- |||||||||| glibenclamide / Generic mfg., carbamazepine / Generic mfg.
Journal: Simultaneous Analysis of Multiclass Contaminants of Emerging Concern in Sediments by Liquid Chromatography with Tandem Quadrupole Mass Spectrometry. (Pubmed Central) - Apr 22, 2020
The method performance was also compared with a well-established US-EPA Method 1694 by analyzing sediment samples collected from Yundang Lagoon (Xiamen, China) with field-incurred CEC residues. The sediment samples were detected with residues of parabens, gemfibrozil, ketoprofen, naproxen, fenoprofen, diclofenac, miconazole, carbamazepine, benzophenon-3, glibenclamide, sildinafil citrate and some bisphenol analogues.
- |||||||||| carbamazepine / Generic mfg.
Journal: Assessment of Impact Breakage of Carbamazepine Dihydrate due to Aerodynamic Dispersion. (Pubmed Central) - Apr 22, 2020
The breakage data are analysed using a modified impact-based breakage model and the breakability index of the carbamazepine dihydrate is determined for the two breakage regimes. The method provides a quick and easy testing of particle breakability, a useful tool for assessing attrition in process plant and grindability in milling operations.
- |||||||||| clonazepam / Generic mfg., carbamazepine / Generic mfg.
Review, Journal, Monotherapy: Clonazepam monotherapy for treating people with newly diagnosed epilepsy. (Pubmed Central) - Apr 17, 2020
Clonazepam was less well tolerated than ethosuximide in a trial of children with absence seizures, however no comparative data on efficacy were provided. There is currently insufficient evidence to support the use of clonazepam as monotherapy treatment for epilepsy.
- |||||||||| carbamazepine / Generic mfg.
Journal: Under the radar - Exceptionally high environmental concentrations of the high production volume chemical sulfamic acid in the urban water cycle. (Pubmed Central) - Apr 16, 2020
Wastewater treatment plant (WWTP) effluent was identified as the dominant source of sulfamate in the urban water cycle, as sulfamate concentrations correlated positively (0.77 > r < 0.99) with concentrations of the wastewater tracer carbamazepine in samples from different waterbodies...Considering the few data on short term ecotoxicity, about 30% of the presented sulfamate levels in ground and surface water samples did exceed the predicted no-effect concentration (PNEC) of sulfamate, and thus effects of sulfamate on the aquatic ecosystem of wastewater-impacted waterbodies in Germany cannot be excluded so far. Toxicological estimations suggest that no risk to human health is expected by concentrations of sulfamate typically encountered in tap water.
- |||||||||| carbamazepine / Generic mfg.
Retrospective data, Review, Journal: The medical treatment of epilepsy in the elderly: A systematic review and meta-analysis. (Pubmed Central) - Apr 15, 2020
There is some evidence for AED use in the elderly with epilepsy. More evidence is required, comparing newer AEDs to prior generations as well as examining the effects of determinants such as frailty, to guide clinicians when treating this rapidly growing patient population.
- |||||||||| carbamazepine / Generic mfg.
Preclinical, Journal: Effect of carbamazepine on spontaneous recurrent seizures recorded from the dentate gyrus in rats with kainate-induced epilepsy. (Pubmed Central) - Apr 14, 2020
Increased doses of CBZ (10-100 mg/kg) suppressed the frequency but not the duration of convulsive and nonconvulsive seizures in the repeated, low-dose kainate model. The repeated-measures, crossover protocol, which requires relatively few animals and compensates for progressive increases in seizure frequency during epileptogenesis after status epilepticus, allowed quantitative analyses of clinically relevant and translatable properties of SRSs.
- |||||||||| carbamazepine / Generic mfg.
Retrospective data, Journal: Drug-Induced Liver Injury in Critically Ill Children Taking Antiepileptic Drugs: A Retrospective Study. (Pubmed Central) - Apr 14, 2020
Five out of 9 patients taking phenobarbitone (55.6%), 9 out of 12 taking phenytoin monotherapy (75%), 7 out of 10 taking phenytoin/phenobarbitone (70%), all 3 receiving phenytoin/phenobarbitone/valproate sodium, and 1 with phenytoin/carbamazepine developed DILI either in the form of hepatocellular injury or liver biochemical test abnormalities...A significant proportion of critically ill children taking antiepileptic drugs experience DILI. Guidelines recommending use of drugs with reduced risk of potential hepatotoxicity for various concomitant disease states in such children admitted to intensive care units receiving antiepileptic drugs are urgently needed.
