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91 Trials |  |
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- | lactulose / Generic mfg.
Trial completion date, Trial primary completion date: Polyethylene Glycol Versus Lactulose on Hepatic Encephalopathy in Patients With Cirrhosis;(PEGHE Trial) (clinicaltrials.gov) - Jul 7, 2021
P4, N=102, Recruiting, Sponsor: Aga Khan University
Trial completion date: May 2021 --> Jun 2022 | Trial primary completion date: Dec 2020 --> Jun 2022
- ||| lactulose / Generic mfg.
How does lactulose work(or not) in #hepaticencephalopathy? Unlikely stool acidification. Need other measures in #cirrhosis. https://t.co/TrDMuFP1eK response to @Sanchit30497977 in @AGA_CGH @doctornikkid @AmerGastroAssn @ebtapper (Twitter) - Jul 4, 2021
- || lactulose / Generic mfg.
Clinical, Journal: Prebiotic Food Intake May Improve Bone Resorption in Japanese Female Athletes: A Pilot Study. (Pubmed Central) - Jul 4, 2021
The aim of the present study was to clarify the influence of inulin and lactulose-fortified prebiotic food intakes on bone metabolism turnover among Japanese female athletes...These results suggest that the prebiotic food used in this study might have beneficial effects on bone health and gut microbial environment among female athletes. Further studies are warranted to identify the mechanism of the prebiotics-gut-bone axis.
- | lactulose / Generic mfg., epinephrine / Generic mfg.
Journal: Diurnal versus Nocturnal Exercise-Impact on the Gastrointestinal Tract. (Pubmed Central) - Jul 4, 2021
Nocturnal exercise instigates greater gastrointestinal functional perturbations and symptoms compared to diurnal exercise. Although there are no circadian differences to gastrointestinal integrity and systemic perturbations in response to the same exertional stress and controlled procedures.
- | lactulose / Generic mfg.
Journal: Lactulose may not pass the "Acid" test in Hepatic Encephalopathy. (Pubmed Central) - Jul 3, 2021
Although there are no circadian differences to gastrointestinal integrity and systemic perturbations in response to the same exertional stress and controlled procedures. No abstract available
- | lactulose / Generic mfg.
Journal: Influences on catch-up growth using relative versus absolute metrics: evidence from the MAL-ED cohort study. (Pubmed Central) - Jul 1, 2021
Across six MAL-ED sites, 942 children had anthropometry data at 24 and 60 months, as well as information about socioeconomic status, maternal height, gut permeability (lactulose-mannitol z-score (LMZ)), dietary intake from 9 to 24 months, and micronutrient status...The study children demonstrated improved growth from 24 to 60 months of age, but only a subset had positive changes in HAD and WAD. The same environmental factors were associated with growth from 24 to 60 months regardless of metric used (change in HAZ or HAD, or WAZ and WAD).
- | lactulose / Generic mfg.
Preclinical, Journal: The different effects of Chinese Herb Solid Drink and lactulose on gut microbiota in rats with slow transit constipation induced by compound diphenoxylate. (Pubmed Central) - Jul 1, 2021
CHSD could elevate gastrin expression, which also promoted intestinal peristalsis in serum, while lactulose did not have this effect. Our findings suggest that CHSD may be an effective and safe therapeutic choice for STC.
- || lactulose / Generic mfg.
Biomarker, Clinical, Journal: Biomarkers of environmental enteric dysfunction are differently associated with recovery and growth among children with moderate acute malnutrition in Sierra Leone. (Pubmed Central) - Jun 30, 2021
Scores derived from host fecal mRNA transcript variably correlated with the L: M test and host fecal proteins. Markers of intestinal inflammation, permeability, and defense were associated with growth outcomes and recovery from MAM.
- || lactulose / Generic mfg.
Retrospective data, Review, Journal: Small Intestinal Bacterial Overgrowth in Functional Dyspepsia: A Systematic Review and Meta-Analysis. (Pubmed Central) - Jun 30, 2021
The quality of evidence is low and can be largely attributed to the type of breath test for SIBO diagnosis and clinical heterogeneity. More appropriately designed studies are required to confirm the link between SIBO and FD.
- || Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Clinical, Review, Journal: Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis. (Pubmed Central) - Jun 30, 2021
Current alternatives for the management of MHE include measures to maintain nutritional status while avoiding sarcopenia, and manipulation of intestinal microbiota with non-absorbable disaccharides such as lactulose, antibiotics such as rifaximin, and administration of different probiotics. This review analyzes the results of clinical studies that evaluated the effects of different treatments for MHE.
