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10 Diseases |  |
2 Trials |
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2 Trials |  |
131 News |  |
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- | Pentasa (mesalamine) / Ferring, Takeda
Enrollment change, Trial withdrawal: The Efficacy of Topical Mesalazine Sustained-Release Tablets in Crohn's Disease Patients With Oral Ulcer (clinicaltrials.gov) - Feb 1, 2023
P3, N=0, Withdrawn, Sponsor: Xijing Hospital of Digestive Diseases
N=40 --> 0 | Unknown status --> Withdrawn
- | esomeprazole / Generic mfg.
Journal: The effect of esomeprazole on the upper GI tract release and systemic absorption of mesalazine from colon targeted formulations. (Pubmed Central) - Apr 29, 2022
The faster release of mesalazine in the GI tract and/or the increased systemic absorption following PPI pre-treatment may reduce the ability of mesalazine to reach the colon. Future research assessing mesalazine disposition in the lower GI tract is warranted.
- | Pentasa (mesalamine) / Ferring, Takeda
Enrollment open, Trial initiation date: MesaCAPP: Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome (clinicaltrials.gov) - Mar 27, 2022
P2, N=260, Recruiting, Sponsor: Ann-Sofie Backman
Future research assessing mesalazine disposition in the lower GI tract is warranted. Not yet recruiting --> Recruiting | Initiation date: Aug 2021 --> Mar 2022
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Retrospective data, Review, Journal: Efficacy and safety of oral Pentasa® (prolonged-release mesalazine) in mild-to-moderate ulcerative colitis: a systematic review and meta-analysis. (Pubmed Central) - Nov 17, 2021
This study confirms oral Pentasa is efficacious and well-tolerated in treating active UC and maintaining remission. The availability of multiple forms of Pentasa supports physicians' ability to individualize treatment and optimize dosing to improve outcomes.
- | Pentasa (mesalamine) / Ferring, Takeda
New P2 trial: MesaCAPP: Mesalamine for Colorectal Cancer Prevention Program in Lynch Syndrome (clinicaltrials.gov) - Jun 9, 2021
P2, N=260, Not yet recruiting, Sponsor: Ann-Sofie Backman
- | Pentasa oral (mesalazine oral) / Ferring, Takeda
Journal: An investigation of the mechanism of rapid relief of ulcerative colitis induced by Five-Flavor Sophora flavescens Enteric-Coated Capsules based on network pharmacology. (Pubmed Central) - Apr 2, 2021
The molecular mechanism of UC remission induced by FSEC was predicted by network pharmacology. These findings provide an important theoretical basis for further study of the effective substances and mechanism of FSEC in the treatment of UC.
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
عذرا دكتور والبنتازا Pentasa من فضلك هل هو آمن ايضاً اثناء الحمل والرضاعه؟؟ (Twitter) - Mar 7, 2021
- | Pentasa oral (mesalazine oral) / Ferring, Takeda
Yo también tomo Inmurel y Pentasa. Pienso, q lo mejor es consultar con nuestro especialista de digestivo. (Twitter) - Feb 24, 2021
- || Remicade (infliximab) / Mitsubishi Tanabe, J&J, Pentasa oral (mesalazine oral) / Ferring, Takeda
استخدمت الـ🧪infliximab خلال الحمل حتى الأسبوع 20 أوقفت الطبيبة العلاج بسبب زيادة الأعراض وتكوين أجسام مضادة لـ🧪ووصفت لي Pentasa لاستخدامه حتى موعد الولادة ثم تغيير الـ🧪 إلى Vedoziulmab بعد الولادة. لم يشجع طبيبي استخدام🧪أثناء🤱🏻ونصح بالإرضاع الصناعي🍼 (Twitter) - Feb 18, 2021
- Pentasa oral (mesalazine oral) / Ferring, Takeda
[VIRTUAL] Patient' survey of PENTASA® Sachet 2g in Korea: In patient's perspective of adherence and compliance (Room 3) - Jan 5, 2021 - Abstract #AOCC2020AOCC_69;
These findings provide an important theoretical basis for further study of the effective substances and mechanism of FSEC in the treatment of UC. Ferring Pharmaceuticals sponsored symposium
- [VIRTUAL] Evaluation of gastroenterology prescribing patterns in a full risk health plan and implementation of an outpatient prescription verification queue to impact specialty prescription use () - Dec 26, 2020 - Abstract #ASHP2020ASHP_2034;
In this review of gastroenterology prescribing, high-cost drugs were prescribed appropriately. However, significant barriers exist from the point of prescribing to receipt of the first dose.
