iloperidone / Generic mfg. 
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  • ||||||||||  iloperidone / Generic mfg.
    Review, Journal:  An Evaluation of Iloperidone for Mania in Bipolar I Disorder. (Pubmed Central) -  Jan 13, 2025   
    QTc prolongation is dose related, so drug interactions involving CYP2D6 and CYP3A4 inhibition can have serious consequences. In the pivotal trial, iloperidone was effective in treating adults with an acute manic or mixed episode associated with bipolar I disorder and was safe and well tolerated.
  • ||||||||||  lithium carbonate ER / Generic mfg., iloperidone / Generic mfg.
    Journal:  Iloperidone (Fanapt) - a new indication for bipolar disorder. (Pubmed Central) -  Jul 15, 2024   
    A personalized approach using low-risk medications when clinically feasible, and at the lowest efficacious dose, offers a promising path toward safer antipsychotic prescribing. No abstract available
  • ||||||||||  asenapine / Generic mfg., iloperidone / Generic mfg., lurasidone / Generic mfg.
    Preclinical, Journal:  The effect of new atypical antipsychotic drugs on the expression of transcription factors regulating cytochrome P450 enzymes in rat liver. (Pubmed Central) -  Jun 15, 2024   
    The changes in the expression of AhR, CAR, and PXR mostly correlate with alterations in the expression and activity of respective CYP enzymes found in our previous studies. Since these transcription factors are also engaged in the expression of phase II drug metabolism and drug transporters, changes in their expression may affect the metabolism of endogenous substrates and pharmacokinetics of concomitantly used drugs.
  • ||||||||||  Journal:  Genetic Variability of CYP4F2, CYP2D6, CYP2E1, and ACE in the Chinese Yi Population. (Pubmed Central) -  Jun 8, 2024   
    Furthermore, the differences in these variants might be related to the effectiveness and toxicity risk of using warfarin, iloperidone, cisplatin cyclophosphamide, and other drugs in the Yi population. Our data complement the pharmacogenomic information of the Yi population and provide theoretical guidance for their personalized treatment.
  • ||||||||||  iloperidone / Generic mfg.
    Clinical, Journal:  Efficacy and Safety of Iloperidone in Bipolar Mania: A Double-Blind, Placebo-Controlled Study. (Pubmed Central) -  Jan 18, 2024   
    P3
    The tolerability and safety profile of iloperidone in bipolar mania is consistent with previous clinical studies of patients with schizophrenia, and no new safety concerns were identified. Trial Registration: ClinicalTrials.gov identifier: NCT04819776; EudraCT: 2020-000405-83.
  • ||||||||||  Vraylar (cariprazine) / Mitsubishi Tanabe, Recordati, Gedeon Richter, AbbVie, Lodopin (zotepine) / Astellas, Serlect (sertindole) / Lundbeck, Abbott
    Retrospective data, Review, Adverse events:  Antipsychotic dose, dopamine D2 receptor occupancy and extrapyramidal side-effects: a systematic review and dose-response meta-analysis. (Pubmed Central) -  Nov 3, 2023   
    Almost all antipsychotics were associated with dose-dependent EPS with varied degrees and the maximum ORs ranged from OR?=?1.57 95%CI [0.97, 2.56] for aripiprazole to OR?=?7.56 95%CI [3.16, 18.08] for haloperidol at 30?mg/d...There was very low quality of findings for cariprazine, iloperidone, and zotepine, and no data for clozapine...In conclusion, we found that the risk of EPS increases with rising doses and differs substantially in magnitude among antipsychotics, yet exceptions were quetiapine and sertindole with negligible risks. Our data provided additional insights into the current DR therapeutic window for EPS.
  • ||||||||||  iloperidone / Generic mfg.
