Not yet recruiting

4

12

 

George Medicines, George Medicines (The George Institute)

Hypertension

 

 

Not yet recruiting

4

24

 

Dr Richard McNeill, Canterbury Medical Research Foundation

Chronic obstructive Pulmonary Disease (COPD), Drug metabolism

 

 

Completed

4

30

 

None ;Losartan 25-50mmHg

Renji Hospital of Shanghai Jiaotong University; Level of the institution：, self-funded

CKD with obvious proteinuria

 

 

Completed

4

156

 

treated with ACEI/ARB( ARB therapy is subjected to patients with cough after use of ACEI) Inhibace (cilazapril): start at 1.25mg/day, increase the dose by 1.25mg/day/week to 2.5-5mg/day Cozaar (losartan): 25~50mg/day, increased to 50~100mg/day Last for one year; Oral prednisone for 6 mos 0.8mg/kg/day x 8 wks Tapered 0.2mg/kg/day/mo in combination with ACEI/ARB

The First Hospital, Peking University; Capital Research Funding for the Development of Medicine, Capital Research Funding for the Development of Medicine

primary IgA nephropathy

 

 

Completed

4

60

 

Glucosidorum Tripterygll Totorum+losartan potassium ;Placebo + losartan potassium

Shanghai Changzheng Hospital; Science and Technology Commission of Shanghai, Shanghai Key Discipline Project.(No:B902) Shanghai Science and Technology Commission Major Research Project.(No:08dz1900601)

Autosomal dominant polycystic kidney disease

 

 

Suspended

4

720

 

shenyankangfu tablets + Losartan potassium tablets mimetic agent×2 ;shenyankangfu tablets mimetic agent +losartan potassium tablets 50mg +losartan potassium tablets mimetic agent ;shenyankangfu tablets mimetic agent +losartan potassium tablets 50mg×2 ;shenyankangfu tablets + Losartan potassium tablets 50mg+ losartan potassium tablets mimetic agent ;shenyankangfu tablets +losartan potassium tablets 50mg×2

Chinese PLA General Hospital; Tianjin TongRenTang Group Co., Ltd., Enterprise Support

Primary Glomerulonephritis and Diabetic Kidney Disease

 

 

Ongoing

4

40

Europe

Cozaar, Carvedilol PCD, Cozaar, Carvedilol PCD

Organisation name was not entered

Turner syndrome, hypertension and aortopathy

 

 

Ongoing

4

40

Europe

perindopril, losartan, furosemid, metoprolol, amlodipin, PRESTARIUM Neo, LORISTA 25, PRESTARIUM Neo Forte, LORISTA 50, LORISTA 100, PRESTARIUM Neo, LORISTA 25, PRESTARIUM Neo Forte, LORISTA 50, LORISTA 100

IKEM, IKEM

Compensation of arterial hypertension in heart transplant recipients. Renal function and its changes in heart transplant recipients.

 

 

Ongoing

4

30

Europe

Losartankalium, Moxonidine, Losartankalium, Moxonidine

University Medical Center Utrecht, ZonMw

Post Partum Hypertension after preeclamptic pregnancy

 

 

Recruiting

4

640

 

Songling Xuemaikang capsule,the placebo of Losartan Potassium ;Losartan Potassium, the placebo of Songling Xuemaikang capsule

Dongzhimen hospital affiliated of Beijing University of Chinese Medicine; Shanghai Changzheng hospital; Dongzhimen hospital affiliated of Beijing University of Chinese Medicine, Pharmaceutical Co., Ltd. Chengdu Nakasone

Primary hypertension

 

 

Completed

4

20

NA

Autologous platelets rich plasma, PRP, Autologous platelets rich plasma + oral LOSARTAN administration, PRP + LOSARTAN

Mostafa Hassanein, Msc

PRP, Losartan, Muscle Injury, Sport Injury

09/17

12/17

Not yet recruiting

4

140

Europe

Spironolactone, Losartan, Tablet, Oral powder in sachet, Coated tablet, Veltassa

Henrik Birn, Vifor Fresenius Medical Care Renal Pharma AG, Graduate School of Health Sciences, Aarhus University

