topic. Being aware of the possible use of dantrolene to treat the associated hyperthermia could assist emergency physicians in the treatment of DNP toxicity.
- |||||||||| dantrolene / Generic mfg.
Review, Journal: S1 guidelines on malignant hyperthermia : Update 2018 (Pubmed Central) - Jan 9, 2020
For outpatient anesthesia a stockage of dantrolene is not necessary as long as the use of MH trigger substances in general is strictly avoided. The introduction of Ryanodex® (Eagle Pharmaceuticals, Woodcliff Lake, NJ, USA), a preparation of dantrolene with clearly improved pharmacological properties, in the clinical practice has not yet been realized in Germany.
- |||||||||| dantrolene / Generic mfg., dalfampridine / Generic mfg.
Preclinical, Journal: Piperine-mediated suppression of voltage-dependent Ca influx and glutamate release in rat hippocampal nerve terminals involves 5HT receptors and G protein βγ activation. (Pubmed Central) - Jan 4, 2020
Because inhibition of glutamatergic excitatory neurotransmission is a possible mechanism involved in neuroprotection, we investigated the effect of piperine on the 4-aminopyridine (4-AP)-evoked release of glutamate from rat hippocampal synaptosomes...In the presence of ω-conotoxin MVIIC, an N- and P/Q-type channel blocker, the piperine-mediated inhibition of 4-AP-evoked glutamate release was markedly reduced; however, dantrolene and CGP37157, which are intracellular Ca2+-release inhibitors, did not alter the piperine effect...The glutamate release-inhibiting effect of piperine was discovered to be prevented by the 5-HT1A receptor antagonist WAY100635 and the G protein βγ subunit inhibitor gallein; however, it was unaffected by the adenylate cyclase inhibitor SQ22536 or the protein kinase A inhibitor PKI622. These results suggest that piperine inhibits glutamate release from rat hippocampal nerve terminals by reducing Ca2+ influx through N- and P/Q-type Ca2+ channels and that the activation of presynaptic 5-HT1A receptors and the G protein βγ subunit is involved in this effect.
- |||||||||| Preclinical, Journal: Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. (Pubmed Central) - Dec 28, 2019
We investigated the role of four chemical analogs, commonly prescribed β-blockers (atenolol, metoprolol, propranolol, and sotalol), on Ca release and whole-cell currents in mammalian cancer cells (PC3 prostate cancer and MCF7 breast cancer cell lines)...The propranolol-induced Ca release was significantly inhibited by the chelation of extracellular calcium with ethylene glycol tetraacetic acid (EGTA) and by dantrolene, an inhibitor of the endoplasmic reticulum (ER) ryanodine receptor channels, and it was completely abolished by 2-aminoethoxydiphenyl borate, an inhibitor of the ER inositol-1,4,5-trisphosphate (IP) receptor channels...Finally, pre-incubation of cells with sotalol or timolol, non-selective blockers of β-adrenoceptors, also reduced the Ca release activated by propranolol. Our results show that different β-blockers have differential effects on whole-cell currents and free Ca release and that propranolol activates store-operated Ca release via a mechanism that involves calcium-induced calcium release and putative downstream transducers such as IP The differential action of class II antiarrhythmics on Ca release may have implications on the pharmacology of these drugs.
- |||||||||| dantrolene / Generic mfg.
Journal: Dantrolene requires Mg2+ and ATP to inhibit the ryanodine receptor. (Pubmed Central) - Dec 19, 2019
Our data provide important complementary information that support the direct, Mg2+-dependent mechanism of dantrolene's action and suggest that dantrolene also requires ATP to inhibit RyR. SIGNIFICANCE STATEMENT: The muscle relaxant dantrolene acts on ryanodine receptor in the presence of magnesium and ATP, which should be considered in therapy.
- |||||||||| Gablofen (baclofen) / Mallinckrodt
Journal: Dexmedetomidine for Acute Management of Intrathecal Baclofen Withdrawal. (Pubmed Central) - Nov 25, 2019
In addition, dexmedetomidine has a superior safety profile compared to propofol or large doses of benzodiazepines. Further research will be useful in supporting the use of dexmedetomidine for this purpose.
- |||||||||| dantrolene / generics
Journal: Ionic and cellular mechanisms underlying TBX5/PITX2 insufficiency-induced atrial fibrillation: Insights from mathematical models of human atrial cells. (Pubmed Central) - Nov 22, 2019
Additionally, our computer simulation results shed new light on the novel cellular mechanism underlying AF by indicating that the imbalance between suppressed outward current I and increased inward sodium-calcium exchanger current (I) resulted from SR calcium leak leads to spontaneous depolarizations. Furthermore, our simulation results suggest that these arrhythmogenic triggers can be potentially suppressed by inhibiting sarcoplasmic reticulum (SR) calcium leak and reversing remodeled I. More importantly, this study has clinically significant implications on the drugs used for maintaining SR calcium homeostasis, whereby drugs such as dantrolene may confer significant improvement for the treatment of AF patients with TBX5/PITX2 insufficiency.
- |||||||||| fentanyl citrate / generics, remifentanil / generics, dantrolene / generics
Preclinical, Journal: Abortive course of malignant hyperthermia following preclinical induction of general anesthesia using succinylcholine (Pubmed Central) - Nov 8, 2019
Anesthesia was maintained using propofol and remifentanil infusion throughout the preoperative period and the subsequent surgical procedure...With an estimated genetic MH prevalence of 1:2000-3000, individuals with known or so far unrecognized MH disposition are likely to be among patients treated in the preclinical setting. If a person develops MH symptoms after exposure to triggering agents, immediate hospital admission is essential in order to initiate guideline-conform treatment without further delay because preclinically the life-saving causal measures are not possible due to the lack of supply of dantrolene.
- |||||||||| dantrolene / generics
Clinical, Journal: Intra-arterial dantrolene for refractory cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. (Pubmed Central) - Nov 8, 2019
If a person develops MH symptoms after exposure to triggering agents, immediate hospital admission is essential in order to initiate guideline-conform treatment without further delay because preclinically the life-saving causal measures are not possible due to the lack of supply of dantrolene. This evidence suggests intra-arterial dantrolene as a safe and effective novel alternative for the treatment of cerebral vasospasm.
- |||||||||| dantrolene / generics
Journal: Malignant Hyperthermia - Update on Pathophysiology, Diagnostics and Treatment (Pubmed Central) - Nov 8, 2019
A predisposition to MH should be investigated in patients following a suspected MH crisis, in relatives from MH-families, after exertional or unexplained perioperative rhabdomyolysis and in patients with idiopathic hyper-CK-aemia. According to recent European guidelines, initial DNA screening is an alternative to muscle biopsy and in-vitro contracture testing, although in cases where no diagnostic variants are found, only contracture testing can safely exclude predisposition to MH.
- |||||||||| Ultane (sevoflurane) / Generic Mfg.
Journal: Pharmacological Treatment of Malignant Hyperthermia: Update 2019 (Pubmed Central) - Nov 8, 2019
Since dantrolene is not easily dissoluble, preparation requires time and manpower. Due to its pharmacological characteristics, ryanodex, a modern nanocrystalline dantrolene sodium suspension, might be a promising alternative in the treatment of MH.
|
