- |||||||||| carbamazepine / Generic mfg.
Journal: Refinement of organic crystal structures with multipolar electron scattering factors. (Pubmed Central) - Jan 10, 2020
Structure refinements were performed on a carbamazepine crystal using electron structure-factor amplitudes determined experimentally [Jones et al...Among others, the method clearly improves model fitting statistics, when compared with IAM, and allows for reliable refinement of atomic thermal parameters. The improvements are more pronounced with poorer-resolution diffraction data.
- |||||||||| methylprednisolone oral / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal: Reversible splenial lesion in a patient with new-onset refractory status epilepticus (NORSE). (Pubmed Central) - Jan 10, 2020
He was diagnosed with NORSE and received a combination treatment with immunotherapy and targeted temperature management (TTM), which effectively decreased his seizures. This case suggests that even for patients with reversible splenial lesions, NORSE should be considered, and that treatment with immunotherapy and TTM may be effective.
- |||||||||| carbamazepine / Generic mfg., Latuda (lurasidone oral) / Sumitomo Dainippon, quetiapine / Generic mfg.
Clinical, Review, Journal: Pharmacological treatment of adult bipolar disorder. (Pubmed Central) - Jan 9, 2020
Treatment of BD-depression remains unsatisfactory but includes some modern antipsychotics (particularly lurasidone, olanzapine + fluoxetine, and quetiapine) and the anticonvulsant lamotrigine; value and safety of antidepressants remain controversial...Long-term treatment of BD also is limited by access to, and support of expert, comprehensive clinical programs. Pursuit of improved, rationally designed pharmacological treatments for BD, as for most psychiatric disorders, is fundamentally limited by lack of coherent pathophysiology or etiology.
- |||||||||| carbamazepine / Generic mfg.
Journal: Allosteric Interactions in Human Cytochrome P450 CYP3A4: The Role of Phenylalanine 213. (Pubmed Central) - Jan 8, 2020
The role of Phe213 in the allosteric mechanism of human cytochrome P450 CYP3A4 was studied using a combination of progesterone (PGS) and carbamazepine (CBZ) as probe substrates...All mutants demonstrated higher activity with CBZ, lower activity with PGS, and reduced activation of CBZ epox-idation by PGS, most pronounced in F213A mutant. Using all-atom molecular dynamics simulations we compared dynamics of WT CYP3A4 and the F213A mutant incorporated in the lipid bilayer and the effect of the presence of PGS molecule at the allosteric peripheral site and evaluated the critical role of Phe213 in mediating the heterotropic allosteric interactions in CYP3A4.
- |||||||||| Review, Journal: Bipolar depression: a major unsolved challenge. (Pubmed Central) - Jan 7, 2020
Evidence of efficacy of lithium and anticonvulsants for bipolar depression is very limited; lamotrigine has long-term benefit, but valproate and carbamazepine are inadequately tested and carry high teratogenic risks. Evidence is emerging of short-term efficacy of several modern antipsychotics (including cariprazine, lurasidone, olanzapine-fluoxetine, and quetiapine) for bipolar depression, including with mixed features, though they risk adverse metabolic and neurological effects.
- |||||||||| carbamazepine / Generic mfg.
[VIRTUAL] VALPROATE INDUCED PARKINSONISM AND COGNITIVE DECLINE IN EPILEPSY (EXHIBITION HALL) - Jan 6, 2020 - Abstract #AATADPD2020AAT_ADPD_673;
Although rare in epilepsy it is more a side effects mainly from valproate. So VPA withdrawn and new generation AEDs introduction (LTG + LEV) in this case was a desirable option for this patient.
- |||||||||| carbamazepine / Generic mfg.
Journal: Advanced treatment of urban wastewater by UV-C/free chlorine process: Micro-pollutants removal and effect of UV-C radiation on trihalomethanes formation. (Pubmed Central) - Jan 2, 2020
Unlike of FC process, UV-C/FC was really effective in the degradation of the target CECs (carbamazepine (CBZ), diclofenac, sulfamethoxazole and imidacloprid) in real wastewater (87% degradation of total CECs within 60 min, Q = 1.33 kJ L), being CBZ the most refractory one (49.5%, after 60 min)...The formation of radicals due to UV-C/FC process can reduce THMs compared to chlorination process, because part of FC reacts with UV-C radiation to form radicals and it is no longer available to form THMs. These results are encouraging in terms of possible use of UV-C/FC process as advanced treatment of urban wastewater even for possible effluent reuse.