Chronic kidney disease with albuminuria Kronisk nyresygdom med albuminuri, Chronic kidney disease with protein in the urine Kronisk nyresygdom med æggehvidestof i urinen, Not possible to specify

 

 

Not yet recruiting

4

252

 

Keluoxin Capsule+Losartan Potassium ;Placebo of Keluoxin Capsule + Losartan Potassium

Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences; Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences, Self-raising

Diabetic Kidney Disease

 

 

Completed

4

66

RoW

Aliskiren, Losartan

Hansung University

Hypertension,Essential, Hyperuricemia

05/24

10/24

Not yet recruiting

4

20

Europe

Tablet, Injection, Forxiga, Jardiance, Ozempic, Telmisartan, Losartan, hydrochlorthiazide, Spironolactone, Trental, Olumiant, Kerendia, Rybelsus

Herlev and Gentofte Hospital, Herlev and Gentofte Hospital

Diabetic Kidney Disease, Kidney Disease due to diabetes mellitus type 2, Diseases [C] - Hormonal diseases [C19]

 

 

Not yet recruiting

4

160

 

oral losartan ;Not taking losartan

Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine; Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai Shen Kang Hospital Development Center

Acquired pulmonary venous obstruction

 

 

Not yet recruiting

4

150

 

placebo ;Losenatide 100ug ;Losenatide 200ug ;Losenatide 300ug ;orlistat

The Second XIANGYA Hospital Of Central South University; The Second XIANGYA Hospital Of Central South University, Supported by China International Medical Exchange Foundation, Sumei China Diabetes Research Foundation in 2020

obese patients with type 2 diabetes mellitus

 

 

Not yet recruiting

4

68

NA

Losartan, Cozaar

Fifth Affiliated Hospital, Sun Yat-Sen University, Third Affiliated Hospital, Sun Yat-Sen University

Hypertension,Nephropathy

06/23

12/23

Active, not recruiting

4

2476

US

High dose potent statin, atorvastatin or rosuvastatin, ACE-I (lisinopril) or ARB (losartan), ACE-I or ARB, Aspirin, Lifestyle Counseling, PACE Lifestyle Intervention, Quality of Life Questionnaires, QOL

University of Florida, United States Department of Defense

Coronary Artery Disease

02/25

09/25

Recruiting

4

40

RoW

Losartan Potassium

Hospital General de Niños Pedro de Elizalde

Uric Acid Nephropathy

12/23

07/24

Recruiting

4

878

Europe

Corticosteroid, Methylprednisolone succinate, prednisolone, Renin-angiotensin sytem blockers, Ramipril, lisinopril, losartan, Sodium-glucose cotransporter 2 inhibitor, dapagliflozin, canagliflozin, empagliflozin

Fondazione Schena, University of Bari

Glomerulonephritis, Immunoglobulin A Nephropathy

06/24

12/26

Withdrawn

4

380

US

Losartan

NYU Langone Health

Arthrofibrosis

12/24

12/24

Recruiting

4

2400

Europe, RoW

RAS-antagonist and beta-blocker up-to maximal dosages, Enalapril 40mg/d, Ramipril 10mg/d, Lisinopril 40mg/d, Cilazapril 5mg/d, Perindopril 8mg/d, Captopril 150mg/d, Spirapril 24mg/d, Quinapril 40mg/d, Trandolapril 4mg/d, Zofenopril 60mg/d, Fosinopril 40mg/d, Candesartan 32mg/d, Valsartan 320mg/d, Irbesartan 300mg/d, Losartan 150mg/d, Eprosartan 800mg/d, Bisoprolol 10mg/d, Metoprololsuccinat 200mg/d, Carvedilol 50mg/d (100mg/d if weight is > 85kg), Nebivolol 10mg/d, RAS-antagonist and beta-blocker none or at stable dose

