ziprasidone / Generic mfg. 
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  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka
    Clinical, Journal:  Examining the dispensing patterns of antipsychotics in Australia from 2006 to 2018 - A pharmacoepidemiology study. (Pubmed Central) -  Aug 4, 2021   
    This is observed through particularly large increase in the dispensing rates of Olanzapine and Quetiapine. Further interdisciplinary investigation is required to ensure that these medications are being prescribed under the appropriate medical rationale, particularly to groups that are vulnerable to the adverse effects of the medications.
  • ||||||||||  olanzapine / Generic mfg., ziprasidone / Generic mfg.
    Trial completion date, Trial suspension, Trial primary completion date, HEOR, Cost effectiveness:  Proposal To Develop A Rapid And Cost-Effective Diagnostic Test For Schizophrenia (clinicaltrials.gov) -  Jul 8, 2021   
    P1,  N=24, Suspended, 
    Decision analysis suggests that quetiapine is the optimal antipsychotic drug for the treatment of patients with delirium and prolonged baseline QTc intervals. Trial completion date: Jul 2020 --> Jan 2023 | Recruiting --> Suspended | Trial primary completion date: Dec 2019 --> Dec 2022
  • ||||||||||  ziprasidone / Generic mfg.
    Review, Journal:  Psychopharmacological Treatment, Intraocular Pressure and the Risk of Glaucoma: A Review of Literature. (Pubmed Central) -  Jul 4, 2021   
    Clinicians should be aware of the possible psychotropic drug induced glaucoma and monitor at risk patients closely in order to prevent this condition. Irrespective of the psychopharmacological regimen taken into consideration, the glaucoma patient should be under the strict supervision of the ophthalmologist.
  • ||||||||||  bictegravir (GS-9883) / Gilead
    FDA event, Journal:  Virtual Screening FDA Approved Drugs against Multiple Targets of SARS-CoV-2. (Pubmed Central) -  Jul 3, 2021   
    By overlaying docked positions of drug candidates onto individual host proteins, it has been further confirmed that the binding site conformations are conserved. The drugs identified in our screening provide potential guidance for experimental confirmation such as in vitro molecular assays, in vivo animal testing as well as incorporation into ongoing clinical studies.
  • ||||||||||  risperidone / Generic mfg., ziprasidone / Generic mfg.
    Clinical, Journal:  Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia. (Pubmed Central) -  Jun 22, 2021   
    The rs1516569 variant (OR = 0.95, P < 3.47 × 10) was a significant risk factor, and a single-nucleotide polymorphism of GRM7 gene- rs9883258 (OR = 0.84, P = 2.18 × 10) has been determined as potential biomarkers for therapeutic responses of seven commonly used antipsychotic drugs (aripiprazole, haloperidol, olanzapine, perphenazine, quetiapine, risperidone and ziprasidone) in Chinese Han population; Significant associations with treatment response for several single-nucleotide polymorphisms in every antipsychotic drugs, such as rs779746 (OR = 1.39, P = 0.03), rs480409 (OR = 0.73, P = 0.04), rs78137319 (OR = 3.09, P = 0.04), rs1154370 (OR = 1.51, P = 0.006) have been identified in our study. Hence our research elucidates that GRM7 variants play the critical role of predicting the risk of schizophrenia and antipsychotic effect of seven common drugs.
  • ||||||||||  ziprasidone / Generic mfg.
    Observational data, Journal:  Longitudinal study of inflammatory markers and psychopathology in schizophrenia. (Pubmed Central) -  Jun 22, 2021   
    Our findings provide additional support that measuring blood inflammatory markers may be relevant to the clinical care of patients with schizophrenia. Specifically, these markers may help guide selection of antipsychotic treatment towards more personalized medicine approaches for patients with schizophrenia.
  • ||||||||||  risperidone / Generic mfg., amisulpride / Generic mfg., ziprasidone / Generic mfg.
    Review, Journal:  Antipsychotics and hemodialysis: A systematic review. (Pubmed Central) -  Jun 22, 2021   
    Though CYP-3A4 remains relatively and transiently unaltered during hemodialysis, none of the antipsychotics are compromised in HD. While selecting an AP during HD, one has to consider the protein binding, clearance by dialysis, duration of an HD session, route of administration of AP, and impaired bowel absorption in HD.
  • ||||||||||  amisulpride / Generic mfg., ziprasidone / Generic mfg.
