| levodopa/benserazide / Generic mfg. |
| Completed | 4 | 135 | | Artane oral 1-2mg, tid,+ Mirapexin, 0.25 mg/d at beginning, and add to 1.0 mg/d at the end of the second week; the dose will be added from the second weekend to the eighth week to 4. 5 mg/d(1.5 mg, tid); maintain the dose during 12 weeks and reduce the dose during 1-4weeks ;Artane oral 1-2mg, tid + Madopar, 62.5~500 mg, 2~4 times a day depends on the serious of disease + Mirapexin, the dose is same as group 1 ;Artane oral 1-2mg, tid+ Benserazide-Levodopa (Madopar), oral 62.5~500 mg, 2~4 times a day depends on the serious of the disease | First Affiliated Hospital of Xinjiang Medical University; First Affiliated Hospital of Xinjiang Medical University, Special-purpose fund for Evidence Based Medicine of First Affiliated Hospital of Xinjiang Medical University | Primary Parkinson's disease | | | | |
ChiCTR-TRC-09000507: fMRI research of characteristics of brain resting-state networks in patients with Parkinson's disease and intervention evaluation |
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| Completed | 4 | 135 | | none ;Scalp Acupuncture ;oral intake of 250 mg Madopar 60min before MRI scan | Guangdong Provincial Hospital of Chinese Medicine; Science and Technology Planned Project of Guangdong Province, Science and Technology Planned Project of Guangdong Province | Parkinson's disease | | | | |
2010-022363-35: Impact of Levodopa vs. Rotigotine on stress hormones and NGF in patients with Parkinson\'s Disease: A randomised, placebo-controlled double-blind trial. |
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| Ongoing | 4 | 24 | Europe | Levodopa / Benserazid, Rotigotin, LD / BE, RO, Madopar LT, Neupro, Madopar LT, Neupro | Clinical research lab for neurodegeneration, Dept. of Neurology, St. Josef-Hospital, Ruhr-University | Parkinson\'s disease | | | | |
2015-002027-26: TARGETING DOPAMINE TO TREAT IMPAIRED MEMORY CONSOLIDATION IN NEURODEGENERATIVE DISEASE: A DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL |
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| Ongoing | 4 | 90 | Europe | Ropinirole, Co-Beneldopa CR 25/100 (Madopar), Capsule, Ropinirole, Madopar CR | University of Bristol, Medical research council, Alzheimer's BRACE Bristol, Wellcome Trust, | Mild Cognitive ImpairmentMild Alzheimer's disease, Memory problem, Psychiatry and Psychology [F] - Psychological processes [F02] | | | | |
ChiCTR2000039201: Pharmacology of levodopa/carbidopa versus levodopa/benserazide in patients with parkinson's disease |
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| Recruiting | 4 | 20 | | phase I: levodopa/carbidopa; phase II: levodopa/benserazide ;phase I: levodopa/benserazide; phase II: levodopa/carbidopa | The Affiliated Brain Hospital of Nanjing Medical University (Nanjing Brain Hospital); Brain Hospital of Nanjing Medical University, self-raised | Parkinson's disease | | | | |
2020-002754-24: Clinical study in early PD patients to investigate the effect of Opicapone 50mg or Levodopa 100 mg in the treatment of motor fluctuations. Estudio clínico en pacientes con EP temprana para investigar el efecto de Opicapone 50 mg o Levodopa 100 mg en el tratamiento de las fluctuaciones motoras. |
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| Ongoing | 4 | 100 | Europe | Capsule, hard, Tablet, Ongentys 50 mg hard capsules, Madopar 125 mg T, tablets, SINEMET 100 mg + 25 mg tablets | Bial - Portela & Ca, S.A., Bial - Portela & Ca, S.A. | Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Parkinson's Disease (PD) Enfermedad de Parkinson (EP), Diseases [C] - Nervous System Diseases [C10] | | | | |
NCT04968613: Dopaminergic Mechanism of Memory Impairment in Parkinson's Disease |
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| Recruiting | 4 | 150 | RoW | Madopar monotherapy, senfrol monotherapy, placebo monotherapy | Peking University Third Hospital, Chinese Academy of Sciences | Parkinson Disease, Memory Impairment | 12/21 | 12/21 | | |
NCT04821687: A Study to Evaluate the add-on Efficacy and Safety of Opicapone 50 mg or an Extra Dose of L-DOPA 100 mg for the Treatment of Wearing-off in Patients With PD |
