- |||||||||| carbamazepine / Generic mfg.
Journal: Enhanced Photocatalytic Degradation of Emerging Contaminants Using TiCT MXene-Supported CdS Quantum Dots. (Pubmed Central) - Mar 9, 2023
Moreover, the quenching experiments demonstrated that superoxide radicals (O), HO, O, and OH are the reactive species involved in CBZ degradation, while O made a major contribution. In addition, the sunlight-driven CdS QDs/TiCT photocatalytic system is widely suitable for the elimination of different emerging pollutants in various water matrices, suggesting its potential practical environmental applications.
- |||||||||| Journal: Chemical and biological tracers to identify source and transport pathways of septic system contamination to streams in areas with low permeability soils. (Pubmed Central) - Mar 9, 2023
These results demonstrate the advantages of using a combined tracer approach, involving a conservative tracer such as acesulfame-K coupled with the human-specific biological indicator Bacteroides (BacHum), to understand not only impacting sources but also potential transport pathways of septic system contamination to nearby streams. Septic systems may be an underappreciated contaminant source in rural hamlets located in fine-grained overburden materials; although, a distinction of specific nutrient sources (septic systems vs. agriculture) remains challenging.
- |||||||||| Korsuva IV (difelikefalin IV) / Cara Therap, Maruishi Pharma, Vifor, carbamazepine / Generic mfg.
Journal: Paroxysmal Neuropathic Pruritus in Patients With Chiari Malformation Type I: A Rare Phenotype. (Pubmed Central) - Mar 7, 2023
The commonly used treatments for neuropathic itch are antiseizure medications, tricyclic antidepressants, gabapentinoids, ketamine, and oral kappa opioids, including butorphanol and difelikefalin. Better structured prospective studies are needed to analyze the prevalence and scales to assess disability caused due to neuropathic itch in CM and may enhance understanding in this area.
- |||||||||| carbamazepine / Generic mfg.
Hair loss after drug reaction with eosinophilia and systemic symptoms: A multicentric retrospective study (ePoster Stage 3; Poster Hall space (NS Building)) - Mar 4, 2023 - Abstract #ISID2023ISID_431;
The most common culprit drug was carbamazepine (4, 40%)...Longstanding suffering can result from various types of alopecia after DRESS, including PA and TE, described first in this study. Medical attention and early intervention are required to the patients with severe DRESS, who belongs to potential vulnerable group for alopecia.
- |||||||||| carbamazepine ER capsule / Generic mfg.
Enrollment change, Trial termination: DB/Maintenance of Equetro (Carbamazepine) in Children With Acute Manic or Mixed Bipolar 1 Disorder (clinicaltrials.gov) - Mar 3, 2023
P4, N=17, Terminated,
Medical attention and early intervention are required to the patients with severe DRESS, who belongs to potential vulnerable group for alopecia. N=161 --> 17 | Completed --> Terminated; No apparent therapeutic effects that was superior to placebo
- |||||||||| carbamazepine / Generic mfg.
Preclinical, Journal: Highly synchronized cortical circuit dynamics mediate spontaneous pain in mice. (Pubmed Central) - Mar 2, 2023
More importantly, restoring a 'normal' range of neural dynamics, through attenuating pain-induced S1 synchronization, alleviated pain-like behavior. These results suggest spontaneous pain pushes S1 regional network into a synchronized state, whereas reversal of this synchronization alleviates pain.
- |||||||||| carbamazepine / Generic mfg.
Biomarker, Review, Journal, Adverse drug reaction: Avoidance of cutaneous adverse drug reactions induced by antiepileptic drugs based on pharmacogenomics. (Pubmed Central) - Mar 2, 2023
In neurology, psychiatry, and neurosurgery, several human leukocyte antigen (HLA) alleles have been reportedly associated with cutaneous adverse drug reactions (cADRs) induced by antiepileptic drugs, which significantly carry the risk of developing cADRs. Prior to using antiepileptic drugs such as carbamazepine and lamotrigine, which are prone to cause severe cADRs, preemptive HLA genetic testing and therapeutic interventions such as drug selection and dosage adjustment based on the results of the tests can reduce the incidence of cADRs in the population before the initiation of treatment.
- |||||||||| carbamazepine / Generic mfg.
