- |||||||||| XEN393 / Neurocrine, carbamazepine / Generic mfg.
XEN393, A Novel Selective Dual Inhibitor of NaV1.2/NaV1.6 Channels Prevents Electrically-Induced Seizures in Mice and Rats (Hall E) - Nov 28, 2019 - Abstract #AES2019AES_235;
Brain concentrations of XEN393 that block the target channels but spare off-target channels like NaV1.1 were well tolerated and prevented electrical induced seizures in mice and rats. This work enables the testing of the hypothesis that dual selective NaV1.2/NaV1.6 inhibitors, such as XEN393, that spare NaV1.1, NaV1.3, and NaV1.5 may provide a new class of more effective seizure prevention AEDs that may be better tolerated in clinical practice.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Micro-scale solubility assessments and prediction models for active pharmaceutical ingredients in polymeric matrices. (Pubmed Central) - Nov 27, 2019
The identified 8 descriptors to be connected to API solubility in polymeric matrices were the number of hydrogen bonding donors, three descriptors related to the hydrophobicity of the molecule, glass transition temperature, fractional negative polar van der Waals surface area, out-of-plane potential energy and the fraction of rotatable bonds. Finally, in addition to our own model, the data set should help researchers in training their own solubility prediction models.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Strategies for selecting indicator compounds to assess attenuation of emerging contaminants during UV advanced oxidation processes. (Pubmed Central) - Nov 27, 2019
Therefore, the proposed ranking system is expected to provide a comprehensive monitoring tool to water reuse utilities for prioritizing a list of indicators to assess the treatment efficacy of UV AOPs that allows for subsequent operational control to achieve the treatment goal. This is the first strategic framework and guidelines for building a customizable tool of process control that depend on the site-specific occurrence profile of wastewater effluents and the UV system (UV lamp spectral output and power density).
- |||||||||| carbamazepine / Generic Mfg.
Journal: Unravelling the role of vegetation in the attenuation of contaminants of emerging concern from wetland systems: Preliminary results from column studies. (Pubmed Central) - Nov 27, 2019
In this study, we monitored planted (Phragmites australis) and unplanted sand columns to assess the effect of vegetation on the attenuation of 5 well-known CECs (benzotriazole, sulfamethoxazole, carbamazepine, bisphenol A, and diclofenac) and link it to the presence of different root exudates...Furthermore, the greater CEC attenuation in planted columns was linked to the release of certain root exudates that may shape the root microbiome. We expect our assay to be a starting point for exploring the role of root exudates in enhancing CEC removal efficiency in wastewater.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Proxies to monitor the inactivation of viruses by ozone in surface water and wastewater effluent. (Pubmed Central) - Nov 27, 2019
Proxies considered were the abatement in UV absorbance at 254 nm (UV) and carbamazepine (CBZ), a ubiquitous organic micropollutant with a similar abatement rate constant as human viruses...All proxies yielded good estimates of the actual MS2 inactivation in the pilot plant, indicating that the proxy-inactivation relationships established in the laboratory can also be applied to flow-through reactors. This study confirms that ozone is a highly effective disinfectant for viruses in both surface water and wastewater, and that the abatement of UV and CBZ can be used to track virus inactivation during water and wastewater treatment.
- |||||||||| carbamazepine / Generic Mfg.
PK/PD data, Preclinical, Journal: Pharmacokinetics and Metabolite Profiling of Trepibutone in Rats Using Ultra-High Performance Liquid Chromatography Combined With Hybrid Quadrupole-Orbitrap and Triple Quadrupole Mass Spectrometers. (Pubmed Central) - Nov 23, 2019
Trepibutone and carbamazepine (internal standard, IS) were quantified using multiple reaction monitoring (MRM) mode with the transitions of m/z 311.09→265.08 and m/z 237.06→194.08, respectively...A total of 30 metabolites were identified in plasma and urine by Q-Exactive high resolution mass spectrometry, and several common metabolic pathways were observed such as dealkylation, oxidation, reduction, glucuronidation, and so on. This research provides more information on trepibutone in pharmacodynamics and toxicology and will assist the usage of trepibutone in clinical.
- |||||||||| carbamazepine / Generic Mfg.