- || lactulose / Generic mfg.
Clinical, Journal: Blood glucose response after oral lactulose intake in type 2 diabetic individuals. (Pubmed Central) - Jun 30, 2021
This review analyzes the results of clinical studies that evaluated the effects of different treatments for MHE. Blood glucose AUC levels in mildly constipated, non-insulin dependent subjects with T2DM are not affected by the carbohydrate impurities contained in 20 g and 30 g crystal or liquid lactulose formulations.
- Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
[VIRTUAL] Rifaximin and Fecal Microbiota Transplant beneficially modulate gut metagenomic virulence factors in cirrhosis: Analysis of two trials () - Jun 27, 2021 - Abstract #EASLILC2021EASL_ILC_1770;
Virulence factors that increase the pathogenicity of Enterobacteriaceae spp are reduced by rifaximin therapy in compen- sated cirrhosis and by capsule FMT in decompensated patients with cirrhosis. Precision therapies aimed at reducing the VFs in pathogens could potentially improve outcomes and may be mechanisms of action of rifaximin and FMT.
- ||| lactulose / Generic mfg.
@ebtapper a cirrhosis question if you would be so kind to consider. 86 yo mom started on Lactulose tid p initial episode of he. Tired of stools, started xifaxin bid & stopped lactulose. Good response. ^ confusion restarted lactulose w/ xifaxin. Should we consider dc xifaxin? Thx (Twitter) - Jun 25, 2021
- || lactulose / Generic mfg., indomethacin / Generic mfg.
Trial completion: A Study Exploring the Use of Challenge Agents in Healthy Volunteers - Intervention Specific Appendix (clinicaltrials.gov) - Jun 25, 2021
P1, N=10, Completed, Sponsor: Janssen Research & Development, LLC
Precision therapies aimed at reducing the VFs in pathogens could potentially improve outcomes and may be mechanisms of action of rifaximin and FMT. Recruiting --> Completed
- | loperamide / Generic mfg.
Preclinical, Journal: Amelioration of gut dysbiosis and gastrointestinal motility by konjac oligo-glucomannan on loperamide-induced constipation in mice. (Pubmed Central) - Jun 24, 2021
Recruiting --> Completed These results suggest that KOG acts as a prebiotic and stimulant laxative for relief and prevention of constipation.
- | lactulose / Generic mfg., omeprazole / Generic mfg.
Journal: Survey of Nurses' Knowledge and Practice Regarding Medication Administration using enteral Tubes. (Pubmed Central) - Jun 24, 2021
Organisations may use these results to develop their local practice pathways for prescribing, dispensing and training around administration of medications through enteral tubes. In a community setting, this paper may improve the awareness of patients, caregivers and prescribers of the possible implications of tubing blockages.
- | lactulose / Generic mfg.
Journal: Supplementation of protease to low amino acid diets containing superdose level of phytase for wean-to-finish pigs: effects on performance, postweaning intestinal health and carcass characteristics. (Pubmed Central) - Jun 24, 2021
Intestinal health in the first 17 d was assessed based on lactulose:mannitol ratio (L:M), serum IgA, and pen diarrhea assessment...Pigs fed protease supplemented diets had lower incidence of diarrhea (χ < 0.05) compared with pigs fed diets without protease. Results of the experiment indicate that dietary protease supplementation benefits intestinal health of nursery pigs.
- | lactulose / Generic mfg.
Journal: Effects of spray-dried bovine plasma protein in milk replacers fed at a high plane of nutrition on performance, intestinal permeability, and morbidity of Holstein calves. (Pubmed Central) - Jun 23, 2021
On d 4, 15, 36, and 57, intestinal permeability was assessed via oral administration of lactulose and d-mannitol followed by analysis of lactulose and mannitol in blood at 60 min after administration...Results of this study indicate that SDP can be included at up to 10% as fed in the MR of calves fed at a high plane of nutrition (1 kg/d of MR powder, as fed) with improvements in average daily gain. Additionally, a 1:1 SDP plus wheat protein blend can be used at 12% inclusion with no difference in most health and growth parameters.
- || lactulose / Generic mfg.
