||||||||||17 beta hydroxysteroid dehydrogenase inhibitor / ElexoPharm PK/PD data, Preclinical, Journal: Potent Dual Inhibitors of Steroid Sulfatase and 17?-Hydroxysteroid Dehydrogenase Type 1 with a Suitable Pharmacokinetic Profile for In Vivo Proof-of-Principle Studies in an Endometriosis Mouse Model. (Pubmed Central) - Jul 14, 2023 Steroid sulfatase (STS) and 17?-hydroxysteroid dehydrogenase type 1 (17?-HSD1) are key enzymes of local estrogen activation...No effect on cell viability was detected up to 31 ?M (HEK293) and 23 ?M (HepG2), respectively, and there was no activation of the aryl hydrocarbon receptor (AhR) up to 3.16 ?M. Single daily application to mice revealed steady-state plasma levels high enough to make this compound eligible for an in vivo proof-of-principle study in a mouse endometriosis model.