- |||||||||| carbamazepine / Generic mfg.
Journal: Biodegradation of pharmaceuticals and personal care products in the sequential combination of activated sludge treatment and soil aquifer treatment. (Pubmed Central) - Jan 1, 2020
Additionally, biodegradation contributed to the effective removal of carboxylic PPCPs (i.e. ketoprofen and gemfibrozil) in both ASTs and SAT, but effective biodegradation of halogenated acid and polycyclic aromatic compounds (i.e. clofibric acid and naproxen) was observed only in SAT (82.1% and 81.8%, respectively)...Considering PPCP biodegradation and substrate metabolism, SAT displays a wider range on the biodegradation than AST. Therefore, we conclude that these two processes can complement each other when used for controlling PPCPs.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Triple Puncture for Primary Trigeminal Neuralgia: A Randomized Clinical Trial. (Pubmed Central) - Dec 28, 2019
The participants in the treatment group received triple puncture treatment of 6 times per week for 4 weeks, and those in control group were given carbamazepine (300-600 mg per day) for at least 1 month...The incidence of adverse events in the treatment group and control group was 9.1% and 24.1% respectively. It can be inferred that triple puncture can effectively improve the quality of life of patients with pTN and has less side effects.
- |||||||||| carbamazepine / Generic mfg.
Journal: Mechanics of Tablet Formation: A Comparative Evaluation of Percolation Theory with Classical Concepts. (Pubmed Central) - Dec 26, 2019
Furthermore, the theoretical knowledge of percolation thresholds of individual powder components in the binary mixture was found to be helpful in improving compaction properties of the poorly compactible material, i.e. carbamazepine. Thus percolation theory can be helpful in predicting compression and compaction behavior of powder materials and serve as a potent tool for the successful design of tablet formulations.
- |||||||||| carbamazepine / Generic mfg., duloxetine delayed release / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Journal: Anticonvulsive activity of duloxetine: A new choice for the epileptic patients with depression. (Pubmed Central) - Dec 26, 2019
Furthermore, pretreatment with thiosemicarbazide (an inhibitor of GABA synthesis enzyme) significantly increased the ED of duloxetine, suggesting the GABAergic system may contribute to the anticonvulsive action of duloxetine. These results support the use of duloxetine in the treatment of coexisting depression and epilepsy.
- |||||||||| carbamazepine / Generic mfg.
Journal: Carbamazepine removal from water by carbon dot-modified magnetic carbon nanotubes. (Pubmed Central) - Dec 23, 2019
This work proposed a method of combining π-bond-rich materials (CNTs and CDs) and magnetite to make separable composite adsorbents with high affinity interactions between carbamazepine and carbon materials. The prepared adsorbent is attractive for carbamazepine removal due to its good performance, moderate cost, ease of separation, and ability to regenerate.
- |||||||||| paclitaxel / Generic mfg., carbamazepine / Generic mfg.
Preclinical, Journal: TsNTxP, a non-toxic protein from Tityus serrulatus scorpion venom, induces antinociceptive effects by suppressing glutamate release in mice. (Pubmed Central) - Dec 23, 2019
Male and female Swiss mice (25-30 g) were exposed to different models of acute pain (tail-flick test and nociception caused by capsaicin intraplantar injection) or neuropathic pain (chronic pain syndrome induced by paclitaxel or chronic constriction injury of the sciatic nerve)...TsNTxP reduced glutamate release from mouse spinal cord synaptosomes following stimulation with potassium chloride (KCl) or capsaicin. Thus, this T. serrulatus protein may be a promising non-toxic drug for the treatment of neuropathic pain.
- |||||||||| carbamazepine / Generic mfg., amoxicillin / Generic mfg.
Journal: Are pharmaceuticals removal and membrane fouling in electromembrane bioreactor affected by current density? (Pubmed Central) - Dec 23, 2019
Membrane fouling rate in eMBR with respect to conventional MBR was reduced by 24, 44 and 45% at current densities of 0.3, 0.5 and 1.15 mA/cm, respectively. The mechanism for pharmaceutical removal in this study proceeded by: (1) charge neutralization between negatively-charged pharmaceutical compounds and positive electro-generated aluminium coagulants to form larger particles and (2) size exclusion by membrane filtration.
- |||||||||| carbamazepine / Generic mfg.
