- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Giant Prolactinomas: An Experience From South India () - Mar 27, 2021 - Abstract #ENDO2021ENDO_3342;
All patients received cabergoline and a mean dose of 2.1 ± 1.7 mg/week (range, 1-7 mg/week) was prescribed to attain a median nadir prolactin level of 48 ng/ml over a median period of 4 months (range, 1-40 months)...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Meet the Professor () - Mar 27, 2021 - Abstract #ENDO2021ENDO_2939;
However, its effect is generally transient and surgery must not be delayed. GnRH agonists are not recommended, as they may be responsible for pituitary apoplexy.
- |||||||||| cabergoline / Generic mfg.
Journal: NEK2 regulates cellular proliferation and cabergoline sensitivity in pituitary adenomas. (Pubmed Central) - Mar 24, 2021
Mechanistically, NEK2 regulated cell proliferation via the Wnt-signaling pathway; and in addition, we demonstrated that USP7 interacted with, deubiquitylated, and stabilized NEK2. Collectively, our results suggest that NEK2 might be a potential therapeutic target for prolactinoma.
- |||||||||| clarithromycin / Generic mfg.
[VIRTUAL] MEDICATION INDUCED RELAPSE OF FGSG (Mini-Orals Hall) - Mar 19, 2021 - Abstract #ERAEDTA2021ERA_EDTA_1575;
Despite limited CYP metabolism, cabergoline does have an interaction with clarithromycin, a known inhibitor of CYP and p-glycoprotein. One rat study suggest that mycophenolate is a substrate for p- glycoprotein, so it is possible that there is some competitive inhibition.
- |||||||||| Isturisa (osilodrostat) / Novartis, Recordati
Journal: Osilodrostat (Isturisa) for Cushing's disease. (Pubmed Central) - Mar 10, 2021
One rat study suggest that mycophenolate is a substrate for p- glycoprotein, so it is possible that there is some competitive inhibition. No abstract available
- |||||||||| bromocriptine / Generic mfg.
Journal: Guidance on the treatment of antipsychotic-induced hyperprolactinemia when switching the antipsychotic is not an option. (Pubmed Central) - Feb 26, 2021
There are treatments available for antipsychotic-induced hyperprolactinemia in patients who are unable to alter their current antipsychotic regimen. However, there remains a need for additional short- and long-term studies to determine the efficacy and safety of these treatment strategies, given that patients taking antipsychotics typically require chronic, life-long treatment for their illnesses.
- |||||||||| cabergoline / Generic mfg., hydrocortisone / Generic mfg., desmopressin / Generic mfg.
[VIRTUAL] THE MYSTERIOUS CASE OF PITUITARY APOPLEXY () - Feb 24, 2021 - Abstract #ICE2021ICE_477;
Clinical This case indicates the recovery of anterior pituitary hormonal profile with lymphocytic hypophysitis despite initial panhypopituitarism. Her gonadotrophin axis and posterior pituitary has still not recovered.
- |||||||||| bromocriptine / Generic mfg.
[VIRTUAL] DO WE NEED A PITUITARY DISEASES REGISTRY IN LATVIA? () - Feb 24, 2021 - Abstract #ICE2021ICE_474;
Based on the study of the pituitary disease registry in Latvia, a unified database of pituitary diseases pts has been created. A state founded registry may be set up in the future.
- |||||||||| Sandostatin LAR Depot (octreotide acetate) / Novartis
[VIRTUAL] THERAPEUTIC CHALLENGES IN A PATIENT WITH AN UNUSUAL AND SEVERE CASE OF MCCUNE-ALBRIGHT SYNDROME AND POLYSOTOTIC FIBROUS DYSPLASIA. () - Feb 24, 2021 - Abstract #ICE2021ICE_356;
From the age of 11 through 18 years old, he received treatment with Cabergoline, Pamidronate EV every 6 months, Cholecalciferol, Calcium and Calcitriol...Octreotide LAR 30 mg every 28 days, Zoledronic acid 5 mg/month, Cabergoline 3 mg/week, Cholecalciferol and calcium were indicated...Clinical The degree of severity, unusual presentation and the low incidence of MAS / DF motivated the communication of this case. Treatment was aimed at optimizing life quality and minimizing the morbidity associated with bone deformities, fractures and compromise of vital structures.