- | Pentasa oral (mesalazine oral) / Ferring, Takeda
New P4 trial: Intestinal concentrations and efficacy of different mesalazine tablets in patients with ulcerative colitis. Valutazioni delle concentrazioni intestinali e dell'efficacia di diverse compresse di mesalazina in paziente con colite ulcerosa. (EUDRACT) - Dec 18, 2020
P4, N=36, Completed, Sponsor: CONSORZIO UNIVERSITARIO UNIFARM
- | Journal: Medicinal products with controlled drug release for local therapy of inflammatory bowel diseases from perspective of pharmaceutical technology. (Pubmed Central) - Nov 12, 2020
Specifically, it focuses on pharmaceutical drugs containing 5-aminosalicylic acid (Asacol®, Pentasa®, Salofalk®) and budesonide (Budenofalk®, Cortiment®, Entocort®). As a part of this paper, basic recommendations and practical information that can be used in clinical practice are also given.
- || Clinical, Review, Journal: Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis. (Pubmed Central) - Oct 10, 2020
High-certainty evidence suggests 5-ASA dosed once daily appears to be as efficacious as conventionally-dosed 5-ASA. There may be little or no difference in efficacy or safety among the various 5-ASA formulations.
- || Clinical, Review, Journal: Oral 5-aminosalicylic acid for maintenance of remission in ulcerative colitis. (Pubmed Central) - Oct 10, 2020
There is probably little or no difference between 5-ASA and placebo, and 5-ASA and SASP in commonly reported AEs such as flatulence, abdominal pain, nausea, diarrhea, headache, and dyspepsia. Oral 5-ASA administered once daily has a similar benefit and harm profile as conventional dosing for maintenance of remission in quiescent UC.
- ||| Pentasa oral (mesalazine oral) / Ferring, Takeda
I will never ever forget the moment a nurse called us as we vacationed in the Cayman Islands and said matter-of-factly: “Calprotectin >2000. Where shall I call in Pentasa”? No diagnosis (Crohn’s). No discussion of options. No next steps. Nothing from our then well-respected GI. (Twitter) - Oct 1, 2020
- ||| Stelara (ustekinumab) / J&J, Pentasa oral (mesalazine oral) / Ferring, Takeda
My Crohn’s laughs at Pentasa 🤣 but on Stelara...it cry’s 😢 (Twitter) - Sep 4, 2020
- || My husband was in Pentasa for years. Humira and Remicade seem like cures in comparison. (I know they are not) (Twitter) - Sep 4, 2020
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Dietary recommendations low sugar and avoidance of tomato/citrus- @ColleenWebbRD are gold! My antibiotic intake has reduced dramatically since adopting these changes (I also take daily Pentasa) (Twitter) - Sep 2, 2020
- ||| Have had Crohns since 1975. Sulfasalazine was effective for 10 yrs. Pentasa and Azacol did not work. Been on 6MP since then and for most part it has made me “normal” (Twitter) - Aug 1, 2020
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Oral Pentasa was more effective than apriso (Twitter) - Jul 29, 2020
- ||| Pentasa oral (mesalazine oral) / Ferring, Takeda
Clinical: yes we advice patients to open Apriso and pentasa . (Twitter) - Jul 28, 2020
- ||| Pentasa oral (mesalazine oral) / Ferring, Takeda, sulfasalazine / Generic mfg.
Clinical: Yes! Pentasa and Apriso can both be opened for easier administration. A great way to give meds in the Peds world when they can’t swallow pills (and apparently in the adult world too!) And there’s always liquid sulfasalazine #oldschool (Twitter) - Jul 28, 2020
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Also Apriso and Pentasa granules can be sprinkled in and mixed with apple sauce #B2B (Twitter) - Jul 25, 2020
- Humira SC (adalimumab/hyaluronidase) / AbbVie, Halozyme, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] OVERLAPPING CROHN'S DISEASE AND SEXUALLY TRANSMITTED DISEASES (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_5596;
Sexually transmitted diseases should be considered in patients with intestinal symptoms and a history of unprotected intercourses. A comprehensive investigation is important before starting any immunosuppressive treatment.