Journal: Transformations between co-amorphous and co-crystal systems and their influence on the formation and physical stability of co-amorphous systems. (Pubmed Central) - Dec 21, 2019
Carbamazepine (CBZ) along with benzoic acid, maleic acid, succinic acid, tartaric acid, saccharin, and nicotinamide were used as materials...Whilst co-amorphous systems were obtained, the physical stability of these was very low, and the samples recrystallized to either co-crystal forms, or the individual components. In conclusion, a possible transformation between the two systems was confirmed, but the resulting co-amorphous systems were highly unstable.
- |||||||||| carbamazepine / Generic mfg.
Journal: Contaminants of emerging concern removal from real wastewater by UV/free chlorine process: A comparison with solar/free chlorine and UV/HO at pilot scale. (Pubmed Central) - Dec 19, 2019
In particular, a total removal of carbamazepine (CBZ) and imidacloprid (IMD) was observed for UV-C/FC process with 0.27 kJ L and 10 mgL of FC, while, in the sunlight/FC process (same FC dose), CBZ total removal took place quite fast (0.50 kJ L), but 90% removal of IMD was observed only after 60 min (7.09 kJ L). In conclusion, UV-C/FC process can be an interesting solution for tertiary treatment of urban wastewater for the removal of CECs and sunlight/FC is worthy of further investigation to evaluate its possible application in small UWTPs.
- |||||||||| carbamazepine / Generic mfg.
Journal: Transformations of organic micropollutants undergoing permanganate/bisulfite treatment: Kinetics, pathways and toxicity. (Pubmed Central) - Dec 19, 2019
Acesulfame (ACE) and carbamazepine (CBZ) were two typical compounds containing olefinic moieties...In addition, transformation products of ACE and CBZ during PM/BS process did not induce higher toxicity. This study provides a preliminary interpretation on the selectivity of PM/BS process according to the micropollutants' chemical structures, which hope to shed light on the future development of PM/BS treatment.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Occurrence and treatment of contaminants of emerging concern in the African aquatic environment: Literature review and a look ahead. (Pubmed Central) - Dec 19, 2019
Removal efficiencies of WSPs and TFs focus mainly on PPCPs and vary significantly, ranging from no removal (e.g. carbamazepine) to better than 99.9% (e.g. paracetamol). Despite the rising adoption of POUs, limited but promising information is available on their performance regarding CECs treatment in drinking water, particularly for the low-cost devices (e.g. ceramic filters and solar disinfection - SODIS) being adopted in Africa and other developing countries.
- |||||||||| carbamazepine / Generic mfg.
Journal: The role of active manganese species and free radicals in permanganate/bisulfite process. (Pubmed Central) - Dec 11, 2019
With the increase of initial pH and the [bisulfite]/[permanganate] molar ratio, a mechanistic changeover from RMnS to radicals occurred during phenol degradation in PM/BS process. The generation of RMnS and radical species, especially SO, could be well explained by the proposed mechanism consisting of radical chain reactions and manganese reduction reactions via both electron transfer and oxygen transfer steps.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Hydroxypropyl-β-cyclodextrin-based fast dissolving carbamazepine printlets prepared by semisolid extrusion 3D printing. (Pubmed Central) - Dec 6, 2019
The results highlight the feasibility of using HPβCD as excipient in printlets of poorly soluble drugs, and the possibilities of tuning drug release profiles through small changes in cellulose ethers nature and ratio. Semisolid extrusion-based 3D printing is revealed as a feasible approach to in situ form carbamazepine-HPβCD complexes and to produce printlets with suitable physical and drug release properties for oral delivery.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Green Analysis: High Throughput Analysis of Emerging Pollutants in Plant Sap by Freeze-Thaw-Centrifugal Membrane Filtration Sample Preparation - HPLC-MS/MS Analysis. (Pubmed Central) - Dec 5, 2019
A novel rapid freeze-thaw/centrifugation extraction followed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) analysis was developed for high-throughput quantification of 11 EFCs with diverse chemical properties, including estriol, codeine, oxazepam, 2,4-dinitrotoluene, 1,3,5-trinitroperhydro-1,3,5-triazine, bisphenol A, triclosan, caffeine, carbamazepine, lincomycin, and DEET, in three representative crops, corn, tomato, and wheat...Developed methods can rapidly screen EFCs in agriculture crops and can assess pollutant distribution at contaminated sites and gain insight on EFCs transport in plants to assess transmembrane migration in vascular organisms. The findings contribute significantly to environmental research, food security, and human health, as it assesses the first step of potential entry into the food chain, that being transmembrane migration and plant uptake, the primary barrier between polluted waters or soils and our food.
