- |||||||||| carbamazepine / Generic mfg.
Reactivity of aromatic organic compounds to radical species under cobalt/peracetic acid advanced oxidation process (Versailles, Sofitel Philadelphia at Rittenhouse Square) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_10859;
Then, the degradation of model contaminants (bisphenol-A, carbamazepine, naproxen and sulfamethoxazole) by Co/PAA was studied...This study significantly advances the fundamental understating of (i) the oxidation conditions under the combined PAA and Co(II)/Co(III), and (ii) organic compounds’ reactivity to carbon-centered radicals generated from activation of PAA. The results will be useful for further development of advanced oxidation technologies utilizing PAA.
- |||||||||| carbamazepine / Generic mfg.
Pyridine and other heteroaryls as phenyl isosteres: SAR Studies of isoform-selective NaV1.6 inhibitors (Exhibit Hall A, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_9017;
Classic NaV inhibitors, such as carbamazepine, are not selective and block all NaV subtypes indiscriminately...These modifications had a large influence on potency, CNS penetration, and ADMET properties as a result of an increase in polar surface area in many cases. Further structural optimization provided key heteroaryl sulfonamide analogues with balanced stability, potency, and isoform selectivity, which demonstrated in vivo efficacy in a mouse model of epilepsy.
- |||||||||| carbamazepine / Generic mfg.
Surface proclivity and interaction of emerging contaminants at the lipid monolayer membrane (Exhibit Hall A, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_8804;
For instance, neutral ECs, including but not limited to, carbamazepine and β-estradiol, did not show modification of the DPPC phases, whereas charged species of amlodipine and triclosan led to significant deviation in DPPC phase domains...It will be demonstrated that the interaction strength of ECs with biological membranes, and thereby their fate and transport in the aquatic medium, is dependent on the molecular identity of the contaminant. The study further shows the suitability of LBT method in generating surface pressure versus molecular area isotherms as a technique to detect and categorize EC-lipid membrane interactions.
- |||||||||| carbamazepine / Generic mfg.
Pharmaceuticals and personal care product accumulation in terminal lakes receiving reclaimed wastewater (Toulouse, Sofitel Philadelphia at Rittenhouse Square) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_7107;
A similar trend was observed with all other PPCPs being higher in reclaimed wastewater influenced terminal lakes as compared to non-wastewater influenced terminal lakes was observed. Ongoing research includes the quantification of these compounds in near-shore soil and sediments.
- |||||||||| carbamazepine / Generic mfg.
Linking dissolved organic matter composition to photolysis of contaminants (Exhibit Hall A, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_6175;
Carbamazepine degrades primarily via 1O2 while atorvastatin degrades primarily through 3DOM*. These results are combined with detailed analyses of DOM composition to explain differences in observed contaminant lifetimes in the waters.
- |||||||||| carbamazepine / Generic mfg.
RTILs as a greener extraction solvent for carbamazepine (Exhibit Hall A, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_6141;
[C7-MIM] [NTF2] and [C9-MIM] [NTF2] were found to have extracted carbamazepine at an average of 83.69% and 98.08% respectively. This was comparable to known extraction solvent dichloromethane which extracted 96.15% of the carbamazepine.
- |||||||||| carbamazepine / Generic mfg.
Pyridine and other heteroaryls as phenyl isosteres: SAR Studies of isoform-selective NaV1.6 inhibitors (Exhibit Hall D, Pennsylvania Convention Center) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_4153;
Classic NaV inhibitors, such as carbamazepine, are not selective and block all NaV subtypes indiscriminately...These modifications had a large influence on potency, CNS penetration, and ADMET properties as a result of an increase in polar surface area in many cases. Further structural optimization provided key heteroaryl sulfonamide analogues with balanced stability, potency, and isoform selectivity, which demonstrated in vivo efficacy in a mouse model of epilepsy.
- |||||||||| carbamazepine / Generic mfg.
Understanding and monitoring the decay of waterborne viruses during ozonation (Toulouse, Sofitel Philadelphia at Rittenhouse Square) - Feb 13, 2020 - Abstract #ACSSp2020ACS_Sp_418;
Both proxies were well-correlated with virus inactivation, and their applicability to virus inactivation monitoring was confirmed in a pilot-scale drinking water treatment setup. Overall, this study confirms that ozone has a high potential to mitigate waterborne viruses in water and wastewater, and provides tools to monitor ozone treatment performance.