Clinical, Journal: Intervention and Mechanisms of Alanyl-glutamine for Inflammation, Nutrition, and Enteropathy: A Randomized Controlled Trial. (Pubmed Central) - Jun 22, 2021
Intermediate dose Ala-Gln promotes short-term improvement in gut integrity and ponderal growth in children at risk of EE. Lower doses produced improvements in ponderal growth in the absence of enhanced gut integrity.
- | lactulose / Generic mfg., loperamide / Generic mfg.
Preclinical, Journal: Modulation of gut microbiota and intestinal metabolites by lactulose improves loperamide-induced constipation in mice. (Pubmed Central) - Jun 22, 2021
Further, the depletion of intestinal flora from loperamide- or (loperamide + lactulose)-treated mice confirmed the significance of gut microbiota in the mediation of constipation. In summary, this study leads us to propose that lactulose may improve constipation through a prebiotic effect on gut microbiota and intestinal metabolites.
- | lactulose / Generic mfg.
Biomarker, Journal: Biomarkers of environmental enteric dysfunction are not consistently associated with linear growth velocity in rural Zimbabwean infants. (Pubmed Central) - Jun 22, 2021
P=N/A
In summary, this study leads us to propose that lactulose may improve constipation through a prebiotic effect on gut microbiota and intestinal metabolites. None of 11 biomarkers of EED were consistently associated with linear growth among Zimbabwean children.This trial was registered at clinicaltrials.gov as NCT01824940.
- | lactulose / Generic mfg.
Journal: Preparation and evaluation of a polymer-based sulfobetaine zwitterionic stationary phase. (Pubmed Central) - Jun 22, 2021
Notably, it exhibits negligible baseline noise level (~0.15 pA) under typical HILIC mobile phase. Excellent selectivity in separation of α- and β-anomers of reducing sugars and lactose/lactulose has also been observed.
- ||||| lactulose / Generic mfg.
Retrospective data: 3/3 @bmj_latest @jlouissaint89 couldn't leave his #HE guru mentor down @ebtapper He had to bring in #HE to close the conference strongly! Here is a meta-analysis on polyethylene glycol vs. lactulose in hepatic encephalopathy https://t.co/69zFh9dDNG (Twitter) - Jun 11, 2021
- | lactulose / Generic mfg.
Journal: Physiological effects, mechanisms of action and application of lactulose (Pubmed Central) - Jun 11, 2021
Perspective directions of lactulose using in combination with probiotics, other prebiotics, and as an encapsulating ingredient for vitamins and other functional nutrition ingredients are determined. In this regard, the study of lactulose interaction with the components of complex products is relevant.
- || lactulose / Generic mfg.
Lactulose works, too 🤷♀️ ... and less $$ (Twitter) - Jun 10, 2021
- || lactulose / Generic mfg.
How best to treat? Any role for lactulose? Following up Amoniacal levels? (Twitter) - Jun 9, 2021
- | lactulose / Generic mfg.
Preclinical, Journal: Evaluation of the efficacy of probiotic VSL#3 and synbiotic VSL#3 and yacon-based product in reducing oxidative stress and intestinal permeability in mice induced to colorectal carcinogenesis. (Pubmed Central) - Jun 8, 2021
These findings corroborate the reduction in intestinal permeability in the probiotic and synbiotic groups, as measured by the percentage of urinary lactulose excretion (CON: 0.93 ± 0.62% × PRO: 0.44 ± 0.05%, p = 0.048; and CON: 0.93 ± 0.62% × SYN: 0.41 ± 0.12%, p = 0.043)...We demonstrated that the use of a commercial mix of probiotic bacteria (VSL#3) isolated or associated with a yacon-based prebiotic, rich in fructooligosaccharides and inulin, is able to reduce the oxidative stress and intestinal permeability in a colorectal carcinogenesis model. These compounds have great potential to be used as a food supplement, or as ingredients in the development of food products.
- || lactulose / Generic mfg.
Clinical, Journal: Modifying gut integrity and microbiome in children with severe acute malnutrition using legume-based feeds (MIMBLE): A pilot trial. (Pubmed Central) - Jun 8, 2021
Baseline measurements of gut permeability (lactulose:mannitol ratio 1.19 ± SD 2.00), inflammation (fecal calprotectin 539.0 μg/g, interquartile range [IQR] 904.8), and satiety (plasma polypeptide YY 62.6 pmol/l, IQR 110.3) confirm gastrointestinal dysfunction...Legume-enriched feeds support aspects of gut function and the microbiome. Trial registration PACTR201805003381361.
