pentoxifylline / Generic mfg. 
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  • ||||||||||  pentoxifylline / Generic mfg., amifostine / Generic mfg.
    Journal:  The impact of radiation therapy in patients with systemic sclerosis and head and neck cancer. (Pubmed Central) -  May 5, 2024   
    While some patients with SSc who received radiation for H&N cancer developed localized skin thickening and reduced neck range of motion, systemic flares of SSc were uncommon. This observational study provides evidence to support the use of radiation therapy for H&N cancer in patients with SSc when radiation is the best treatment option.
  • ||||||||||  pentoxifylline / Generic mfg.
    Journal:  Phalangeal microgeodic syndrome: case report of a (Pubmed Central) -  Apr 29, 2024   
    This observational study provides evidence to support the use of radiation therapy for H&N cancer in patients with SSc when radiation is the best treatment option. Pharmacological treatment was deemed necessary for symptomatic relief, but a
  • ||||||||||  ceftriaxone / Generic mfg., pentoxifylline / Generic mfg.
    Journal:  Comparative study of oral microbiota in the experimental long-term opioid exposure, after its withdrawal and the use of complex drug correction. (Pubmed Central) -  Apr 24, 2024   
    After 10 weeks of experiment with opioid administration for 6 weeks and the use of ceftriaxone and pentoxifylline on the background of 4-week opioid withdrawal, a significant reduction of quantitative indicators of opportunistic bacteria and elimination of pathogenic species of microorganisms was determined. The use of complex drug correction on the background of 10 weeks of opioid exposure led to a significant reduction in the quantitative indicators of opportunistic pathogens and contributed to the elimination of most pathogenic species of microbiota under the action of ceftriaxone.
  • ||||||||||  methylprednisolone acetate / Generic mfg.
    Review, Journal:  Isolated Depo-Medrol Administration under Tenon's Capsule for Post-COVID-19 Uveitis in a Child: A Case Report and Literature Review. (Pubmed Central) -  Apr 9, 2024   
    In addition, acetylsalicylic acid (150 mg) and pentoxifylline (100 mg, orally) were administered throughout the course of the disease as well as up to 12 months after its termination, until a complete improvement in visual acuity and the withdrawal of ocular lesions were achieved. It can be assumed that this type of treatment is far more beneficial for pediatric patients, with an effect comparable to systemic steroid administration with a preserved improvement in retinal-vascular circulation, without exposing the child to systemic post-steroid complications.
  • ||||||||||  selonsertib (GS-4997) / Gilead, Olumiant (baricitinib) / Incyte, Eli Lilly
    Review, Journal:  Recent Advances in the Management of Diabetic Kidney Disease: Slowing Progression. (Pubmed Central) -  Apr 1, 2024   
    We also explore the additional value of combing these therapies to develop novel treatment strategies. Drawing from the current understanding of DKD pathogenesis, we propose HIF inhibitors, AGE inhibitors, and epigenetic modifications as promising therapeutic targets for the future.
  • ||||||||||  pentoxifylline / Generic mfg., baclofen / Generic mfg., naltrexone / Generic mfg.
    A GLOBAL SURVEY ON THE MANAGEMENT OF ALCOHOL-ASSOCIATED HEPATITIS (201 - Walter E. Washington Convention Center) -  Mar 14, 2024 - Abstract #DDW2024DDW_6185;    
    Of the 700 surveys sent, 416 were partially completed and 344 were fully completed, with a completed response rate of 49%. Practice patterns varied by region and practice setting (transplant hospital vs. non-transplant) hospital.
  • ||||||||||  pentoxifylline / Generic mfg.
    ANTIBIOTIC USE IN SEVERE ALCOHOL-RELATED HEPATITIS (Hall A) -  Mar 14, 2024 - Abstract #DDW2024DDW_5830;    
    Over 60% of patients received antibiotics, and among them over a quarter received antibiotics without a suspected source. Further, 38.8% of patients who received antibiotics did not meet IDSA criteria for infection.
  • ||||||||||  sildenafil / Generic mfg., pentoxifylline / Generic mfg., papaverine / Generic mfg.
    Horizontal Plication and Reduction Corporoplasty for Penile Girth Discrepancy (Chritmas Tree Deformity) (Video Abstract Theater) -  Mar 12, 2024 - Abstract #AUA2024AUA_1887;    
    Attempts at treatment, including pentoxifylline, traction devices, and collagenase injections, yielded no improvement...During surgery, papaverine-induced artificial erections were utilized without a tourniquet... The successful outcome, evidenced by the patient's ability to engage in satisfactory sexual intercourse and maintain good erections with pharmacological support, demonstrates the potential of this technique in enhancing the quality of life for patients suffering from similar conditions.
  • ||||||||||  pentoxifylline / Generic mfg.
    Journal:  To Determine the Efficacy of Pentoxifylline in the Management of Bell's Palsy. (Pubmed Central) -  Mar 5, 2024   
    This highlights the benefit of vasoactive agent in the management of Bell's palsy by improving the oxygen delivery to the affected tissues. The online version contains supplementary material available at 10.1007/s12070-023-04298-9.