    Clinical, Journal:  Application value of UPLC-MS/MS in detecting serum concentration of anti-schizophrenic drugs in patients with mental illnes. (Pubmed Central) -  Jun 22, 2021   
    Risperidone was associated with the highest risk of switching and as expected, clozapine was associated with the lowest risk of switching than that associated with the other SGAs. Given that UPLC-MS/MS renders more accurate results in detecting the concentration of psychotropic drugs, it can be applied clinically to detect the concentration of therapeutic drugs in patients with mental illness.
  • ||||||||||  risperidone / Generic mfg., ziprasidone / Generic mfg.
    Journal, Adverse events:  Characteristics of voluntary reporting of adverse drug events related to antipsychotics in Australia: 14-year analysis. (Pubmed Central) -  Jun 10, 2021   
    The most common adverse event in adults, and reported with a number of antipsychotic drugs, was neuroleptic malignant syndrome. There were significant differences between causality, death and the management of adverse events between adult and paediatric populations (5-19 years).Keywords: Antipsychotics, adverse effects, adverse events, safety.
  • ||||||||||  risperidone / Generic mfg., amisulpride / Generic mfg., ziprasidone / Generic mfg.
    Clinical, Journal:  Comparative cardiometabolic risk of antipsychotics in children, adolescents and young adults. (Pubmed Central) -  May 11, 2021   
    Antipsychotics' various risk profiles for cardiometabolic events merit consideration when selecting appropriate regimes. Due to cardiometabolic risk, we suggest clinicians may consider to select alternative antipsychotics to olanzapine in children, adolescents and young adults.
  • ||||||||||  ziprasidone / Generic mfg.
    [VIRTUAL] Effects of Herbs on the Metabolism of Psychoactive Drugs Cleared by Cytochrome P450: A Case Report () -  May 2, 2021 - Abstract #APA2021APA_1381;    
    The most likely cause of his improvement was the discontinuation of Bacopa monnieri and Centella asiatica in the herbal supplement. This case serves to highlight the importance of monitoring drug- herbal interactions for potential clinical effects, as well as reports on two specific commercially- available herbs that are potentially of concern to prescribers.
  • ||||||||||  Rexulti (brexpiprazole) / Lundbeck, Otsuka
    [VIRTUAL] Decompensation of Mental Illness After Covid-19 Infection: A Case Series () -  May 2, 2021 - Abstract #APA2021APA_712;    
    His symptoms were successfully maintained on ziprasidone 60mg daily since 2007...He was trialed on several additional psychotropic medications, including lithium, olanzapine, lurasidone, aripiprazole, and brexpiprazole...He returned to the hospital two months later, where he exhibited auditory hallucinations, was noted to be responding to internal and unseen stimuli, and exhibited paranoid ideations regarding COVID-19. He was unable to care for himself and warranted involuntary placement to the inpatient psychiatric unit, where he stayed for nine days and eventually stabilized on long-acting paliperidone preparation.
  • ||||||||||  lorazepam / Generic mfg., gabapentin / Generic mfg., ziprasidone / Generic mfg.
    [VIRTUAL] Sometimes the Hoofbeats Are Zebras: The Role of Psychiatry in the Inter-Disciplinary Management of CNS Vasculitis () -  May 2, 2021 - Abstract #APA2021APA_553;    
    Specifically, we will address psychiatry’s role in management of agitation and affective lability, both during the hospitalization as well as in the outpatient setting, as part of an integrated care system. Implications: PACNS requires a multi-faceted and multi-disciplinary approach for which psychiatrists can play an important role, particularly in management of a patient’s affective lability, co-existing psychiatric illnesses, and aggression through various care settings.
  • ||||||||||  risperidone / Generic mfg., lorazepam / Generic mfg., ziprasidone / Generic mfg.
    [VIRTUAL] Frozen in Fear: A Case of Malignant Catatonia () -  May 2, 2021 - Abstract #APA2021APA_414;    
    She was also continued on Risperidone...IV fluids were given with IV Lorazepam...Her course was complicated again at the inpatient psychiatric facility after switching antipsychotics to Haldol 5 mg PO q am and qhs... This case highlights the fact that early diagnosis and intervention for malignant catatonia improves mortality and morbidity.
  • ||||||||||  ziprasidone / Generic mfg.
    [VIRTUAL] Wernicke Korsakoff Syndrome Versus Autoimmune Encephalitis () -  May 2, 2021 - Abstract #APA2021APA_352;    
    She finished a course of 5 IVIG treatments followed by rituximab...We recommend that thiamine levels should be evaluated in all patients presenting with AMS, especially in patients with AUD. Early treatment can reduce the progression of the deficits caused by WKS but may not completely reverse memory impairment.