- |||||||||| Painful Legs and Moving Toes (PLMT) Syndrome in a 67 Years Old Parkinsonism Patient: Response to a Botulinum Toxin Application Protocol () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_1295;
We injected 1000 units of AbobotulinumtoxinA in the following left lower limb points and their doses: Gastrocnemius 300U, Soleus 100U, Later Tibialis 150U, Flexor hallucis longus 100U, Adductor hallucis 25U, Fibularis longus 100U, Extender hallucis longus 100U and Tibialis Previous 100U...The blocked points were the agonists and antagonists of the observed movement, even perceiving a predominance of the posterior muscles in this case. Conclusions : This therapeutic technique may help other similar cases and the development of more relevant studies.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Atypical Trigeminal Neuralgia in The Setting of Recurrent Tongue Squamous Cell Cancer: A Case Report. () - Feb 11, 2020 - Abstract #ISPRM2020ISPRM_520;
Case Diagnosis : The patient had minimal pain relief with a regimen of hydromorphone and gabapentin...First line therapy is carbamazepine or oxcarbazepine...The mechanism of analgesia is unknown.Conclusions : Constant burning pain in multiple dermatomes can raise suspicion for atypical TN. Oropharyngeal tumors can be a possible cause of atypical TN.
- |||||||||| topiramate / Generic mfg., carbamazepine / Generic mfg.
Clinical, Review, Journal, Monotherapy: Topiramate versus carbamazepine monotherapy for epilepsy: an individual participant data review. (Pubmed Central) - Feb 9, 2020
For individuals with focal onset seizures, there is moderate-certainty evidence that carbamazepine is less likely to be withdrawn and high-certainty evidence that 12-month remission will be achieved earlier than with topiramate. We did not find any differences between the drugs in terms of the other outcomes measured in the review and for individuals with generalised tonic-clonic seizures or unclassified epilepsy; however, we encourage caution in the interpretation of results including small numbers of participants with these seizure types.Future trials should be designed to the highest quality possible and take into consideration masking, choice of population, classification of seizure type, duration of follow-up, choice of outcomes and analysis, and presentation of results.
- |||||||||| carbamazepine / Generic mfg.
Journal: Unappropriate recommendation grades for carbamazepine and valproate (Pubmed Central) - Feb 8, 2020
We did not find any differences between the drugs in terms of the other outcomes measured in the review and for individuals with generalised tonic-clonic seizures or unclassified epilepsy; however, we encourage caution in the interpretation of results including small numbers of participants with these seizure types.Future trials should be designed to the highest quality possible and take into consideration masking, choice of population, classification of seizure type, duration of follow-up, choice of outcomes and analysis, and presentation of results. No abstract available
- |||||||||| carbamazepine / Generic mfg., escitalopram / Generic mfg.
Journal: Recurrence of DRESS syndrome to escitalopram or neosensitization? (Pubmed Central) - Feb 7, 2020
Membrane fouling results in an increase in sulfamethoxazole rejection while carbamazepine rejection decreases due to membrane fouling. No abstract available
- |||||||||| Review, Journal: Myalgia in myositis and myopathies. (Pubmed Central) - Feb 7, 2020
Pregabalin, gabapentin, or amitriptyline can be tried in conditions with myalgic pain. This review summarizes the symptoms, diagnostic strategies, and therapeutic approach in neuromuscular disorders that present with myalgia.
- |||||||||| carbamazepine / Generic mfg.
Primary Neuroendocrine Tumor of the Central Nervous Sistem, a Case Report and Literature Review (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_3095;
Patient currently maintain left hemiparesis, frequent pain, taking carbamazepine due to epileptic seizures, and considerable weight loss...Due to relapse, palliative radiotherapy was initiated in the region of the tumors. Conclusion The patient had a poor outcome in relation to cancer, with little possibility of treatment due to poor tumor differentiation and poor performance status.
- |||||||||| metformin / Generic mfg., carbamazepine / Generic mfg.
Should Vitamin B12 Status Monitoring Be Implemented for Patients Taking Metformin? (ENDOExpo) - Feb 7, 2020 - Abstract #ENDO2020ENDO_2671;
However, neurologic deficits and macrocytic anemia could be prevented through monitoring cobalamin levels in diabetics receiving metformin treatment. This monitoring might be needed more in patients with seizure disorderon Carbamazebin.