- | lactulose / Generic mfg.
Deceitful Anus. I saw them on "Rectum Damn Near Killed 'Em" tour. If I remember correctly, the opening act was The Lactulose Cowboys. (Twitter) - Jun 6, 2021
- | lactulose / Generic mfg.
Journal: Complexions therapy and severe intoxication by Thallium salts. (Pubmed Central) - Jun 3, 2021
Group I comprised 20 patients with severe thallium salt poisoning, who were prescribed with potassium-iron hexacyanoferrate in a dose of 250 mg/kg/day per os, intravenous potassium infusions, furosemide intravenously in amount of 40 mg three times per, and hemodialysis until the thallium level in the blood dropped below 10 mg/L, lactulose 30 mL two times per day per os...The clinical picture of severe poisoning with thallium salts is characterized by lesions of the gastrointestinal tract, nervous system (central and peripheral), alopecia, heart rhythm disorders, and myocardial ischemia zones. Extension of standard therapy with potassium-iron by adding hexacyanoferrate deferasirox showed better effect on thallium elimination rate and improved functional state of liver and kidneys in patients with severe thallium salt poisoning.
- ||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Choose your own adventure, Hepatology style. 60’s. Refractory ascites, MELD 10. Hx of overt HE in setting of severe AH 18 months ago. None since as liver improved. Weaned off lactulose and rifaximin. Now with severe sleep alteration, but no other symptoms. (Twitter) - Jun 3, 2021
- || Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Clinical, Journal: Serotonin Pathway of Tryptophan Metabolism in Small Intestinal Bacterial Overgrowth-A Pilot Study with Patients Diagnosed with Lactulose Hydrogen Breath Test and Treated with Rifaximin. (Pubmed Central) - Jun 3, 2021
In conclusion, the serotonin pathway of Trp metabolism may play a role in the pathogenesis of hydrogen-positive SIBO and it may influence the diversification of SIBO into variants with diarrhea or constipation. As urinary 5-HIAA concentration correlates with LHBT, TPH-1 expression in colonic mucosa and TH-5 in serum of SIBO patients, it can be considered as a non-invasive marker of this condition.
- || Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Clinical, Journal, Real-world evidence: Real-World Experience of the One-Year Efficacy of Rifaximin Add-On to Lactulose Is Superior to Lactulose Alone in Patients with Cirrhosis Complicated with Recurrent Hepatic Encephalopathy in Taiwan. (Pubmed Central) - Jun 3, 2021
Except for concern over price, no patients discontinued rifaximin due to adverse events or complications. The above results provide evidence for the one-year use of rifaximin add-on to lactulose in reducing HE recurrence and HE-related hospitalization for patients with decompensated cirrhosis.
- || lactulose / Generic mfg.
Clinical, Journal: Effectiveness of Xinglou Chengqi decoction on constipation in patients with acute ischemic stroke: a randomized controlled trial. (Pubmed Central) - Jun 2, 2021
Treatment with XLCQ decoction effectively alleviated the overall symptoms of constipation in acute ischemic stroke patients. The status of bowel movements in acute ischemic stroke can reflect the severity of neurological impairment and predict neurological outcomes at 1 month.
- | lactulose / Generic mfg.
Journal: Valproate-induced fatal acute hyperammonaemia-related encephalopathy in late-onset ornithine transcarbamylase deficiency. (Pubmed Central) - Jun 2, 2021
The patient's hospital course was complicated by progressive cerebral oedema, which resulted in worsening encephalopathy, seizures and death. We discuss the pathophysiology of hyperammonaemia in OTC deficiency, and various management strategies, including lactulose, levocarnitine, scavenger therapy and haemodialysis.
- ||||| Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
Clinical: So, in patients with compromised hepatic function, prevent GI bleed, infection, avoid excess use of diuretics, use Lactulose and gut antibiotics like Rifaximin and keep blood Ammonia low and you will prevent those pesky false neurotransmitters. Avoid Asterixis. (Twitter) - May 31, 2021
- || lactulose / Generic mfg.
We use lactulose often. It’s Galactoside fructose, a disaccharide. Besides being osmotic laxative, it’s split and anerobically metabolized by colonic bacteria to make H+ ions that traps colonic NH3 as insoluble NH4+ thus reducing portal venous NH3 level. (Twitter) - May 31, 2021
- || lactulose / Generic mfg.
