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27 Diseases |  |
1 Trial |
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1 Trial |  |
100 News |  |
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- | levalbuterol / Generic mfg., epinephrine / Generic mfg.
Journal: Beta2-Adrenergic Suppression of Neuroinflammation in Treatment of Parkinsonism, with Relevance for Neurodegenerative and Neoplastic Disorders. (Pubmed Central) - Aug 31, 2024
Upon toxic activation with mononuclear antibodies, levalbuterol inhibited (1) the release of the eosinophil attractant chemokine eotaxin-1, which is implicated in CNS and peripheral inflammatory disorders, (2) elaboration of the tumor-promoting angiogenic factor VEGFa, and (3) release of the pro-inflammatory cytokine IL-13 from activated PBMCs. These observations suggest possible translation to Parkinson's disease, other neurodegenerative syndromes, and malignancies, via several mechanisms.
- | Kalydeco (ivacaftor) / Vertex
Journal: Development and preliminary validation of the personalized cystic fibrosis medication questionnaire (PCF-MQ). (Pubmed Central) - Jun 9, 2024
The PCF-MQ was correlated with another measure of general CF knowledge, but not health beliefs; because of the small sample size, this should be considered preliminary evidence of its validity. Advantages over existing CF knowledge measures include its practicality for use to help assess pwCF's knowledge about their prescribed regimen.
- | levalbuterol / Generic mfg.
Retrospective data, Journal, HEOR: Quantifying the Length of Stay and Economic Impact of Albuterol and Levalbuterol in Hospitalized Patients With Chronic Obstructive Pulmonary Disease: A Retrospective Cohort Study. (Pubmed Central) - May 28, 2024
Patients aged 60 or older were more likely to experience longer LOS and higher direct costs. Conclusion This retrospective cohort analysis supports that albuterol was associated with longer LOS and higher costs than levalbuterol.
- levalbuterol / Generic mfg., furosemide / Generic mfg., fluticasone propionate/salmeterol xinafoate inhalation powder / Generic mfg.
Coughing Up Chyle: A Rare Case of Pulmonary Lymphangiomatosis With Chyloptysis (San Diego Convention Center, Area G (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_4006;
Other treatments include diuretics to mobilize lymph from the airways, intravenous immunoglobulin for hypogammaglobulinemia and hypoproteinemia in cases with protein-losing enteropathy, and embolization of lesions. Due to its rarity and variance in presentation, each case report provides insight into how this condition may be successfully managed.
- levalbuterol / Generic mfg., ipratropium bromide / Generic mfg.
Levalbuterol Utilization in Hospitalized Patients (Bayou AB) - Aug 31, 2023 - Abstract #AARC2023AARC_292;
The large number of unindicated therapy was seen to be distinctly high in the study location, it can be assumed this is a common finding in many other facilities. There was also, no improvement of oxygen saturation post-delivery of the bronchodilator treatment.
- levalbuterol / Generic mfg.
Albuterol Shortage Patient Impact in a Pediatric Emergency Setting (Bayou AB) - Aug 31, 2023 - Abstract #AARC2023AARC_185;
There was also, no improvement of oxygen saturation post-delivery of the bronchodilator treatment. Switching from 0.5 mL albuterol ampules to 90
- IF I MOVE, DOES IT EXPLODE? LUNG BULLAE IN INTERSTITIAL LUNG DISEASE ASSOCIATED WITH ACUTE VIRAL PNEUMONIA (Convention Center Exhibit Hall) - Aug 4, 2023 - Abstract #CHEST2023CHEST_5068;
- Fasenra (benralizumab) / AstraZeneca
Pancreatitis Unveiled: A Case Report of IVIG-Induced Acute Pancreatitis (Exhibit Hall) - Jul 29, 2023 - Abstract #ACG2023ACG_577;
Case Description/ A 70-year-old female with a history of Eosinophilic Asthma on Benralizumab and IVIG, type 2 diabetes, cholecystectomy, and hyperlipidemia presented with right upper quadrant abdominal pain radiating to her back and bloating for 1 day...Medications were notable for Fexofenadine, Insulin, F luticasone Propionate nasal spray , Levalbuterol, and Omeprazole...She previously taken Fenofibrate but stopped 5 months ago...Subsequent workup with EUS is warranted to evaluate further for microlithiasis or other etiology. Figure: Acute intersitial pancreatitis observed on CT abdomen coronal and axial views
- levalbuterol / Generic mfg.