- |||||||||| cabergoline / Generic mfg.
Journal: Spontaneous coronary artery dissection in association with cabergoline therapy. (Pubmed Central) - Feb 23, 2021
Here, we describe SCAD in a 37-year-old woman on long-term cabergoline therapy with no other cardiac risk factors. Cabergoline-induced SCAD should be considered in patients presenting with an acute coronary syndrome who are treated with this medication.
- |||||||||| rapamycin topical (PTX-022) / Palvella Therapeutics, Ligand, Signifor LAR (pasireotide) / Novartis
Journal: Treatment options for gonadotroph tumors: current state and perspectives. (Pubmed Central) - Feb 20, 2021
Gonadotroph tumors need better phenotyping in terms of both tumor cells and associated tumor microenvironment in order to improve their treatment. Until formal recommendations will be available, we provide the readers with our suggested approach for the management of gonadotroph tumors, management that should be discussed within multidisciplinary teams.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] ACTH-Producing Thymic Carcinoid: A Rare Cause of Cushing's Syndrome (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_2199;
The presence of two MEN1-associated tumors in this patient, macroprolactinoma and thymic carcinoid, is highly suggestive of a clinical diagnosis of MEN 1. Unless otherwise noted, all poster abstracts presented at ENDO 2021 are embargoed until 11 AM Eastern on Saturday, March 20.
- |||||||||| methimazole / Generic mfg., cabergoline / Generic mfg., prednisone / Generic mfg.
[VIRTUAL] A Case of TSH-Secreting Pituitary Adenoma With Unusual Positive Staining for SF1 (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1955;
When such tumors secrete multiple hormones, this has been used as evidence to support the argument that such tumors arise from a stem cell population(1). However, the implications for our patient remain unclear.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Thyrotropin-Secreting Pituitary Adenoma Successfully Treated With Cabergoline. (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1939;
Her TSH was noted to be suppressed at that time, and her Amour thyroid was changed to Levothyroxine 25 mcg daily, which was eventually stopped as her symptoms persisted...Atenolol 25 mg daily was added temporarily for the management of her sympathetic symptoms...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| progesterone / Generic mfg., cabergoline / Generic mfg., hydrocortisone / Generic mfg.
[VIRTUAL] Primary Amenorrhea and Hyperandrogenism: Presenting Features of a Growth Hormone Producing Pituitary Adenoma in a Female Adolescent (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1599;
Laboratory evaluation was notable for prolactin (PRL) 147.8 ng/dL (2.6-18.0), LH <0.02 mIU/mL, FSH <0.09 mIU/mL, estradiol 23 pg/mL, total testosterone 81 ng/dL (<41), androstenedione 673 ng/mL (43-180), DHEA-S 627 mcg/dL (42-162), dyslipidemia and normal 17 hydroxy-progesterone and thyroid function tests...Treatment with cabergoline 0.5 mg/week and maintenance hydrocortisone were initiated...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| cabergoline / Generic mfg., thyroxine / Generic mfg.
[VIRTUAL] Pituitary Macroprolactinoma Apoplexy in a Prepubertal Girl (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1595;
We report a rare case of macroprolactinoma in a prepubertal girl associated with pituitary apoplexy. Complete assessment and prompt intervention were essential to recover the visual field and to prevent major sequelae.
- |||||||||| Somavert (pegvisomant) / Pfizer, Somatuline Depot (lanreotide prolonged-release subcutaneous) / Ipsen, Teijin, Sandostatin LAR Depot (octreotide acetate) / Novartis
[VIRTUAL] Clinical Presentation and Management of Patients With Acromegaly at a University Hospital (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1560;
Twelve patients were subsequently excluded from this analysis - nine patients who had been recently diagnosed and were awaiting surgical treatment as well as three patients who had been lost to follow-up. The study sample (n=60) included forty females patients (67%).
- |||||||||| bromocriptine / Generic mfg.
