carbamazepine / Generic mfg. 
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  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Roles of reactive oxygen species in antibiotic resistant bacteria inactivation and micropollutant degradation in Fenton and photo-Fenton processes. (Pubmed Central) -  Mar 19, 2022   
    Results showed ARB and carbamazepine (CBZ) elimination efficiency in the order: EDDS modified photo-Fenton process > photo-Fenton process > Fenton process...The present study highlighted that the hydroxyl radical (HO) plays a dominant role, while singlet oxygen (O) and superoxide radical anion (O) exhibit moderate effects to remove the hazards. Our findings provide mechanistic insights into the role of various reactive oxygen species on degrading micropollutants and inactivating ARB.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Occurrence and distribution of Pharmaceuticals and Personal Care Products (PPCPs) in wastewater related riverbank groundwater. (Pubmed Central) -  Mar 17, 2022   
    N,N-diethyl-meta-toluamide (DEET), carbamazepine, and caffeine had the highest detection frequencies (>90%)...Significant correlations between PPCP concentrations and thirteen physicochemical factors of groundwater were discovered, including nitrate, potassium, and manganese. Overall, this study provides important evidence on the role of lithology and hydrological conditions on the composition, distribution, and influential physicochemical factors of PPCPs in riverbank groundwater.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Long-Term Outcome of Hemimasticatory Spasm. (Pubmed Central) -  Mar 16, 2022   
    This report highlights the long-term outcome of HMS in our patients. Our patients reported a significant reduction or complete resolution of symptoms after treatment, and eventually, two patients were asymptomatic while off treatment.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Metabolic, cellular and defense responses to single and co-exposure to carbamazepine and methylmercury in Dreissena polymorpha. (Pubmed Central) -  Mar 15, 2022   
    Data globally supported that a higher number of hyperactive cells compensated cellular alterations in the digestive gland of mussels exposed to CBZ or MeHg alone, while CBZ + MeHg co-exposure overwhelmed this compensation after 7 days. Those effects were unpredictable based on cellular responses to CBZ and MeHg alone, highlighting the need to consider molecular toxicity pathways for a better anticipation of effects of pollutants in biota in complex environmental conditions.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Marine heatwaves hamper neuro-immune and oxidative tolerance toward carbamazepine in Mytilus galloprovincialis. (Pubmed Central) -  Mar 15, 2022   
    MHW appeared to strongly modulate accumulation of CBZ, paralleled by weakened immunocompetence and onset of oxidative disturbance that finally evolved to cellular damages and lipid metabolism disorders. Elaboration of the overall results through a quantitative Weight of Evidence model, revealed the highest hazard in organisms exposed to both the stressors 10 days after the end of the heatwave, suggesting that MHWs could leave a footprint on the capability of mussels to counteract CBZ toxicity, thus affecting their vulnerability and predisposition to adverse effects toward multiple stressors.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Pharmaceutical pollution of the world's rivers. (Pubmed Central) -  Mar 15, 2022   
    Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.
  • ||||||||||  carbamazepine / Generic mfg.
    Clinical, Journal:  On-Site Biolayer Interferometry-Based Biosensing of Carbamazepine in Whole Blood of Epileptic Patients. (Pubmed Central) -  Mar 11, 2022   
    Validation of Direct FO-BLI using six paired sera and whole blood from epileptic patients showed excellent agreement with ultra-performance liquid chromatography. Being automated and able to achieve high throughput, Direct FO-BLI proved itself to be more effective for integration into the clinic by delivering CBZ values from whole blood within minutes.
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Zebrafish Oatp1d1 Acts as a Cellular Efflux Transporter of the Anionic Herbicide Bromoxynil. (Pubmed Central) -  Mar 11, 2022   
    This was also seen for diclofenac but not for carbamazepine, examined for comparison...The effect of BSP on accumulation of bromoxynil and diclofenac was enhanced in further advanced embryo stages, indicating increased efflux activity in those stages. An action of Oatp1d1 as an efflux transporter of ionic environmental compounds in zebrafish embryos should be considered in future TK assessments.
  • ||||||||||  carbamazepine / Generic mfg.
    Trial primary completion date:  Electroacupuncture Therapy for Change of Pain in Classical Trigeminal Neuralgia (clinicaltrials.gov) -  Mar 10, 2022   
    P=N/A,  N=120, Active, not recruiting, 
    It is important to check and to prevent the consequences of the interaction between CBZ and other AED in order to avoid inefficiency and toxicity. Trial primary completion date: Dec 2021 --> Dec 2022
  • ||||||||||  carbamazepine / Generic mfg.
    Journal:  Influence of nanoparticle size on blood-brain barrier penetration and the accumulation of anti-seizure medicines in the brain. (Pubmed Central) -  Mar 8, 2022   
    Therefore, we designed a methoxy poly(lactide-co-glycolide)-b-poly(ethylene glycol) methyl ether (mPEG-PLGA) nanoparticle delivery system and explored the cell uptake efficiency of nanoparticles with different sizes and their ability to penetrate the BBB while carrying carbamazepine (CBZ)...To summarize, our study demonstrated that drug delivery to the brain using nanocarriers is size dependent. Nanoparticles with the smallest particle size can be internalized more effectively, and easily penetrate the BBB, and accumulate in the brain.