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| Completed | 4 | 169 | RoW | Ongentys 50mg, Madopar Tab. 125 or Perkin Tab. 25-100mg | SK Chemicals Co., Ltd. | Parkinson Disease | 08/22 | 08/22 | | |
NCT06115538: Comparison of Dopamin Level in Idiopathic Parkinson's Patients |
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| Enrolling by invitation | 4 | 96 | RoW | Levodopa, dopalevo madopar | Ankara Ataturk Sanatorium Training and Research Hospital | Parkinson Disease, Treatment Adherence | 10/24 | 04/25 | | |
2017-004006-18: The effect of inhaled levodopa on the recovery from off periods in patients with Parkinson's disease Het effect van inhaleerbare levodopa op het herstel van off-periodes bij patiënten met de ziekte van Parkinson |
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| Ongoing | 2 | 8 | Europe | Levodopa powder for inhalation, Levodopa Cyclops, Inhalation powder, Orodispersible tablet, Madopar 125 mg, orodispersible tablet | Pharmaceutical Technology and Biopharmacy, University of Groningen, Parkinson Vereniging, Martini Ziekenhuis Groningen, University of Groningen | Parkinson's disease is a progressive neurodegenerative disorder characterized by a lack of dopamine production due to the loss of dopamine producing cells in the substantia nigra. This lack of dopamine causes disruption of motor circuits in the brain resulting in motor function impairments like tremor, rigidity and bradykinesia. De ziekte van Parkinson is een progressieve neurodegeneratieve ziekte die wordt gekenmerkt door een tekortschietende dopamineproductie als gevolg van het verlies van dopamineproducerende cellen in de substantia nigra. Een tekort aan dopamine leidt tot de verstoring van motorische verbindingen in de hersenen. Dit resulteert in motorische functiestoornissen, zoals tremor, rigiditeit en bewegingstraagheid., Parkinson's disease is a movement disorder, caused by a lack of the neurotransmitter dopamine in the brain. The main symptoms are shaking, stiffness and slowness of movement. Bij de ziekte van Parkinson is er een tekort aan het stofje dopamine in de hersenen, wat zorgt voor verstoringen van de manier van bewegen. De klachten zijn trillen, stijfheid en traag bewegen., Diseases [C] - Nervous System Diseases [C10] | | | | |
| Active, not recruiting | 1/2 | 60 | Europe | Fecal Microbiota Transfer provided by Human Biome Institute, Pretreatment with rifaximin 3x 400 mg PO for 7 days, Assessment of levodopa/benserazide 100+25 mg tablet absorption before and 90 days after intervention: 20,40, 60, 90, 120, 150, 180 and 240 min since intervention- Area under the curve (AUC), Cmax, Assessment in clinical scales | Medical University of Warsaw, Human Biome Institute S.A. | Parkinson Disease | 10/23 | 12/24 | | |
ChiCTR-ORC-08000305: To Explore Brain Function Imaging Mechanism of Head Electro-acupuncture Treatment of Parkinson's Disease by PET Technology |
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| Completed | 1 | 30 | | Manage by head electro-acupuncture go with Madopar one month, to observe the therapeutic efficacy by PET and SPECT before the intervention then after the intervention. ;To take the Madopar one month, to observe the therapeutic efficacy PET and SPECT before the intervention then after the intervention. | Southern Medical University and Guang Dong Province Poeple's Hospital; Natural Science Foundation of Guangdong Province, Science and Technology Informantion Building, Project supported by the Natural Science Foundation of Guangdong Province, China | Parkinson's Disease | | | | |
ChiCTR2200058725: Research on Clinical Treatment Strategy and Mechanism of Parkinson's Disease Based on Nourishing Kidney and Activating Blood |
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| Not yet recruiting | 1 | 240 | | Bushen huoxue granule ;Madopar | Chinese PLA General Hospital; Chinese PLA General Hospital, Key project of National Natural Science Foundation of China | Parkinson's disease | | | | |
ChiCTR-TRC-12002150: Study on Optimization of The Comprehensive Therapeutic Plan for Parkinson's Disease in Different Stages |
