- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal, Real-world evidence, Real-world: Real-World Anti-Seizure Medication Treatment Outcomes in Drug-Resistant Focal Epilepsy Patient. (Pubmed Central) - Dec 4, 2023
Overall, reported findings indicated that patient history at baseline and the early selection of an ASM all influenced treatment outcomes. Findings pointed to the complex nature of ASM treatment in drug-resistant focal epilepsy patients calling for additional research to identify the optimal treatment to achieve beneficial patient outcomes.
- |||||||||| levetiracetam / Generic mfg., topiramate / Generic mfg., carbamazepine / Generic mfg.
Journal: Changes over 24 (Pubmed Central) - Dec 4, 2023
Findings pointed to the complex nature of ASM treatment in drug-resistant focal epilepsy patients calling for additional research to identify the optimal treatment to achieve beneficial patient outcomes. The increasing use of newer ASMs in pregnant women has been associated with overall advantages in relation to the frequency and severity of foetal malformation and with advantages in relation to freedom from epileptic seizures.
- |||||||||| Observational data, Journal: The impact of a newly established specialized pediatric epilepsy center in Tanzania: An observational study. (Pubmed Central) - Dec 4, 2023
The increasing use of newer ASMs in pregnant women has been associated with overall advantages in relation to the frequency and severity of foetal malformation and with advantages in relation to freedom from epileptic seizures. Our data depicted the epilepsy spectrum and highlighted the prognostic implications of improving the availability of ASMs such as sodium valproate and second- and third-generation ones in resource-limited countries.
- |||||||||| clonazepam / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Feasibility of psychological screening in a tertiary epilepsy clinic. (Pubmed Central) - Dec 4, 2023
Our data depicted the epilepsy spectrum and highlighted the prognostic implications of improving the availability of ASMs such as sodium valproate and second- and third-generation ones in resource-limited countries. Implementation of simple psychological screening using self-administered questionnaires was feasible in a busy tertiary epilepsy clinic.
- |||||||||| AR882 / Arthrosi
Enrollment closed: A drug-drug interaction trial between AR882, fluconazole, carbamazepine, celecoxib, and sulfasalazine in healthy particpants (EUDRACT) - Dec 1, 2023
P1, N=40, Active, not recruiting,
While most cases of DiHS/DRESS with cardiac involvement present with myocarditis, the possibility of ischemic heart disease should be considered in patients with cardiac involvement under shock. Recruiting --> Active, not recruiting
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Preclinical, Journal, Reflex: Cenobamate enhances the anticonvulsant effect of other antiseizure medications in the DBA/2 mouse model of reflex epilepsy. (Pubmed Central) - Nov 30, 2023
CNB, at 5 mg/kg, enhanced the antiseizure activity of ASMs, such as diazepam, clobazam, levetiracetam, perampanel, phenobarbital, topiramate, and valproate...The increase in antiseizure activity was associated with a comparable intensification in motor impairment; however, the therapeutic index of combined treatment of ASMs with CNB was more favorable than the combination with vehicle except for carbamazepine, phenytoin, and oxcarbazepine...Overall, this study shows the ability of CNB to counteract generalized reflex seizures in mice. Moreover, our data documented an evident synergistic antiseizure effect for the combination of CNB with ASMs including phenobarbital, benzodiazepines, valproate, perampanel, topiramate, and levetiracetam.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Retrospective data, Review, Journal: The extent of CYP3A Induction by Antiseizure Medications: A Systematic Review and Network Meta-Analysis. (Pubmed Central) - Nov 28, 2023
When possible, ASM classification as inducers should apply cutoff values tailored to the outcome. Prescribers should monitor plasma concentrations or clinical effects of CYP3A substrates and consider selecting concomitant medications accordingly.
- |||||||||| carbamazepine / Generic mfg.
Journal: Application of passive sampling device for exploring the occurrence, distribution, and risk of pharmaceuticals and pesticides in surface water. (Pubmed Central) - Nov 27, 2023
It was found that the concentrations and ecological risks in the northern area of Yangtze River were higher than those in the southern area of Yangtze River, implying that economic development and population density were not the main contributors to the discovered pollution. The total concentration of pharmaceuticals and pesticides in Qinhuai River increased gradually with the direction of water flow, demonstrating the success of water diversion project in flushing and scouring pollutants.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: A bibliometric analysis of emerging contaminants (ECs) (2001-2021): Evolution of hotspots and research trends. (Pubmed Central) - Nov 27, 2023
Quantitative trend analysis revealed that antibiotics, microplastics, endocrine disrupting chemicals (EDCs), per/poly-fluoroalkyl substances (PFAS), pesticides, heavy metals, and nanoparticles are attracting increasing attention, whereas conventional pharmaceuticals, persistent organic pollutants, and materials such as benzotriazole, diclofenac, bisphenol A, carbamazepine, triclosan, and titanium dioxide exhibit a downward trend...Furthermore, analysis of research linkage and the developing stages of ECs could be possible approach to determine the evolution of hotspots in ECs study. This study provides objective and comprehensive insights into the research landscape of ECs, which may shed light on future developmental directions for researchers interested in this field.
