- |||||||||| Journal: Non-antibiotic pharmaceuticals promote conjugative plasmid transfer at a community-wide level. (Pubmed Central) - Aug 22, 2022
Considering the high possibility of co-occurrence of pathogenic bacteria, conjugative IncP1-α plasmids and non-antibiotic pharmaceuticals in various environments (e.g., activated sludge systems), our findings illustrate the potential risk associated with increased dissemination of antibiotic resistance promoted by non-antibiotic pharmaceuticals in complex environmental settings. Video abstract.
- |||||||||| carbamazepine / Generic mfg.
Journal: Activation of Bisulfite with Pyrophosphate-Complexed Mn(III) for Fast Oxidation of Organic Pollutants. (Pubmed Central) - Aug 22, 2022
An approximate 71% removal of carbamazepine (CBZ) was achieved by the Mn(III)/HSO process at pH 7.0 within 20 s, while negligible CBZ was degraded by Mn(III) or HSO alone...The pH and PP:Mn(III) ratio affect the reactivity of Mn(III) towards HSO. The water background constituents, such as Cl and dissolved organic matter, induce considerable loss of the treatment efficiency in different ways.
- |||||||||| clarithromycin / Generic mfg., carbamazepine / Generic mfg.
Journal: Screening and Control Measures for New Priority Pollutants in Surface Water of Tianjin (Pubmed Central) - Aug 18, 2022
Pollutants with low removal rates in sewage treatment plants should be treated with combined technologies to improve the removal efficiency. In addition, industry substitution work should be accelerated to reduce emissions of PFOS, PFOA, and PFHxA.
- |||||||||| VentaProst (epoprostenol inhalation) / Aerogen Pharma
EP(ILEPT)IC COMPLICATIONS (Convention Center Exhibit Hall: Poster Area) - Aug 16, 2022 - Abstract #CHEST2022CHEST_2728;
CASE PRESENTATION: A 71-year-old female with medical history significant for epilepsy status post right temporal lobectomy on Carbamazepine, left breast cancer status post resection, radiation and hormone therapy, asthma, and migraines presented to the emergency department with progressive shortness of breath, presyncope, fevers and joint stiffness...She was given vancomycin, Piperacillin-tazobactam and IV TMP-SMX- despite this she continued to decline, requiring intubation and ICU admission with trial of inhaled Epoprostenol and proning...Patient was initiated on 1000 mg solumedrol for 5 days with extended and slow taper resulting in great improvement and near resolution of symptoms over several weeks... This case highlights the importance that temporality to drug initiation may not be as pertinent as an appropriate lab work up including ANA, antihistone antibodies and cell counts in serum and BAL when ruling out possible drug induced lung injury.
- |||||||||| Anesthesia Dolorosa In Patient With Recurrent Trigeminal Neuralgia (Hall C) - Aug 15, 2022 - Abstract #ASA2022ASA_2522;
Standard treatment for trigeminal neuralgia was unable to be prescribed due to allergies to carbamazepine, gabapentin, and oxcarbazepine. Currently prescribed multidisciplinary treatment, this highlights the valuable opportunity within Pain Medicine to provide a treatment for a rare complication of anesthesia dolorosa after surgery.
- |||||||||| carbamazepine / Generic mfg.
Journal: Carbamazepine-induced follicular mucinosis-like drug eruption. (Pubmed Central) - Aug 14, 2022
Currently prescribed multidisciplinary treatment, this highlights the valuable opportunity within Pain Medicine to provide a treatment for a rare complication of anesthesia dolorosa after surgery. No abstract available
- |||||||||| carbamazepine / Generic mfg.
Journal: Lethal toxicity induced by combined ingestion of dietary acetic acid and carbamazepine. (Pubmed Central) - Aug 12, 2022
Liver damage, demonstrated by histopathological examination may be a consequence of both massive accumulation of carbamazepine in the liver and toxicity of food acetic acid. In conclusion, the hepatotoxicity induced by high level of carbamazepine was suspected of increasing the risk of multiple organ failure, in the context of acetic acid acute toxicity, highlighting the particularities of the case.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Journal: Drug-drug interactions between psychotropic medications and oral contraceptives. (Pubmed Central) - Aug 12, 2022
Compared to CHCs, the propensity of progestin-only pills for DDIs has been investigated less. We provide a summary table for clinicians containing recommendations based on literature and package inserts; whenever evidence was available, we provided dose-correction factors.
- |||||||||| carbamazepine / Generic mfg., naproxen / Generic mfg.