- |||||||||| carbamazepine / Generic mfg., Trileptal (oxcarbazepine) / Novartis
Clinical, Review, Journal: Clinical characteristics and epilepsy in genomic imprinting disorders: Angelman syndrome and Prader-Willi syndrome. (Pubmed Central) - Apr 11, 2020
Notably, carbamazepine, oxcarbazepine, and vigabatrin should be avoided, since these may induce nonconvulsive status epilepticus...Early diagnosis and teamwork intervention, including geneticists, neurologists, rehabilitation physicians, and pulmonologists, are important. Epilepsy is common in patients with AS, and after proper treatment, seizures could be effectively controlled in late childhood or early adulthood for both AS and PWS patients.
- |||||||||| carbamazepine / Generic mfg.
Journal: Effects of antiepileptic drugs on cortical excitability in humans: A TMS-EMG and TMS-EEG study. (Pubmed Central) - Apr 10, 2020
Findings corroborate the view that the P25 represents axonal excitability of the corticospinal system, the N100 in the nonstimulated hemisphere propagated activity suppressed by inhibition of presynaptic neurotransmitter release, and the P180 late activity particularly sensitive to VGSC blockade. Pharmaco-physiological characterization of TEPs will facilitate utilization of TMS-EEG in neuropsychiatric disorders with altered excitability and/or network connectivity.
- |||||||||| carbamazepine / Generic mfg.
Journal: An Evaluation of Metabolite Profiling of Six Drugs Using Dried Blood Spot. (Pubmed Central) - Apr 10, 2020
In the present study, we investigated the use of DBS for metabolite profiling of genistein, carbamazepine, losartan, sunitinib, sildenafil and zoniporide representing a range of Phase I and Phase II biotransformations following oral and intravenous dosing to rats...3. In summary, this study showed that in addition to PK bioanalytical analysis, DBS samples may also be utilized for metabolite profiling and a comparison of plasma and DBS metabolite profiling can also provide partitioning/association of major circulating metabolites compared to the parent drug even in the absence of a metabolite standard.
- |||||||||| clarithromycin / Generic mfg., carbamazepine / Generic mfg., Lacromid (bezafibrate) / Remedica
Journal: Occurrence, source estimation and risk assessment of pharmaceuticals in the Chaobai River characterized by adjacent land use. (Pubmed Central) - Apr 10, 2020
The results indicate that the multi-substance potentially affected fraction (msPAF) values of the sampling sites were below 0.04%, whereas nearly half of RQ values were higher than 1. Caffeine was proposed as a priority compound due to its high contribution rate (i.e., 79%) to the cumulative msPAF value, which implies that increased control and management of untreated wastewater sources along the Chaobai River is necessary.
- |||||||||| Journal: Pharmaceutical pollution of water resources in Nakivubo wetlands and Lake Victoria, Kampala, Uganda. (Pubmed Central) - Apr 10, 2020
Ciprofloxacin (antibiotic), cetirizine (anti-allergy), metformin (anti-diabetes), metronidazole (antibiotic) and omeprazole (gastric therapy) were reported by pharmacies to be the PhACs most commonly sold in the study area...Other PhACs such as atenolol (anti-hypertensive), carbamazepine (anti-epileptic) and diclofenac (anti-inflammatory) were also found at all study sites except Lake Victoria...Thus, Bugolobi WWTP needs to be upgraded to improve PhACs removal from wastewater. Considering the high occurrence of antibiotics in the water system in Kampala, development and spread of antimicrobial resistance within the area should also be investigated.
- |||||||||| carbamazepine / Generic mfg.
[VIRTUAL] Epilepsy and pediatric multiple sclerosis (Room Amsterdam) - Apr 9, 2020 - Abstract #EAN2020EAN_2287;
As epilepsy started before the MS onset and before DMT using in some patients, so seizures can be one of the clinical disease manifestations. Epilepsy in MS is focal and well treatable.
- |||||||||| amitriptyline / Generic mfg., carbamazepine / Generic mfg.
[VIRTUAL] Treating chronic SUNCT with a nerve blockade in an anticoagulated patient (Room: Screen B5) - Apr 9, 2020 - Abstract #EAN2020EAN_1968;
SON blockade may be an effective treatment for SUNCT and may even be considered in anticoagulated patients. The presence of migrainous features may predict a better outcome of peripheral blockades for SUNCT.
- |||||||||| Vistide (cidofovir) / Gilead, carbamazepine / Generic mfg.