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| Recruiting | N/A | 320 | | Xifeng Dingchan Pill ;Madopar tablets ;Xifeng Dingchan Pill, Madopar tablets and Piribedil tablets | Henan University of Traditional Chinese Medicine; The State Administration of Traditional Chinese Medicine, The Scientific Research of Special Traditional Chinese Medicine Trade of State Administration of Traditional Chinese Medicine | Parkinson's Disease | | | | |
ChiCTR-INR-17013201: Effect of Jin three-needle therapy on quality of life in patients of Parkinson Disease: a multicenter randomized controlled study |
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| Recruiting | N/A | 162 | | Acupuncture，Madopar ;Madopar | College of TCM, Southern Medical University; College of TCM, Southern Medical University, Supported by Science and Technology Planning Project of Guangdong Province, China | Parkinson Disease | | | | |
ChiCTR2100042625: Pilot study to evaluate the Pharmacokinetics of Levodopa and Benserazide Hydrochloride Tablets in healthy subjects. |
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| Recruiting | N/A | 18 | | R-R-T ; R-T-R ; T-R-R ;R-R-T ; R-T-R ; T-R-R | Dongyang Hengdian Hospital; Huayuan Pharmaceutical Co., Ltd, Huayuan Pharmaceutical Co., Ltd | Pharmacokinetic study | | | | |
ChiCTR2100043848: Pilot study to evaluate the pharmacokinetics of Levodopa and Benserazide Hydrochloride Tablets in healthy subjects. |
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| Recruiting | N/A | 9 | | Delivery order ;Delivery order ;Delivery order | Dongyang Hengdian hospital; Huayuan Pharmaceutical Co., Ltd, Huayuan Pharmaceutical Co., Ltd | Pharmacokinetic study | | | | |
ChiCTR1900027798: Optimization of clinical regimen of traditional Chinese medicine therapy for Parkinson's disease based on AMPK/SIRT3/GSK3β /LC3 signaling pathway |
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| Recruiting | N/A | 60 | | Xifeng dingchan pill combined with madopar and other Western medicines ;madopar and other Western medicines | The First Affiliated Hospital of Henan University of Traditional Chinese Medicine; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Special funds and matching funds | Parkinson's disease | | | | |
| Recruiting | N/A | 60 | RoW | single-dose madopar, single-dose propranolol, and single-dose placebo by order, single-dose madopar, single-dose placebo, and single-dose propranolol by order, single-dose propranolol, single-dose madopar, and single-dose placebo by order, single-dose propranolol, single-dose placebo, and single-dose madopar by order, single-dose placebo, single-dose propranolol, and single-dose madopar by order, single-dose placebo, single-dose madopar, and single-dose propranolol by order | Sir Run Run Shaw Hospital | Healthy | 03/24 | 09/24 | | |
| Recruiting | N/A | 90 | Europe | Levodopa administration, Madopar® tablets (Levodopa and Berazidhydrochlorid; Roche), Placebo administration, Placebo tablets (P-Tabletten White, Lichtenstein) | University Hospital Tuebingen, German Research Foundation, Uppsala University | Hormonal Changes, Menstrual Cycle | 12/25 | 12/25 | | |
ChiCTR2400085128: A clinical observational study of Yangpafang in the treatment of Parkinson's disease |
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| Not yet recruiting | N/A | 90 | | Basic drug therapy; Basic drug therapy+ Add 1/2 tablet of Levodopa and Benserazide Hydrochloride Tablets; Basic drug therapy+ Yangpafang | The First Affiliated Hospital of Anhui University of Chinese Medicine; The First Affiliated Hospital of Anhui University of Chinese Medicine, 2021 Anhui Province Outstanding Talents Cultivation Funding Project for Universities | Parkinson's disease | | | | |
ChiCTR2400084562: Clinical study of Madopar in the treatment of early stage steroid-induced osteonecrosis of the femoral head |
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| Not yet recruiting | N/A | 280 | | Madopar + Calcium carbonate + Vitamin D3; Calcium carbonate + Vitamin D3 | the First Affiliated Hospital of Soochow University; the First Affiliated Hospital of Soochow University, National Natural Science Foundation of China (82072425, 82272567) | Steroid-induced osteonecrosis of the femoral head | | | | |