  • ||||||||||  Uses of Antiepileptic Drugs Among Pregnant Women with Epilepsy in Taiwan, a 15-Year Cohort Study (Virtual) -  Mar 8, 2022 - Abstract #ISPOR2022ISPOR_446;    
    In the first part, AEDs (phenytoin, carbamazepine, oxcarbazepine, valproic acid, lamotrigine, topiramate, levetiracetam and others) used among pregnant women were assessed annually from 2004 to 2018. Our study provides “real-world data” of uses of AEDs in pregnant women with epilepsy in Taiwan from 2004 to 2018.
  • ||||||||||  Fintepla (low-dose fenfluramine) / Zogenix
    Serotonin and Focal Epilepsy: A Therapeutic Role? (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_3922;    
    P2
    Design/ We performed a pilot trial of PRX-00023 (Nalutozan), a high affinity 5HT1A agonist , in patients with focal epilepsy that showed promise in trials for anxiety and depression (Investigator initiated IND 110522; NCT01281956)...Subjects on benzodiazepines, phenobarbital, or phenytoin were excluded... Our two small pilot trials do not provide any suggestion that 5HT1A agonists have a treatment role in focal epilepsy.
  • ||||||||||  everolimus / Generic mfg., carbamazepine / Generic mfg.
    Everolimus for Treatment of Refractory Seizures in Tuberous Sclerosis (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2884;    
    She was on Phenytoin and brivaracetam when she presented to us and was experiencing 5-6 seizures per month... Everolimus has been shown to be of tremendous benefit to Tuberous Sclerosis patients, both in reducing tumor size as well as a treatment for intractable epilepsy. Physicians should consider the use of Everolimus as an adjunctive treatment for refractory epilepsy in patients with Tuberous sclerosis to help decrease seizure burden and improve quality of life.
  • ||||||||||  dexamethasone / Generic mfg., gabapentin / Generic mfg., carbamazepine / Generic mfg.
    Fluoroscopy Guided Block in Nervus Intermedius Neuralgia (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2864;    
    Due to its rarity, there is inconclusive evidence for treatment guidelines. Current treatment includes carbamazepine, gabapentin, baclofen or neurosurgical procedures if medication fails.
  • ||||||||||  carbamazepine / Generic mfg.
    Recurrent Progressive Peripheral Vertigo: Revisiting Vestibular Paroxysmia (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2641;    
    Diagnosis is based on: at least ten attacks of spontaneous spinning or non-spinning vertigo, duration <1 minute, stereotyped phenomenology, response to treatment with carbamazepine/oxcarbazepine and not better accounted for by another diagnosis. This case looks into the findings of vestibular paroxysmia, its work-up, and potential other diagnoses that need to be excluded (i.e. BPPV, Meniere’s disease, Vestibular Neuritis, Labyrinthitis) as it’s an uncommon cause of peripheral vertigo.
  • ||||||||||  acetylcysteine solution / Generic mfg., carbamazepine / Generic mfg.
    Vestibular Paroxysmia Successfully Treated with N-acetylcysteine: A Case Report (Poster Hall) -  Mar 6, 2022 - Abstract #AAN2022AAN_2640;    
    This case looks into the findings of vestibular paroxysmia, its work-up, and potential other diagnoses that need to be excluded (i.e. BPPV, Meniere’s disease, Vestibular Neuritis, Labyrinthitis) as it’s an uncommon cause of peripheral vertigo. N-acetylcysteine should be considered an alternative treatment for vestibular paroxysmia especially when comorbidities or patient preference preclude treatment with oxcarbazepine and carbamazepine.
  • ||||||||||  carbamazepine / Generic mfg.
    Therapeutic Basis of Generic Substitution of Antiseizure Medications () -  Mar 6, 2022 - Abstract #AAN2022AAN_2215;    
    Rather, it is imperativethat physicians and pharmacists provide adequate patient education on what to expect whenswitching to generic ASMs, including changes in medication shape and color. Anothersuggestion would be to consider that all ASMs be considered for inclusion in NTI class toprevent the clinical outcome issues associated with generic ASM switching.
  • ||||||||||  carbamazepine / Generic mfg.
    When to resect: Benign yet debilitating neurological symptoms related to rare cases of skull-based Epidermoid cysts. ([VIRTUAL]) -  Mar 6, 2022 - Abstract #AAN2022AAN_2117;    
    According to the current literature, neurological symptoms are typically reversible with early surgical intervention. Because surgical intervention was delayed in both of our patients, there had already been atrophy and tumor invasion of affected structures; the first patient’s prognosis is unclear given presence of CN V atrophy, and the second patient required resection of mesial temporal lobe structures in addition to the EC for treatment of epilepsy.
  • ||||||||||  Briviact (brivaracetam) / UCB
    Real-world Study of Brivaracetam in the United States () -  Mar 6, 2022 - Abstract #AAN2022AAN_1569;    
    Main eligibility criteria included a history of focal seizures, age ≥16 years, and lifetime history or concomitant use of ≥1 of four specific antiseizure medications (ASMs): levetiracetam/lamotrigine/oxcarbazepine/carbamazepine. BRV demonstrated long-term effectiveness in this US observational study.
  • ||||||||||  carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
    Maternal Symptomatic Toxicity and Oxcarbazepine Free Fraction during Pregnancy in Women with Epilepsy () -  Mar 6, 2022 - Abstract #AAN2022AAN_1566;    
    Adjusting oxcarbazepine dosages during pregnancy to maintain the individualized baseline target concentration based on total MHD serum concentrations may result in maternal symptomatic toxicity and undue fetal over-exposure to oxcarbazepine. Free MHD concentrations should be made available for therapeutic drug monitoring use during pregnancy.