Enhanced degradation of micropollutants in a Peracetic Acid-Fe(III) system with picolinic acid (Virtual-only (Zoom)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_10984;
Oxidation products of methylene blue, naproxen and sulfamethoxazole by PAA-Fe(III)-PICA were characterized and supported the proposed mechanism. This work demonstrates that PICA is an effective complexing ligand to assist the Fenton reaction of PAA by extending the applicable pH range and accelerating the catalytic ability of Fe(III).
- |||||||||| carbamazepine / Generic mfg.
Unraveling the roles of intermediate manganese species in contaminant abatement by permanganate and colloidal manganese dioxide (Virtual-only (Zoom)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_7518;
With this method, our results revealed that Mn(VI/V) played a remarkable role in the abatement of As(III), methyl phenyl sulfoxide (MPSO), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonate), and phenol while scarcely contributed to carbamazepine degradation by Mn(VII)...Via this method, the significant contribution of Mn(III) to the abatement of organic contaminants with phenolic and amino moieties was revealed and its contribution generally decreased as pH elevated from 5.0 to 9.0. Overall, this study gained deep insights into the overlooked role of unstable IMSs in contaminant abatement during Mn(VII) and colloidal Mn(IV) oxidation process, which offered novel mechanistic knowledge for decontamination by Mn(VII) and Mn(IV).
- |||||||||| carbamazepine / Generic mfg.
On the proclivity of pharmaceutical contaminants for the air/aqueous and biological interfaces (W196c (McCormick Place Convention Center)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_5341;
Interfacial proclivities of amlodipine, β-estradiol, carbamazepine, and 4-propylphenol have been measured...The thermodynamic parameters obtained in this work helps to differentiate the binding interactions the pharmaceuticals are likely to have with polymeric interfaces representative of natural organic matter and microplastics. Thus, this research not only advance our fundamental understanding of pharmaceutical interactions with soft interfaces but also provide insights into the environmental fate and transport of these emerging contaminants.
- |||||||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Review, Journal: COVID-19 and antiepileptic drugs: an approach to guide practices when nirmatrelvir/ritonavir is co-prescribed. (Pubmed Central) - Aug 6, 2022
Therefore, in this report, we identified drugs that require dose adjustment because of drug-drug interactions (DDIs) between nirmatrelvir/ritonavir and AEDs. We hereby used four databases (Micromedex Drug Interaction, Liverpool Drug Interaction Group for COVID-19 Therapies, Medscape Drug Interaction Checker, and Lexicomp Drug Interactions) and DDI-Predictor.In the light of applying the DDI-Predictor, for carbamazepine, clobazam, oxcarbazepine, eslicarbazepine, phenytoin, phenobarbital, pentobarbital, rufinamide, and valproate as CYP3A4 inducers, we recommend that a dose adjustment of short-term nirmatrelvir/ritonavir as a substrate (victim) drug would be more appropriate instead of these AEDs to avoid impending DDI-related threats in patients with epilepsy.
- |||||||||| Review, Journal: Antiseizure Drugs and Movement Disorders. (Pubmed Central) - Aug 6, 2022
Although little information is available on the adverse effects or benefits on movement disorders of newer antiseizure drugs (such as brivaracetam, cenobamate, eslicarbazepine, lacosamide, and rufinamide), the evidence collected in this review should guide the choice of antiseizure drugs in patients with concomitant epilepsy and movement disorders. Finally, these notions can lead to a better understanding of the mechanisms involved in the pathophysiology and treatments of movement disorders.
- |||||||||| carbamazepine / Generic mfg., bezafibrate / Generic mfg.
Journal: Comparison of pharmaceutical removal in two membrane bioreactors with/without powdered activated carbon addition. (Pubmed Central) - Aug 4, 2022
Efficient removal (>95%) of sulfamethoxazole, carbamazepine and diclofenac were highly dependent on the PAC dosage...Decreasing the SRT as done in the second approach, not only increased the PAC amount, but also decreased the mass of activated sludge and reduced the capability to degrade complex organic matter. Consequently, biodegradability and adsorbability played decisive roles in the removal of each compound.
- |||||||||| oxcarbazepine / Generic mfg.
Journal: Crystal Structure and Twisted Aggregates of Oxcarbazepine Form III. (Pubmed Central) - Aug 3, 2022
A crystal structure determination of OXCBZ III from powder X-ray diffraction methods, assisted by crystal structure prediction (CSP), reveals that OXCBZ III, similar to carbamazepine form II, contains void channels in its structure with the channels, aligned along the c crystallographic axis, oriented parallel to the twist axis of the aggregates. The likely role of structural misalignment at the lattice or nanoscale is explored by considering the role of molecular and closely related structural impurities informed by crystal structure prediction.