[VIRTUAL] Pituitary Diseases Registry Study in Latvia. Part 1. (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1550;
A state register may be set up in the future. Unless otherwise noted, all poster abstracts presented at ENDO 2021 are embargoed until 11 AM Eastern on Saturday, March 20.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Acute Ischaemic Stroke With Hyperprolactinemia:A Case Report (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1483;
The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021. This is a case report of acute ischaemic stroke with markedly hyperprolactinemia secondary to incidentaloma macroprolactinoma.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Diagnosis of a Rare Case of Acromegaly Secondary to Pituitary Macroadenoma Debuting as Sudden DKA (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1464;
Patient initially treated with Cabergoline, uncontrolled diabetes was managed and was referred to Neurosurgery service for further evaluation and tumor removal...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Macroprolactinoma Presenting With Hyponatremia; A Rare Case Report (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1457;
Only two cases found in the literature reporting SIADH secondary to prolactin producing pituitary adenoma, with our case being the third reported case. Unless otherwise noted, all poster abstracts presented at ENDO 2021 are embargoed until 11 AM Eastern on Saturday, March 20.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Discordance Between Prolactinoma Size and Prolactin Level: An Unusual Laboratory Finding (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1455;
Unless otherwise noted, all poster abstracts presented at ENDO 2021 are embargoed until 11 AM Eastern on Saturday, March 20. Cabergoline 0.25 mg twice weekly resulted in significant improvement in PRL level...Our case illustrates that assumptions about prolactinoma size should not be made based on laboratory findings alone.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] A Follicular Stimulating Hormone Secreting Adenoma (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1454;
Medical treatment, if surgery is contraindicated, is limited to cabergoline, which can initially decrease FSH and estradiol levels...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| dexamethasone / Generic mfg.
[VIRTUAL] Antipsychotic Medication Use Delays Diagnosis of Acromegaly (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1453;
Unless otherwise noted, all poster abstracts presented at ENDO 2021 are embargoed until 11 AM Eastern on Saturday, March 20. For oral presentations, the abstracts are embargoed until the session begins.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] A Challenging Case of Pituitary Macroprolactinoma During Pregnancy (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1452;
It is essential to periodically assess visual fields during pregnancy particularly in patients with macroadenomas. Dopamine agonists are discontinued during pregnancy unless symptomatic enlargement of prolactinoma occurs.
- |||||||||| bromocriptine / Generic mfg.
[VIRTUAL] Giant Prolactinoma Causing Proptosis and Stroke (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1448;
Bromocriptine was initially started and titrated and later changed to cabergoline. This case demonstrates an unusually aggressive macroprolactinoma causing severe proptosis, ischemic stroke and death and adds to the very few cases previously reported [2].
- |||||||||| acetazolamide / Generic mfg., cabergoline / Generic mfg.
[VIRTUAL] Cerebrospinal Fluid Leak After Medical Management of Prolactinoma (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1438;
CSF leaks can increase a patient's risk for meningitis and subsequent morbidity and mortality. The management of patients with large prolactinomas with local invasion should involve a multidisciplinary approach for decision making, extensive patient education, and close follow up in order to identify and treat a CSF leak should it develop.
- |||||||||| [VIRTUAL] A Case of Giant Prolactinoma Characterized by a Nasopharyngeal Extension and Diagnosed by Nasal Cavity Biopsy (On-Demand) - Feb 2, 2021 - Abstract #ENDO2021ENDO_1431;
Cabergoline (0.5 mg/w), levothyroxine (100 mcg/d) and testosterone propionate (250 mg/m) were started...Five years after surgery, secondary hypocortisolism has emerged, and 5 mg/day prednisolone was added to the therapy...For oral presentations, the abstracts are embargoed until the session begins. The Endocrine Society reserves the right to lift the embargo on specific abstracts that are selected for promotion prior to or during ENDO 2021.
- |||||||||| cabergoline / Generic mfg.
[VIRTUAL] Faculty (Live) - Feb 2, 2021 - Abstract #ENDO2021ENDO_192;
Some tumors require larger than standard (< 2mg/wk) doses ofcabergoline to control prolactin levels and tumor size...When dopamine agonists arethen stopped, the risks of tumor enlargement during pregnancy are 2.5% formicroadenomas and 18% for macroadenomas. Tumor enlargement during pregnancy almost always responds toreintroduction of the dopamine agonist.
- |||||||||| cabergoline / Generic mfg.
Journal: Phenotype and resistance patterns of 10 resistant prolactinomas. (Pubmed Central) - Feb 2, 2021
Isolated MR and combined MR+BR are the most frequent patterns of DA resistance whereas isolated BR seems to be uncommon. Our data support a high tumor size but not male gender as a risk factor for DA resistance.
|
