- |||||||||| hydrochlorothiazide / Generic mfg.
[VIRTUAL] IDIOPATHIC HYPERCALCIURIA AND BONE IMPAIRMENT: REPORT OF A CASE () - Feb 24, 2021 - Abstract #ICE2021ICE_341;
In the context of a likely Secondary Hyperparathyroidism, treatment based on Vitamin D is entitled, correcting PTH levels. During treatment, bone densitometry shows a fast improvement, which may be associated with hydrochlorothiazide and bisphosphonates treatment.
- |||||||||| hydrochlorothiazide / Generic mfg., furosemide / Generic mfg., amiodarone / Generic mfg.
Journal: Fast and furious: flecainide toxicity presenting as monomorphic ventricular tachycardia. (Pubmed Central) - Feb 23, 2021
A 63-year-old woman on flecainide, furosemide, and triamterene-hydrochlorothiazide presented with weakness and diarrhoea...She was haemodynamically stable and treated with aggressive electrolyte repletion and amiodarone...We emphasise the importance of close outpatient monitoring of electrolytes in a patient on diuretics and flecainide to prevent life-threatening arrhythmias. We discourage use of multiple diuretics in patients taking flecainide.
- |||||||||| irbesartan / Generic mfg.
Journal: Irbesartan (a comprehensive profile). (Pubmed Central) - Feb 20, 2021
This article discusses, by a critical comprehensive review of the literature on irbesartan in terms of its description, names, formulae, elemental composition, appearance, and therapeutic uses. The article also discusses the methods for preparation of irbesartan, its physical-chemical properties, analytical methods for its determination, pharmacological-toxicological properties, and dosing information.
- |||||||||| hydrochlorothiazide / Generic mfg.
[VIRTUAL] VAPING CARBOXY-TETRAHYDROCANNABINOL UNMASKS BRUGADA PATTERN AND INDUCES VENTRICULAR FIBRILLATION IN BRUGADA SYNDROME (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_4134;
We report a case of unmasked Type-1 Brugada pattern (BrP) presenting with ventricular fibrillation that was induced by a combination of carboxy-tetrahydrocannabinol (THC) vaping and hypokalemia.Case: A 48 year-old male with a past medical history of hypertension treated with hydrochlorothiazide and back pain controlled with carboxy-THC vaping presented with ventricular fibrillation... This case highlights the diagnostic challenge in BrS and the combination of hypokalemia and carboxy-THC as potential agents that unmask Type-1 BrP and trigger arrhythmic events.
- |||||||||| labetalol / Generic mfg.
[VIRTUAL] RESISTANT HYPERTENSION IN A PATIENT WITH HYPOKALEMIA AND ADRENAL MASS (eAbstract site) - Feb 17, 2021 - Abstract #ACC2021ACC_4008;
Clinical features of hypercortisolism and hyperadrenalism from adrenocortical cancer may be difficult to differentiate as this type of hypercortisolism may not show typical facies of Cushing's syndrome, and may cause hypokalemia from non aldosterone mineralocorticoid release. Diagnosis of exact cause is however important in initiating appropriate treatment and achieving control or potential cure of HTN.
- |||||||||| hydrochlorothiazide / Generic mfg.
[VIRTUAL] A Novel Case of Hyperinsulinemic Hypoglycemia in a Neonate With SARS-CoV-2 Infection (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1581;
Pt was started on Diazoxide 10mg/kg/day divided q8h, and hydrochlorothiazide (HCT) 5mg/day...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| NTX-303 / PinotBio
[VIRTUAL] Paget ‘s Disease: Not So Typical for Atypical Femur Fracture (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_938;
Her medications were primidone, levothyroxine, lisinopril-hydrochlorothiazide, and vitamin D. She did not smoke tobacco or drink alcohol...Urine NTx 303 BCE/mM Cr (<89)...She was given zoledronic acid 5 mg IV...The ASBMR task force recommended that bisphosphonates should be discontinued in patients with bisphosphonate-associated AFF due to their severely suppressed bone turnover status. On the other hand, the AFF in patients with PD may heal in response to bisphosphonate treatment.
- |||||||||| hydrochlorothiazide / Generic mfg., pamidronate disodium / Generic mfg.
