- |||||||||| methylphenidate tablet / Generic mfg., atomoxetine / Generic mfg., carbamazepine / Generic mfg.
Pharmacogenetics in Child and Adolescent Psychiatry: A Clinical Update () - Oct 19, 2022 - Abstract #AACAP2022AACAP_1283;
Conclusions The clinical application for pharmacogenetic testing in child and adolescent psychiatry remains limited (eg, screening for HLA-B*15:02 in patients from Southeast Asia prior to carbamazepine therapy). However, more research is needed before establishing its broad use in a clinically meaningful way.
- |||||||||| How Much Is Too Much?: A Review of Current Treatments for Catatonia () - Oct 19, 2022 - Abstract #AACAP2022AACAP_869;
Compared to monotherapy with lorazepam or ECT alone, a combination treatment offers a synergistic and superior response. Further research on the safety of high-dose benzodiazepine therapy needs to be conducted along with an investigation of agents of augmentation.
- |||||||||| Pharmacology of Conduct Disorders (Virtual) - Oct 19, 2022 - Abstract #AACAP2022AACAP_587;
Conclusions Pharmacological interventions for conduct disorder can be part of a multidisciplinary intervention (such as multisystemic approaches). Psychostimulants have been shown to have the best risk-benefit ratio.
- |||||||||| Know Your CYPs! Meaningful Cytochrome p450 Interactions in the Treatment of Psychosis () - Oct 19, 2022 - Abstract #AACAP2022AACAP_286;
Some CYP1A2 substrates include olanzapine, clozapine, propranolol, and caffeine...Conclusions Many medications prescribed for patients experiencing early psychosis have important cytochrome p450 interactions. Knowledge of these interactions is important for providers at all levels.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3069;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3068;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3067;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| And my legs? () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_3066;
After several consultations, he assessed severe paraparesis with sensory alteration and sphincter involvement, with little chance of recovery.The patient was discharged to a specialized spinal cord injury center with rehabilitation, bladder catheterization, anticoagulant, anticonvulsant medication, and corticosteroids.Faced with a sudden onset with weakness or loss of strength in the lower limbs, we must always rule out spinal cord compression.In the event that the symptoms persist, although a first result does not refer to alterations, we must continue with the diagnostic procedure and even repeat complementary tests, establishing treatment as soon as possible.Spinal cord infarction is a rare cause of paraplegia that constitutes less than 1% of all ischemic infarctions.It is one of the most serious and feared complications of thoracic and/or abdominal aortic aneurysm surgery.It is due to injury to an extravertebral feeding artery or the aorta, more often than due to intrinsic disorders of the spinal artery. There is no specific treatment and corticosteroids, used in the acute phase, have not shown clear long-term improvement.
- |||||||||| Review, Journal: Pathophysiology of Drug-Induced Hyponatremia. (Pubmed Central) - Oct 15, 2022
In brief, nephrogenic antidiuresis, or NSIAD, is the major mechanism for drug-induced hyponatremia. The associations between pharmacogenetic variants and drug-induced hyponatremia is an area of ongoing research.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Occurrence of emerging organic contaminants and endocrine disruptors in different water compartments in Mexico - A review. (Pubmed Central) - Oct 14, 2022
Although the contamination of water resources represents one of the most environmental concerns in Mexico, this review brings to light the lack of studies on the occurrence of EOCs in Mexican waters, which is important for public health policies and for developing legislations that incorporates EOCs as priority contaminants in national water quality guidelines. Consequently, the development of legislations will support regulatory compliance for wastewater and drinking water, reducing the human exposure.
- |||||||||| Psychopharmacology and metabolic syndrome: a descriptive study in a short stay unit (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1385;
In our study second generation antipsychotics were the most prescribed drugs in patients with metabolic syndrome, which also is found in scientific literature related to this topic. Despite the known association of mental disorders and cardiovascular risk factors, further research is needed in order to develop new strategies to minimize the metabolic impact of the current psychopharmacology.
- |||||||||| lithium carbonate ER / Generic mfg., carbamazepine / Generic mfg.
Bipolar spectrum disorder: we do not treat it if we miss it (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1274;
These medications are typically medications like lithium, valproic acid, lamotrigine, carbamazepine, and atypical antipsychotics...The study of pharmacogenomics in mental health is quickly evolving, and it has allowed the identification of some genetic assets associated with bipolar spectrum disorders, which may provide the groundwork for the identification of genetic risk factors and personalized pharmacological profiles. Pharmacogenomics may offer a safer use of drugs, optimizing dosages and pharmacological combinations.
- |||||||||| fluoxetine / Generic mfg., carbamazepine / Generic mfg.
