hydrochlorothiazide / Generic mfg. 
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  • ||||||||||  hydrochlorothiazide / Generic mfg.
    Journal:  Unveiling polyamorphism and polyamorphic interconversions in pharmaceuticals: the peculiar case of hydrochlorothiazide. (Pubmed Central) -  Oct 27, 2023   
    Furthermore, polyamorphs I and III could be converted into polyamorph II after QC, while polyamorph II did not convert to any other polyamorph after SD or BM. Molecular dynamics simulations show that HCT dihedral angle distributions are significantly different for polyamorphs I and II, which is postulated as a possible explanation for their different physicochemical properties.
  • ||||||||||  Farxiga (dapagliflozin) / Ono Pharma, AstraZeneca
    Trial completion date, Trial primary completion date:  Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients (clinicaltrials.gov) -  Oct 23, 2023   
    P4,  N=32, Not yet recruiting, 
    Molecular dynamics simulations show that HCT dihedral angle distributions are significantly different for polyamorphs I and II, which is postulated as a possible explanation for their different physicochemical properties. Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Jul 2023 --> Dec 2024
  • ||||||||||  hydrochlorothiazide / Generic mfg.
    Journal:  HTLV-1 Presenting as an Incidental Finding after a Cosmetic Procedure. (Pubmed Central) -  Oct 3, 2023   
    The patient had a medical history of significantly well-controlled hypertension for 4 years treated with hydrochlorothiazide and amlodipine...Physical examination failed to evidence lymph-adenopathy or masses. The patient denied weight loss, night sweats, or fever; however, due to her Caribbean heritage, adult T-cell leukemia/ lymphoma was considered and submitted for further histologic workup.
  • ||||||||||  CoAprovel (irbesartan hydrochlorothiazide) / Sanofi
    Journal:  Alcohol consumption and antihypertensive treatment effect in male patients with hypertension. (Pubmed Central) -  Sep 28, 2023   
    fluminea was the species with the highest detection frequency, and P. clarkii had the highest average concentrations, so its use is prioritized for biomonitoring studies. Alcohol drinkers compared with non-drinkers required a higher dosage of antihypertensive drug treatment to achieve similar blood pressure control.
  • ||||||||||  chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
    Journal:  Chlorthalidone No Better Than Hydrochlorothiazide for Hypertension. (Pubmed Central) -  Sep 23, 2023   
    Alcohol drinkers compared with non-drinkers required a higher dosage of antihypertensive drug treatment to achieve similar blood pressure control. No abstract available
  • ||||||||||  hydrochlorothiazide / Generic mfg., lisinopril / Generic mfg.
    PK/PD data, Journal:  Pharmacokinetic and Bioequivalence Study of Lisinopril/Hydrochlorothiazide Tablet Under Fasting and Postprandial Conditions in Healthy Chinese Subjects. (Pubmed Central) -  Sep 18, 2023   
    Pharmacokinetic results indicate a large food effect for lisinopril, meaning that there is a loss of approximately 20%-25% of systemic exposure from fasting to postprandial administration for both preparations. The study demonstrated that a single oral dose of generic lisinopril/hydrochlorothiazide is bioequivalent to the reference product and well tolerated, with no significant adverse events observed, and that both products are similarly safe in a cohort of healthy Chinese male and female participants, following administration under fasting and postprandial conditions.
  • ||||||||||  hydrochlorothiazide / Generic mfg.
    Journal:  Synthesis and characterization of TiO-carbon filter materials for water decontamination by adsorption-degradation processes. (Pubmed Central) -  Sep 16, 2023   
    The elaborated heterostructures were compared with commercial TiO materials for their ability to degrade five emerging contaminants (caffeine, hydrochlorothiazide, saccharin, sulfamethoxazole, and sucralose)...The reuse of the materials was tested and showed no reduction in efficiency after four removal/regeneration cycles. Overall, this study presents novel TiO/AC heterostructures with increased photocatalytic efficiency that can serve as an efficient material for removing contaminants at large scales (e.g., water treatment plants).