[VIRTUAL] Iatrogenic Hypocalcemia With Treatment of Milk-Alkali Syndrome (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_892;
When seen in consultation, history revealed that patient was consuming more than eight calcium carbonate antacid tablets daily and was also on hydrochlorothiazide...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| [VIRTUAL] “Relieving the Pressure” With Unilateral Adrenalectomy in a Case of Chronic Resistant Hypertension From Primary Aldosteronism (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_749;
The patient had uncontrolled hypertension despite atenolol 50 mg, nifedipine XL 60 mg, triamterene-hydrochlorothiazide 37.5-25 mg, lisinopril 40 mg daily...Despite adding clonidine 0.1 mg three times daily, hydralazine 25 mg three times daily and spironolactone 100 mg daily (which substituted triamterene-hydrochlorothiazide) after AVS, her blood pressure remained uncontrolled with blood pressure ranging from 150-180/90-110 mmHg...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| indapamide / Generic mfg.
[VIRTUAL] A Rare Case of Pseudohypoaldosteronism Type II or Gordon Syndrome (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_733;
It should be suspected in adolescent or adult patients with hyperkalemia with normal glomerular filtartion, accompanied by hypertension (can be absent), metabolic acidosis, hyperchloremia, decreased plasma renin, relatively suppressed aldosteronism and family history of similar findings. Unless otherwise noted, all poster abstracts presented at ENDO 2021 are embargoed until 11 AM Eastern on Saturday, March 20.
- |||||||||| hydrochlorothiazide / Generic mfg., indomethacin / Generic mfg.
Journal: Involvement of Muscarinic Receptors in Hypotensive and Diuretic Effects of Aqueous Soluble Fraction from Asphodelus tenuifolius Cav. (Pubmed Central) - Jan 30, 2021
The diuretic effects of AT-Cr, AS-AT, BS-AT, and DS-AT at 100, 200, and 300 mg/kg, p.o. doses, were also evaluated in comparison with hydrochlorothiazide (HCTZ, 10 mg/kg, p.o)...Previous treatment with atropine significantly reduced the hypotensive and diuretic action of AS-AT, but pretreatment with indomethacin or L-NAME did not affect these effects...This research supports and extends the traditional use of A. tenuifolius as a hypotensive and diuretic agent. The results showed that AS-AT from A. tenuifolius could present compounds responsible for hypotensive and diuretic activities through the activation of muscarinic receptors.
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: In Brief: Hydrochlorothiazide and skin cancer. (Pubmed Central) - Jan 29, 2021
The results showed that AS-AT from A. tenuifolius could present compounds responsible for hypotensive and diuretic activities through the activation of muscarinic receptors. No abstract available
- |||||||||| CoAprovel (irbesartan hydrochlorothiazide) / Sanofi, Aprovasc (amlodipine/irbesartan) / Sanofi, Sumitomo Dainippon, Shionogi
Preclinical, Journal: An In Vitro-In Vivo Simulation Approach for the Prediction of Bioequivalence. (Pubmed Central) - Jan 28, 2021
In this study, the IVIVS approach predicted successfully the BE outcome of the three drugs. During the development of generics, the IVIVS approach can save time and expenses.
- |||||||||| hydrochlorothiazide / Generic mfg., furosemide / Generic mfg.
Clinical, Journal: Effects of diuretics furosemide and hydrochlorothiazide on CKD-MBD: A prospective randomized study. (Pubmed Central) - Jan 26, 2021
To evaluate the effects of diuretics on CKD-MBD, we have performed a prospective randomized trial comparing hydrochlorothiazide with furosemide in a stage 3CKD population followed for 1 year. Furosemide increased bone remodeling and parathormone levels, whereas hydrochlorothiazide attenuated parathyroid hormone rise and decreased bone turnover markers.
- |||||||||| carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Journal: Mobility of contaminants of emerging concern in soil column experiments. (Pubmed Central) - Jan 23, 2021
Soils were then analyzed at different depths and vertical concentration profiles were plotted. Overall, highest concentrations were measured in the top most layers for contaminants in the soil column with higher clay content (C), whereas vertical profiles were more uniform in that with lower clay content (S).
