levomepromazine / Generic mfg. 
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  • ||||||||||  lorazepam / Generic mfg.
    Retrospective data, Journal:  Sedatives and Sedation at the End of Life in Nursing Homes: A Retrospective Multicenter Cohort Study. (Pubmed Central) -  Jul 2, 2021   
    Our data indicate a lower prevalence of sedation compared to international data and considerable differences regarding prevalence between institutions. These differences, potential setting-specific challenges, and need for support measures for consistent best practice of sedation in nursing homes should be further explored.
  • ||||||||||  dexamethasone / Generic mfg., midazolam hydrochloride / Generic mfg.
    [VIRTUAL] A REVIEW OF 48-HOUR CONTINUOUS SUBCUTANEOUS INFUSION UTILISATION IN A COMMUNITY PALLIATIVE CARE SETTING () -  May 10, 2021 - Abstract #MASCCISOO2021MASCC_ISOO_98;    
    Dexamethasone 0.5mg was added to 97% of infusions...All 48-hour CSCI prescriptions included at least 2 medications, with 55% containing 4 drugs. Conclusion These results confirm that 48-hour CSCI’s have been used safely and effectively to administer medications in a community palliative care setting.
  • ||||||||||  Abilify Maintena (aripiprazole depot formulation) / Otsuka, Lundbeck, Invega Sustenna (paliperidone palmitate extended-release 1-month injection) / J&J, Invega Trinza (paliperidone palmitate extended-release 3-month injection) / J&J
    [VIRTUAL] Assessment of hospitalizations in schizophrenia patients treated with Paliperidone 1-monthly (PP1M), Paliperidone 3-monthly (PP3M), Aripiprazole once-monthly (AOM) and other oral antipsychotics (OAP) in clinical practice. (e-Poster Gallery) -  Apr 26, 2021 - Abstract #EPA2021EPA_965;    
    However, limited real world evidence is available as to whether there are differences among the various formulations marketed.  Objectives This study aims to assess the impact on several prognosis variables of PP1M,PP3M,AOM and OAP drugs.  Methods All adults (≥18 years) with schizophrenia who were initiated on PP1M, PP3M, AOM, or OAP treatment (chlorpromazine,levomepromazine,fluphenazine,haloperidol,ziprasidone,zuclopenthixol,olanzapine,quetiapine,asenapine,amisulpride, risperidone,aripiprazole,paliperidone) between 2017 and 2018 were identified in IQVIA’s database(1.8M of inhabitants from 4 Spanish areas)...01) for PP3M (23%) than for PP1M (36.9%), OAP (43.5%),and AOM (46.2%). Persistence rates were higher for PP3M (91%) than for any other treatment (p<0.01).  Conclusions Our results outline that patients treated with PP3M experienced fewer relapses and decompensations compared to all other treatments analyzed, which might help improve the prognosis and quality of life of patients.
  • ||||||||||  olanzapine / Generic mfg., levomepromazine / Generic mfg.
    Clinical, Journal:  An autopsy case of heatstroke under the influence of psychotropic drugs. (Pubmed Central) -  Mar 24, 2021   
    Due to the blocking mechanism of both olanzapine and levomepromazine against muscarinic receptors, they might depress sweating and impair heat dissipation. Based on autopsy findings, results of toxicological examination, and investigation by the authorities, we concluded that the cause of death was heatstroke under the influence of olanzapine and levomepromazine.
  • ||||||||||  chlorprothixene / Generic mfg., levomepromazine / Generic mfg.
    Journal:  Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2. (Pubmed Central) -  Mar 13, 2021   
    These three compounds have not been previously reported to have anti-SARS-CoV-2 activities, although their antiviral activities against SARS-CoV and Ebola virus have been reported. These results demonstrate that this comprehensive data set is a useful resource for drug repurposing efforts, including design of new drug combinations for clinical trials for SARS-CoV-2.
  • ||||||||||  Saphris (asenapine) / Lundbeck, Meiji Seika, AbbVie
    Clinical, Journal:  Effects of Antipsychotics on Arrhythmogenic Parameters in Schizophrenia Patients: Beyond Corrected QT Interval. (Pubmed Central) -  Feb 7, 2021   
    Levomepromazine, olanzapine, brexpiprazole and lithium were positively correlated with Tp-e...According to our results, the prediction of the risk of sudden cardiac death by each index was inconsistent. We should evaluate the predictive factor of ventricular arrhythmia according to various electrocardiogram indexes because QTc alone could not identify the risk of sudden cardiac death.