Journal: Influence of EPHX1 c.337 (Pubmed Central) - Mar 1, 2023
Strategies with potential to prevent transmission via this pathway are presented. The results of our study done in 115 PWE showed there was a lack of association between SNPs of EPHX1 c.337
- |||||||||| Journal: Quantitative CYP3A4 induction risk assessment using human hepatocytes complemented with pregnane X receptor (PXR)-activating profiles. (Pubmed Central) - Feb 27, 2023
Significance Statement The established correlation of CYP3A4 mRNA in human hepatocytes to PXR activation provides a clear cut-off to identify a compound showing an in vitro induction risk, complementing current regulatory guidance. Also, the demonstrated in vitro-in vivo translation of induction data strongly supports clinical development program although limitations remain for drug candidates showing complex disposition pathways such as involvement of auto-inhibition/induction, active transport and high protein binding.
- |||||||||| carbamazepine / Generic mfg., celecoxib oral / Generic mfg.
Journal: Melt Crystallization of Celecoxib-Carbamazepine Cocrystals with the Synchronized Release of Drugs. (Pubmed Central) - Feb 27, 2023
Melt crystallization is an alternative, efficient and eco-friendly approach for preparing drug-drug cocrystals on a large scale. The synchronized drug release by drug-drug cocrystals can be used to modulate the release profiles of parent drugs in the fixed-dose combination products.
- |||||||||| carbamazepine / Generic mfg.
Review, Journal: TREATMENT OPTIONS FOR TRIGEMINAL NEURALGIA. (Pubmed Central) - Feb 24, 2023
The drug of choice for treating trigeminal neuralgia is still carbamazepine. If pharmacological treatment fails, invasive surgical microvascular decompression, stereotactic radiation therapy (gamma knife), percutaneous balloon micro compression, percutaneous glycerol rhizolysis, and percutaneous radiofrequency (RF) may be used.
- |||||||||| Journal: Pharmaceutical active compounds in a heavily industrialized and urbanized bay, Eastern China. (Pubmed Central) - Feb 22, 2023
If pharmacological treatment fails, invasive surgical microvascular decompression, stereotactic radiation therapy (gamma knife), percutaneous balloon micro compression, percutaneous glycerol rhizolysis, and percutaneous radiofrequency (RF) may be used. Carbamazepine, lincomycin, diltiazem, propranolol, venlafaxine, anhydro erythromycin, and ofloxacin had the highest detection rate (??93%)...Typical PhACs such as venlafaxine, ofloxacin, norfloxacin, roxithromycin, and clarithromycin were significantly and positively correlated with nitrate and total nitrogen (r?>?0.26, p?<?0.05) based on Pearson's correlation analysis...Some PhACs, i.e., ofloxacin, ciprofloxacin, carbamazepine, and amitriptyline posed medium to high
- |||||||||| carbamazepine / Generic mfg.
Oxygen vacancies driven peroxymonosulfate activation for highly efficient singlet-oxygen dominated PPCPs removal using magnetic-recyclable reduced ZnFe2O4 (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_11894;
The r-ZnFe2O4 achieved excellent performance in activating PMS for PPCPs degradation, evidenced by 2 ppm carbamazepine (CBZ) being completely degraded in 2 minutes using 0.1 g/L r-ZnFe2O4 and 1 mM PMS...The catalyst also exhibits exceptional anti-interference ability and the capacity to degrade CBZ in different conditions, maintaining good performance in varying PH ranges and the presence of various water matrices. This work developed a magnetic r-ZnFe2O4 to efficiently activate PMS through a non-radical activation pathway for PPCPs degradation, which can meet the future needs of water treatment due to: (i) no energy input, environmental-friendly process; (ii) excellent anti-interference ability because of non-radical dominant degradation of PPCPs; (iii) pH independent; and (iv) easy recycling to reduce secondary pollution caused by the catalyst.Mechanism of PPCPs degradation by PMS activation using r-ZnFe2O4.
- |||||||||| carbamazepine / Generic mfg.
Photoelectrochemical degradation kinetics and pathways of the recalcitrant pharmaceutical compound carbamazepine (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_11854;
These simulations were able to help further understand the kinetic and mechanistic breakdown of CBZ via visible light and the radical present in the photoelectrochemical cell. The use of an EDA-CDT photoanode-based photoelectrochemical cell system with visible light utilizing hole oxidation through reactive chlorine radicals provides a more versatile application for water remediation.
- |||||||||| carbamazepine / Generic mfg., naproxen / Generic mfg.
Synergistic effects of Mn(II) and picolinic acid to enhance advanced oxidation by peracetic acid (Room 136 (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_6994;
PICA has little adverse environmental impact and manganese is ubiquitous in natural aquatic and terrestrial environments. Thus, the PAA-Mn(II)-PICA oxidation process could be a promising advanced oxidation technology that can efficiently remove MPs in environmental water matrices.
- |||||||||| carbamazepine / Generic mfg.