Hospital Level Variation in the Use of Bronchodilators in Patients With ARDS (Walter E. Washington Convention Center, Room 201 (Level 2)) - Mar 25, 2023 - Abstract #ATS2023ATS_2975;
The use of routine bronchodilators in ARDS varied widely based upon hospital admission. Though we found no association between a hospital
- ||| levalbuterol / Generic mfg., oseltamivir / Generic mfg., amoxicillin / Generic mfg.
Clinical: Hospital pharmacist here. Amoxicillin, augmentin, albuterol, levalbuterol, tamiflu, etomidate, albumin, anything with lidocaine in it. The list goes on and on. Scary times we are living in (Twitter) - Jan 3, 2023
- || levalbuterol / Generic mfg.
I literally just got an order for xopenex for the airway leak (Twitter) - Dec 14, 2022
- levalbuterol / Generic mfg.
BILATERAL PNEUMOTHORAX, PNEUMOMEDIASTINUM, AND SUBCUTANEOUS EMPHYSEMA: A CASE OF A RARE SYNCHRONOUS TRIAD IN ASTHMA EXACERBATION (Convention Center Exhibit Hall: Poster Area) - Aug 16, 2022 - Abstract #CHEST2022CHEST_1889;
Though we found no association between a hospital Our case demonstrates the importance of suspicion of barotrauma in patients with asthma attacks not responding adequately to therapy or developing worsening hypoxia which can be detrimental.
- Trend and Disparities in Cardiovascular Death in Amyloidosis: A Population-Based Retrospective Study in the United States From 1999 to 2020 (Zone 2, Science and Technology Hall, Level 200) - Aug 11, 2022 - Abstract #AHA2022AHA_4037;
Our case demonstrates the importance of suspicion of barotrauma in patients with asthma attacks not responding adequately to therapy or developing worsening hypoxia which can be detrimental. Abstract is embargoed at this time.
- | levalbuterol / Generic mfg.
Journal, HEOR: Levalbuterol versus albuterol for hospitalized patients with COPD in China: cost-utility and budget impact analysis. (Pubmed Central) - Aug 4, 2022
The sensitivity analysis indicated that the results were robust to the changes in input parameter values. Levalbuterol is a cost-saving option for treating hospitalized patients with COPD in China.
- |||| levalbuterol / Generic mfg., QVAR (beclomethasone dipropionate hydrofluoroalkane inhalation) / Teva
Reimbursement, Medicare: Medicare has been giving fits about covering my asthma medicines. So that. Insurance needs to cover ALL asthma medicines. Not just albuterol, but also levalbuterol. Not just pulmicort, but also QVAR. Etc. (Twitter) - May 4, 2022
- || levalbuterol / Generic mfg.
Xopenex (Twitter) - Mar 27, 2022
- levalbuterol / Generic mfg.
A Comparison of the Clinical and Economic Outcomes Associated with Short-Acting Bronchodilator Modes of Delivery Among Patients with Chronic Obstructive Pulmonary Disease (COPD) (In-person & Virtual) - Mar 8, 2022 - Abstract #ISPOR2022ISPOR_1613;
Results suggest that short-acting bronchodilator delivery method does not play a large role on patient outcomes. The mixed-use group may represent a group with poorly controlled COPD.
- | levalbuterol / Generic mfg.
New P4 trial, Adverse events: Levalbuterol Compared to Albuterol Regarding Cardiac Side Effects and Potassium Lowering Effects. (clinicaltrials.gov) - Dec 29, 2021
P4, N=30, Recruiting, Sponsor: University of Aleppo
- | Xopenex HFA (levalbuterol tartrate) / Sumitomo Dainippon
Reimbursement, Journal, Medicaid: Trends in Medicaid spending on inhalers in the United States, 2012-2018. (Pubmed Central) - Dec 16, 2021
The funders had no role in study design, data collection, and analysis, decision to publish, or preparation of the manuscript. The authors declare no conflicts of interest.