  • ||||||||||  hydrochlorothiazide / Generic mfg., clonidine / Generic mfg.
    Trial completion date, Trial termination:  ATLAS: Anxiety-mediated Impairments in Large Elastic Artery Function and the Autonomic Nervous System (clinicaltrials.gov) -  Sep 6, 2023   
    P4,  N=30, Terminated, 
    Overall, this study presents novel TiO/AC heterostructures with increased photocatalytic efficiency that can serve as an efficient material for removing contaminants at large scales (e.g., water treatment plants). Trial completion date: Dec 2023 --> Jun 2023 | Active, not recruiting --> Terminated; Funding ended
  • ||||||||||  hydrochlorothiazide / Generic mfg.
    Onset of vitiligo in a patient after phototoxicity induced by hydrochlorothiazide (e-Poster Hall) -  Aug 30, 2023 - Abstract #EADV2023EADV_4265;    
    Further studies should be carried out to provide greater insight into this complex association. https://www.sciencedirect.com/topics/medicine-and-dentistry/subacute-cutaneous-lupus-erythematosus#https://www.sciencedirect.com/topics/medicine-and-dentistry/pseudoporphyria ##11 OCTOBER - 14 OCTOBER 2023 POWERED BY M-ANAGE.COM
  • ||||||||||  methotrexate / Generic mfg.
    Fixed Drug Eruption to methotrexate: A Case Report With a Unique Presentation (e-Poster Hall) -  Aug 30, 2023 - Abstract #EADV2023EADV_2296;    
    The localization of FDE plaques in injection sites is an uncommon presentation that has been documented with other medications. It is important to recognize the features of FDE to make an accurate diagnosis, prevent further exposure to the offending drug, and improve patient outcomes.
  • ||||||||||  amlodipine/valsartan / Generic mfg., chlorthalidone / Generic mfg., candesartan cilexetil / Generic mfg.
    Enrollment open:  OPTION TREAT: Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT (clinicaltrials.gov) -  Aug 24, 2023   
    P3,  N=698, Recruiting, 
    It is important to recognize the features of FDE to make an accurate diagnosis, prevent further exposure to the offending drug, and improve patient outcomes. Not yet recruiting --> Recruiting
  • ||||||||||  hydrochlorothiazide / Generic mfg., tolvaptan / Generic mfg.
    Medical Management of Multifactorial Hyponatremia in the Perioperative Period (Exhibit Hall) -  Aug 23, 2023 - Abstract #ASA2023ASA_4976;    
    Despite holding his diuretic and restricting daily fluid intake to 2 liters, his sodium increased to just 128. He was then started on tolvaptan with further improvement in sodium to 134, allowing him to undergo an uneventful lumbar laminectomy.
  • ||||||||||  dapsone / Generic mfg., hydrochlorothiazide / Generic mfg.
    Journal:  Metal-organic framework based drug delivery systems as smart carriers for release of poorly soluble drugs hydrochlorothiazide and dapsone. (Pubmed Central) -  Aug 9, 2023   
    The release study of these drugs was carried out under simulated physiological conditions that shows sustained release of the drug molecules from the MOFs up to 72 h. Cell viability studies through MTT assays show insignificant cytotoxicity signalling biocompatibility of the proposed DDSs. Our investigations suggest MIL-100(Fe) and MIL-53(Fe) are potential DDSs for enhancing the performance of poorly soluble drugs HCT and DAP.
  • ||||||||||  Benign Capillary Hemangioma Masquerading as Colon Cancer (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3568;    
    Solitary bleeding lesions such as this case should be managed with surgical resection. Figure: Figure 1: (A) Colonoscopy showing a 3-cm friable mass at the splenic flexure, suggestive of malignancy, and (B) Histopathological examination (H&E stain, 100x) of the surgical specimen showing closely packed thin-walled capillaries, consistent with a capillary hemangioma.
