- |||||||||| metformin / Generic mfg., ropinirole IR / Generic mfg., nifedipine immediate release / Generic mfg.
EXPERTS-ALS: what can we learn from patient experiences? (Poster Hall at the Palais de Congres Montreal; 517b/c) - Nov 7, 2024 - Abstract #ALSMND2024ALS_MND_605;
Secondly, by understanding participant preferences, barriers and facilitators to participation, to identify why someone living with ALS may choose to participate in EXPERTS-ALS rather than other trials, particularly Phase III. This information can help inform the delivery of all trials and provide researchers with advice on information sharing when communicating complex information with people with ALS and their families.
- |||||||||| ropinirole IR / Generic mfg.
PK/PD data, Journal, Machine learning: Simulating realistic patient profiles from pharmacokinetic models by a machine learning postprocessing correction of residual variability. (Pubmed Central) - Nov 4, 2024
The methodology was tested in a PK study of ropinirole, for which a PopPK model was developed while a second deliberately misspecified model was also considered...The ML model was able to correct individual predictions as inspected in diagnostic plots and most importantly it simulated realistic profiles that resembled the real data and canceled out the artifacts introduced by the elevated RUV, even in the case of the heavily misspecified model. Furthermore, a metric to quantify the extent of model misspecification was introduced based on the R2 between IRES and IRESML, following the rationale that the greater the extent of variability explained by the ML model, the higher the degree of model misspecification present in the original model.
- |||||||||| ropinirole IR / Generic mfg.
Journal: Structure Elucidation of Pharmaceutically Relevant Compounds within Pyrene-based Frameworks. (Pubmed Central) - Aug 16, 2024
Furthermore, we successfully encapsulated important pharmaceutical and biologically relevant compounds, such as lidocaine, ropinirole, adenosine, thymidine, and others. Notably, we present a workflow for investigating host-guest complex formation using powder X-ray diffraction and high throughput experimentation.
- |||||||||| Ingrezza (valbenazine) / Neurocrine, Austedo (deutetrabenazine) / Teva
Comorbid Tardive Dyskinesia (TD) and Restless Leg Syndrome (RLS) (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_661;
Reduced dopaminergic signaling is implicated in RLS. TD is thought to arise from dopamine hypersensitivity in the nigrostriatal pathway due to long-term neuroleptic use.
- |||||||||| ropinirole IR / Generic mfg.
Trihexyphenidyl Use in a Parkinsonian Phenotype of Gerstman-Str (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_384;
This is likely limited by both rarity of this disorder, as well as the wide phenotypic range. Trihexyphenidyl use for GSS has not been previously described in review of the literature.
- |||||||||| carbidopa/levodopa / Generic mfg., ropinirole IR / Generic mfg.
AI for Personalized Medication Management in Parkinson's Disease (Poster Hall (Exhibit Hall A)) - Aug 9, 2024 - Abstract #MDSCongress2024MDS_Congress_343;
Notably, our findings align with existing literature by 1) facilitating trust for Carbidopa-Levodopa as the primary therapeutic choice for PD 2) suggesting Dopamine Agonists (Ropinirole and Rotigotine) as a second-line therapy for PD and 3) underscoring the role of age in PD progression, as it emerged as the second-most influential predictor in our models. In comparative analysis, XGBoost demonstrates superior performance, achieving a higher AUC requiring less iterations than CatBoost.
- |||||||||| doxycycline / Generic mfg.
Journal: Pharmacological approach using Doxycycline and Tocopherol in rotenone induced oxidative stress, neuroinflammation and Parkinson's like symptoms. (Pubmed Central) - Aug 1, 2024
and TNF-?) and activity of MAO-A, MAO-B.ResultDoxycycline and tocopherol in combination significantly attenuated behavioral, neurotransmitters and biochemical alterations induced by rotenone in experimental rats as compared to alone treatment with DOX and TOCO. Similarly, DOX and TOCO combination significantly reduced the level of inflammatory markers, prevented the biochemical changes, decreased MAO-A and MAO-B and improved complex-I, complex-IV, cAMP levels significantly.ConclusionThe current study revealed that a combination of doxycycline with tocopherol contributed to the prevention of PD like symptoms in rats by antioxidant, anti-inflammatory, MAO inhibitory and neuromodulatory mechanisms.
