- |||||||||| carbamazepine / Generic mfg.
Journal: Roles of MnO Colloids and Mn(III) during the Oxidation of Organic Contaminants by Permanganate. (Pubmed Central) - Dec 31, 2022 This study showed that the apparent second-order rate constants (k) of Mn(VII) oxidation of methyl phenyl sulfoxide and carbamazepine remained constant with time...The kinetic models revealed that the overall contributions of MnO colloids and Mn(III) ranged within 6.6-67.9% during the autoaccelerating oxidation of phenolic contaminants by Mn(VII). These findings advance the understanding of the roles of MnO colloids and Mn(III) in the Mn(VII) oxidation process.
- |||||||||| sodium valproate / Generic mfg., levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Journal: Association Between Antiepileptic Drugs and Incident Parkinson Disease in the UK Biobank. (Pubmed Central) - Dec 28, 2022 This study, the first to systematically look at PD risk in individuals prescribed the most common AEDs, to our knowledge, found evidence of an association between AEDs and incident PD. With the recent literature demonstrating an association between epilepsy and PD, this study provides further insights.
- |||||||||| LY3410738 / Eli Lilly
Trial completion date, Trial termination, Trial primary completion date: Study of the Effects of Itraconazole and Carbamazepine on LY3410738 in Healthy Participants (clinicaltrials.gov) - Dec 28, 2022 P1, N=27, Terminated, With the recent literature demonstrating an association between epilepsy and PD, this study provides further insights. Trial completion date: Jan 2023 --> Apr 2022 | Active, not recruiting --> Terminated | Trial primary completion date: Jan 2023 --> Apr 2022; Data from part 2 no longer deemed necessary for this program.
- |||||||||| hydrochlorothiazide / Generic mfg., irbesartan / Generic mfg., carbamazepine / Generic mfg.
Journal: The removal of micropollutants from treated effluent by batch-operated pilot-scale constructed wetlands. (Pubmed Central) - Dec 27, 2022 Besides, the presence of bark-biochar also enhanced the removal of total nitrogen during 10 months of operation, but no improvement was observed on the total organic carbon and total phosphorus removal. Considering the application in a batch-operated CW, MP removal can be greatly enhanced by replacing sand with bark-biochar that will act as MP adsorbing matrix.
- |||||||||| phenobarbital / Generic mfg., carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
Journal: Clinical Characteristics of Seizures and Epilepsy in Individuals With Recurrent Deletions and Duplications in the 16p11.2 Region. (Pubmed Central) - Dec 20, 2022 Seizures responded favorably to phenobarbital, carbamazepine, and oxcarbazepine in the deletion group, specifically in the Se(F)IE, and to various antiseizure medications in the duplication group. These findings delineate the spectrum of seizures and epilepsies in the recurrent 16p11.2 deletions and duplications and provide potential diagnostic, therapeutic, and prognostic information.
- |||||||||| carbamazepine / Generic mfg.
Journal: Integrating anodic sulfate activation with cathodic HO production/activation to generate the sulfate and hydroxyl radicals for the degradation of emerging organic contaminants. (Pubmed Central) - Dec 13, 2022 In the presence of sulfates, the electrocatalysis system shows superior activities towards the degradation of pharmaceutical and personal care products (PPCPs), with the optimal performance of completely degrading the representative pollutant carbamazepine (CBZ, 0.2 mg L) within 150 s...The quasi-steady-state concentrations of ·OH and SOwere estimated to be 0.51×10 M and 0.56×10 M, respectively. This study provides insight into the synergistic generation of ·OH/SO from the integrated electrochemical anode oxidation of sulfate and cathode reduction of dissolved oxygen, which indicates a potential practical approach to efficiently degrade the emerging organic water contaminants.
- |||||||||| carbamazepine / Generic mfg.
Journal: Assembled mixed co-cultures for emerging pollutant removal using native microorganisms from sewage sludge. (Pubmed Central) - Dec 12, 2022 To evaluate the emerging-pollutant degradation rate, the best 10 co-cultures, and those which contained the social strains were then challenged with three different Pharmaceutical Active compounds (PhACs): diclofenac, carbamazepine and ketoprofen...These consortia transformed the PhACs to derivate molecules through hydroxylation and were released to the media, resulting in a low ecotoxicity effect. High-throughput screening of co-cultures provides a quick, reliable and efficient method to narrow down suitable degradation co-cultures for emerging PhAC contaminants while avoiding toxic metabolic derivatives.
- |||||||||| Meridia (sibutramine) / AbbVie
Journal: Uptake and Transport of Different Concentrations of PPCPs by Vegetables. (Pubmed Central) - Dec 12, 2022 At the same time, it was demonstrated that there was an obvious uptake transfer phenomenon of PPCPs by plants, and the trend of uptake transfer became more and more obvious as the concentration of external environmental pollutants increased. In addition, amantadine, chlorpheniramine maleate, carbamazepine, N, N-desmethyl sibutramine, hemosibutramine, and chlorosibutramine showed more active translocation in some plants (TF > 1.0).
- |||||||||| carbamazepine / Generic mfg., quetiapine / Generic mfg.
Journal: Development of two fully automated quick, easy, cheap, effective, rugged, and safe pretreatment methods for the extraction of psychotropic drugs from whole blood samples. (Pubmed Central) - Dec 9, 2022 Method 1 provided higher recovery rates (80%-91%) than method 2 (72%-86%), whereas method 2 provided higher detection sensitivities (limits of detection, 0.003-0.094 ng/mL) than method 1 (0.025-0.47 ng/mL) owing to the effectiveness of its dispersive solid-phase extraction cleanup step. These fully automated extraction methods realize reliable, labor-saving, user-friendly, and hygienic extraction of target analytes from whole blood samples.