  • ||||||||||  bromocriptine / Generic mfg., ziprasidone / Generic mfg.
    [VIRTUAL] Early Detection of Neuroleptic Malignant Syndrome in the Setting of Delirium () -  May 2, 2021 - Abstract #APA2021APA_309;    
    Over the course of his ED stay he was given standing quetiapine as well as quetiapine, olanzapine, and Geodon as needed for agitation nearly every day...The patient was transferred to a higher level of care where he received IV fluids, dantrolene, and bromocriptine which eventually resolved his NMS...This case illustrates the importance of detecting NMS early, as any delay in recognizing its symptoms and starting treatment can rapidly lead to fatal outcome. We will discuss typical and atypical NMS features associated with second generation antipsychotics, evidence for treatment, and the development of NMS during antipsychotic treatment of delirium or agitation in medically ill patients.
  • ||||||||||  olanzapine / Generic mfg., ziprasidone / Generic mfg.
    [VIRTUAL] A Case Report and Literature Review of Olanzapine- Induced Neutropenia () -  May 2, 2021 - Abstract #APA2021APA_271;    
    Clinicians should be aware of this potentially serious side effect. Large scale trials are needed to assess the incidence of neutropenia with olanzapine and to establish whether guidelines are needed to monitor neutrophil counts in patients receiving olanzapine.
  • ||||||||||  risperidone / Generic mfg., oxycodone controlled release / Generic mfg., ziprasidone / Generic mfg.
    Trial primary completion date:  Reducing the Abuse of Opioids in Drug Users (clinicaltrials.gov) -  Apr 30, 2021   
    P1,  N=25, Recruiting, 
    Studies related to management of substance induced agitation are limited to case reports and case series which recommend antipsychotics. Trial primary completion date: Mar 2021 --> Sep 2021
  • ||||||||||  lorazepam / Generic mfg., ziprasidone / Generic mfg.
    Journal:  In Reply: In Fact, One Size (or Dose) Does Not Fit All. (Pubmed Central) -  Apr 27, 2021   
    We greatly appreciate your comments on our manuscript "Randomized Double-blind Trial of Intramuscular Droperidol, Ziprasidone, and Lorazepam for Acute Undifferentiated Agitation in the Emergency Department" and agree, one size does not fit all when managing agitation in the ED. The concerns you raise about agitated, elderly patients is a very important issue for EP's to consider.
  • ||||||||||  Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck, Invega Sustenna (paliperidone palmitate extended-release 1-month injection) / J&J, Invega Trinza (paliperidone palmitate extended-release 3-month injection) / J&J
    [VIRTUAL] Assessment of hospitalizations in schizophrenia patients treated with Paliperidone 1-monthly (PP1M), Paliperidone 3-monthly (PP3M), Aripiprazole once-monthly (AOM) and other oral antipsychotics (OAP) in clinical practice. (e-Poster Gallery) -  Apr 26, 2021 - Abstract #EPA2021EPA_965;    
    However, limited real world evidence is available as to whether there are differences among the various formulations marketed.  Objectives This study aims to assess the impact on several prognosis variables of PP1M,PP3M,AOM and OAP drugs.  Methods All adults (≥18 years) with schizophrenia who were initiated on PP1M, PP3M, AOM, or OAP treatment (chlorpromazine,levomepromazine,fluphenazine,haloperidol,ziprasidone,zuclopenthixol,olanzapine,quetiapine,asenapine,amisulpride, risperidone,aripiprazole,paliperidone) between 2017 and 2018 were identified in IQVIA’s database(1.8M of inhabitants from 4 Spanish areas)...01) for PP3M (23%) than for PP1M (36.9%), OAP (43.5%),and AOM (46.2%). Persistence rates were higher for PP3M (91%) than for any other treatment (p<0.01).  Conclusions Our results outline that patients treated with PP3M experienced fewer relapses and decompensations compared to all other treatments analyzed, which might help improve the prognosis and quality of life of patients.
  • ||||||||||  risperidone / Generic mfg., ziprasidone / Generic mfg.
    [VIRTUAL] Therapeutic Management of Psychotic Mania- A Literature Review () -  Apr 20, 2021 - Abstract #ISBD2021ISBD_114;    
    Conclusion More trials in the field of psychotic mania are needed, in order to establish the efficacy of antipsychotic monotherapy versus a combination of mood-stabilizers and antipsychotics. This is an important aspect that may relate to the pharmaco-economic dimension, but also to the quality of life, overall functionality, and risk of long-term adverse events.