- Pentasa oral (mesalazine oral) / Ferring, Takeda
[VIRTUAL] MESALAZINE INDUCES EARLY HISTO-ENDOSCOPIC MUCOSAL HEALING IN ACTIVE MILD-MODERATE ULCERATIVE COLITIS: POST-HOC ANALYSIS OF POOLED DATA FROM 4 DOUBLE-BLIND, DOUBLE-DUMMY, MULTICENTER, RANDOMIZED TRIALS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_4543;
Higher doses of mesalazine were superior to the low dose of 1.5g/d. A mesalazine dose of 3g/d was found as the optimal dose, confirming previous results on other endpoints (1).
- Humira SC (adalimumab/hyaluronidase) / AbbVie, Halozyme, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] OVERLAPPING CROHN'S DISEASE AND SEXUALLY TRANSMITTED DISEASES (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_3620;
Sexually transmitted diseases should be considered in patients with intestinal symptoms and a history of unprotected intercourses. A comprehensive investigation is important before starting any immunosuppressive treatment.
- Pentasa oral (mesalazine oral) / Ferring, Takeda
[VIRTUAL] MESALAZINE INDUCES EARLY HISTO-ENDOSCOPIC MUCOSAL HEALING IN ACTIVE MILD-MODERATE ULCERATIVE COLITIS: POST-HOC ANALYSIS OF POOLED DATA FROM 4 DOUBLE-BLIND, DOUBLE-DUMMY, MULTICENTER, RANDOMIZED TRIALS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_2567;
Higher doses of mesalazine were superior to the low dose of 1.5g/d. A mesalazine dose of 3g/d was found as the optimal dose, confirming previous results on other endpoints (1).
- Humira SC (adalimumab/hyaluronidase) / AbbVie, Halozyme, Humira (adalimumab) / Eisai, AbbVie
[VIRTUAL] OVERLAPPING CROHN'S DISEASE AND SEXUALLY TRANSMITTED DISEASES (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_1636;
Sexually transmitted diseases should be considered in patients with intestinal symptoms and a history of unprotected intercourses. A comprehensive investigation is important before starting any immunosuppressive treatment.
- Pentasa oral (mesalazine oral) / Ferring, Takeda
[VIRTUAL] MESALAZINE INDUCES EARLY HISTO-ENDOSCOPIC MUCOSAL HEALING IN ACTIVE MILD-MODERATE ULCERATIVE COLITIS: POST-HOC ANALYSIS OF POOLED DATA FROM 4 DOUBLE-BLIND, DOUBLE-DUMMY, MULTICENTER, RANDOMIZED TRIALS (Poster Exhibition) - Jul 19, 2020 - Abstract #UEGW2020UEGW_583;
Higher doses of mesalazine were superior to the low dose of 1.5g/d. A mesalazine dose of 3g/d was found as the optimal dose, confirming previous results on other endpoints (1).
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
As someone on Pentasa this has me a little worried. Are there any other indications that make ir so high risk? Average age etc... (Twitter) - May 22, 2020
- | prednisolone / Generic mfg., Pentasa oral (mesalazine oral) / Ferring, Takeda
Exercise helped me come off pentasa and prednisolone. That has helped me lots and doing a food diary and speaking to a nutritionist and dietician. (Twitter) - May 4, 2020
- || Clinical, Journal: Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis. (Pubmed Central) - Mar 22, 2020
Mezavant yielded higher mucosal 5-ASA concentrations than Pentasa. 5-ASA may have beneficial effects on the mucosal microbiome, and high concentrations possibly amend dysbiosis in UC.
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Clinical, Journal: Effects of pentasa-combined probiotics on the microflora structure and prognosis of patients with inflammatory bowel disease. (Pubmed Central) - Mar 4, 2020
5-ASA may have beneficial effects on the mucosal microbiome, and high concentrations possibly amend dysbiosis in UC. The combination of probiotics and pentasa can improve microflora composition in patients with IBD and reduce the level of inflammatory cytokines; therefore, it is worthy of further clinical validation.
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
"No sir, I meant Pentasa!" (Twitter) - Mar 4, 2020
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Clinical, Journal: The culprit of mesalamine intolerance: case series and literature review. (Pubmed Central) - Feb 7, 2020
5-aminosalicylic acid and excipients should be taken into consideration together when mesalamine-related adverse events occur. Of note, a diagnosis of excipient intolerance should be paid more attention in the patients with the presentation of acute skin symptoms.