Suicidal behaviors – risk factors in patients with schizophrenia (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1088;
Having side effects of neuroleptics like sialorrhea and dyslipidemia was a significant risk of suicidal behavior( p<10-3). Conclusion : Suicidal behavior is a serious problem and the most common cause of death among patients with schizophrenia. Thus, it should be investigated among all patients with schizophrenia and measures should be taken in order to prevent this behavior.Preventing suicidal behaviors in schizophrenia involves the identification of risk factors and early treatment of the mental disease.
- |||||||||| lithium carbonate ER / Generic mfg.
Journal, Adverse events: Analysis of adverse drug events in patients with bipolar disorders using the Japanese Adverse Drug Event Report database. (Pubmed Central) - Oct 13, 2022
Among 24 ADEs (PT) that were reported in more than 50 patients, lamotrigine was associated with increased risks of 13 ADEs (PT), followed by carbamazepine with increased risks of 8 ADEs (PT)...Lithium carbonate was associated with increased risks of rash (PT), drug interaction (PT), and tubulointerstitial diseases (SMQ)...The risk of hyperglycemia/new onset diabetes mellitus (SMQ) was increased by olanzapine, quetiapine fumarate, and risperidone. We are presenting the profiles of ADEs in patients with bipolar disorders using the JADER database, and propose risk factors for 19 ADEs (PT) and 4 ADEs (SMQ).
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: Ocular neuromyotonia: a review of diagnosis and treatment. (Pubmed Central) - Oct 12, 2022
Diagnosis of ONM relies upon a thorough history and clinical exam, with particular attention to history of radiotherapy and eccentric gaze testing. Treatment with carbamazepine remains first-line therapy, although other membrane stabilizing agents and surgical interventions can be effective.
- |||||||||| carbamazepine / Generic mfg.
PK/PD data, Preclinical, Journal: Metabolites identification and pharmacokinetic profile of hirsuteine, a bioactive component in Uncaria in rats by ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. (Pubmed Central) - Oct 12, 2022
Furthermore, plasma concentrations of hirsuteine and its four metabolites, 4-hirsuteine N-oxide, 3,4-dehydrohirsuteine, 11-hydroxyhirsuteine, and 11-hydroxyhirsuteine-11-O-glucuronide were simultaneously quantified in rat plasma, using carbamazepine as the internal standard...The lower limit of quantitation in the rat plasma was 5 ng/ml for hirsuteine. This study is the first to comprehensively investigate the metabolism process of hirsuteine and the pharmacokinetic profiles of hirsuteine and its major metabolite, and will provide a scientific basis to further elucidate the pharmacodynamic material basis and therapeutic mechanism of Uncaria prescriptions.
- |||||||||| Review, Journal: Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force (Pubmed Central) - Oct 11, 2022
High infant levels (30% up to 100% of maternal serum concentrations) have been reported with ethosuximide, phenobarbital and zonisamide...It is concluded that breastfeeding should in general be encouraged in women taking ASMs, given the well-established benefits of breastfeeding with regard to both short- and long-term infant health in the general population. Counselling needs to be individualized including information on the current knowledge regarding the woman's specific ASM treatment.
- |||||||||| ezogabine (XEN496) / Xenon
The amygdala-kindling model: Toward the development of a high performance screening platform to accelerate the identification of novel anti-seizure medications (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_12298;
Conversely, ethosuximide at 100 mg/kg did not show any effect on motor components of the seizure nor on ADD.This study was intended to shed light on translational aspects of the amygdala-kindling model as a potential asset for characterizing new entities with improved tolerability and efficacy. The combination of this model and a cross-over design will provide a decision-enabling screening platform for the identification of novel compounds for the prevention, treatment, and modification of epilepsy, wherein pharmacoresistant seizures constitute the greatest challenge for treatment.
- |||||||||| metformin / Generic mfg., carbamazepine / Generic mfg.
Coadministration of metformin and carbamazepine in rat formalin test (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_9761;
Experimentally, the effective dose 50 (ED50 E) was significantly lower (460.58 ± 50.57mg/kg), indicating the presence of synergism for the combination. Results show that the oral coadministration of metformin and carbamazepine can interact synergistically and could provide a therapeutic alternative for inflammatory pain.
- |||||||||| lorazepam / Generic mfg., nimodipine / Generic mfg., carbamazepine / Generic mfg.
Elucidating the mechanisms of transcranial ultrasound for modulation of human motor cortex. (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_7450;
These results provide the first assessment of the pharmacological mechanisms of TUS brain stimulation in human and will be conducive to the development of TUS as a potential treatment of neurological and psychiatric disorders, as well as a tool for the study of the brain. Data collection is ongoing and more subjects are being recruited, increasing sample size in time for the conference.