- |||||||||| ciprofloxacin / Generic Mfg., carbamazepine / Generic Mfg.
Journal: Sorption properties and behaviour at laboratory scale of selected pharmaceuticals using batch experiments. (Pubmed Central) - Dec 2, 2019
Batch experiments suggest that sorption behaviour was governed by compound-specific properties rather than by sediment properties. These results contribute to the understanding sorption behaviour of pharmaceuticals in heterogeneous sediments, although some inconsistencies were revealed between laboratory scale results and field scale observations.
- |||||||||| carbamazepine / Generic Mfg.
Journal, Heterogeneity: Generation of active Mn(III)(aq) by a novel heterogeneous Electro-permanganate (E-PM) process with manganese(II) as promoter and stabilizer. (Pubmed Central) - Dec 1, 2019
In addition, the soluble Mn(III) generated in the E-PM-Mn process was demonstrated to be very efficient for the degradation and mineralization of diclofenac (DCF) as well as methyl blue, carbamazepine, phenol, sulfamethoxazole, and nitrobenzene...Possible degradation pathways of DCF in E-PM-Mn2+ process were also proposed. The results demonstrated that the E-PM-Mn2+ system based on active Mn(III)(aq) could create a more efficient, sustainable, and less energy costing technology for water treatment.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Degradation of Organic Micro-pollutants in UV/NH2Cl Advanced Oxidation Process. (Pubmed Central) - Dec 1, 2019
In this study, the degradation of five representative OMPs, including triclosan, carbamazepine, sulfamethoxazole, estradiol (E2), and ethinylestradiol (EE2), was examined in different water matrices...Based on quantitative analysis of the impact on OMP degradation from co-solutes (including Cl-, HCO3-, NOM) as well as pH and NH2Cl doses, we developed a kinetic model for the prediction of OMP degradation in complex water matrices. In environmental water matrices, the performance and radical contributions in UV/NH2Cl and UV/H2O2 systems were taken into comparison, which showed faster degradation of OMPs and a more significant contribution of CO3•- in the UV/NH2Cl process.
- |||||||||| carbamazepine / Generic Mfg.
Journal: In Situ Photoelectrochemical Chloride Activation Using WO Electrode for Oxidative Treatment with Simultaneous H Evolution under Visible Light. (Pubmed Central) - Dec 1, 2019
The degradation of 4-chlorophenol, bisphenol A, acetaminophen, carbamazepine, humic acid, and fulvic acid and the inactivation of E. coli were remarkably enhanced by in situ RCS generated in PEC conditions, whereas the activities of the PC and EC processes were negligible...The H generation was observed only at PEC condition and negligible at PC and EC conditions. On the other hand, the oxidation of chloride on WO photoanode produced chlorate (ClO) as a toxic byproduct under UV irradiation but visible light-irradiated PEC system generated no chlorate.
- |||||||||| carbamazepine / Generic Mfg.
Journal: Induction of microbial oxidative stress as a new strategy to enhance the enzymatic degradation of organic micropollutants in synthetic wastewater. (Pubmed Central) - Dec 1, 2019
A distance-based redundancy analysis was used to show that DO perturbations correlate with the abundance of Pseudomonadaceae and Rhodocyclaceae families, activities of peroxidases and cytochromes, and the degradation of OMPs. DO perturbation of 0.25 and 0.5 cycles/hr led to most abundance of Pseudomonadaceae and Rhodocyclaceae families, showed higher activity of peroxidase and cytochrome, and gave largest removal of OMPs (removal of 92±3% for sulfamethoxazole, 84±3% for naproxen, 82±3% for ibuprofen, 66±2% for carbamazepine, 57±15% for tylosin, and 88±1% for atrazine).
- |||||||||| carbamazepine / Generic Mfg.
Journal: PATERNAL EXPOSURE TO CARBAMAZEPINE IMPACTS ZEBRAFISH OFFSPRING REPRODUCTION OVER MULTIPLE GENERATIONS. (Pubmed Central) - Dec 1, 2019
The offspring of CBZ exposed males had lower 11KT, reproductive output, and altered courtship, aggression, and sperm morphology compared to the lineage from unexposed parents. Our results indicate that parental carbamazepine exposure history impacts the unexposed progeny up to the F4 generations and that paternal, but not maternal, exposure is most important for the reproductive health of male offspring.
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