- |||||||||| CoAprovel (irbesartan hydrochlorothiazide) / Sanofi, Erivedge (vismodegib) / Roche
Amlodipine-induced gingival hypertrophy, a less known side effect to dermatologists () - Jul 3, 2023 - Abstract #WCD2023WCD_6122;
BACKGROUND: Multiple factors may lead to Gingival hypertrophy (GH), including taking certain drugs (Phenytoin, Ciclosporin) but is uncommon for calcium channel blockers (CCB)...OBSERVATIONS: A 73-year-old man followed for basal cell carcinoma of the zygomatic region, touching the facial nerve, is in complete remission after partial excision and Vismodegib...We advise on replacing the CCB by Irbesartan / Hydrochlorothiazide and dental care...The prevalence of GH on calcium channel blocker varies according to the type of CCB, Amlodipine being estimated between 1.1 and 3.3% compared to 20% for Nifedipine...The earliest possible detection of GH is desirable. CCBs must therefore be known to dermatologists as being responsible for GH
- |||||||||| CoAprovel (irbesartan hydrochlorothiazide) / Sanofi
Insidious mole, an infrequent collision tumor () - Jul 3, 2023 - Abstract #WCD2023WCD_6084;
Immunohistochemistry with HMB45, marked positivity of neoplastic cells distributed throughout the thickness of the epidermis and surgical margins free of neoplasia. KEY MESSAGE: We present the first case reported worldwide of malignant melanoma in situ on a long-standing cherry angioma, an infrequent collision tumor, and its successful treatment using a Hughes Tarsoconjunctival flap and upper eyelid skin graft
- |||||||||| Rinvoq (upadacitinib) / AbbVie
Efficacy of Upadacitinib in Managing Refractory Symptomatic Dermographism () - Jul 3, 2023 - Abstract #WCD2023WCD_4419;
Upadacitinib can be a promising therapy for refractory cases of SD-CIndU with a rapid onset of action. This case highlights the potential of upadacitinib as a new treatment option for managing severe and recalcitrant forms of symptomatic dermographism
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: Characterization and Validation of a New 3D Printing Ink for Reducing Therapeutic Gap in Pediatrics through Individualized Medicines. (Pubmed Central) - Jun 28, 2023
The print cartridges were stable for up to 72 h after processing, and orodispersible printlets containing 6 mg to 24 mg of hydrochlorothiazide can be produced using the same print cartridge and during the same printing process with guaranteed content and chemical stability. The proposed workflow for the development of new printing inks containing APIs will allow the optimization of feedstock material and human resources in pharmacy or hospital pharmacy services, thus speeding up their development and reducing costs.
- |||||||||| hydrochlorothiazide / Generic mfg., sotalol / Generic mfg.
Journal: Biological Oxygen-dosed Activated Carbon (BODAC) filters - A bioprocess for ultrapure water production removing organics, nutrients and micropollutants. (Pubmed Central) - Jun 25, 2023
During the 2 years of observation, the filters consistently removed some OMPs such as hydrochlorothiazide, metoprolol, sotalol, and trimethoprim by at least 70 %. Finally, through microbial community analysis, we found that nitrifying and manganese-oxidizing bacteria were detected in high relative abundance on BODAC granules, supporting BODAC performance in removing OMPs and manganese as well as converting nitrogenous species in the water.
- |||||||||| Journal: Comparison of hospitalization costs for the same adverse reaction associated with different medications. (Pubmed Central) - Jun 8, 2023
Although we found few differences in the cost of hospitalization when comparing drugs with similar indications and the same adverse reaction, there were specific drug-ADR pairs that merit attention and consideration of interventions to improve safe and appropriate medication use. Evaluation of the effect of those interventions on the incidence of ADRs is an area for future study.
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: Outcomes of Surgical Treatment of Malar Mounds and Festoons. (Pubmed Central) - May 31, 2023
They are persistent in nature and require close-interval, long-term follow-up as additional injections and reoperations are warranted. Our approach to malar mound and festoon correction is safe and effective and provides long-lasting results.
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: What is the relationship between photosensitizing drugs and skin cancer? (Pubmed Central) - May 29, 2023
Recently, a warning related to increased skin cancer risk was added to the labeling of the popular diuretic hydrochlorothiazide. This article reviews some photosensitizing medications and describes patient education on preventing and recognizing photosensitivity reactions and skin cancer.