- |||||||||| phenobarbital / Generic mfg., carbamazepine / Generic mfg.
Journal: Psychiatric Comorbidities in Epilepsy. (Pubmed Central) - Aug 3, 2022
Epilepsy is associated with PC, the most frequent being depression, AD, psychosis, dementia and BAD. The absence of a relationship between depression and brain damage; anxiety disorder with education, types of epilepsy and etiology; psychosis with sex and time of epilepsy evolution were significant.
- |||||||||| vixotrigine (BIIB074) / Biogen, GSK, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Journal: Pharmacotherapeutic Management of Trigeminal Neuropathic Pain: An Update. (Pubmed Central) - Jul 31, 2022
In real-world clinical practice, baclofen, cannabinoids, eslicarbazepine, levetiracetam, brivaracetam, lidocaine, misoprostol, opioids, phenytoin, fosphenytoin, pimozide, sodium valproate, sumatriptan, tizanidine, tocainide, tricyclic antidepressants, and vixotrigine are sometimes used, either as monotherapy or in combination...While there is no optimal pharmacotherapy for treating trigeminal neuropathy, advancements in our understanding of the underlying mechanisms of this condition and drug development indicate promise for NaV inhibitors, despite the fact that not all patients respond to them and they may have potentially treatment-limiting side effects. Nevertheless, better understanding of NaV channels may be important avenues for future drug development for trigeminal neuropathy.
- |||||||||| carbamazepine / Generic mfg.
Journal: Novel solar-driven ferrate(VI) activation system for micropollutant degradation: Elucidating the role of Fe(IV) and Fe(V). (Pubmed Central) - Jul 30, 2022
Furthermore, the effect of pH on carbamazepine (CBZ) degradation was studied and the quantum yields of Fe(VI) were determined, with (1.98 ± 0.16)× 10 mol∙einstein, (5.90 ± 0.27)× 10 mol∙einstein, and (1.66 ± 0.14)× 10 mol∙einstein at pH 7.0, 8.0, and 9.0, respectively...Finally, the solar-Fe(VI) process exhibited good applicability in authentic waters and under different irradiation (natural sunlight, ultraviolet light, and visible light from solar cut-off emission). Overall, this study provides a new routine for efficient micropollutant elimination and reveals the photochemistry of Fe(VI).
- |||||||||| carbamazepine / Generic mfg.
Preclinical, Journal: Characterization in Inhibitory Effectiveness of Carbamazepine in Voltage-Gated Na and Erg-Mediated K Currents in a Mouse Neural Crest-Derived (Neuro-2a) Cell Line. (Pubmed Central) - Jul 29, 2022
The docking results regarding the interaction of CBZ and voltage-gate Na (Na) channel predicted the ability of CBZ to bind to some amino-acid residues in Na due to the existence of a hydrogen bond or hydrophobic contact. It is conceivable from the current investigations that the I (I, I, I, and I) residing in Neuro-2a cells are susceptible to being suppressed by CBZ, and that its block on I is larger than that on I. Collectively, the magnitude and gating of Na channels produced by the CBZ presence might have an impact on its anticonvulsant and analgesic effects occurring in vivo.
- |||||||||| carbamazepine / Generic mfg.
Journal: High-Throughput Microbial Community Analyses to Establish a Natural Fungal and Bacterial Consortium from Sewage Sludge Enriched with Three Pharmaceutical Compounds. (Pubmed Central) - Jul 29, 2022
An enrichment experiment was performed, fortifying the sewage sludge with carbamazepine, ketoprofen and diclofenac as model compounds, with the aim to obtain strains with the capability to transform these pollutants...Population shifts in bacterial and fungal communities were also studied during the selective pressure using Illumina MiSeq. These analyses showed a predominance of Ascomycota (Dothideomycetes and Aspergillaceae) and Actinobacteria and Proteobacteria, suggesting the possibility of selecting native microorganisms to carry out bioremediation processes using tailored techniques.
- |||||||||| carbamazepine / Generic mfg.
Journal: Removal of Carbamazepine in Aqueous Solution by CoS/Fe/PMS Process. (Pubmed Central) - Jul 29, 2022
The sustainability test demonstrated that the repeated use of CoS for 8 successive cycles resulted in little function decrease (<10%). These findings suggest that CoS/Fe/PMS may be a promising method for advanced treatment of tailwater from sewage treatment plant.
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