lactulose / Generic mfg. 
Welcome,         Profile    Billing    Logout  
 0 Diseases   91 Trials   91 Trials   2364 News 


«12...1920212223242526272829...4142»
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Abnormal Food Timing and Predisposition to Weight Gain: Role of Barrier Dysfunction and Microbiota. (Pubmed Central) -  Aug 11, 2021   
    The effect of abnormal time of eating was associated with increased gut permeability, estimated by sucralose and/or lactulose ratio and disrupted intestinal barrier marker...Overall, our data supported that dysbiosis was characterized by increased intestinal permeability and decreased beneficial barrier butyrate-producing bacteria/metabolite to mechanistically link the time of eating to obesity. This data provides basis for non-invasive microbial-targeted interventions to improve intestinal barrier function as new opportunities for combating circadian rhythm disruption induced metabolic dysfunction.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Bifidobacterium response to lactulose ingestion in the gut relies on a solute-binding protein-dependent ABC transporter. (Pubmed Central) -  Aug 11, 2021   
    By quantifying faecal abundance of LT-SBP orthologues, which is defined by phylogenetic analysis, we find that subjects with 10 to 10 copies of the genes per gram of faeces before lactulose ingestion show a marked increase in Bifidobacterium after ingestion, suggesting the presence of thresholds between responders and non-responders to lactulose. These results help predict the prebiotics-responder and non-responder status and provide an insight into clinical interventions that test the efficacy of prebiotics.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Journal:  Percutaneous treatment of splenorenal shunt with atrial septal closure device. (Pubmed Central) -  Aug 6, 2021   
    It is decided to perform percutaneous treatment in close collaboration between interventional radiology and interventional cardiology in order to implant an atrial septal closure device. Succesfull closure of the defect with no other episodes of encephalopathy during the following up.
  • ||||||||||  lactulose / Generic mfg.
    Retrospective data, Review, Journal:  Hyperammonemia in patients receiving valproic acid in the hospital setting: A retrospective review. (Pubmed Central) -  Jul 29, 2021   
    The administration of VPA in the general adult inpatient population resulted in a 20.4% incidence of hyperammonemia, with a lower rate of diagnosed VPA-induced hyperammonemia. Clinicians should be encouraged to obtain ammonia levels in patients receiving VPA if symptoms of altered mental status or encephalopathy develop.
  • ||||||||||  lactulose / Generic mfg.
    Clinical, Journal:  Lactulose-induced pneumatosis intestinalis following colonoscopy: a case report. (Pubmed Central) -  Jul 28, 2021   
    This suggests that a combination of factors may lead to the development of PI, and while some cases require emergent intervention including surgery, others may be treated conservatively. Awareness of risk factors that may precipitate PI and specific clinical predictors may help to both mitigate and manage PI appropriately.
  • ||||||||||  lactulose / Generic mfg.
    Clinical, Journal:  Babao Dan improves neurocognitive function by inhibiting inflammation in clinical minimal hepatic encephalopathy. (Pubmed Central) -  Jul 24, 2021   
    The online version contains supplementary material available at 10.1007/s12088-021-00955-1. Our study provided for the first time clinical and experimental evidence supporting the use of BBD in MHE, and revealed that BBD could play a crucial role in targeting and regulating TLR4 inflammatory pathway to improve neurocognitive function in MHE patients.
  • ||||||||||  lactulose / Generic mfg.
    Retrospective data, Review, Journal:  Prevalence and predictors of small intestinal bacterial overgrowth in systemic sclerosis: a systematic review and meta-analysis. (Pubmed Central) -  Jul 23, 2021   
    Subgroup analyses showed that the prevalence of SIBO in SSc was higher in studies using the lactulose hydrogen breath test (LHBT) for diagnosis (56%, 95% CI 46-67%) compared with those that used the glucose hydrogen breath test (GHBT) (27%, 95%CI 20-35%) and a jejunal aspirated culture (JAC) (35%, 95%CI 25-51%)...• Diarrhoea, but not gender, SSc subset, digital ulcer and pulmonary fibrosis, was associated with SIBO in SSc patients. • For SSc patients with SIBO, antibiotic treatment can lead to eradication of SIBO and gastrointestinal symptomatic improvement.