Clinical, Journal: Eagle's Syndrome: An Underdiagnosed Condition-Case Series in a Tertiary Care Hospital. (Pubmed Central) - Nov 22, 2019
Conservative management with carbamazepine was tried but only temporary relief was noticed in these patients...Eagle's syndrome is not a rarity, but underdiagnosed and missed most of the times. Hence all cases of chronic neck pain should be evaluated thoroughly by taking complete history and proper clinical examination, along with radiological investigations.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Efficient degradation of pharmaceutical micropollutants in water and wastewater by Fe-NTA-catalyzed neutral photo-Fenton process. (Pubmed Central) - Nov 20, 2019
In addition, the degradation of pharmaceuticals mixtures (including CBZ, crotamiton (CRMT) and ibuprofen (IBP)) in wastewater effluents from a biological aerated filter (BAF) by UVA/Fe-NTA/HO was studied in continuous-flow mode...More than 92% degradation efficiencies of CBZ, CRMT and IBP were obtained in continuous-flow mode under the given conditions of 0.178 mM Fe-NTA (1:1), 4.54 mM HO, UVA intensity 4.05 mW cm, hydraulic retention time (HRT) 2 h, influent pH 7.6 (±0.2) and temperature 20 °C. The results presented herein suggest that Fe-NTA-catalyzed neutral photo-Fenton reaction can be an alternative tertiary process for the treatment of pharmaceutical micropollutants in secondary wastewater effluents.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Transport of pharmaceuticals during electrodialysis treatment of wastewater. (Pubmed Central) - Nov 19, 2019
Some transport of micropollutants such as atenolol, metoprolol and hydrochlorothiazide was observed to the concentrate product...Transport of pharmaceuticals across the ED membranes was concluded to be dominated mainly by the molecule hydrophobicity/hydrophilicity as well as electrostatic interactions between pharmaceutical molecules and ED membranes. Particularly excluded were those having a negative charge and high hydrophobicity such as diclofenac and ibuprofen.
- |||||||||| carbamazepine / Generic Mfg., propranolol / Generic Mfg.
Journal: Phenotypical and molecular changes induced by carbamazepine and propranolol on larval stages of Mytilus galloprovincialis. (Pubmed Central) - Nov 18, 2019
Both compounds induced down-regulation of shell-specific and neuroendocrine related transcripts, while distinct effects were observed on antioxidant, lysosomal, and immune-related transcripts, also depending on the larval stage investigated. The results demonstrate that CBZ and PROP can affect development and gene transcription in mussel early larvae at environmental concentrations.
- |||||||||| carbamazepine / Generic Mfg., abacavir / Generic Mfg.
Review, Journal: Controversies in drug allergy: Testing for delayed reactions. (Pubmed Central) - Nov 14, 2019
It was noted that there have been advances in the science of delayed T cell-mediated reactions that have shed light on immunopathogenesis and provided a mechanism of preprescription screening in the case of HLA-B*57:01 and abacavir hypersensitivity and HLA-B*15:02 and carbamazepine Stevens-Johnson syndrome/toxic epidermal necrolysis in Southeast Asian subjects. Future directions should include the collaboration of large international networks to develop and standardize in vivo diagnostic approaches, such as skin testing and patch testing, combined with ex vivo and in vitro laboratory approaches.
- |||||||||| Fycompa (perampanel) / Eisai, carbamazepine / Generic Mfg.
Preclinical, Journal: AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. (Pubmed Central) - Nov 14, 2019
Incubation with perampanel up-regulated glutamine synthetase expression in glioblastoma cells, whereas treatment with valproic acid and levetiracetam downregulated excitatory amino acid transporter-2 expression. Overall, our data suggest that perampanel acts as an anticonvulsive drug and additionally mediated anti-tumorigenic effects.
- |||||||||| Botox (onabotulinumtoxin A) / GSK, Allergan, carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Review, Journal: Botulinum toxin type A as an alternative way to treat trigeminal neuralgia: a systematic review. (Pubmed Central) - Nov 14, 2019
These findings call for in-depth risk analysis to ensure that the environmental presence of CBZ and other drugs is not causing irreversible ecological and public-health damages. BoNT-A therapy is a safe and effective method of treating trigeminal neuralgia.
- |||||||||| carbamazepine / Generic Mfg., Trileptal (oxcarbazepine) / Novartis
Journal: Migraine Headache Prophylaxis. (Pubmed Central) - Nov 10, 2019
Acebutolol, oxcarbazepine, lamotrigine, and telmisartan are ineffective...The complementary treatments petasites, feverfew, magnesium, and riboflavin are probably effective. Nonpharmacologic therapies such as relaxation training, thermal biofeedback combined with relaxation training, electromyographic feedback, and cognitive behavior therapy also have good evidence to support their use in migraine prevention.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Human pharmaceuticals in three major fish species from the Uruguay River (South America) with different feeding habits. (Pubmed Central) - Nov 10, 2019
Hydrochlorothiazide, metoprolol, venlafaxine, propranolol, codeine, and the carbamazepine metabolite, 2-hydroxycarbamazepine, were accumulated at higher levels showing maximum concentrations between 1 and 10 μg/kg (w/w), but infrequently (<50%)...Acceptable daily intake and predicted no effect concentrations would indicate that measured muscle concentrations in fish from the Uruguay River do not pose a serious risk for human consumption nowadays. Further studies will be necessary for assessing the potential adverse effects on studied fish species.
- |||||||||| citalopram / Generic Mfg., sertraline / Generic Mfg., carbamazepine / Generic Mfg.