- |||||||||| ropinirole IR / Generic mfg.
Biomarker, Journal: Proteomic insights into extracellular vesicles in ALS for therapeutic potential of Ropinirole and biomarker discovery. (Pubmed Central) - Jul 13, 2024
Similarly, DOX and TOCO combination significantly reduced the level of inflammatory markers, prevented the biochemical changes, decreased MAO-A and MAO-B and improved complex-I, complex-IV, cAMP levels significantly.ConclusionThe current study revealed that a combination of doxycycline with tocopherol contributed to the prevention of PD like symptoms in rats by antioxidant, anti-inflammatory, MAO inhibitory and neuromodulatory mechanisms. Despite the limited sample size, this study pioneers in reporting time-series proteomic alterations in serum and CSF EVs from SALS patients, offering comprehensive insights into SALS pathogenesis, ROPI-induced changes, and potential prognostic and diagnostic biomarkers.
- |||||||||| ropinirole IR / Generic mfg.
Journal: PEO-b-PCL/Tween 80/cyclodextrin systems: from bioinspired fabrication to possible nasal administration of ropinirole hydrochloride. (Pubmed Central) - May 28, 2024
These systems showed a high RH content (%), and in vitro diffusion experiments revealed that more than 90% of the loading dose was released under pH and temperature conditions that simulate the conditions of the nasal cavity. Promising drug release performance was observed with all tested formulations, worth further investigation to explore both ex vivo permeation through the nasal mucosa and in vivo performance in an experimental animal model.
- |||||||||| Eyevinal (ibudilast) / MediciNova
Journal, Next-generation sequencing: A new potential therapeutic approach for ALS: A case report with NGS analysis. (Pubmed Central) - Mar 6, 2024
The described therapy using AI-PRS, offering personalized drug-dose combinations technology is a potential approach in treating ALS. The promising outcomes warrant further evaluation in clinical trials for searching a personalized, more effective combinational treatment for ALS patients.
- |||||||||| ropinirole IR / Generic mfg., pramipexole IR / Generic mfg.
Journal: Dopamine agonist serum concentrations and impulse control disorders in Parkinson's disease. (Pubmed Central) - Nov 13, 2023
The use of pramipexole may in itself confer high ICD risk, whereas ICDs among ropinirole users depend more on serum concentration and drug exposure. The pharmacokinetic properties of ropinirole make it challenging to predict its effects on patients, which supports the need for therapeutic drug monitoring to reduce risk of ICD.
- |||||||||| ropinirole IR / Generic mfg.
Journal: An experimental study of consecutive administration of ropinirole and apomorphine for emesis induction in dogs. (Pubmed Central) - Nov 9, 2023
The pharmacokinetic properties of ropinirole make it challenging to predict its effects on patients, which supports the need for therapeutic drug monitoring to reduce risk of ICD. The safety and efficacy profiles of this experimental study support that ropinirole and apomorphine could be administered consecutively in cases where the treatment using 1 substance has resulted in an incomplete evacuation of the stomach contents, and the attending veterinarian considers the use of a different agent to have benefits that outweigh the risks.
- |||||||||| ropinirole IR / Generic mfg.
Ropinirole hydrochloride suppresses cholesterol synthetic pathway in ALS spinal motor neurons. (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_12936;
The safety and efficacy profiles of this experimental study support that ropinirole and apomorphine could be administered consecutively in cases where the treatment using 1 substance has resulted in an incomplete evacuation of the stomach contents, and the attending veterinarian considers the use of a different agent to have benefits that outweigh the risks. Suppression of the cholesterol synthetic pathway in MNs is one of the possible mechanisms by which ROPI attenuates ALS pathogenesis.
- |||||||||| ropinirole IR / Generic mfg.
Journal: Ropinirole for the Treatment of Hyperprolactinemia: A Dose Escalation Study of Efficacy and Tolerability. (Pubmed Central) - Sep 16, 2023
We conclude that ROP's protective effects in reducing oxidative stress and modulating mitochondrial function might have a propensity in AD pathogenesis. These data demonstrate the efficacy and tolerability of ropinirole for the treatment of hyperprolactinemia in patients with microprolactinomas and idiopathic hyperprolactinemia and suggest ropinirole may represent a novel therapeutic alternative for treating hyperprolactinemic disorders in patients with ergot DA intolerance.