- || levalbuterol / Generic mfg.
Clinical, Journal: Incidence of supraventricular tachycardia after inhaled short-acting beta agonist treatment in children. (Pubmed Central) - Oct 2, 2021
No examined variables were associated with SABA-induced SVT. SVT is rare during hospital-based treatment for acute asthma using inhaled SABAs and has low morbidity and mortality.
- | levalbuterol / Generic mfg., ipratropium bromide / Generic mfg.
Clinical, Journal: Case report: Paradoxical responses to short acting beta-agonists in a pediatric patient. (Pubmed Central) - Sep 17, 2021
This case highlights the need to include paradoxical response to SABAs in the differential of a patient with poorly controlled asthma. It also provides an example of successful treatment of a pediatric patient with a class of medications previously reserved for adults with chronic obstructive pulmonary disease.
- ||| levalbuterol / Generic mfg.
They mutated into ASTHMA. But I soaked them in xopenex and stuffed them back in. (Twitter) - Jul 30, 2021
- | levalbuterol / Generic mfg.
Journal: Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase. (Pubmed Central) - Jun 10, 2021
Levalbuterol stabilized TH with reduced affinity compared to dopamine, the end-product and regulatory feedback inhibitor of TH, but without compromising enzymatic activity. Moreover, levalbuterol also delays the formation of TH aggregates and makes the enzyme less sensitive to dopamine, effects that could contribute to ameliorate disorders related to TH, such as THD and PD.
- montelukast / Generic mfg., levalbuterol / Generic mfg., fluticasone / Generic mfg.
[VIRTUAL] Landscape Of Clinical Studies In Exercise-induced Bronchoconstriction And Bronchospasm () - May 29, 2021 - Abstract #ACSM2021ACSM_1470;
Clinical studies in EIBC and EIBS utilize a wide variety of protocols and interventions with drugs and/or exercise. This heterogeneity may result in challenging comparisons among different studies testing similar hypotheses that could make real-world applications more complex.
- || levalbuterol / Generic mfg.
But is that flovent and levalbuterol? 🤣 (Twitter) - Mar 20, 2021
- levalbuterol / Generic mfg.
[VIRTUAL] Cost effectiveness of levalbuterol versus albuterol in cardiovascular intensive care unit (CVICU) patients () - Dec 26, 2020 - Abstract #ASHP2020ASHP_4462;
Primary endpoint will be analyzed using Student t test or Wilcoxon-Mann-Whitney U test with p value of less than 0.05 and confidence interval of 95 percent. Student t test or Wilcoxon-Mann-Whitney U test and Chi-squared or Fisher’s exact test will be utilized for continuous and categorical variables, respectively.
- levalbuterol / Generic mfg.
[VIRTUAL] Comparison of change in heart rate after administration of nebulized levalbuterol versus albuterol in the emergency department () - Dec 26, 2020 - Abstract #ASHP2020ASHP_3718;
The primary outcome and parametric secondary outcomes will be analyzed using analysis of variance. Indication of use will be analyzed using chi-square test.
- levalbuterol / Generic mfg.
[VIRTUAL] Mean change in heart rate with the use of albuterol versus levalbuterol () - Dec 26, 2020 - Abstract #ASHP2020ASHP_964;
The primary outcome will be reported in beats/min and assessed using a paired t-test. The secondary outcome of length of hospital stay will be reported as a mean ± standard deviation.
- | levalbuterol / Generic mfg.
Enrollment change: Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults (clinicaltrials.gov) - Oct 28, 2020
P=N/A, N=24, Completed, Sponsor: Children's Hospital Los Angeles
The secondary outcome of length of hospital stay will be reported as a mean ± standard deviation. N=40 --> 24
- levalbuterol / Generic mfg.
[VIRTUAL] SLEEP DISORDERED BREATHING FEATURES, EVOLUTION AND MANAGEMENT OF A PATIENT WITH ROHHAD SYNDROME () - Oct 12, 2020 - Abstract #CHEST2020CHEST_2572;
AVAPS improves ventilation and delays or may even prevent the need for surgical airway. Additionally, behavioral interventions, NIV titration, oxygen saturation above 95% and CO2 levels between 35-45 mmHg are measures that also seem to render a better prognosis.