  • ||||||||||  hydrochlorothiazide / Generic mfg.
    Hydrochlorothiazide Induced Small Bowel Ulceration (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_3122;    
    Early diagnosis is important to prevent progression of inflammation and potential for small bowel obstruction. Figure: A : 2 cm Ulcer in the Terminal Ileum ; B: Healthy Terminal Ileum without ulcerations
  • ||||||||||  Carafate (sucralfate) / AbbVie
    Unmasking Cameron Lesions: A Rare Etiology of Massive Upper Gastrointestinal Bleeding and Hemodynamic Instability (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_2526;    
    These strategies should consider the patient's general health, bleeding intensity, and the potential surgical risks and benefits involved. Figure: The Images present a detailed visualization of Cameron ulcers occurring in conjunction with a hiatal hernia, shedding light on their coexistence and interaction within the gastrointestinal system.
  • ||||||||||  hydrochlorothiazide / Generic mfg., furosemide / Generic mfg.
    A Case of Pseudomelanosis Duodeni: Incidental Finding or Related to GI Bleed? (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_1058;    
    Histopathological biopsies would rule out other causes but no guidelines regarding management or the need for follow up have been established. Figure: Endoscopic imaging showing speckled pigmentation pattern in duodenum
  • ||||||||||  hydrochlorothiazide / Generic mfg., lisinopril / Generic mfg.
    An Interesting Case of Microscopic Colitis Flare Induced by Diuretics and ACE-I (Exhibit Hall) -  Jul 29, 2023 - Abstract #ACG2023ACG_759;    
    This could lead to some mucosal injury and cause an acute flare of the MC. Upon literature review there are currently no case reports that indicate a similar presentation to this patient, however, there are very few reported cases of ACE-I-induced MC flare.
  • ||||||||||  Postoperative Cognitive Dysfunction In The Elderly (South: Hall D-7) -  Jul 20, 2023 - Abstract #ASA2023ASA_2508;    
    Her medications include hydrochlorothiazide, simvastatin and metformin...In the postoperative period she is in considerable pain and receives hydromorphone patient-controlled analgesia (PCA) for pain management...However, on her outpatient follow up visit 4 weeks later she is noted to have difficulty with recall. 10)Are there any other medication options for POCD?11) Does POCD affect patient outcomes?
  • ||||||||||  Neuroanesthesia Myths And Dogmas (South: Hall D-7) -  Jul 20, 2023 - Abstract #ASA2023ASA_1840;    
    10)Are there any other medication options for POCD?11) Does POCD affect patient outcomes? The patient
  • ||||||||||  Postoperative Cognitive Dysfunction In The Elderly (South: Hall D-7) -  Jul 20, 2023 - Abstract #ASA2023ASA_957;    
    Her medications include hydrochlorothiazide, simvastatin and metformin...In the postoperative period she is in considerable pain and receives hydromorphone patient-controlled analgesia (PCA) for pain management...However, on her outpatient follow up visit 4 weeks later she is noted to have difficulty with recall. 10)Are there any other medication options for POCD?11) Does POCD affect patient outcomes?
  • ||||||||||  Neuroanesthesia Myths And Dogmas (South: Hall D-7) -  Jul 20, 2023 - Abstract #ASA2023ASA_54;    
    10)Are there any other medication options for POCD?11) Does POCD affect patient outcomes? The patient
  • ||||||||||  chlorthalidone / Generic mfg., hydrochlorothiazide / Generic mfg.
    Review, Journal:  Arterial Hypertension-clinical trials update 2023. (Pubmed Central) -  Jul 14, 2023   
    The hypertension trials update summarizes the most important clincal trials on hypertension research in 2022 and early 2023. CTD - chlorthalidone, CV - cardiovascular, HCT - hydrochlorothiazide, SBP - systolic blood pressure, RDN - renal denervation *depicts systolic blood pressure only.