Passive ozone injection through gas-permeable membrane for advanced in situ groundwater remediation (Room 136 (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_6991;
Carbamazepine removal was dependent on liquid velocity, where higher removal (80%) was obtained at the lowest liquid velocity examined (340 cm day-1), which is also more relevant to natural groundwater velocities. Overall, this study highlights the practical potential using of permeable membranes in groundwater ISCO3 technology.
- |||||||||| carbamazepine / Generic mfg.
Low operational carbon emissions multifunctional photoelectrochemical system for saline sewage treatment to simultaneously remove organic compounds, ammonia, and bacteria coupled with generating H2 (Room 133 (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_6291;
The saline sewage could be treated by the PEC/r-BiVO4 system to meet local WWTPs' discharge standard at 2.0 V vs. Ag/AgCl in 40 minutes, and complete degradation of carbamazepine (one of the EOPs) was reached, coupled with the substantial evolution of H2...The PEC system exhibits operational feasibility at a wide pH range and total suspended solids levels and possesses exceptional reusability and stability, illustrating its promising practical potential. The developed PEC system can cater to the future perspectives of sewage treatment due to: (i) low operational carbon emissions, favoring carbon neutrality; (ii) better effluent quality because of the EOPs removal; (iii) chemical-free in the operation; and (iv) accessible reuse and recycling without secondary pollution.Mechanism of the low operational carbon emissions multifunctional PEC system for saline sewage treatment.
- |||||||||| atorvastatin / Generic mfg., sulphadiazine / Generic mfg., carbamazepine / Generic mfg.
Role of dissolved organic matter in the photolysis of environmental contaminants (Hall F-H (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_5077;
For atorvastatin, sulfadiazine, and carbamazepine, 3DOM and 1O2 appear to be the reactive intermediates primarily responsible for degradation. 3DOM, 1O2, and hydroxyl radical all impact the degradation of benzotriazole.
- |||||||||| carbamazepine / Generic mfg.
Highly efficient photocatalytic foams for organic micropollutant removal (Room 134 (Indiana Convention Center)) - Feb 14, 2023 - Abstract #ACSSp2023ACS_SP_3621;
3DOM, 1O2, and hydroxyl radical all impact the degradation of benzotriazole. Photocatalytic recirculation and single-pass reactor configurations were investigated for carbamazepine, as a model pollutant, as a function of the flow-rate, catalyst length and chemical and mechanical stability of the foams...In particular a quantum yield of 6.3
- |||||||||| carbamazepine / Generic mfg.
Journal: PRRT2-positive self-limited infantile epilepsy: initial seizure characteristics and response to sodium channel blockers. (Pubmed Central) - Feb 12, 2023
Our results delineated the clinical characteristics of PRRT2-positive SeLIE, differentiating it from other genetic infantile epilepsies, and discovered the effective anti-seizure medications for initial clustered seizure control. If afebrile bilateral tonic-clonic seizures develop in a normally developed infant as a clustered pattern, PRRT2-positive SeLIE should be considered as a possible diagnosis, and sodium channel blockers should be administered as the first medication for seizure control.
- |||||||||| carbamazepine / Generic mfg.
Journal: MD Investigation on the Interaction between Carbamazepine and Two CYP Isoforms, CYP3A4 and CYP3A5. (Pubmed Central) - Feb 12, 2023
The specificity directly leads to a binding environment difference at the active sites of the two isoforms, as represented by the electrostatic surface potential maps, which further results in the varied dynamic behavior of CBZ in the two isoforms. Our research will help to deepen the understanding of the physiological functions of CYP isoforms and opens the door for the rational design and development of isoform-specific inhibitors.
- |||||||||| carbamazepine / Generic mfg., clopidogrel / Generic mfg.
Biomarker, Journal: Pharmacogenomics in Asians: differences and similarities with other human populations. (Pubmed Central) - Feb 10, 2023
In contrast, both Caucasian and Asian patients inheriting the SLCO1B1*5 variant possessed a similar magnitude of muscle toxicity, i.e., myopathy. Asian countries should take measures toward expanding PGx research, as well as initiatives for the purposes of obtaining clinical benefits from this newly evolving and economically viable treatment model.
- |||||||||| topiramate / Generic mfg., carbamazepine / Generic mfg.
Journal: Chemicals of emerging concern in coastal aquifers: Assessment along the land-ocean interface. (Pubmed Central) - Feb 5, 2023
Among them, the perfluoroalkyl and polyfluoroalkyl substances (PFAS), along with the pharmaceuticals carbamazepine and topiramate, were revealed to be good markers for tracing anthropogenic contamination in ground- and seawater, in concrete situations (e.g., highly contaminated sites). Additionally, non-target analysis expanded the number of potential tracers, making it a promising tool for identifying both the source and the fate of pollutants.
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