- Entyvio (vedolizumab) / Takeda
[VIRTUAL] A Rare Manifestation of Cryptogenic Organizing Pneumonia in a Patient With Ulcerative Colitis Being Treated With an Anti-TNF Biosimilar () - Sep 15, 2020 - Abstract #ACG2020ACG_2311;
There have been case reports detailing COP in patients undergoing therapy with Infliximab, however, this is the first known case of COP with a biosimilar. The improvement in pulmonary symptoms with discontinuing Inflectra, which was controlling her UC, and starting vedolizumab to continue control of the UC with subsequent improvement in her COP suggests the biosimilar, Inflectra, as opposed to an extra intestinal manifestation of UC, was the cause of COP.
- Seebri Breezhaler (glycopyrronium bromide) / Novartis, Vectura, Sosei
[VIRTUAL] Possible Low-Value Medication Use by Persons with Idiopathic Pulmonary Fibrosis (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_6452;
One hundred seventeen (117, 28%) persons were first treated with a proton pump inhibitor following IPF diagnosis. Two hundred eleven (211, 50%) persons used a SABA.
- Seebri Breezhaler (glycopyrronium bromide) / Novartis, Vectura, Sosei
Possible Low-Value Medication Use by Persons with Idiopathic Pulmonary Fibrosis (PENNSYLVANIA CONVENTION CENTER, Hall D-E (200 Level), Area K) - Mar 15, 2020 - Abstract #ATS2020ATS_9137;
One hundred seventeen (117, 28%) persons were first treated with a proton pump inhibitor following IPF diagnosis. Two hundred eleven (211, 50%) persons used a SABA.
- | NN1213 / Novo Nordisk
Enrollment change, HEOR: COPD Assessment and Management Bundle Versus Usual Care (clinicaltrials.gov) - Nov 2, 2019
P=N/A, N=56, Completed, Sponsor: University of Illinois at Chicago
Two hundred eleven (211, 50%) persons used a SABA. N=122 --> 56
- Rituxan (rituximab) / Roche, Biogen
Dieulafoy’s Lesion and Granulomatosis With Polyangitis (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2702;
Further workup confirmed the diagnosis of granulomatosis with polyangiitis, and she was started on Rituxan and solumedrol...She was discharged to inpatient rehab, where she continued to receive Protonix, Rituxan, prednisone, Xopenex, and Pulmicort...EGD is an important tool for diagnosis and treatment of these lesions in the upper GI tract. Awareness of this potential association can help physicians anticipate and prevent fatal outcomes while inducing remission of this disease.
- | Xopenex (levalbuterol) / Sumitomo Dainippon
Journal: Paradoxical Bronchoconstriction with Short-Acting Beta Agonist. (Pubmed Central) - Apr 17, 2019
...PFTs were performed with levalbuterol (Xopenex) and albuterol (ProAir), yielding significant decrease in forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC)...Removal of excipients or use of anticholinergic inhalers improved respiratory function. Clinicians should be aware of paradoxical bronchospasm as an adverse effect with common inhaler formulations containing β₂-agonists and counsel patients accordingly in the appropriate clinical setting.
- ||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Trial completion: Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest) (clinicaltrials.gov) - Dec 15, 2017
P3, N=1902, Completed, Sponsor: Sanofi
Clinicians should be aware of paradoxical bronchospasm as an adverse effect with common inhaler formulations containing β₂-agonists and counsel patients accordingly in the appropriate clinical setting. Active, not recruiting --> Completed
- | levalbuterol / Generic mfg.