- |||||||||| Keytruda (pembrolizumab) / Merck (MSD)
Rare Case of Pembrolizumab Induced Primary Hypoparathyroidism (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_2428;
After 10 months, he developed immune mediated hypothyroidism treated with levothyroxine...Hydrochlorothiazide (HCTZ) added as calcium remained low... It is important clinicians be aware of the risk for hypocalcemia and its unpredictable presentation to help with timely recognition and management.
- |||||||||| Lantus (insulin glargine) / Sanofi
Pheochromocytoma - A Silent Killer (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1956;
Interestingly, prior to admission, patient's BP was not controlled (ranges 140s-170s/60s-90s) even on three antihypertensives (Hydrochlorothiazide (HCTZ), Valsartan, & Amlodipine)...On discharge he was maintained on Prazosin, valsartan, and amlodipine for hypertension and Lantus 28-unit qAM along with Aspart 4-unit premeal for diabetes. This case highlights the importance of familiarity with the different presentations of pheochromocytoma (i.e. uncontrolled and challenging hyperglycemia, persistent uncontrolled hypertension, without any obvious physical signs) to healthcare providers as it can be mistreated if left undiagnosed.
- |||||||||| candesartan cilexetil / Generic mfg., hydrochlorothiazide / Generic mfg., metoprolol succinate / Generic mfg.
Cystic Pheochromocytoma (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1955;
Uniform guidelines for surgical management of these lesions have not been well established. Patients with symptoms such as abdominal pain, biochemical abnormalities, complications such as pressure on adjacent organs or rupture with cyst content leakage, suspicion of malignancy, cysts larger than 5 cm or increasing size of the cyst should be considered for surgical intervention (5, 6).In patients presenting with abdominal pain and hypertension who are found to have a cystic adrenal lesion pheochromocytoma should be considered.
- |||||||||| Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly, Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
Treating Pheochromocytoma for Glycemic and Blood Pressure Control (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1933;
Her medical regimen consisted of linagliptin 5mg daily, metformin 1000mg twice daily, insulin glargine 40 units daily, losartan 50mg twice daily, amlodipine 10mg daily and hydrochlorothiazide 25mg daily...Additionally, UACR improved to 1352.94 mg/g and empagliflozin was added to avoid diabetic kidney progression...Detection of resistant HTN should had prompted earlier detection of pheochromocytoma in this patient. As physicians, we should be aware of endocrine causes of diabetes and HTN, such as Cushing syndrome, Acromegaly, Primary Aldosteronism, and Pheochromocytoma and Paraganglioma, as treating these may lead to better quality of life, and less disease-related complications and polypharmacy.
- |||||||||| Henletor (torsemide) / Orchid
A Case of Nephrotic Syndrome Presenting With Hyperlipidemia. (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1897;
The abnormalities of serum lipids seen in nephrotic syndrome are largely due to the impaired clearance rather than biosynthesis and can lead to multiple complications. Making the diagnosis of nephrotic syndrome is very important as it is associated with significant cardiovascular and renal disease.
- |||||||||| Prolia (denosumab) / Amgen, Daiichi Sankyo
Complicated Course and Management after Denosumab Discontinuation: A Case Report (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_1831;
Past bone health history was notable for treatment with alendronate for approximately 11 years as a premenopausal woman...Labs were only notable for hypercalciuria for which hydrochlorothiazide (HCTZ) was initiated...Thus in 1/2022, she started romosozumab (ROMO) in an attempt to prevent new VFx...In 5/2022, she received a dose of zoledronic acid (ZOL)...In addition, this report does not support transitioning from long-term DMAb to ROMO in order to prevent a rapid increase in the bone resorption marker, CTX. Rather, treatment with ZOL every 12 weeks based on frequent CTX monitoring successfully maintained BMD stable following long-term DMAb discontinuation.
- |||||||||| A Case of Pheochromocytoma Initially Presenting as Takotsubo-like Cardiomyopathy (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_823;
Background: Takotsubo-like cardiomyopathy (TCM) is a known but rarely seen clinical complication associated with pheochromocytoma that is important to recognize.Case Presentation: A 68 year old woman with a history of hypertension on verapamil, lisinopril-hydrochlorothiazide, clonidine, hyperlipidemia, asthma, and chronic kidney disease presents for nausea and vomiting associated with pressure like chest pain...She was discharged home on beta blocker and losartan therapy...Alpha blocker tamsulosin was initiated and beta blocker therapy was discontinued...Earlier recognition of a potential pheochromocytoma would also have discouraged the use of a beta blocker initially until pheochromocytoma was ruled out. An individualized, multidisciplinary approach helps lead to a timely diagnosis and appropriate treatment decisions for these rare tumors.