- |||||||||| ropinirole IR / Generic mfg., levodopa/benserazide / Generic mfg., entacapone/levodopa/carbidopa / Generic mfg.
Observations on 5 Parkinson () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1533;
One patient was able to reduce levodopa/carbidopa/entacapone from a levodopa effective dose 600 to 200 mg/d by adding 7.5g/d Mucuna with an improvement of total UPDRS from 43 to 24 over 10 months.Most patients tolerated Mucuna well... To explore potential benefits and tolerability of extracts from Mucuna pruriens for dopaminergic treatment of Parkinson
- |||||||||| Lecigon (carbidopa/levodopa/entacapone) / LobSor, Comtan (entacapone) / Novartis, Orion Corp
Levodopa-Entacapone-Carbidopa Intestinal Gel in advanced Parkinson () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1530;
To explore potential benefits and tolerability of extracts from Mucuna pruriens for dopaminergic treatment of Parkinson Most patients (81.2%) were also being treated with dopamine agonists, namely pramipexole (3 patients, 18.6%; mean dose 2.4
- |||||||||| ropinirole IR / Generic mfg.
Identification of xylopropamine as a potential dopamine D2 receptor agonist through computational drug discovery pipeline () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_1503;
Docking studies and ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) properties evaluation of xylopropamine with dopamine D2 receptor showed that this ligand is a drugable molecule which docked well with the receptor. Therefore, xylopropamine plays an important role in stimulating dopamine (D2) receptors and thus should be implicated as a potential therapeutic agent in Parkinson
- |||||||||| ropinirole IR / Generic mfg., rasagiline / Generic mfg.
Constipation in Parkinson () - Aug 30, 2023 - Abstract #MDSCongress2023MDS_Congress_612;
DBS may provide patients with a neurosurgical treatment option for established parkinsonism in CTX. He was diagnosed with Parkinson
- |||||||||| ropinirole IR / Generic mfg., pramipexole IR / Generic mfg.
Review, Journal: The Park Sleep subtype in Parkinson's disease: from concept to clinic. (Pubmed Central) - Aug 10, 2023
In clinic, Park Sleep recognition may drive lifestyle changes (e.g. driving) along with therapy adjustments as Park Sleep patients may be sensitive to dopamine D3 active agonists, such as ropinirole and pramipexole. Specific dashboard scores based personalized management options need to be implemented and include pharmacological, non-pharmacological, and lifestyle linked advice.
- |||||||||| ropinirole IR / Generic mfg.
Preclinical, Journal: Ropinirole Cotreatment Prevents Perivascular Glial Recruitment in a Rat Model of L-DOPA-Induced Dyskinesia. (Pubmed Central) - Aug 2, 2023
None of these markers were significantly upregulated in animals treated with L-DOPA-ropinirole or ropinirole alone. In summary, although ropinirole cotreatment does not prevent L-DOPA-induced dyskinesia, it protects from maladaptive gliovascular changes otherwise associated with this disorder, with potential long-term benefits to striatal tissue homeostasis.
- |||||||||| ropinirole IR / Generic mfg.
Journal: Metabolism of ropinirole is mediated by several canine CYP enzymes. (Pubmed Central) - Jul 21, 2023
Although human metabolism of ropinirole is mainly mediated through CYP1A2, the current study shows that several canine CYP isoforms are able to contribute to the clearance of ropinirole in dogs. This is expected to reduce a possible impact of canine CYP1A2 polymorphism on ropinirole pharmacokinetics.
- |||||||||| ropinirole IR / Generic mfg.
Journal: iPSC-based research in ALS precision medicine. (Pubmed Central) - Jun 7, 2023
Limitations include small sample sizes and high attrition rates in the open-label extension period, requiring further validation. In this issue, Morimoto et
- |||||||||| ropinirole IR / Generic mfg.
Leveraging Technology for Youth Suicide Crisis Intervention Through a Smartphone App (Sapphire AB) - Apr 29, 2023 - Abstract #SOBP2023SOBP_639;
Funding Source SafeUT Research and Quality Improvement Program (ReQuIP), Utah State Board of Education Background Text-based crisis interventions have been successful with youth...Efforts should be made to collect follow-up contact information to evaluate the effectiveness and helpfulness of active rescues. This example and the knowledge?gained can inform other states as they continue to enable the?988?call and text services.
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