Trial completion, Enrollment change: Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults (clinicaltrials.gov) - Dec 8, 2017
P=N/A, N=40, Completed, Sponsor: Children's Hospital Los Angeles
Active, not recruiting --> Completed Enrolling by invitation --> Completed | N=60 --> 40
- ||||||| Dupixent (dupilumab) / Sanofi, Regeneron
Trial completion: LIBERTY ASTHMA VENTURE: Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma (clinicaltrials.gov) - Nov 21, 2017
P3, N=210, Completed, Sponsor: Sanofi
Enrolling by invitation --> Completed | N=60 --> 40 Active, not recruiting --> Completed
- |||| Dupixent (dupilumab) / Sanofi, Regeneron
Trial primary completion date: Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest) (clinicaltrials.gov) - Jun 16, 2017
P3, N=1858, Active, not recruiting, Sponsor: Sanofi
Active, not recruiting --> Completed Trial primary completion date: Nov 2017 --> Jul 2017
- ||||| Dupixent (dupilumab) / Sanofi, Regeneron
Enrollment closed: LIBERTY ASTHMA VENTURE: Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma (clinicaltrials.gov) - Apr 25, 2017
P3, N=180, Active, not recruiting, Sponsor: Sanofi
Trial primary completion date: Nov 2017 --> Jul 2017 Recruiting --> Active, not recruiting
- ||||| Dupixent (dupilumab) / Sanofi, Regeneron
Enrollment change: LIBERTY ASTHMA VENTURE: Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma (clinicaltrials.gov) - Mar 10, 2017
P3, N=180, Recruiting, Sponsor: Sanofi
Recruiting --> Active, not recruiting N=150 --> 180
- |||| Dupixent (dupilumab) / Sanofi, Regeneron
Trial primary completion date: LIBERTY ASTHMA VENTURE: Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma (clinicaltrials.gov) - Feb 10, 2017
P3, N=150, Recruiting, Sponsor: Sanofi
N=150 --> 180 Trial primary completion date: Nov 2017 --> Mar 2018
- levalbuterol / Generic mfg.
Trial primary completion date: Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults (clinicaltrials.gov) - Dec 28, 2016
P=N/A, N=60, Enrolling by invitation, Sponsor: Children's Hospital Los Angeles
Trial primary completion date: Nov 2017 --> Mar 2018 Trial primary completion date: Sep 2016 --> Sep 2017
- levalbuterol / Generic mfg.
Trial completion, HEOR: COPD Assessment and Management Bundle Versus Usual Care (clinicaltrials.gov) - Oct 25, 2016
P=N/A, N=122, Completed, Sponsor: University of Illinois at Chicago
Trial primary completion date: Sep 2016 --> Sep 2017 Active, not recruiting --> Completed
- |||| Dupixent (dupilumab) / Sanofi, Regeneron
Trial primary completion date: LIBERTY ASTHMA VENTURE: Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma (clinicaltrials.gov) - Oct 13, 2016
P3, N=150, Recruiting, Sponsor: Sanofi
Active, not recruiting --> Completed Trial primary completion date: Aug 2017 --> Nov 2017
- ||||| Dupixent (dupilumab) / Sanofi, Regeneron
Enrollment closed: Evaluation of Dupilumab in Patients With Persistent Asthma (Liberty Asthma Quest) (clinicaltrials.gov) - Aug 31, 2016
P3, N=1638, Active, not recruiting, Sponsor: Sanofi
Trial primary completion date: Aug 2017 --> Nov 2017 Recruiting --> Active, not recruiting
- levalbuterol / Generic mfg.
New trial: Change in Oxygen Consumption Following Inhalation Beta Agonists in Healthy Adults (clinicaltrials.gov) - Jun 16, 2016
P=N/A, N=60, Enrolling by invitation, Sponsor: Children's Hospital Los Angeles
- Xopenex HFA (levalbuterol tartrate) / Sumitomo Pharma
Trial primary completion date: A Study of Levalbuterol Tartrate HFA Inhalation Aerosol Metered Dose Inhaler (MDI) in Pediatric Subjects (clinicaltrials.gov) - Feb 3, 2016
P3, N=18, Terminated, Sponsor: Sunovion
Recruiting --> Active, not recruiting Trial primary completion date: Jul 2016 --> Dec 2014
- levalbuterol / Generic mfg.
Enrollment closed, Trial primary completion date, HEOR: COPD Assessment and Management Bundle Versus Usual Care (clinicaltrials.gov) - Dec 6, 2015
P=N/A, N=122, Active, not recruiting, Sponsor: University of Illinois at Chicago
Trial primary completion date: Jul 2016 --> Dec 2014 Enrolling by invitation --> Active, not recruiting | Trial primary completion date: Sep 2015 --> May 2016