- |||||||||| Olumiant (baricitinib) / Incyte, Eli Lilly
COVID-19 Pneumonia and Primary Hyperparathyroidism Exacerbation (ENDOExpo) - May 11, 2023 - Abstract #ENDO2023ENDO_737;
However, a significant rise in Ca approaching parathyroid crisis range was seen shortly thereafter, despite normalization of Cr.Whereas hypocalcemia has been noted in most cases of Ca dysfunction associated with COVID-19 infection, in this case, we postulate that the COVID-19 infection may have triggered parathyroiditis, thus exacerbating the underlying PHPT.One such mechanism is the use of receptors like angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) by COVID-19 virus, which are found on endocrine glands including the parathyroid. Similarly, COVID-19 virus exerts its inflammatory effects using IL-6, which is also a key cytokine that causes hypercalcemia by stimulating bone resorption.Furthermore, COVID-19 infection is notorious for causing nausea/vomiting, and diarrhea, culminating in dehydration which worsens hypercalcemia.It is therefore necessary that physicians foresee impending complications of COVID-19 infection with concurrent parathyroid disease and take early steps to prevent and treat them.
- |||||||||| hydrochlorothiazide / Generic mfg.
Trial completion date, Trial primary completion date, HEOR: HYDRO-PROTECT: HYDROchlorothiazide to PROTECT Polycystic Kidney Disease Patients and Improve Their Quality of Life (clinicaltrials.gov) - May 9, 2023
P3, N=300, Not yet recruiting,
Similarly, COVID-19 virus exerts its inflammatory effects using IL-6, which is also a key cytokine that causes hypercalcemia by stimulating bone resorption.Furthermore, COVID-19 infection is notorious for causing nausea/vomiting, and diarrhea, culminating in dehydration which worsens hypercalcemia.It is therefore necessary that physicians foresee impending complications of COVID-19 infection with concurrent parathyroid disease and take early steps to prevent and treat them. Trial completion date: Dec 2028 --> Jul 2029 | Trial primary completion date: Feb 2027 --> Jul 2028
- |||||||||| Journal: Human footprint on the water quality from the northern Antarctic Peninsula region. (Pubmed Central) - May 2, 2023
Following risk assessment, citalopram, clarithromycin, nicotine, venlafaxine, and hydrochlorothiazide should be considered of concern in this area, and hence, included in future monitoring of Antarctic waters and biota. This work provides evidence on the fact that current measures taken to protect the pristine environment of Antarctica from human activities are not effective to avoid CEC spread in its aquatic environment.
- |||||||||| hydrochlorothiazide / Generic mfg.
Cerebral/Renal Salt Wasting: Typical Cases and Pathophysiology (Room 1) - Apr 15, 2023 - Abstract #KSN2023KSN_55;
HPRWSP can serve as a biomarker for RSW to simplify diagnosis of RSW on first encounter, direct proper therapy, improve clinical outcomes and identifying a new syndrome of RSW in AD. Development of an inhibitor to HPRWSP will more effectively treat patients with RSW.
- |||||||||| terbinafine HCL / Generic mfg.
A Rare Side Effect of Terbinafine () - Apr 6, 2023 - Abstract #AFMRSER2023AFMR_SER_14;
Rhabdomyolysis with ensuing acute kidney injury is not a well-known adverse effect of terbinafine. The purpose of this case report is to ensure providers are aware of this potential effect and monitor creatinine levels in patients taking this medication.
- |||||||||| hydrochlorothiazide / Generic mfg., paracetamol / Generic mfg., celecoxib oral / Generic mfg.
Journal: Influence of formulation variables on the processability and properties of tablets manufactured by fused deposition modelling. (Pubmed Central) - Mar 25, 2023
Furthermore, PVA presenting the fastest swelling rate, promoted the fastest drugs' releases in comparison with the other polymers studied. Overall, the study enabled the identification of the key factors affecting the properties of printed tablets, with the proposal of a model that has valued the relative contribution of each factor to the overall performance of tablets.
- |||||||||| High-dose Insulin Therapy in Management of Refractory Shock From Multiple Drug Overdose (Walter E. Washington Convention Center, Area A, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_7915;
Management of vasodilatory shock with multiple pressors and other therapies, such as methylene blue, may not be adequate necessitating extracorporeal support. Our patient received > 10L/day and early CVVHD initiation was required to prevent fluid overload.
|