  • ||||||||||  lactulose / Generic mfg., acarbose / Generic mfg., L-ornithine-L-aspartate / Generic mfg.
    Review, Journal:  Pharmacologic Management of Hepatic Encephalopathy. (Pubmed Central) -  Jul 21, 2021   
    This article covers the specific mainstays of therapies, such as antimicrobials and laxatives, with an established evidence base. This article also covers newer modalities of therapies, such as fecal microbiota transplant, probiotics, bioartificial support systems, small molecular therapies such as l-ornithine l-aspartate, branched chain amino acids, l-carnitine, zinc, and other forms of therapy currently under review.
  • ||||||||||  lactulose / Generic mfg.
    Review, Journal:  Nonpharmacologic Management of Hepatic Encephalopathy: An Update. (Pubmed Central) -  Jul 21, 2021   
    Emerging literature suggests that fecal microbiota transplants could offer a novel strategy to treat gut dysbiosis and favorably impact HE. Finally, liver support devices and liver transplantation could offer a last-resort treatment option for persistent HE.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Review, Journal:  Social Impact of Hepatic Encephalopathy. (Pubmed Central) -  Jul 21, 2021   
    Multiple tools exist to assess quality of life, including the CLD-Q questionnaire. Common treatments for HE, including rifaximin and lactulose, have been shown to improve overall quality of life.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Review, Journal:  Novel Therapies in Hepatic Encephalopathy. (Pubmed Central) -  Jul 21, 2021   
    Several agents have surfaced over recent years with promise to treat hepatic encephalopathy and mitigate the cognitive impairment associated with this disease process. The purpose of this article is to highlight the leading emerging therapies in hepatic encephalopathy as well as their therapeutic targets.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    [VIRTUAL] TRANSVENOUS OBLITERATION PROCEDURE IN THE MANAGEMENT OF PARASTOMAL VARICEAL BLEEDING – A CASE REPORT (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_5313;    
    Portal hypertension as etiology of this entity may compel to a specific approach to prevent recurrence of bleeding, including conjugation of endovascular procedures. The authors present a case of PVB, initially submitted to a variety of treatment options including BRTO, which was successfully addressed with conjugated treatment of TIPS and PTO.
  • ||||||||||  lactulose / Generic mfg.
    [VIRTUAL] ORO-ANAL TRANSIT IS ASSOCIATED WITH POSTPRANDIAL SYMPTOMS, BREATH HYDROGEN AND METHANE IN IRRITABLE BOWEL SYNDROME (Hall 3) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_3324;    
    Introduction: Abnormal oro-anal transit time (OATT) and visceral hypersensitivity are key pathophysiological factors in irritable bowel syndrome (IBS).OATT is linked with stool consistency and frequency (Törnblom et al AJG 2012) and stool consistency is strongly associated with gut microbiota composition (Vandeputte et al Gut 2016).Visceral hypersensitivity, which can be assessed by rectal sensitivity testing, is associated with gastrointestinal (GI) symptom severity in IBS (Simrén et al Gut 2018).The Lactulose Nutrient Challenge Test (LNCT) has been developed as a physiologic test of visceral sensitivity and gut microbial fermentation in IBS (LeNevé et al AJG 2013)... Based on two prospective studies in IBS, OATT is not only associated with increased GI symptoms and gut microbial fermentation, but also specifically with postprandial symptom responses, highlighting its relevance in the pathophysiology of IBS.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    [VIRTUAL] TRANSVENOUS OBLITERATION PROCEDURE IN THE MANAGEMENT OF PARASTOMAL VARICEAL BLEEDING – A CASE REPORT (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_3133;    
    Portal hypertension as etiology of this entity may compel to a specific approach to prevent recurrence of bleeding, including conjugation of endovascular procedures. The authors present a case of PVB, initially submitted to a variety of treatment options including BRTO, which was successfully addressed with conjugated treatment of TIPS and PTO.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    [VIRTUAL] TRANSVENOUS OBLITERATION PROCEDURE IN THE MANAGEMENT OF PARASTOMAL VARICEAL BLEEDING – A CASE REPORT (Poster Exhibition) -  Jul 20, 2021 - Abstract #UEGW2021UEGW_1302;    
    Portal hypertension as etiology of this entity may compel to a specific approach to prevent recurrence of bleeding, including conjugation of endovascular procedures. The authors present a case of PVB, initially submitted to a variety of treatment options including BRTO, which was successfully addressed with conjugated treatment of TIPS and PTO.