  • ||||||||||  pentoxifylline / Generic mfg., hydrocortisone / Generic mfg., dexamethasone injection / Generic mfg.
    Review, Journal:  Interventions for managing oral submucous fibrosis. (Pubmed Central) -  Feb 28, 2024   
    High-quality, adequately powered intervention trials with a low risk of bias that compare biologically plausible treatments for OSF are needed. It is important that relevant participant-reported outcomes are evaluated.
  • ||||||||||  pentoxifylline / Generic mfg.
    Review, Journal:  Penile fibrosis-still scarring urologists today: a narrative review. (Pubmed Central) -  Feb 26, 2024   
    We examine the evidence for preoperative patient evaluation and penile ultrasound (US), oral phosphodiesterase-5 inhibitors, pentoxifylline, and L-arginine, vacuum device therapy and the use of surgical approaches and tools in the context of complex penile fibrosis cases...The management of penile fibrosis remains a challenge but there are multiple options to assist clinicians. Complex cases should be managed and studied at high volume centers.
  • ||||||||||  pentoxifylline / Generic mfg.
    Journal:  Relapsing subcutaneous nodules of the penis in a pediatric patient. (Pubmed Central) -  Feb 13, 2024   
    Surgery should be considered a second-line option since 5/8 of treated cases eventually recurred. The pentoxifylline-treated case witnessed a relapse after drug discontinuation, while topical steroids lead to complete recovery without relapses.
  • ||||||||||  pentoxifylline / Generic mfg., paclitaxel / Generic mfg.
    Trial completion, Trial completion date, Trial primary completion date:  "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients" (clinicaltrials.gov) -  Jan 23, 2024   
    P2/3,  N=66, Completed, 
    Thus, it may represent a potential neuroprotective drug for diabetics. Recruiting --> Completed | Trial completion date: Apr 2023 --> Sep 2023 | Trial primary completion date: Feb 2023 --> Sep 2023
  • ||||||||||  pentoxifylline / Generic mfg.
    Journal:  Design and preparation of an electromechanical implant prototype for an on-demand drug delivery. (Pubmed Central) -  Jan 14, 2024   
    Due to the lack of drug leakage and other mechanical studies, the electromechanical implant produced by the FDM 3D printer was chosen as the optimal electromechanical implant in this study. Along with the designed small circuit, this implant can release a drug dosage in the patient's body at the physician's demand.
  • ||||||||||  pentoxifylline / Generic mfg.
    Journal:  7-Methylxanthine Inhibits the Formation of Monosodium Urate Crystals by Increasing Its Solubility. (Pubmed Central) -  Dec 27, 2023   
    For example, the hepatic metabolism of theobromine leads to significant plasma levels of 7-methylxanthine (14% of the initial theobromine concentration) and 3-methylxanthine (6% of the initial theobromine concentration); however, 7-methyluric acid is present at very low concentrations in the plasma. It is important to consider that several of the specific molecules we examined (theobromine, caffeine, theophylline, dyphylline, etophylline, and pentoxifylline) did not directly affect crystallization.
  • ||||||||||  pentoxifylline / Generic mfg.
    Review, Journal, Surgery:  Oral Surgery and Osteoradionecrosis in Patients Undergoing Head and Neck Radiation Therapy: An Update of the Current Literature. (Pubmed Central) -  Dec 23, 2023   
    Post-RT preventive strategies, in case of dento-alveolar surgery, have been proposed and include antibiotics, hyperbaric oxygen (HBO), and the combined use of pentoxifylline and tocopherol ("PENTO protocol"), but currently there is a lack of established standards of care...Overall, established standards of care and high-quality evidence are lacking concerning both preventive strategies for ORN as well as the timing of the dental surgery. There is an urgent need to improve research for more efficacious clinical decision making.
  • ||||||||||  pentoxifylline / Generic mfg., hydralazine hydrochloride / Generic mfg., timolol maleate ophthalmic solution / Generic mfg.
    Preclinical, Journal:  The Role of Osteogenic Effect and Vascular Function in Bone Health in Hypertensive Rats: A Study of Anti-hypertensive and Hemorheologic Drugs. (Pubmed Central) -  Dec 16, 2023   
    Pentoxifylline (PTX), a hemorheological drug, improves blood flow by reducing blood viscosity and angiogenesis, also has an osteogenic effect...To test this, we screened various anti-hypertensive drugs for their in vitro osteogenic effect, from which timolol and hydralazine were selected...PTX also restored the bone vascular and angiogenesis parameters that had been impaired in OVX SHR compared to sham SHR. This study demonstrates the importance of vascular function in addition to increased bone mass for improving bone health as achieved by PTX without affecting BP, and suggests a promising treatment option for osteoporosis in hypertensive patients, particularly at-risk postmenopausal women.