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: Sorting nexin 1 loss results in increased oxidative stress and hypertension. (Pubmed Central) - Jan 21, 2021
Among HT African-Americans, three of the 12 single nucleotide polymorphisms interrogated for the SNX1 gene were associated with a decrease in systolic BP in response to hydrochlorothiazide (HCTZ). The results illustrate a new paradigm for the development of hypertension and imply that the trafficking protein SNX1 may be a crucial determinant for hypertension and response to antihypertensive therapy.
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: Pre-eclampsia with severe features: management of antihypertensive therapy in the postpartum period. (Pubmed Central) - Jan 2, 2021
Postpartum, the commonest combination therapy was alpha-methyldopa and amlodipine on day 0; alpha-methyldopa and amlodipine as a regimen as well as alpha-methyldopa, amlodipine and hydrochlorothiazide as another regimen on day 1; alpha-methyldopa and amlodipine on day 2; and many amlodipine-based regimens on day 3. a variety of antihypertensive drug combinations were used in the postpartum period indicating the need for standardised guidelines; however, detailed studies are required to evaluate their efficacies completely.
- |||||||||| indapamide / Generic mfg., hydrochlorothiazide / Generic mfg.
Journal: Unravelling the inhibitory and cytoprotective potential of diuretics towards amyloid fibrillation. (Pubmed Central) - Dec 30, 2020
In addition, molecular docking results revealed that both the drugs interacts with HSA and HL through hydrophobic interactions as well as hydrogen bonding, and also showed non-hemolytic activity on human RBCs demonstrated by the Hemolytic assay. Thus, both INDP and HCTZ could be propitious as a therapeutic agent and aid in the cure of amyloid related diseases.
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: Hydrochlorothiazide Associated with Risk of Skin Cancer. (Pubmed Central) - Dec 30, 2020
Thus, both INDP and HCTZ could be propitious as a therapeutic agent and aid in the cure of amyloid related diseases. No abstract available
- |||||||||| Jynarque (tolvaptan) / Otsuka
Clinical, Journal: Relationship between Soluble (pro)Renin Receptor and Renin Activity in Patients with Severe Heart Failure. (Pubmed Central) - Dec 30, 2020
There was a significant positive correlation with a high correlation coefficient (CC) between PRA and PRC (p < 0.0001, CC = 0.76), and a negative correlation with weak CC between BNP and s(P)RR (p = 0.01, CC = -0.45). In conclusion, s(P)RR was always high and had no correlations with disease state and PRA/PRC in severe HF patients.
- |||||||||| Trileptal (oxcarbazepine) / Novartis
[VIRTUAL] Symptomatic oxcarbazepine-induced hyponatremia: case report () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2964;
Other co-medications on her medication list, Lisinopril/Hydrochlorothiazide, were also considered to contribute to hyponatremia...Oxcarbazepine is an antiepileptic drug developed as a keto-derivative of Carbamazepine...Pharmacists play a role in helping avoid potentially severe complications of Oxcarbazepine-induced hyponatremia by closely monitoring serum Na and hyponatremic symptoms, especially in patients at risk who take co-medications with overlapping toxicity, develop hypovolemia, or take high dose Oxcarbazepine. Oxcarbazepine can potentially cause severe hyponatremia and should be suspected in symptomatic patients.
- |||||||||| hydrochlorothiazide / Generic mfg.
Journal: Prevention of nephrolithiasis - Preliminary results of the Swiss Kidney Stone Cohort (SKSC) and the NOSTONE trial (Pubmed Central) - Dec 15, 2020
However, the understanding of the pathophysiology and molecular genetic basis of nephrolithiasis is incomplete and complicates the development of new treatments. In this context, the Swiss Kidney Stone Cohort (SKSC) aims to improve the understanding of nephrolithiasis and the NOSTONE trial aims to confirm the efficacy of hydrochlorothiazide in the recurrence prevention of calcium containing kidney stones.
- |||||||||| hydrochlorothiazide / Generic mfg.
Trial completion: guanhctz: Treatment of OSA Associated Hypertension With Alpha 2 Agonist or Diuretic (clinicaltrials.gov) - Dec 4, 2020
P4, N=41, Completed,
In this context, the Swiss Kidney Stone Cohort (SKSC) aims to improve the understanding of nephrolithiasis and the NOSTONE trial aims to confirm the efficacy of hydrochlorothiazide in the recurrence prevention of calcium containing kidney stones. Active, not recruiting --> Completed
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