- Asacol foam (mesalazine rectal foam) / Nogra Pharma, Pentasa oral (mesalazine oral) / Ferring, Takeda
NON-ADHERENCE TO MAINTENANCE MEDICATIONS IN PREGNANT ULCERATIVE COLITIS PATIENTS CONTRIBUTES TO DISEASE FLARES AND ADVERSE PREGNANCY OUTCOMES-A MULTICENTER PROSPECTIVE STUDY () - Jan 28, 2020 - Abstract #DDW2020DDW_3559;
Non-adherence to mesalamine was underestimated by physicians in pregnant UC patients and contributed to boht disease relapse and pregnancy outcomes. Preconceptional education regarding safety of medications and risk of self-discontinuation is warranted
- Pentasa oral (mesalazine oral) / Ferring, Takeda
RAPID HISTO-ENDOSCOPIC MUCOSAL HEALING WITH (HIGH DOSE) MESALAMINE IN ACTIVE MILD-MODERATE ULCERATIVE COLITIS: POST-HOC ANALYSIS OF POOLED DATA FROM 4 DOUBLE-BLIND, DOUBLE-DUMMY, MULTICENTER, RANDOMIZED TRIALS () - Jan 28, 2020 - Abstract #DDW2020DDW_2629;
Higher doses of mesalamine were superior to the low dose of 1.5g/d. A mesalamine dose of 3g/d was found as the optimal dose, confirming previous results on other endpoints (1).
- |||| Pentasa oral (mesalazine oral) / Ferring, Takeda
Clinical: Having read all the studies, I think the proclaimed death of 5ASA in Crohn’s was premature. I think it does help, albeit mildly, maybe moreso for colonic phenotype, and better in oral + rectal combo. Anecdotally, I know many kids in long-term remission with Pentasa + diet. (Twitter) - Jan 24, 2020
- || Pentasa oral (mesalazine oral) / Ferring, Takeda, Azulfidine (sulfasalazine) / Generic mfg.
Shoulders and neck. Stopped Pentasa, returned to Sulfasalazine. Works on both. Symptoms hugely reduced. (I had previously been switched from Sulfa - having taken for 30 years, to Pentasa.) (Twitter) - Jan 16, 2020
- Differences in persistence of oral mesalazine preparations as monotherapy in patients with ulcerative colitis (Hall C - Poster exhibition) - Jan 7, 2020 - Abstract #ECCOIBD2020ECCO_IBD_1670;
The number of prescribed DDD the first year after diagnosis was slightly higher in MEZ users (MEZ 1.75, ASA 1.36, PEN 1.42, SAL 1.40).Conclusion There were significant differences in drug persistence between oral preparations that were not explained by differences in prescription at regional level, but could partially be related to differences in disease severity. These differences could have clinical implications and bear further investigations.
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Seriously right @DCharabaty! Pentasa?!?!?! (Twitter) - Dec 13, 2019
- ||| Pentasa oral (mesalazine oral) / Ferring, Takeda
😂😂 Indeed despite deflated data Pentasa dominates SB Crohns ! (Twitter) - Nov 14, 2019
- ||| Pentasa oral (mesalazine oral) / Ferring, Takeda
All week I have tried to come up with a comparison of @NEPatriots and their dominance for the past decade—maybe Pentasa market share in SB Crohns? (Twitter) - Nov 13, 2019
- ||| mongersen (GED-0301) / Celgene, Pentasa oral (mesalazine oral) / Ferring, Takeda
Well the @Browns are mongersen. Lots of hype but ineffective. The @patriots maybe cyclosporine. Effective but everyone is suspicious of it. @dolphins may just be Pentasa for Crohn’s disease. @mchiorean4 @DCharabaty @MRegueiroMD (Twitter) - Nov 12, 2019
- ||| Pentasa oral (mesalazine oral) / Ferring, Takeda
Does Pentasa work for anyone? I don't remember the dosage but my wife was on a massive dose of Pentasa and it seemed to have zero effect on Crohn's or any symptoms (Twitter) - Nov 3, 2019
- ||| Pentasa oral (mesalazine oral) / Ferring, Takeda
Interesting concept; could VDZ or UTK dominate Humira by the time biosimilar ADA hits market? 🤔 Not likely; GI community moves slowly...still using Pentasa for Crohn’s disease 🙄 (Twitter) - Oct 24, 2019
- || Pentasa oral (mesalazine oral) / Ferring, Takeda
Wow! I didn't know that. I've been on Pentasa for a very long time and add Entocort when I flare. (Twitter) - Oct 20, 2019
- || 5-ASA’s = Asacol, Lialda, Mesalamine, Pentasa, Apriso, etc. (Twitter) - Oct 19, 2019