- |||||||||| norfloxacin / Generic mfg., atenolol / Generic mfg., carbamazepine / Generic mfg.
Journal: Distribution, ecological risks and priority of pharmaceuticals in the coastal water of Qinhuangdao, China. (Pubmed Central) - Nov 27, 2023
This study provides objective and comprehensive insights into the research landscape of ECs, which may shed light on future developmental directions for researchers interested in this field. The results indicate that 14 compounds were detected in seawater, with concentrations ranging from <1 to 201.4
- |||||||||| indomethacin / Generic mfg., thalidomide / Generic mfg., carbamazepine / Generic mfg.
Preclinical, Journal: In vivo analgesic activity of new N-arylphthalimides derivatives in mice. (Pubmed Central) - Nov 27, 2023
This study provides a new synthesis strategy of a photocatalyst for sulfite activation and expands the potential uses of Bi-based photocatalysts in degrading difficult-to-remove organic pollutants. This information may be useful in the development of a more potent phthalimide as an analgesic agent that acts as a sodium channel blocker and COX inhibitor.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Systematic Review of the Clinical Characteristics and Management of Isaac Syndrome. (Pubmed Central) - Nov 18, 2023
These patients should be screened for thymoma and other malignancies such as lymphomas. The management of IS symptoms can be challenging, but based on our review, the combination of multiple immunosuppressives such as IV steroids and plasmapheresis with anticonvulsants such as carbamazepine seems to achieve the best results.
- |||||||||| Journal: Characterization of critical parameters using an air-liquid interface model with RPMI 2650 cells for permeability studies of small molecules. (Pubmed Central) - Nov 18, 2023
Elevation of the experimental concentration of carbamazepine, propranolol, and metoprolol in the donor compartment had an increasing effect on the P values, while prolonging the assay time did not have a significant influence. Based on the results reported here, RPMI 2650 cells cultured under ALI conditions offer the possibility of a standardized high-throughput screening model for small molecules and their formulations for in vitro drug permeation studies to predict and select optimal conditions for their nasal delivery.
- |||||||||| An Exotic Presentation: Managing Pain in a Patient with a Rare Axonal Variant of Guillain Barre Syndrome () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_901;
Current literature champions the use of gabapentin and carbamazepine as opposed to opioids in the management of GBS-related pain refractory to NSAIDs or Tylenol. When managing severe and intractable pain in patients with GBS, especially in patients with sensory nerve fiber involvement, utilizing a multimodal pharmacologic approach may be more efficacious than a single agent alone.
- |||||||||| phenobarbital / Generic mfg., carbamazepine / Generic mfg.
A 23 Year Delay: A Case Report of Antiepileptic Sedation () - Nov 16, 2023 - Abstract #AAPMR2023AAPMR_707;
Patients who have been seizure free for two years may be able to discontinue their anti-epileptics. The differential for altered mentation is broad.
- |||||||||| carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
Biomarker, Retrospective data, Journal: Pharmacogenetics to prevent hypersensitivity reactions to antiepileptic drugs: is testing performed when indicated? (Pubmed Central) - Nov 15, 2023
Notably, pharmacogenetic results were not discretely entered into the EHR, and the results were only found as attached documents in the miscellaneous section of the EHR. There remains a significant opportunity for improving HLA-B*15:02 pre-screening for patients starting carbamazepine and oxcarbazepine to prevent SCARs in the USA.
- |||||||||| Journal, Monotherapy, Real-world evidence, Real-world: Anti-Seizure Monotherapy and Early Abortion Under Real-World Conditions. (Pubmed Central) - Nov 10, 2023
Although the sample size of our study was small, these results indicate that the use of anti-seizure monotherapy in pregnant epilepsy patients may not increase the risk of early miscarriage. Larger prospective studies are needed for sufficient statistical analysis.
- |||||||||| glibenclamide / Generic mfg., carbamazepine / Generic mfg.
