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Journal, Surgery: Inter-Semispinalis Plane Block Versus General Anesthesia for Postoperative Analgesia in Posterior Cervical Spine Surgery: A Randomized Controlled Trial. (Pubmed Central) - May 10, 2024 The study assessed intraoperative fentanyl use, postoperative VAS pain levels, the need for rescue analgesia, and complications...Additionally, the ISPB group required less postoperative pethidine (20% vs. 64%, P = 0.002) and had a longer delay before requesting pethidine (hazard ratio 0.215, P = 0.001)...The ISPB is an effective analgesic technique for posterior cervical spine surgery, reducing opioid consumption, providing better pain control, and enhancing surgeon satisfaction without increasing complications. This approach has the potential to improve postoperative care and patient outcomes in this surgical population.
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Journal: Pharmacological labour pain interventions: South African midwives' perspective. (Pubmed Central) - Mar 15, 2024 The midwives were restricted to use Pethidine and Phenergan prescribed by doctors for labour pain relief, which disrupted labour pain management and obliged them either to wait for a physician or follow telephone instructions...Health facilities need to train and supply analgesics to midwives. Midwives ought to be familiar with pharmacological pain relievers.
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Patterns of Outpatient Opioid Prescriptions in Yinzhou, China: A Decade-Long Study (2011-2021) () - Mar 8, 2024 - Abstract #ISPOR2024ISPOR_238; This is the first report detailing outpatient opioid prescription duration, daily OME, and initial user patterns in China, revealing lower opioid use rates, average durations, and doses compared to North America, UK, and Australia, suggesting relatively safe opioid use in China. However, the presence of high-risk prescriptions highlights the need for enhanced monitoring of adverse events and pain assessment in outpatient settings.
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Trial completion date, Trial primary completion date, Surgery: Intrathecal Injection of Pethidine Plus Dexamethasone Versus Bupivacaine Alone (clinicaltrials.gov) - Mar 2, 2024 P2/3, N=46, Active, not recruiting, However, the presence of high-risk prescriptions highlights the need for enhanced monitoring of adverse events and pain assessment in outpatient settings. Trial completion date: Dec 2023 --> Dec 2024 | Trial primary completion date: Nov 2023 --> Nov 2024
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Trial completion date: CODEPAD (Collaborative Outcomes of DEpression and Pain Associated With Delivery) (clinicaltrials.gov) - Oct 4, 2023 P2/3, N=881, Active, not recruiting, FURL, combined with an S-UAS under LA, is a feasible option and provides satisfactory clinical outcomes for appropriately selected patients. Trial completion date: Dec 2023 --> Dec 2024
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Journal: Chinese mini percutaneous nephrolithotomy for upper urinary calculi under local infiltration anesthesia. (Pubmed Central) - Oct 3, 2023 Pethidine and Phenergan were intramuscularly injected 30 minutes preoperatively...Ropivacaine hydrochloride and lidocaine were injected into the whole percutaneous channel for local anesthesia...No severe complications were observed in any patients. Chinese MPCNL under LIA was a feasible option and achieved good outcomes in appropriately selected patients, and it may become the routine procedure for general patients.
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Trial completion date, Trial primary completion date, Surgery: Intrathecal Injection of Pethidine Plus Dexamethasone Versus Bupivacaine Alone (clinicaltrials.gov) - Jul 12, 2023 P2/3, N=46, Active, not recruiting, Further studies are needed to clarify the efficacy of dexmedetomidine to treat postanesthetic shivering. Trial completion date: Jul 2022 --> Dec 2023 | Trial primary completion date: Jun 2022 --> Nov 2023
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal, pethidine / Samaritan Pharma
Clinical, Journal: Reducing Opioid Use for Chronic Pain With a Group-Based Intervention: A Randomized Clinical Trial. (Pubmed Central) - May 27, 2023 In people with chronic pain due to nonmalignant causes, compared with usual care, a group-based educational intervention that included group and individual support and skill-based learning significantly reduced patient-reported use of opioids, but had no effect on perceived pain interference with daily life activities. isrctn.org Identifier: ISRCTN49470934.
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Clinical, Journal, Surgery: Effect of Intranasal Dexamethasone on the Incidence of Nausea and Vomiting After Adult Strabismus Surgery. (Pubmed Central) - Mar 21, 2023 The findings of the present study show that the intranasal use of dexamethasone with a dose of 8 mg compared to saline is associated with a decrease in PONV and postoperative pain, a decrease in the use of ondansetron and pethidine, and an increase in patient's satisfaction. Intranasal use of dexamethasone may be an effective and safe method, especially in cases where we do not have access to an intravenous line.
- |||||||||| Journal: Unusual Cause of Iatrogenic Calcifications. (Pubmed Central) - Feb 27, 2023
In addition, we reveal that cetirizine combined with midazolam and fentanyl may be an ideal strategy for treating severe burns. We report a case of extended and painful subcutaneous calcifications due to local injections with pethidine.
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Journal: Opioid Drug Detection in Hair Samples Using Polyoxometalate-Based Frameworks. (Pubmed Central) - Dec 29, 2022 Also, the ability of 1-4 (as the first polyoxomolybdate-containing frameworks) as sorbents for the extraction and quantitative determination of opioid drugs (morphine, methadone, and pethidine) was investigated by using dispersive micro-solid-phase extraction (D-μSPE) and high-performance liquid chromatography (HPLC). The method showed wide linear ranges in the range of 0.3 to 300 ng mg and low limits of detection (LODs) ranged from 0.1 to 0.2 ng mg of hair.
- |||||||||| pethidine / Samaritan, Chirocaine (levobupivacaine) / Purdue, AbbVie
Review, Journal: Transversus Abdominis Plane Block as a Strategy for Effective Pain Management in Patients with Pain during Laparoscopic Cholecystectomy: A Systematic Review. (Pubmed Central) - Dec 12, 2022 Ten different drug solutions (i.e., esmolol, Dexamethasone, Magnesium Sulfate, Ketorolac, Oxycodone, Epinephrine, Sufentanil, Tropisetron, normal saline, and Dexmedetomidine) were used as adjuvants...Instead of 0.25% Bupivacaine, 1% Pethidine could be used for the TAP block procedures...Analgesia with TAP blockade decreases opioid consumption significantly and provides effective analgesia. Further studies should identify the long-term effects of different TAP block procedures.
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Journal: A nationwide study on consumption of opioid analgesics in Iran from 2000 to 2018. (Pubmed Central) - Dec 6, 2022 Despite considerable growth in the consumption of opioid analgesics in Iran over nearly two decades, the consumption amount remained low, which might signal sub-optimal pain management. On the other hand, misuse and abuse seem to be the main reason behind significant increases in the consumption of opioid analgesics with less controlled distribution.
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