- |||||||||| carbamazepine / Generic mfg.
Journal: Antiepileptic Overdose. (Pubmed Central) - Feb 6, 2020
The most common drugs implicated in overdose include phenytoin, sodium valproate, carbamazepine, and phenobarbital...Murty S. Antiepileptic Overdose. Indian J Crit Care Med 2019;23(Suppl 4):S290-S295.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Ospolot (sultiam) / AOP Orphan Pharma, Diacomit (stiripentol) / Biocodex, Meiji Seika
Trial completion date, Trial primary completion date: EPIPOP: Population Pharmacokinetics of Antiepileptic in Pediatrics (clinicaltrials.gov) - Feb 5, 2020
P=N/A, N=1000, Recruiting,
Indian J Crit Care Med 2019;23(Suppl 4):S290-S295. Trial completion date: Jun 2019 --> Jun 2022 | Trial primary completion date: Jun 2019 --> Jun 2022
- |||||||||| Triglide (fenofibrate) / Vectura, Shionogi, carbamazepine / Generic mfg.
Review, Journal: Therapy in Sleep-Related Hypermotor Epilepsy (SHE). (Pubmed Central) - Jan 31, 2020
The increasing understanding of the role of neuronal nicotinic acetylcholine receptor (nAChR) in SHE pathophysiology has led to the evaluation of compounds able to modulate this receptor system, including nicotine patches and fenofibrate...Therefore, a prospective study in a large cohort of sporadic SHE patients is necessary in order to provide clinicians with an evidence-based treatment for this rare form of epilepsy. An early and effective anti-epileptic treatment is mandatory for SHE patients, in order to prevent the risk of increasing seizure frequency throughout the disease course with relevant impact on patients' cognitive profile and daytime performances.
- |||||||||| carbamazepine / Generic mfg.
Journal: Water-insoluble polymers as binders for pellet drug layering: Effect on drug release and performance upon compression. (Pubmed Central) - Jan 30, 2020
Carbamazepine was layered on sugar cores in fluidized bed coater using isopropanol (IPA):water solution or aqueous dispersion of ethylcellulose, polyvinyl acetate or ammonium-methylmethacrylate copolymer...This problem could be minimized by using a higher amount of the binder, addition of a plasticizer or using polymers of higher viscosity grade. In conclusion, the use of water-insoluble polymers as binder for pellets drug layering is an effective tool to extend the drug release without additional coating step.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. (Pubmed Central) - Jan 30, 2020
Herein, on the basis of available literature reports and our own recent findings of in vitro as well as in vivo experimental studies, we discuss the therapeutic and pathophysiological implications of altered P450 ERAD and its plausible clinical relevance. We specifically (i) describe the P450 ERAD-machinery and how it may be repurposed for the generation of antigenic P450 peptides involved in P450 autoantibody pathogenesis in drug-induced acute hypersensitivity reactions and liver injury, or viral hepatitis; (ii) discuss the relevance of accelerated or disrupted P450-ERAD to the pharmacological and/or toxicological effects of clinically relevant P450 drug substrates; and (iii) detail the pathophysiological consequences of disrupted P450 ERAD, contributing to non-alcoholic fatty liver disease (NAFLD)/non-alcoholic steatohepatitis (NASH) under certain synergistic cellular conditions.
- |||||||||| carbamazepine / Generic mfg.
Biomarker, Clinical, Journal: Genetic literacy series: clinical application of pharmacogenetics for adverse reactions to antiepileptic drugs. (Pubmed Central) - Jan 29, 2020
This article, beginning with a case of an adverse drug reaction induced by carbamazepine, will answer four key questions about pharmacogenetics of adverse drug reactions: (1) What types of adverse drug reactions can be caused by antiepileptic drugs?...and (4) How do we apply pharmacogenetic testing in clinical practice? Our goal is to increase awareness of the contributions of genetic variation to adverse drug reactions of antiepileptic drugs.
- |||||||||| carbamazepine / Generic mfg., amoxicillin / Generic mfg.