    Enrollment change:  REPRIEVE: Relapse Prevention Study in Patients With Schizophrenia (clinicaltrials.gov) -  Jul 17, 2023   
    P3,  N=635, Completed, 
    Our data provided additional insights into the current DR therapeutic window for EPS. N=303 --> 635
  • ||||||||||  Fanapt LAI (iloperidone depot injectable formulation) / Vanda
    Trial completion, Enrollment change:  A Study to Evaluate Iloperidone Long-acting Injection (LAI) for the Treatment of Schizophrenia (clinicaltrials.gov) -  Jun 29, 2023   
    P1,  N=42, Completed, 
    Recruiting --> Active, not recruiting | Trial completion date: May 2023 --> Aug 2023 | Trial primary completion date: May 2022 --> Sep 2022 Recruiting --> Completed | N=24 --> 42
  • ||||||||||  iloperidone / Generic mfg.
    Efficacy and Safety of Iloperidone in Acute Manic and Mixed Episodes Associated With Bipolar I Disorder (Regency Ballroom A-C) -  Jun 15, 2023 - Abstract #ISBD2023ISBD_128;    
    Iloperidone at the maximum dose of 24mg/day (12mg/day for CYP2D6 poor metabolizers) was significantly more effective than placebo in the treatment of acute manic or mixed episodes associated with bipolar I disorder. No new safety concerns were identified with this population and the overall tolerability and safety profile was consistent with that seen in previous studies in patients with schizophrenia.
  • ||||||||||  Lodopin (zotepine) / Astellas
    Retrospective data, Review, Journal:  Long-term efficacy of antipsychotic drugs in initially acutely ill adults with schizophrenia: systematic review and network meta-analysis. (Pubmed Central) -  May 9, 2023   
    In terms of overall symptoms, olanzapine was on average more efficacious than ziprasidone (standardized mean difference, SMD=0.37, 95% CI: 0.26-0.49), asenapine (SMD=0.33, 95% CI: 0.21-0.45), iloperidone (SMD=0.32, 95% CI: 0.15-0.49), paliperidone (SMD=0.28, 95% CI: 0.11-0.44), haloperidol (SMD=0.27, 95% CI: 0.14-0.39), quetiapine (SMD=0.25, 95% CI: 0.12-0.38), aripiprazole (SMD=0.16, 95% CI: 0.04-0.28) and risperidone (SMD=0.12, 95% CI: 0.03-0.21)...The differences between olanzapine and lurasidone, amisulpride, perphenazine, clozapine and zotepine were either small or uncertain...Concerning weight gain, the impact of olanzapine was higher than all other antipsychotics, with a mean difference ranging from -4.58 kg (95% CI: -5.33 to -3.83) compared to ziprasidone to -2.30 kg (95% CI: -3.35 to -1.25) compared to amisulpride. Our data suggest that olanzapine is more efficacious than a number of other antipsychotic drugs in the longer term, but its efficacy must be weighed against its side effect profile.
  • ||||||||||  ifenprodil tartrate / Chiba University Hospital
    Journal:  Pharmacological agents selectively acting on the channel moieties of TRPM6 and TRPM7. (Pubmed Central) -  Sep 10, 2022   
    Finally, the effects of iloperidone and VER155008 were found to be suitable for blocking native endogenous TRPM6 and TRPM7 in a collection of mouse and human cell models. Hence, the identification of iloperidone, ifenprodil, and VER155008 allows for the first time to selectively manipulate TRPM6 and TRPM7 currents.
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka, Nuplazid (pimavanserin) / Acadia Pharma
    Journal:  Comparative Safety Signal Assessment of Hospitalization Associated With the Use of Atypical Antipsychotics. (Pubmed Central) -  Jun 24, 2022   
    This cross-sectional assessment of data from FAERs (2004-2021) suggested that users of clozapine, olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone were more likely to report being hospitalized than users of other AAPs. Given that the FAERs database only contains spontaneous reports of AEs experienced by persons exposed to a drug but without information on exposed persons who did not have an event, a cohort study comparing hospitalizations among new users of individual AAPs against each other is needed to delineate these safety signals further.
  • ||||||||||  iloperidone / Generic mfg.