Journal: Soil influences on uptake and transfer of pharmaceuticals from sewage sludge amended soils to spinach. (Pubmed Central) - Nov 10, 2019
However, in the case of some other compounds (i.e. sertraline, amitriptyline, mirtazapine, metoprolol), uptake and the subsequent translocation and transformation from 3 soils of a higher pH and base cation saturation (Stagnic Chernozem Siltic, Haplic Chernozem and Greyic Phaeozem) significantly differed from 4 soils with a lower pH and base cation saturation (Haplic Luvisol, Haplic Cambisol, Dystric Cambisol and Arenosol Epieutric). Such observations proved strong compound dependent influences of soil conditions on various compounds bioaccumulations in plants and necessity of studying these processes always in diverse soils.
- |||||||||| carbamazepine / Generic Mfg.
Clinical, Journal: A Case of Trigeminal Neuralgia Treated with Microvascular Decompression 10 years after Gamma Knife Radiosurgery (Pubmed Central) - Nov 10, 2019
Carbamazepine was prescribed and the dosage increased...There were no abnormal findings such as arachnoid thickening, adhesions between vessels and nerves, or atherosclerotic plaque in the affected vessels. Pain completely abated following surgery, and side effects such as numbness of the face have not been observed at the time of writing this report.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Fate and distribution of pharmaceutically active compounds in mesocosm constructed wetlands. (Pubmed Central) - Nov 8, 2019
Plants played an essential and positive role in removing PhACs, resulting from direct phytoremediation and indirectly enhancing sorption and biodegradation. Our study provides knowledge to understand removal mechanisms of PhACs in CWs and to potentially enhance PhAC removal by developing pre-photocatalysis, adding dead plant biomass, and optimizing vegetation.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Kinetics and mechanisms of the degradation of PPCPs by zero-valent iron (Fe°) activated peroxydisulfate (PDS) system in groundwater. (Pubmed Central) - Nov 8, 2019
The abatement of pharmaceuticals and personal care products (PPCPs), including carbamazepine (CBZ), acetaminophen (ACP) and sulfamethoxazole (SMX), by zero-valent iron (Fe°) activated peroxydisulfate (PDS) system (Fe°/PDS) in pure water and groundwater was investigated...The first-order constants of CBZ, ACP and SMX increased from 0.021, 0.242 and 0.013 min- to 0.239, 2.536 and 0.259 min, and to 0.172, 1.516 and 0.197 min, respectively, with increasing the concentrations of SO and Cl to 100 mg/L and 10 mg/L, respectively. This study firstly reports the unexpected enhancement of groundwater matrix on the degradation of micropollutants by Fe°/PDS, demonstrating that Fe°/PDS can be an efficient technology for groundwater remediation.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Nerve Compression Syndromes in the Posterior Cranial Fossa. (Pubmed Central) - Nov 8, 2019
In such cases, a microvascu- lar decompression operation is indicated. This is a causally directed form of treat- ment that generally yields very good results.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Removal of the environmental pollutant carbamazepine using molecular imprinted adsorbents: Molecular simulation, adsorption properties, and mechanisms. (Pubmed Central) - Nov 8, 2019
The simulation and measurement of the ultraviolet spectrum of the imprinting system showed that a new interaction system was formed between the template and monomers, and that multiple binding conformations between them took place when specific recognition occurred. Energy calculation and hydrogen bond analysis revealed that the van der Waals force, including the π-π conjugate and electrostatic forces including hydrogen bonding, played an important role during selective adsorption, which was confirmed by infrared spectroscopy analysis.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Data on removal kinetics of pharmaceutical compounds, artificial sweeteners, and perfluoroalkyl substances from water using a passive treatment system containing zero-valent iron and biochar. (Pubmed Central) - Nov 7, 2019
The removal data (concentration vs. residence time) for each target contaminant were fitted to the first-order (exponential decay equation) or zero-order (linear equation) model using SigmaPlot. The removal rate, removal rate constant (k ), mass normalized rate constant (k ), surface area normalized rate constant (k , specific reaction rate constant), and half-life (t ) of target contaminants in Columns ZVI, BC, and (ZVI + BC) were calculated and summarized in this dataset.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Combining ozone with UV and HO for the degradation of micropollutants from different origins: lab-scale analysis and optimization. (Pubmed Central) - Nov 6, 2019
The optimal dosages of HO concentration were at 0.75, 0.2, 0.47, 0.75 and 0.63mM, and pH were at 10, 10, 7, 10 and 10, and reaction time at 38.5, 33.5 43, 6 and 6min, respectively. Ozone-based AOP and in particular combination of UV with ozone and HO is efficient to degrade atrazine, alachlor, carbamazepine, 17-α-ethinylestradiol and pentachlorophenol, and is attractive for future application of real wastewater treatment.
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