- |||||||||| vixotrigine (BIIB074) / Biogen, GSK
Spontaneous activity in organotypic cultures of human spinal cord slices: potential for use in the drug discovery process (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_3993;
Conversely, the SA IC50 for vixotrigine was right-shifted relative to its FTPC range, in agreement with prior studies indicating that it is a well-tolerated drug. In conclusion, these initial data indicate that SA can be reliably measured in adult human CNS tissue up to 3 weeks in vitro and that organotypic hSC slice cultures can provide a valuable translational tool for the evaluation of the safety and possible efficacy of novel CNS drug candidates.
- |||||||||| atenolol / Generic mfg., carbamazepine / Generic mfg., ibuprofen / Generic mfg.
Journal: A super-hydrophilic partially reduced graphene oxide membrane with improved stability and antibacterial properties. (Pubmed Central) - Oct 7, 2022
The retention order of salts was NaSO > MgSO > MgCl > NaCO > CaCl > NaCl, while the rejection for four kinds of pharmaceuticals followed the order of ibuprofen (92%) > carbamazepine (87%) > amlodipine (80%) > atenolol (76%), indicating that the negatively charged membrane could improve the retention performance by the electrostatic repulsive effect. Moreover, the enhanced antibacterial performance of membrane attributed to the dual effects of the super-hydrophilicity and the tea polyphenols antibacterial material loading, which may alter the charge distribution on and within the membrane, leading to loss of cell viability.
- |||||||||| brivaracetam / Generic mfg.
Journal: Retention of brivaracetam in adults with drug-resistant epilepsy at a single tertiary care center. (Pubmed Central) - Oct 5, 2022
Brivaracetam was effective at a broad range of doses in managing drug-resistant epilepsy across various phenotypes, but less effective than LEV in those who switched due to poor tolerability on LEV. There were no new tolerability issues, but 77% of the individuals experiencing side effects on BRV also experienced similar side effects on LEV.
- |||||||||| carbamazepine / Generic mfg.
Journal: SpeedMixing: Rapid Tribochemical Synthesis and Discovery of Pharmaceutical Cocrystals without Milling or Grinding Media. (Pubmed Central) - Oct 4, 2022
We present SpeedMixing, a rapid blending technology, as an approach for fast mechanosynthesis and discovery of model pharmaceutical cocrystals through rapid spinning in the absence of bulk solvents and milling/grinding media. Syntheses of pharmaceutical cocrystals based on the active pharmaceutical ingredients (APIs) carbamazepine, dihydrocarbamazepine, and nicotinamide demonstrate SpeedMixing as a method for rapid, scalable, as well as controllable and selective synthesis of cocrystals, cocrystal polymorphs and stoichiomorphs, including the discovery of an unexpected methanol solvate of the archetypal cocrystal of carbamazepine and saccharin, which has eluded numerous extensive screens over 20 years.
- |||||||||| Tradjenta (linagliptin) / Boehringer Ingelheim, Eli Lilly
Concomitant medication (conmed) interactions with novel hormonal agents (NHAs) in metastatic castration resistant prostate cancer (mCRPC) (Hall 407) - Oct 1, 2022 - Abstract #ESMOAsia2022ESMO_Asia_317;
Table: 160MO Common interacting drug classes and culprit drugs Drug Class Patients on drug class, n Interacting Drug AA interaction ENZ interaction Statin 93 AtorvastatinSimvastatin CC Antiplatelet 63 Clopidogrel D Anticoagulant 32 ApixabanRivaroxabanWarfarin DDD Diuretic 44 SpironolactoneFrusemideHydrochlorothiazideIndapamide XCCC CCC Beta blocker 44 BisoprololMetoprololNebivololPropranololSotalol CCCD C CD Calcium channel blocker 38 FelodipineLercanidipineNifedipineDiltiazemVerapamil DCDDD Anti-arrhythmic 9 AmiodaroneDigoxinFlecainide D C DDC Hypoglycaemic 30 GliclazideGlimepirideLinagliptin CCD Opioid 56 BuprenorphineCodeineFentanylOxycodoneTramadol C C CCCCC Anti epileptic 32 CarbamazepineSodium valproate D DC Conclusions In our real-world cohort, potential conmed interactions with NHAs were common, involving routinely prescribed drug classes. Poorer outcomes in patients with significant conmed interactions highlight the importance of conmed review in treatment selection.
- |||||||||| sulphadiazine / Generic mfg., carbamazepine / Generic mfg.
Journal: Enhancive and inhibitory effects of copper complexation on triplet dissolved black carbon-sensitized photodegradation of organic micropollutants. (Pubmed Central) - Sep 30, 2022
Cu complexation can also enhance the electron transfer ability, thereby producing more ∙OH in Cu(II)-DBC complex, which explains the promoting effect of Cu complexation on carbamazepine photodegradation in view of its low triplet reaction rate. These indicate that DBC* reactivity differences of organic micropollutants may explain their photodegradation kinetics differences in DBC system with/without Cu, which was supported by the linearized relationship between the photodegradation rate ratios of ten micropollutants with/without Cu and their triplet reaction activity.
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