Journal: The effect of protocatechuic acid on neuropathic pain and possible mechanism. (Pubmed Central) - Nov 10, 2023
It can be said that PCA has similar effects with carbamazepine, which is used in clinical practice, and that PCA can take place as an adjuvant drug in neuropathic pain with the combination group. In addition, it is seen that the undesirable effects that drugs can cause alone can be avoided and a more effective treatment potential can be created with multiple mechanisms.
- |||||||||| carbamazepine / Generic mfg.
Journal: A case of a pathological variant of the PRRT2 gene in twins with paroxysmal kinesiogenic dyskinesia (Pubmed Central) - Nov 9, 2023
The administration of carbamazepine, which is the drug of choice in the treatment of this category of patients, has achieved significant control over hyperkinesis in twins. Thus, molecular genetic diagnosis helps confirm the diagnosis of paroxysmal dyskinesias, but careful analysis of the clinical picture, considering the provoking factor, remains the basis of diagnosis.
- |||||||||| carbamazepine / Generic mfg.
Journal: 300-fold higher neuro- and (Pubmed Central) - Nov 6, 2023
Our predictive method may support toxicity predictions for other substances and conditions 'similar' to the current case study via interpolation. This paves the way for a more coherent, effective and easier risk assessment of transformation products.
- |||||||||| carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Journal: LED-driven photo-Fenton process for micropollutant removal by nanostructured magnetite anchored in mesoporous silica. (Pubmed Central) - Nov 6, 2023
This paves the way for a more coherent, effective and easier risk assessment of transformation products. In this context, the application of heterogeneous photo-Fenton based on magnetite nanoparticles supported on mesoporous silica (SBA15) is proposed to carry out the non-specific degradation of the model compounds ibuprofen, carbamazepine, hormones, bisphenol A and the dye ProcionRed
- |||||||||| carbamazepine / Generic mfg.
Journal: Differential effects of HLA-B*15:11 and HLA-A*31:01 on carbamazepine-induced cutaneous adverse reactions. (Pubmed Central) - Nov 4, 2023
In this context, the application of heterogeneous photo-Fenton based on magnetite nanoparticles supported on mesoporous silica (SBA15) is proposed to carry out the non-specific degradation of the model compounds ibuprofen, carbamazepine, hormones, bisphenol A and the dye ProcionRed HLA-B*15:11 and HLA-A*31:01 would be used as biomarkers in predicting the risk of CBZ-induced cADRs in the populations where allele frequency of HLA-B*15:02 is extremely rare.
- |||||||||| verapamil / Generic mfg., carbamazepine / Generic mfg.
Preclinical, Journal: Chronic Administration of Ion Channel Blockers Impact Microglia Morphology and Function in a Murine Model of Alzheimer's Disease. (Pubmed Central) - Nov 3, 2023
Both Verapamil and Carbamazepine reduced the surveillance speed of microglia processes and changed microglia morphology in the cortex compared to the Control group. Due to their complex molecular machinery, microglia are potentially affected by drugs that do not target them specifically, and, as such, investigating these interactions could prove beneficial in our management of neurodegenerative pathologies.
- |||||||||| ALG-097558 / Aligos Therap
Enrollment open: A Study in Healthy Volunteers to Evaluate the Safety, Tolerability, Pharmacokinetics, and Drug-Drug Interaction Potential of Single and Multiple Doses of ALG-097558 (clinicaltrials.gov) - Nov 3, 2023
P1, N=144, Recruiting,
Due to their complex molecular machinery, microglia are potentially affected by drugs that do not target them specifically, and, as such, investigating these interactions could prove beneficial in our management of neurodegenerative pathologies. Not yet recruiting --> Recruiting
- |||||||||| carbamazepine / Generic mfg.
Brain distribution by use of MetaQuant microdialysis in rat and minipig (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_12437;
We determined the biodistribution of the brain penetrant anti-epileptic carbamazepine in both rats and minipigs...The comparison of the levels in the two species illustrates how this new non-rodent minipig microdialysis model can bring additional value during the preclinical research phase. Potential differences or similarities in biodistribution between these species can be used to support translation to human biodistribution and brain penetration in the clinical phase.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
A BEHAVIOURAL AND BIOMARKER ASSESSMENT OF MOUSE CORNEAL KINDLING AS A MODEL FOR EPILEPSY, CNS NEUROINFLAMMATION AND GLIOSIS (WCC Halls A-C) - Nov 3, 2023 - Abstract #Neuroscience2023NEUROSCIENCE_5777;
Cytokine analysis was also performed for biomarkers of inflammation, including TNF?, IL-1?, IL-6. Taken together, these data provide valuable insights into the corneal kindling process as it relates to behavioural changes and neuroinflammatory biomarkers - and consequently an approach to study novel treatments across these domains.
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