  • ||||||||||  NN1213 / Novo Nordisk
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  APIC: Antipsychotic Induced Structural and Functional Brain Changes (clinicaltrials.gov) -  Nov 25, 2020   
    P4,  N=174, Terminated, 
    In this comprehensive analysis of a national cohort lorazepam had a lower mortality rate compared to other sedatives. N=544 --> 174 | Trial completion date: Apr 2019 --> Aug 2020 | Recruiting --> Terminated | Trial primary completion date: Sep 2018 --> Aug 2020; slow patient recruitment, low patient-commpliance, high dropout rates,
  • ||||||||||  Preclinical, Journal:  In vitro effects of antipsychotics on mitochondrial respiration. (Pubmed Central) -  Sep 2, 2020   
    Mitochondrial respiratory rate was significantly inhibited by all tested APs, except for olanzapine...Due to the complicated processes associated with mitochondrial activity, it is necessary to measure not only the effect of the drug on individual mitochondrial enzymes but also the respiration rate of the mitochondria or a similar complex process. The experimental approach used in the study can be applied to mitochondrial toxicity testing of newly developed drugs.
  • ||||||||||  risperidone / Generic mfg., Egis
    [VIRTUAL] SATB2-associated syndrome: behavioral challenges – case report (Poster Area) -  Aug 5, 2020 - Abstract #ECNP2020ECNP_1125;    
    Children with SAS are at risk for behavioral disturbances like difficult behavior, that often necessitates medical management. The potential complexity and worsening of the behavioral issues with age illustrates de need for objective neurobehavioral data on the SAS population.
  • ||||||||||  [VIRTUAL] Comparative effectiveness of antipsychotics for risk of attempted or completed suicide among persons with schizophrenia (Poster Area) -  Aug 5, 2020 - Abstract #ECNP2020ECNP_814;    
    In addition, adjunctive pharmacotherapies including antidepressants, mood stabilisers (carbamazepine, valproic acid, lamotrigine, lithium), benzodiazepines and Z-drugs were investigated...The results from two large nationwide cohorts provide the first evidence on comparative real-world effectiveness of specific antipsychotics in the prevention of severe suicidal behavior. Clozapine was the only pharmacological treatment associated with a substantially decreased risk of attempted or completed suicide and should be considered as first-line treatment for patients with suicidal ideation or behavior.
  • ||||||||||  Imperan (metoclopramide) / Generic mfg.
    Journal:  Fragmentation studies of selected drugs utilized in palliative care. (Pubmed Central) -  Jun 12, 2020   
    On their basis, transitions for quantitative analysis are selected and chromatographic conditions for the determination of the palliative care drugs are proposed as well. These results enable future studies on palliative care drugs in elderly patients including both their quantitation in body fluids and easier identification of their metabolites.
  • ||||||||||  trifluoperazine / Generic mfg.
    Review, Journal:  Antimicrobial Properties on Non-Antibiotic Drugs in the Era of Increased Bacterial Resistance. (Pubmed Central) -  Mar 7, 2020   
    Further studies are required in the field to further investigate these antimicrobial properties in different populations. This is of paramount importance in the antimicrobial resistance era, where clinicians have limited therapeutic options to combat problematic infections.
  • ||||||||||  amitriptyline / Generic mfg., paroxetine / Generic mfg., quetiapine / Generic mfg.
    Preclinical, Journal:  Stability of ten psychotropic drugs in formalin-fixed porcine liver homogenates. (Pubmed Central) -  Feb 21, 2020   
    These data suggest that the concentrations of drugs in PLHs measured after formalin fixation decreased to varying degrees compared with their initial concentrations. These time-dependent changes in drug concentration were due to degradation during preservation in formalin solution and metabolism by hepatic microsomal enzymes.
  • ||||||||||  amantadine / Generic mfg.
    [VIRTUAL] Antipsychotic-Induced Generalized Tardive Dystonia – case report (All Screens in Poster Area) -  Feb 20, 2020 - Abstract #EPA2020EPA_2193;    
    In clinical practice, it is important to know the mechanism of action of the drugs used and their potential adverse effects. In the case of antipsychotics, it should be noted that their use may be a cause of generalized late dystonia.