Martin Huelsmann

Heart Diseases, Diabetes Mellitus, Type 2

12/25

12/26

Ongoing

3/4

120

Europe

Losartan, Capsule, hard, Losartan

Academisch medisch centrum, ICIN

To study the effect of losartan in adult patients with Tetralogy of Fallot and right ventricular dysfunction, defined as right ventricular ejection fraction <50%. Without severe valvular lesions., Research into the effect of the drug losartan in patients with tetralogy of Fallot and decreased right heart chamber function, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Ongoing

3

400

Europe

Cozaar, Cozaar

Unit of Esophageal and Gastric Research Dep. of Molecular Medicine and Surgery Karolinska Institutet

The clinical diagnosis of acute pancreatitis is set by a combination of symptoms (abdominal pain) and increased blood levels of pancreatic enzymes (i.e. amylase and lipase). The most common complication of Endoscopic Retrograde Cholangio-Pancreatography (ERCP) is acute pancreatitis (7%, Freeman et al 1996). Increased blood levels of amylase and lipase is seen in 25-40% of cases after ERCP (Tsujino et al 2005).

 

 

Not yet recruiting

3

300

 

Traditional Chinese medicine group will be given San-qi Granula and Cozaar placebo for 2 months, Sang-Qi granule will be taken every morning and evening, 10g every time, and the Cozaar placebo will be taken 50mg every morning. ;Western medicine group will be given Cozaar and San-qi Granula placebo for 2 months, and Cozaar will be taken 50mg every morning, Sang-Qi granule placebo will be taken every morning and evening, 10g every time. ;Traditional Chinese medicine+ Western medicine group will be given San-qi Granula and Cozaar for 2 months, Sang-Qi granule will be taken every morning and evening, 10g every time, and the Cozaar will be taken 50mg every morning.

China-Japanese Friendship Hospital; China-Japanese Friendship Hospital, Funding for scientific research on capital health development in 2018, The State Administration of traditional Chinese medicine

primary hypertension

 

 

Terminated

3

101

Europe

Amlodipine, Losartan, Atenolol

Ludwig-Maximilians - University of Munich, University of Edinburgh, Maastricht University Medical Center, UMC Utrecht, University of Oxford

Cerebral Small Vessel Diseases

07/22

07/22

Not yet recruiting

3

280

Europe

Losartan-Kalium, Prednisolon 10 mg, Prednisolon, Capsule, hard, Losartan-Kalium TAD® 12,5 mg Filmtabletten, Losartan-Kalium TAD® 25 mg Filmtabletten, Prednisolon 10 mg JENAPHARM®, Prednisolon 5 mg JENAPHARM®

Goethe University Frankfurt, Bayer AG

Inflammatory cardiovascular involvement due to COVID-19, defined by Cardiovascular magnetic resonance imaging, COVID-19 disease with cardiovascular inflammatory involvement, Diseases [C] - Virus Diseases [C02]

 

 

Recruiting

3

120

US

Losartan, Cozaar, Amlodipine, Placebo

Mayo Clinic, National Heart, Lung, and Blood Institute (NHLBI)

Coarctation of Aorta, High Blood Pressure

06/28

06/28

Recruiting

3

20000

Europe, Canada, Japan, US, RoW

Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir

UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore

Community-acquired Pneumonia, Influenza, COVID-19

02/26

02/28

Completed

2

288

 

Allisartan 80mg, orally taken once daily for 8 weeks ;Allisartan 160mg, orally taken once daily for 8 week ;Allisartan 240mg, orally taken once daily for 8 weeks ;losartan 50mg, orally taken once daily for 8 weeks

Peking University People's Hospital; Shanghai Allist Pharmaceuticals, Shanghai Allist Pharmaceuticals, Inc.