  • ||||||||||  lactulose / Generic mfg.
    Biomarker, Preclinical, Journal:  The Role of Processed Aloe vera Gel in Intestinal Tight Junction: An In Vivo and In Vitro Study. (Pubmed Central) -  Jul 18, 2021   
    Our results show that oral treatment of 143 mg/kg PAG daily for 10 days improves the age-related leaky gut condition in old mice, by reducing their individual urinal lactulose/mannitol (L/M) ratio...This was induced by activation of the MAPK/ERK signaling pathway, which inhibits the translation repressor 4E-BP1. In conclusion, we propose that consuming PAG as a complementary food has the potential to benefit high-risk patients.
  • ||||||||||  lactulose / Generic mfg.
    Clinical, Journal:  Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects With Decompensated Cirrhosis With Ascites. (Pubmed Central) -  Jul 13, 2021   
    Results We evaluated nine patients with a diagnosis of decompensated cirrhosis with ascites. Subjects had a mean Model for End-Stage Liver Disease (MELD) score of 11.6 ± 3.0 and were not taking lactulose or antibiotics. All subjects tolerated SBI well with no significant adverse events or changes to any of the six domains of the CLDQ. Laboratory tests including liver tests and MELD score remained stable over the course of treatment. There were no significant changes in the rates of small intestinal bacterial overgrowth (55.6% vs 55.6%, p = 1.00) or serum levels of lipopolysaccharide-binding protein, intestinal fatty acid-binding protein, or soluble CD14 (p-values 0.883, 0.765, and 0.748, respectively) when comparing values prior to and immediately after treatment. Conclusions No adverse events or significant changes to the quality of life were detected while on treatment. There were no statistically significant differences in our outcomes when comparing individuals before and after treatment in this small prospective proof-of-concept pilot study. Further prospective randomized studies could be beneficial.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Angiotensin-Converting Enzyme Gene Polymorphism Influences Gastrointestinal Motility in Type 2 Diabetes Mellitus. (Pubmed Central) -  Jul 10, 2021   
    Orocecal transit time (OCTT) was measured using non-invasive lactulose breath test...Moreover, more number of diabetes patients with constipation (90%) belonged to DD genotype and their OCTT was significantly delayed (166.7 ± 7.3 min) as compared to ID (143.5 ± 4.2 min) or II (121.8 ± 4.9 min) genotype. From this study, it could be concluded that ACE gene polymorphism could be an important contributing factor to influence the gut motility and thus giving rise to the GI symptoms for T2DM patients.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Association of thermal food processing methods and small intestinal bacterial overgrowth syndrome (Pubmed Central) -  Jul 9, 2021   
    We performed retrospective single center database search to identify unique depersonalized records of patients with SIBO and the data of lactulose breath test and nutritional assessment with the use of 24-hours dietary recall...We found no association between thermal food processing patterns and SIBO. It seems that thermal food processing patterns has no influence on SIBO and its variants.