  • ||||||||||  olanzapine / Generic mfg.
    [VIRTUAL] Use of oral Olanzapine in a pregnancy woman with Bipolar disorder. Case report. (All Screens in Poster Area) -  Feb 20, 2020 - Abstract #EPA2020EPA_1955;    
    Nevertheless, it is accepted to keep the treatment during pregnancy in cases of severe Bipolar disorder such as this, since the benefits, both for the mother and the fetus, are greater than the possible risks. Artificial breastfeeding is recommended in these cases.
  • ||||||||||  quetiapine / Generic mfg.
    Clinical, Journal:  Forskrivning av antipsykotika til hjemmeboende eldre 2006–18. (Pubmed Central) -  Dec 22, 2019   
    Therefore, the anticholinergic properties of these antipsychotics could attenuate the effects of cholinesterase inhibitors. Attention should be paid to the increase in prescribing of antipsychotic drugs for the youngest age group of older patients (65-74 years) in the last four years, along with the increase in prescribing of quetiapine for older patients.
  • ||||||||||  Tisercin (levomepromazine) / Egis
    Retrospective data, Journal:  Sedatives and sedation at the end of life: a nursing home retrospective cohort study. (Pubmed Central) -  Dec 1, 2019   
    Compared with published data on continuous deep sedation, moderate or deep sedation was less frequent in this nursing home and never labelled as 'sedation'. Multicentre mixed-methods research is needed to gain representative and more detailed data on sedation practices at the end of life in nursing homes.
  • ||||||||||  olanzapine / Generic Mfg.
    "SUBCLINICAL" BUT "MASSIVE" HAEMOPTYSIS () -  Nov 21, 2019 - Abstract #APSR2019APSR_658;    
    A case of massive haemoptysis paradoxically presented with a small volume of blood expectoration. Cough reflex which was inhibited by drug (an antipsychotic drug) and underlying conditions (schizophrenia) might be a cause for a clinical mismatch between the disease severity and its relevant symptom.
  • ||||||||||  Atarax (hydroxyzine hydrochloride) / Alliance, Tisercin (levomepromazine) / Egis
    Journal, IO Biomarker:  Role of TCTP for Cellular Differentiation and Cancer Therapy. (Pubmed Central) -  Jul 21, 2019   
    Recently, we found that two antihistaminics, levomepromazine and buclizine, inhibited cancer cell growth by direct binding to TCTP and induction of cell differentiation. These data confirmed that TCTP is an exquisite target for anticancer differentiation therapy and antihistaminics have potential to be lead compounds for the direct interaction with TCTP as new inhibitors of human TCTP and tumor growth.
  • ||||||||||  Enrollment open:  APIC: Antipsychotic Induced Structural and Functional Brain Changes (clinicaltrials.gov) -  Dec 22, 2017   
    P4,  N=544, Recruiting, 
    Our findings imply that excess mortality in patients co-treated with antipsychotic and diuretic drugs is related to serum potassium levels and independent of antipsychotic drugs. Active, not recruiting --> Recruiting
  • ||||||||||  Enrollment change, Trial termination, Trial primary completion date, Adverse events:  Pharmacovigilance in Gerontopsychiatric Patients (clinicaltrials.gov) -  Oct 19, 2017   
    P3,  N=407, Terminated, 
    These new guidelines, based on the existing (but poor) evidence, could help clinicians manage more effectively the complex and challenging symptoms of N & V in advanced cancer. N=2000 --> 407 | Recruiting --> Terminated | Trial primary completion date: Feb 2017 --> Jun 2017
  • ||||||||||  Lazanda (fentanyl) / Assertio, Kyowa Kirin, Epistatus (midazolam oromucosal solution) / Veriton Pharma
    Trial initiation date, Trial primary completion date:  Nasal Fentanyl and Buccal Midazolam for Dying Patients (clinicaltrials.gov) -  Apr 18, 2017   
    P4,  N=20, Recruiting, 
    N=2000 --> 407 | Recruiting --> Terminated | Trial primary completion date: Feb 2017 --> Jun 2017 Initiation date: Apr 2014 --> Jan 2017 | Trial primary completion date: Apr 2015 --> Jan 2018