    Enrollment open:  A Study to Evaluate Iloperidone for the Treatment of Parkinson's Disease Psychosis (clinicaltrials.gov) -  Jun 3, 2022   
    P2,  N=24, Recruiting, 
    Given that the FAERs database only contains spontaneous reports of AEs experienced by persons exposed to a drug but without information on exposed persons who did not have an event, a cohort study comparing hospitalizations among new users of individual AAPs against each other is needed to delineate these safety signals further. Not yet recruiting --> Recruiting
  • ||||||||||  Psychiatry and Prolactin—a Review of Literature () -  May 5, 2022 - Abstract #APA2022APA_1023;    
    The ranking in order of Hyperprolactinemia presented by these authors: Paliperidone > Risperidone > Lurasidone > Ziprasidone > Iloperidone > Olanzapine > Asenapine > Placebo > Quetiapine > Aripiprazole...Cabergoline is preferable to Bromocriptine...Another type of treatment: Alternative and symptomatic management can also be attempted. Estrogens or testosterone for hypogonadism and/or decreased BMD, PDE5 inhibitors for erectile dysfunction, promoting healthy diet and physical exercise, avoiding tobacco and alcohol, for amenorrhea>6 months OCPs can be given to prevent osteoporosis, If low Vitamin D levels, then supplementation etc Psychiatrists need to work corroboratively with other specialties of Medicine and keep abreast of recent evidence base to manage this problem.
  • ||||||||||  iloperidone / Generic mfg.
    Journal:  Effects of iloperidone on hERG 1A/3.1 heterotetrameric channels. (Pubmed Central) -  Feb 8, 2022   
    The magnitude of weight gain and development of comorbidities were similar for patients with BD-I and SZ. Our results indicated that iloperidone concentration-dependently inhibited hERG 1A/3.1 currents by preferentially interacting with the open states of channels, but not by the disruption of membrane trafficking or surface membrane expression of hERG 1A and hERG 1A/3.1 channel proteins.
  • ||||||||||  Fanapt LAI (iloperidone depot injectable formulation) / Vanda
    Preclinical, Journal:  The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms. (Pubmed Central) -  Sep 22, 2021   
    At the same time, the level of GHRH, GH, and corticosterone decreased while that of T increased, with no changes in IL-2 and IL-6. The presented results indicate neuroendocrine regulation of the investigated CYP enzymes during chronic iloperidone treatment and suggest a possibility of pharmacokinetic/metabolic interactions produced by the neuroleptic during prolonged combined treatment with drugs that are substrates of iloperidone-affected CYP enzymes.
  • ||||||||||  iloperidone / Generic mfg.
    PK/PD data, Journal:  Pharmacokinetic and pharmacodynamic studies of iloperidone loaded lipid nanoemulsions via oral route of administration. (Pubmed Central) -  May 20, 2021   
    Physical stability testing indicated the stability of all LNEs and optimized LNE-IL4 was found stable for three months at both refrigerated (4 °C) and room temperature (25 °C). During in vivo studies in wistar rats, the optimized LNE showed 2.47 fold improvement in the oral bioavailability and superior (1.22 fold) pharmacodynamic activity when compared to marketed tablet suspension (Ilosure-4®) in suppressing the hyperlocomotor activity, being induced by MK-801 (Dizocilpine).
  • ||||||||||  asenapine / Generic mfg., risperidone / Generic mfg.
    [VIRTUAL] The Perils of Placebo: Developing Medications for Persons with Schizophrenia () -  Apr 13, 2021 - Abstract #ASCP2021ASCP_224;    
    Iloperidone was also approved for schizophrenia based on 2 out of 4 clinical trials, with disagreement between the US Food and Drug Administration and the manufacturer as to which studies were considered ‘positive’ for iloperidone...Be aware of the challenges in studying persons with schizophrenia in placebo-controlled trials 2. Understand some of the ways to increase the probability of differentiating study drug from placebo in clinical trials in persons with schizophrenia