Mild to moderate essential hypertension

 

 

Ongoing

2

25

Europe

Losartan, LOSARTAN \"Hexal\" 50 mg - Filmtabletten, LOSARTAN \"Hexal\" 50 mg - Filmtabletten

Medizinische Universität Wien, Univ.Klinik für Kinder-und Jugendheilkunde

Marfan-Syndrom

 

 

Not yet recruiting

2

280

Europe

losartan, C09CA01, Tablet, losartan

Odense Universitets Hospital, Odense Universitetshospital

Aortic valve stenosis Aortastenose, Aortic valve narrowing Hovedpulsåreklapforsnævring, Diseases [C] - Cardiovascular Diseases [C14]

 

 

Active, not recruiting

2

168

US

FOLFIRINOX, Losartan, Nivolumab, SBRT, Surgery

Massachusetts General Hospital, Bristol-Myers Squibb, Stand Up To Cancer, Lustgarten Foundation

Pancreatic Cancer

07/22

06/27

Not yet recruiting

2

34

Europe

Losartan DOC 12,5 mg, LORTAAN, [Losartan DOC 12, 5 mg], [LORTAAN], Film-coated tablet, LOSARTAN DOC GENERICI - 12.5 MG COMPRESSE RIVESTITE CON FILM 21 COMPRESSE IN BLISTER PVC/PVDC/PELLICOLA DI ALLUMINIO, LORTAAN - 50 MG COMPRESSE RIVESTITE CON FILM 28 COMPRESSE

ISTITUTO SCIENTIFICO ROMAGNOLO PER LO STUDIO E LA CURA DEI TUMORI (IRST) S.R.L. IRCCS

Unresectable locally advanced, non-metastatic pancreatic cancer (as described by NCCN guidelines version 1.2022) Tumore del pancreas localmente avanzato non resecabile (come da linee guida NCCN versione 1.2022), Locally advanced non-metastatic and non-operable pancreatic cancer Tumore del pancreas localmente avanzato non metastatico e non operabile, Diseases [C] - Cancer [C04]

 

 

Recruiting

2

100

RoW

Sacubitril-valsartan, Entresto, Amlodipine-losartan, Amosartan

Samsung Medical Center

Aortic Valve Insufficiency

12/23

12/24

Recruiting

2

24

US

Losartan

Children's Hospital Medical Center, Cincinnati

Sickle Cell Disease, Diffuse Myocardial Fibrosis

12/25

12/26

Active, not recruiting

2

60

US

Capecitabine, Ro 09-1978/000, Xeloda, Fluorouracil, 5 Fluorouracil, 5 Fluorouracilum, 5 FU, 5-Fluoro-2,4(1H, 3H)-pyrimidinedione, 5-Fluorouracil, 5-Fluracil, 5-Fu, 5FU, AccuSite, Carac, Fluoro Uracil, Fluouracil, Flurablastin, Fluracedyl, Fluracil, Fluril, Fluroblastin, Ribofluor, Ro 2-9757, Ro-2-9757, Irinotecan Hydrochloride, Campto, Camptosar, Camptothecin 11, Camptothecin-11, CPT 11, CPT-11, Irinomedac, Irinotecan Hydrochloride Trihydrate, Irinotecan Monohydrochloride Trihydrate, U-101440E, Leucovorin Calcium, Adinepar, Calcifolin, Calcium (6S)-Folinate, Calcium Folinate, Calcium Leucovorin, Calfolex, Calinat, Cehafolin, Citofolin, Citrec, Citrovorum Factor, Cromatonbic Folinico, Dalisol, Disintox, Divical, Ecofol, Emovis, Factor, Citrovorum, Flynoken A, Folaren, Folaxin, FOLI-cell, Foliben, Folidan, Folidar, Folinac, Folinate Calcium, folinic acid, Folinic Acid Calcium Salt Pentahydrate, Folinoral, Folinvit, Foliplus, Folix, Imo, Lederfolat, Lederfolin, Leucosar, leucovorin, Rescufolin, Rescuvolin, Tonofolin, Wellcovorin, Losartan Potassium, Cozaar, losartan, Oxaliplatin, 1-OHP, Ai Heng, Aiheng, Dacotin, Dacplat, Diaminocyclohexane Oxalatoplatinum, Eloxatin, Eloxatine, JM-83, Oxalatoplatin, Oxalatoplatinum, RP 54780, RP-54780, SR-96669, Radiation Therapy, Cancer Radiotherapy, ENERGY_TYPE, Irradiate, Irradiated, Irradiation, Radiation, Radiation Therapy, NOS, Radiotherapeutics, Radiotherapy, RT, Therapy, Radiation, Resection, Surgical Resection, Diagnostic Imaging, Medical Imaging, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection

OHSU Knight Cancer Institute, Oregon Health and Science University

Pancreatic Adenocarcinoma, Stage 0 Pancreatic Cancer AJCC v8, Stage I Pancreatic Cancer AJCC v8, Stage III Pancreatic Cancer AJCC v8, Stage IV Pancreatic Cancer AJCC v8

04/25

10/25

Completed

2

223

US

Aerobic exercise, Perindopril, Losartan, HCTZ

University of Alabama at Birmingham, University of Colorado, Denver, AdventHealth Translational Research Institute

Hypertension, Aging, Sedentary Lifestyle

09/24

09/24

Recruiting

2

42

US

Losartan, Placebo

University of Kansas Medical Center

Cystic Fibrosis

05/27

10/27

Enrolling by invitation

2

165

Europe

Losartan

Kyrre Eeg Emblem

Glioblastoma, Brain Metastases

10/24

12/24

Recruiting

2

120

US

Anti-hypertensive agent: amlodipine, Anti-hypertensive agent: Chlorthalidone, Anti-hypertensive agent: Losartan, Home BP monitoring with cuffed device, Home BP monitoring with cuffed device + BP patch, Home BP monitoring with cuffed device + BP watch

University of California, San Francisco

Hypertension

05/25

05/27

Withdrawn

2

34

Europe

Losartan, Gemcitabine, Nab paclitaxel, Stereotactic Body Radiation Therapy

Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori

Pancreatic Cancer

12/24

12/24

Recruiting

2

180

US

Angiotensin II Receptor Blockers (ARBs, losartan) and Calcium Channel Blockers (CCB, amlodipine), PCP

Rong Zhang, National Institute on Aging (NIA), Texas Health Resources, Michigan State University

Cognitively Normal Older Adults, Hypertension, Subjective Cognitive Decline, Family History of Dementia

06/27

12/27

Terminated

1/2

8

US

Losartan, Placebo

James J. Irrgang, Brooke Army Medical Center, Wake Forest University

Hamstring Injury

12/22

12/22

Not yet recruiting

1/2

46

RoW

Ethosomal gel bearing losartan 5%, triamcinolone acetonide 10 mg/ml, TA 10 mg/ml

Yuni Eka Anggraini, Gadjah Mada University

Keloid

09/24

10/24

Active, not recruiting

1/2

100

US

Fisetin, Novusetin, 7,3',4'-flavon-3-ol, 3,3',4',7-tetrahydroxyflavone, Losartan, Losartan potassium, Placebo - Losartan, Placebo Oral Capsule, Placebo Fisetin

Steadman Philippon Research Institute, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Osteoarthritis, Knee

02/25

06/25

Not yet recruiting

1

36

 

NSW Health via the Hunter New England Local Health District

COVID-19

 

 

Completed

1

720

 

losartan 50mg, orally taken once daily for 12 week ;Allisartan 240mg, orally taken once daily for 12 weeks

Peking University People's Hospital; Shanghai Allist Pharmaceuticals, Inc., Shanghai Allist Pharmaceuticals, Inc.

Mild to moderate essential hypertension

 

 

Not yet recruiting

1

16

 

phase I: Allisartan; phase II: Losartan ;phase I: Losartan; phase II: Allisartan.

The Third Xiangya Hospital of Central South University; Shenzhen Salubris Pharmaceuticals Co., Ltd., Sponsor

Hypertension