We use lactulose often. It’s Galactoside fructose, a disaccharide. Besides being osmotic laxative, it’s split and anerobically metabolized by colonic bacteria to make H+ ions that traps colonic NH3 as insoluble NH4+ thus reducing portal venous NH3 level. (Twitter) - May 31, 2021
- || lactulose / Generic mfg.
PEG, must have been used for overt HE for resolution of that episode, for long term I believe we r left with lactulose, for which we need to device better targets of therapy. (Twitter) - May 30, 2021
- || lactulose / Generic mfg.
Could you comment on arterial ammonia please? Does it predict reponse to lactulose? QoL? Outcome? Cognitivir function? Thank you! (Twitter) - May 30, 2021
- || lactulose / Generic mfg.
Suggest targeting stool ph may be better to see adequacy of lactulose than number of times . Also amount of stool seems more important than number of times (Twitter) - May 30, 2021
- lactulose / Generic mfg.
[VIRTUAL] Colonic Acetate Production in Youth with and without Obesity () - May 29, 2021 - Abstract #ADA2021ADA_1294;
Insulin, glucose, and C-peptide levels were lower at the end of the study than at baseline in both groups (all P0.05). These data suggest that 1) obese youth either ferment lactulose to a lesser degree or experience a higher hepatic uptake of acetate; 2) acetate may cause a reduction in FFA during the fasting state that is more marked in lean youth; 3) acetate may be associated with changes in glucose metabolism, although herein, it is difficult to differentiate between the effect of acetate infusion and prolonged fasting.
- ||| lactulose / Generic mfg.
Biomarker, Clinical: What this tells me: 1️⃣lets not torture our patients with more Lactulose if they don’t need 2️⃣cog function *as we measure it* does not matter but QOL, functioning/PROs, risk of overt HE do - let’s study them 3️⃣develop stool/blood/PRO biomarkers of Lactulose response (Twitter) - May 29, 2021
- || lactulose / Generic mfg.
Clinical, Journal: Recurrent noncirrhotic hyperammonemia causing acute metabolic encephalopathy in a patient with a continent ileocecal pouch: a case report. (Pubmed Central) - May 29, 2021
In addition, overproduction of ammonia from urea-producing organisms can lead to abnormal absorption into the blood and subsequent oversaturation of hepatic metabolic capacity with consequent hyperammonemic encephalopathy. Although this is a rare case, prompt identification and treatment of these metabolic abnormalities is critical to prevent severe central nervous system complications such as altered mental status, coma, and even death in patients with urinary diversions.
- || lactulose / Generic mfg.
See here's another interesting thought along this line: using faecel pH tests (using faecal stripts) to guide lactulose therapy. https://t.co/VDQJnXsQcZ @AGA_CGH (Twitter) - May 29, 2021
- ||| lactulose / Generic mfg.
HEOR: The paper by @doctornikkid is great. Will tweet about it soon. Cognitive function is one target but it is a surrogate with significant limitations. Quality of life and freedom from HE are the only 'hard' outcomes. Not everyone acidifies stool on lactulose - microbiota-dependent (Twitter) - May 28, 2021
- ||| lactulose / Generic mfg.
Retrospective data, Review: Peg vs lactulose systematic review and meta-analysis #livertwitter https://t.co/7GzwvWRz21 (Twitter) - May 28, 2021
- || lactulose / Generic mfg.
Yes. It surely is time to rethink. Read in an @ebtapper #Tweetorial that even low dose lactulose causes acidification and since then have started using lower doses of lactulose with a similar improvement in HE. (Twitter) - May 28, 2021
- | lactulose / Generic mfg.
Journal: Prebiotic galactooligosaccharides production from lactose and lactulose by Lactobacillus delbrueckii subsp. bulgaricus CRL450. (Pubmed Central) - May 27, 2021
The obtained results support the potential of L. delbrueckii subsp. bulgaricus CRL450 for the production of the prebiotics GOS and OsLu and encourage the optimization of their synthesis for the design of new functional food ingredients.
- Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
[VIRTUAL] Cost-Effectiveness of Rifaximin/alpha versus Lactulose in preventing recurrent episodes of overt hepatic encephalopathy: a systematic review and meta-analysis (Poster area) - May 26, 2021 - Abstract #EASLILC2021EASL_ILC_1481;
Rifaximin-α as an add-on treatment to lactulose in the 2L setting or as monotherapy in the 1L setting would be cost- effective. Summary of MA results.