[VIRTUAL] Severe human herpesvirus 7 (HHV-7) encephalitis in a patient with rheumatoid arthritis (Room: Screen B6) - Apr 9, 2020 - Abstract #EAN2020EAN_1465;
The pathogenic role of HHV-7 in encephalitis is controversial but it should be considered and aggressively treated in immunosuppressed patients. The current case reports the evolution of HHV-7 encephalitis which can contribute to the current knowledge of this serious disease.
- |||||||||| carbamazepine / Generic mfg.
[VIRTUAL] Parry Romberg: neurological manifestations after 20 years (Room: Screen A6) - Apr 9, 2020 - Abstract #EAN2020EAN_1444;
To our knowledge, this is the 1st PR case with neurological symptoms presenting 20 years after disease onset, when skin atrophy was already stable for the previous 10 years. In our patient, the autoimmune background (thyroiditis) and the presence of oligoclonal bands suggest that an autoimmune mechanism may contribute to the PR pathogeny.
- |||||||||| carbamazepine / Generic mfg.
[VIRTUAL] Cerebral cavernomatosis as a chameleon of Parkinson’s disease (ePoster) - Apr 9, 2020 - Abstract #EAN2020EAN_566;
However, the good response to levodopa should raise the possibility of IPD. This differentiation between IPD and secondary causes is important not only for the choice of treatment but also for the prognosis of patients.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: 120th Anniversary of the Kraepelinian Dichotomy of Psychiatric Disorders. (Pubmed Central) - Apr 4, 2020
The recent results for similarities and differences in the immune system, cognitive functions, and neurodevelopmental mechanisms have also been presented and discussed. As of 2019, the Kraepelinian dichotomy has been still partly valid although the results of recent clinical, neurobiological, and pharmacological studies provided a large number of data for an intermediate space between schizophrenia and bipolar disorder.
- |||||||||| Journal: Pharmaceuticals in a Mediterranean Basin: The influence of temporal and hydrological patterns in environmental risk assessment. (Pubmed Central) - Apr 4, 2020
In specific periods, the high concentrations of pharmaceuticals detected may induce risk for the organisms of lowest trophic levels, damaging the balance of the ecosystems at these streams. The risk quotient optimised approach (RQf) integrating exposure, toxicity and persistence factors, ranks the pharmaceuticals investigated in terms of risk for the aquatic ecosystems as follows: diclofenac, ibuprofen and carbamazepine (high risk), clarithromycin (moderate risk), acetaminophen, ofloxacin and bezafibrate (endurable risk), and hydrochlorothiazide (negligible risk).
- |||||||||| carbamazepine / Generic mfg.
Clinical, Review, Journal: A Scoping Review of Medications Studied in Pediatric Polypharmacy Research. (Pubmed Central) - Apr 3, 2020
While characterizing the literature on pediatric polypharmacy in terms of the types of medication studied, we further identified substantive gaps within this literature outside of epilepsy and psychiatric disorders. Medications frequently identified in use of polypharmacy for treatment of epilepsy and psychiatric disorders reveal opportunities for enhanced medication management in pediatric patients.
- |||||||||| pregabalin / Generic mfg., carbamazepine / Generic mfg.
Review, Journal: All about pain pharmacology: what pain physicians should know. (Pubmed Central) - Apr 3, 2020
Most drugs, except NSAIDs, need an updose titration period. The principle of polypharmacy for analgesia in case of mixed components of pain is increasing therapeutic effects while reducing ADRs, based on the origin of the pain.
- |||||||||| carbamazepine / Generic mfg.
Clinical, Journal: Hypersensitivity reactions to antiepileptic drugs in children. (Pubmed Central) - Apr 1, 2020
It was found that the method developed is rapid, sensitive, reliable, and can be used to monitor the concentration of carbamazepine and metabolite in patients' saliva. Considering that there are not specific tests to distinguish between a viral infection and hypersensitivity reactions to AEDs in the acute phase, a diagnostic work-up should be performed in all children with suspected hypersensitivity reactions to AEDs, as well as infectious agent study, to remove a false label of hypersensitivity.
- |||||||||| carbamazepine / Generic mfg.
Primary Neuroendocrine Tumor of the Central Nervous Sistem, a Case Report and Literature Review (ENDOExpo, Booth 217) - Apr 1, 2020 - Abstract #ENDO2020ENDO_4342;
Patient currently maintain left hemiparesis, frequent pain, taking carbamazepine due to epileptic seizures, and considerable weight loss...Due to relapse, palliative radiotherapy was initiated in the region of the tumors. Conclusion The patient had a poor outcome in relation to cancer, with little possibility of treatment due to poor tumor differentiation and poor performance status.
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