lactulose / Generic mfg. 
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  • ||||||||||  lactulose / Generic mfg., bisacodyl / Generic mfg.
    Clinical, Journal:  Content analysis of bowel protocols for the management of constipation in adult critically ill patients. (Pubmed Central) -  May 25, 2021   
    LP17 could ameliorate LPS-induced acute intestinal dysfunction, which was associated with inhibition of intestinal apoptosis and inflammation response. Bowel protocols have variable initiation, escalation, and discontinuation criteria incorporating different classes of laxatives, reflecting unclear evidence about optimal bowel management strategies in ICU.
  • ||||||||||  lactulose / Generic mfg., indomethacin / Generic mfg.
    [VIRTUAL] INTESTINAL PERMEABILITY IN SPONDYLOARTHRITIS: A SYSTEMATIC REVIEW OF THE LITERATURE () -  May 21, 2021 - Abstract #EULAR2021EULAR_2950;    
    The results of our review suggest that increased intestinal permeability is present in SpA patients even in the absence of NSAIDs use and regardless of the method used to assess intestinal permeability. The effects of NSAIDs on intestinal permeability in SpA patients is more controversial and further studies are needed to clarify them.
  • ||||||||||  lactulose / Generic mfg., azithromycin / Generic mfg.
    Journal:  Intestinal microbiome analysis demonstrates azithromycin post-treatment effects improve when combined with lactulose. (Pubmed Central) -  May 21, 2021   
    The effects of NSAIDs on intestinal permeability in SpA patients is more controversial and further studies are needed to clarify them. It is suggested that during azithromycin treatment, lactulose is able to reinstate the microbiome equilibrium much faster as it promotes saccharolytic microbes and provides a homeostatic effect that minimizes the opportunistic pathogen colonization.
  • ||||||||||  lactulose / Generic mfg.
    Clinical, Journal:  A Surviving Child from Acute Liver Failure after an Ingestion of Cassia occidentalis Seeds. (Pubmed Central) -  May 21, 2021   
    The patient also experienced with cardiogenic shock and transient distal renal tubular acidosis, which were all spontaneously resolved. The liver chemistries returned to normal 3 months after the ingestion, without receiving liver assisted device or liver transplantation.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Journal:  Gut Microbial Signature of Hepatocellular Cancer in Men with Cirrhosis. (Pubmed Central) -  May 20, 2021   
    Rothia was specific for other complications. Despite age, sex and MELD-matching and accounting for other complications, gut microbiota composition and predicted function is different in men with cirrhosis with and without prior HCC and can be extended toward future HCC development.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  H-NMR and LC-MS Based Metabolomics Analysis of Wild and Cultivated Amaranthus spp. (Pubmed Central) -  May 14, 2021   
    Other compounds that were found in both wild and cultivated A. cruentus and A. hybridus are trehalose, trigonelline, lactulose, betaine, valine, alanine, fumarate, formate and kynurenine...On the contrary, L-tryptophan, kaempferol, phenylalanine and quercetin were detected only in wild A. cruentus. Amaranth is not only rich in macro and micronutrients, but the leaves also contain phytochemicals that vary between species and cultivated plants, and might, therefore, affect the medicinal properties of the material.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Selective Isolation of Bifidobacterium From Human Faeces Using Pangenomics, Metagenomics, and Enzymology. (Pubmed Central) -  May 11, 2021   
    The results indicated that Bifidobacterium contains core GHs for utilizing raffinose, D-trehalose anhydrous, D(+)-cellobiose, melibiose, lactulose, lactose, D(+)-sucrose, resistant starch, pullulan, xylan, and glucan...Furthermore, the species significantly (p < 0.05) varied among samples from different individuals. Results suggested that xylan might be a prebiotic that benefits host health, and it is feasible to screen and isolate bifidobacteria using the oligosaccharides corresponding to the specific GHs of bifidobacteria as the carbon sources of the selective media.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Structural resolution of disaccharides through halogen anion complexation using negative trapped ion mobility spectrometry. (Pubmed Central) -  May 4, 2021   
    Based on the comparison of different halogen adducts, the [M + I] ion form exhibited more powerful ability for isomeric disaccharide differentiation with an average resolution (R) of 1.17, which results in a 34.5% improvement as compared to the corresponding chloride adducts. This result indicates that the use of negative charge states, especially the complexation of an iodide anion, could be a supplemental strategy to commonly used positive ion analysis for carbohydrate separation.
  • ||||||||||  fentanyl citrate / Generic mfg., lactulose / Generic mfg.
    Clinical, Journal:  Hypermagnesemia in critically ill patients with cancer: A case report. (Pubmed Central) -  May 4, 2021   
    Prudence and caution must therefore be exercised while using these agents in critically ill patients with cancer to avoid increased complications and mortality. Herein, the current study reports three cases of critically ill patients with cancer admitted into intensive care who had refractory hypermagnesemia.
  • ||||||||||  lactulose / Generic mfg.
    Review, Journal:  Small Intestinal Bacterial Overgrowth Syndrome: A Guide for the Appropriate Use of Breath Testing. (Pubmed Central) -  Apr 29, 2021   
    The lactulose breath test (LBT) is based upon an incorrect premise and therefore incorrect interpretations which has resulted in the over-diagnosis of SIBO and the excessive use of antibiotics in clinical practice...This review suggests guidelines for the optimal use and appropriate interpretation of the GBT for suspected SIBO. The LBT should be discarded from future use, and the literature based upon the LBT should be discounted accordingly.
  • ||||||||||  lactulose / Generic mfg.
    Trial completion date, Trial primary completion date:  Validation of the Small Intestine Microbiome Aspiration (SIMBA) Capsule (clinicaltrials.gov) -  Apr 29, 2021   
    P=N/A,  N=22, Not yet recruiting, 
    The LBT should be discarded from future use, and the literature based upon the LBT should be discounted accordingly. Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Jun 2021 --> Aug 2022
  • ||||||||||  lactulose / Generic mfg.
    Clinical, Journal:  Helicobacter pylori Eradication in Parkinson's Disease: A Randomized Placebo-Controlled Trial. (Pubmed Central) -  Apr 28, 2021   
    Trial completion date: Dec 2021 --> Dec 2022 | Trial primary completion date: Jun 2021 --> Aug 2022 HP eradication does not improve clinical outcomes in PD, suggesting that there is no justification for routine HP screening or eradication with the goal of improving PD symptoms.