Journal: Tuning down the environmental interests of organoclays for emerging pollutants: Pharmaceuticals in presence of electrolytes. (Pubmed Central) - Jan 29, 2020
In the presence of electrolytes (NaCl at a concentration of 1 × 10 mol L), both nonionic and cationic organoclays show a decrease of their efficiencies, whereas the adsorption is particularly enhanced for Na-Mt except for the cationic species (trimethoprim and metoprolol). Thus, in realistic experimental conditions close to those of natural effluents, raw clay mineral appears as the most appropriate sorbent for the studied pharmaceuticals while it raises the question of the usefulness of organoclays in water remediation strategy.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Review, Journal: Subacute sclerosing panencephalitis: clinical phenotype, epidemiology, and preventive interventions. (Pubmed Central) - Jan 29, 2020
Seizures and abnormal movements may respond to carbamazepine...WHAT THIS PAPER ADDS: Measles contracted under 5 years of age has highest risk of developing subacute sclerosing panencephalitis (SSPE). Children with, or exposed to, human immunodeficiency virus infection, who contract measles may be at increased risk of SSPE.
- |||||||||| carbamazepine / Generic mfg.
Journal: Anaerobic-aerobic biofilm-based digestion of chemical contaminants of emerging concern (CEC) and pathogen indicator organisms in synthetic wastewater. (Pubmed Central) - Jan 28, 2020
The efficacy of biofilm based anaerobic-aerobic treatment to reduce caffeine, carbamazepine, and three estrogens (Estrone (E1), 17β-estradiol (E2), and 17α-ethynylestradiol (EE2)), as well as E. coli (CN-13) and F+ specific coliphage (MS2), from synthetic wastewater was investigated...Estrone (E1) and 17β-estradiol (E2) showed minimal reduction in the UAnPBBR but 99.67% reduction in the TF, while EE2 was reduced 1.62% in the AnPBBR and 20.36% in the TF. On average, a 3-log reduction of E. coli (CN-13) and a 1-log reduction of F+ specific coliphage (MS2) concentration was observed across the overall reactor system.
- |||||||||| carbamazepine / Generic mfg.
Journal: Adsorptive removal of endocrine-disrupting compounds and a pharmaceutical using activated charcoal from aqueous solution: kinetics, equilibrium, and mechanism studies. (Pubmed Central) - Jan 25, 2020
Bisphenol A (BPA), diethyl phthalate (DEP), and carbamazepine (CBZ) have been widely used in chemical and pharmaceutical fields, and their residues are detected in various environments...After 3 cycles of adsorption/desorption, AC still maintained 92, 100, and 82% of initial adsorption capacities for DEP, BPA, and CBZ, respectively. Therefore, the AC is an effective adsorbent for the removal of endocrine-disrupting chemicals and pharmaceuticals from aqueous solution.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Observational data, Journal: The number and kind of antiepileptics affect propofol dose requirement for anesthesia: observational study. (Pubmed Central) - Jan 24, 2020
Patients were categorized according to the number of antiepileptics (none, single agent, two kinds, and three or more kinds of antiepileptics) and the kind of antiepileptic (carbamazepine, valproate, phenobarbital, phenytoin, zonisamide, clobazam, or topiramate) being received...In particular, valproate and clobazam reduce the propofol dose requirement, while phenobarbital increases this.Clinical trial registration UMIN No. UMIN000014179.
- |||||||||| carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Clinical, Retrospective data, Review, Journal: First bite syndrome: clinical study of six cases and review of the literature (Pubmed Central) - Jan 24, 2020
The cause of the disease may be related to intraoperative injury to the sympathetic plexus of the parotid gland. Currently, there is no standard treatment method, but the symptoms are usually relieved within a few months.
- |||||||||| ciprofloxacin / Generic mfg., carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Journal: Occurrence, distribution, and ecotoxicological risk assessment of selected pharmaceutical compounds in water from Lake Victoria, Uganda. (Pubmed Central) - Jan 22, 2020
Ecotoxicological risk assessment showed that sulfamethoxazole, oxytetracycline, erythromycin, and diclofenac pose a high toxic risk to aquatic organisms in the lake, while ciprofloxacin, norfloxacin, and ibuprofen pose a medium risk. This study is the first of its kind to report the levels and ecotoxic risks of pharmaceutical compounds in Lake Victoria waters, of Uganda, and East Africa as a whole.
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