- |||||||||| Epidiolex (cannabidiol) / Jazz, Fintepla (low-dose fenfluramine) / UCB
Journal: Cannabidiol reveals a disruptive strategy for 21st century epilepsy drug discovery. (Pubmed Central) - Dec 6, 2022 This commentary aims to review the historical relevance of cannabidiol's (CBD; Epidiolex) approval for epilepsy in the context of other ASMs brought to market...DS is a pediatric developmental epileptic encephalopathy with high mortality, frequent spontaneous recurrent seizures, and marked resistance to conventional ASMs, such as phenytoin and carbamazepine...Because of the clinical approval of CBD as a novel, cannabis plantderived ASM for DS, CBD has revealed a new strategy in ASM discovery to reignite 21st century therapeutic development for epilepsy. In this commentary, we review the major preclinical and clinical milestones of the late 20th century that made CBD, a compound historically subjected to regulatory restrictions, a key driver of a new discovery strategy for epilepsy in the 21st century.
- |||||||||| Paxlovid (nirmatrelvir and ritonavir) / Pfizer
Journal: Paxlovid Information From FDA and Guidance for AES Members. (Pubmed Central) - Dec 2, 2022 ASMs that are metabolized, at least in part, by CYP3A4 include cannabidiol, carbamazepine, clobazam, clonazepam, diazepam, ethosuximide, everolimus, felbamate, lacosamide, midazolam, oxcarbazepine, perampanel, stiripentol, tiagabine, and zonisamide. Patients receiving these medications may warrant closer monitoring while being treated with Paxlovid.
- |||||||||| Biomarker, Journal: Utilization of Drugs with Pharmacogenetic Dosing Recommendations in Switzerland: A Descriptive Study Using the Helsana Database. (Pubmed Central) - Dec 1, 2022
Preemptive pharmacogenetic testing is reimbursed by health care insurance for only seven drugs (abacavir, carbamazepine, 6-mercaptopurine, azathioprine, 5-fluorouracil, capecitabine, and irinotecan) although, it is proposed to be a cost-effective approach to personalized medicine...Ibuprofen, pantoprazole, and tramadol had the highest number of users...The prevalence of PGx drug prescriptions is high in the Swiss population. Therefore, intensified preemptive testing may be a useful option as a substantial amount of the Swiss population might benefit.
- |||||||||| flunarizine / Generic mfg., carbamazepine / Generic mfg.
Expanding the Allelic Spectrum in atp1a3-related Disorders with 3 Novel Mutations and Clinic Features: A Case Series (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1732; Although it is not possible to generalize from only 7 patients, the results may suggest that patients with AHC might tend to present later and have milder neurological signs than patients without AHC, and that they usually show resolution of hemiplegic episodes spontaneously or after anticonvulsant treatment and in one patient persistence of AHC seem to be associated with severe neurological dysfunction. The fact that both Group 2 patients were female while the Group 1 sex distribution was approximately equal does not necessarily indicate a gender predilection.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Long-term Effect of Cenobamate in a Cohort of Therapy Refractory Adult Patients with Different Types of Epilepsies (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1344; The comedication was lamotrigine (49), valproate (41), clobazam (35), brivaracetam/levetiracetam (37), lacosamide (15), oxcarbazepine (15), perampanel (7), zonisamide (5), stiripentol (5), topiramate (4), phenobarbital (2), rufinamide (1), felbamate (1), carbamazepine (1). Overall, adjunct CNB has been found to be generally safe and effective for treatment-resistant seizures in adult pts, a few therapy-resistant pts got seizure free and the retention rate, a mixture of effect and side effects was 91.4% after 6 months.
- |||||||||| The Gain of Function SCN1A Disorder Spectrum: Novel Epilepsy Phenotypes and Therapeutic Implications (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1288;
Our study expands the spectrum of gain of function SCN1A-related epilepsy phenotypes, defines key clinical features, provides novel insights into the underlying disease mechanisms between SCN1A-related epilepsy and FHM3, and identifies sodium channel blockers as potentially efficacious therapies. Gain-of-function disease should be considered in early onset epilepsies with a pathogenic SCN1A variant and non-Dravet syndrome phenotype.
- |||||||||| levetiracetam / Generic mfg., carbamazepine / Generic mfg.
Effects of Anti-seizure Medication Exposure on Pcos-like Symptoms in Women with Epilepsy (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1252; We used Student’s t-test for continuous variables of equal variances, chi-square test for categorical variables, and Fisher’s exact test for categorical variables with frequencies of less than 5. Significance was set at p< 0.05.
- |||||||||| Fycompa (perampanel) / Eisai, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Practice Trends in Women with Epilepsy (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1220; Based on available data, several organizations including the AAN (American Academy of Neurology) and the AES (American Epilepsy Society) recommend avoidance of valproate use in women of child bearing age group due to substantial risk of major congenital malformations and adverse neuro-cognitive outcomes and recommend use of folic acid supplementation. However, our study finds that there is a practice gap between recommendations and clinician practice trends illustrating the need for more clinician education and need for involvement of epileptologists in the care of these patients to ensure best outcomes.
- |||||||||| Fycompa (perampanel) / Eisai
Efficacy and Safety of Perampanel as First or Only Adjunctive Therapy in Patients with Focal-onset Seizures (FOS) or Generalized Tonic-clonic Seizures (GTCS) in Studies 412, 501, 410, and 509 (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1195; P, P=N/A, Based on the available data from these studies, perampanel as a first or only adjunctive ASM was found to be efficacious and generally well tolerated. These data support the use of perampanel as an early-line treatment option for patients with various seizure types (FOS, FBTCS, and GTCS).
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