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  • ||||||||||  cyclosporine / Generic mfg.
    HYPERAMMONEMIA SYNDROME IN A COMBINED HEART-KIDNEY TRANSPLANT (Poster Hall_Hall C) -  Jan 28, 2022 - Abstract #ACC2022ACC_6299;    
    We applied therapies described in solid-organ transplant literature which resulted in successful resolution of HS. Prompt recognition of encephalopathy and evaluation of ammonia levels in the postoperative period after heart transplant can improve survival in this population.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Intestinal Biopsies for the Evaluation of Environmental Enteropathy and Environmental Enteric Dysfunction. (Pubmed Central) -  Jan 27, 2022   
    The majority of studies of EED have employed functional tests based on lactulose permeation to define the presence of abnormal leak in the gut...We review histology, electron microscopy, transcription and protein expression, physiological measures, and the microbiome. We conclude that while non-invasive biomarkers of enteropathy and intestinal dysfunction permit large scale studies of unquestionable value, intestinal biopsies are still required to investigate pathophysiology in depth.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Early step-down weaning of dairy calves from a high milk volume with glutamine supplementation. (Pubmed Central) -  Jan 27, 2022   
    The paracellular permeability of the intestinal epithelium was assessed with lactulose-to-mannitol ratio (LMR) in the blood on 1 d before, and 3 and 7 d after the initiation of weaning...The postprandial serum concentration of Gln, Met, Trp, and β-hydroxybutyrate were greater for EWG than EW during weaning. Beginning step-down weaning at 35 d with a Gln supplement can help maintain the gut barrier function and wean dairy calves with a satisfactory CSI at 7 wk of age without affecting postweaning growth.
  • ||||||||||  Amitiza (lubiprostone) / Takeda, Mallinckrodt
    Enrollment open:  Lubiprostone for Functional Constipation in the Under 18 Years Patients (clinicaltrials.gov) -  Jan 27, 2022   
    P3,  N=274, Recruiting, 
    Beginning step-down weaning at 35 d with a Gln supplement can help maintain the gut barrier function and wean dairy calves with a satisfactory CSI at 7 wk of age without affecting postweaning growth. Not yet recruiting --> Recruiting
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Clinical, Journal:  A Case of Severe Hyperammonemic Encephalopathy in a Dialysis Patient Following mFOLFOX6 Therapy (Pubmed Central) -  Jan 21, 2022   
    After treatment with daily hemodialysis, branched-chain amino acid solutions, lactulose and rifaximin, his conscious level improved on day 9. Intensive chemotherapy in dialysis patients should be carefully performed considering the serious adverse events including hyperammonemia.
  • ||||||||||  5-fluorouracil / Generic mfg., lactulose / Generic mfg.
    Clinical, Journal:  Hyperammonemic encephalopathy after treatment with modified FOLFOX6 regimen for recurrent gastric cancer:a case report (Pubmed Central) -  Jan 14, 2022   
    A 64-year-old female received modified FOLFOX6 therapy with continuous administration of a high concentration of 5-fluorouracil (5-FU) for recurrence of peritoneal dissemination after total gastrectomy...The consciousness and hepatic function improved the following day after treatment with branched-chain amino acid formulation, lactulose, fresh frozen plasma, and continuous hemodiafiltration...Improvement of dehydration and renal dysfunction would be important for avoiding the risk of developing the side effects. Because recurrent gastric cancer is often a progressive condition, post-treatment might be promptly transferred to the other posterior regimen without 5-FU as required.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Generation of 3-deoxypentulose by the isomerization and β-elimination of 4-O-substituted glucose and fructose. (Pubmed Central) -  Jan 13, 2022   
    Aldose-ketose isomerization is commonly used to prepare rare oligosaccharides such as maltulose (4-O-α-d-glucopyranosyl-d-fructose) and lactulose (4-O-β-d-galactopyranosyl-d-fructose)...In contrast, the formation of isosaccharinic acid via benzylic acid rearrangement, not the 3-deoxypentulose, was reported under the strongly alkaline conditions (Knill and Kennedy, 2003). The heat treatment of 1→4 linked oligo- and polysaccharides possessing glucose or fructose residue at the reducing end under neutral pH conditions could be applied for the practical preparation of a 3-deoxypentulose.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Clinical, Journal:  Interaction of bacterial metagenome and virome in patients with cirrhosis and hepatic encephalopathy. (Pubmed Central) -  Jan 12, 2022   
    Unlike bacteria, faecal phages are sparsely linked with cirrhosis characteristics and 90-day outcomes. Phage and bacterial linkages centred on urease-producing, ammonia-generating Streptococcus species were affected by disease progression and rifaximin therapy and were altered in patients who experienced 90-day hospitalisations.
  • ||||||||||  lactulose / Generic mfg.
    Clinical, Journal:  Small Intestinal Bacterial Overgrowth in Subclinical Hypothyroidism of Pregnant Women. (Pubmed Central) -  Jan 11, 2022   
    Lactulose-based hydrogen and methane breath test was performed to evaluate the growth of intestinal bacteria...The occurrence of subclinical hypothyroidism is related to SIBO, and the excessive growth of small intestinal bacteria may affect gastrointestinal symptoms. http://www.chictr.org.cn/index.aspx, identifier ChiCTR1900026326.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Journal:  Appropriate and Potentially Inappropriate Medication Use in Decompensated Cirrhosis. (Pubmed Central) -  Jan 8, 2022   
    Patients with decompensated cirrhosis are not filling indicated medications as often or as long as is recommended, and are also filling medications that are potentially harmful. Future steps include integrating pharmacy records with medical records to obtain a complete medication list and counseling on medication use with patients at each visit.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Effect of Guo Qing Yi Tang combined with Western medicine cluster therapy on acute pancreatitis. (Pubmed Central) -  Dec 22, 2021   
    GQYT combined with cluster therapy for the treatment of AP has definite curative effect and rapid onset, reduces the level of inflammatory factors, and improves intestinal mucosal barrier function and APACHE II score. Thus, it has obvious clinical therapeutic advantages and can be used as a new therapeutic regimen for AP.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  COLIGENTA treatment of small intestinal bacterial overgrowth. Results of an open study. (Pubmed Central) -  Dec 21, 2021   
    Thus, it has obvious clinical therapeutic advantages and can be used as a new therapeutic regimen for AP. The present study shows that 10-days of COLIGENTA treatment has a high SIBO clinical improvement rate and can be used as the first or second treatment line.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    HYPERAMMONEMIA IN FIBROLAMELLAR HEPATOCARCINOMA. (Rehearsal Room (Sunset Center)) -  Dec 20, 2021 - Abstract #WSMRF2022WSMRF_551;    
    She was experiencing persistent hyperammonemia ranging from 200?250 umol/L despite CRRT, so she was treated with intravenous arginine and Ammonul (sodium phenylacetate and sodium benzoate)...Other medication options, including lactulose, rifaximin, and other oral medications were not able to be given due to her ongoing GI bleed...ODC in turn catalyzes the decarboxylation of ornithine in polyamine synthesis, shunting ornithine away from the urea cycle and inhibiting OTC activity. In order to investigate this proposed mechanism, we intend to conduct further studies to measure polyamine synthesis, a downstream effect of the aforementioned mechanism.
  • ||||||||||  Xifaxan (rifaximin) / Alfa Wassermann, Bausch Health, Norgine, ASKA Pharma
    Clinical, Clinical data, Review, Journal:  Overt Hepatic Encephalopathy: Current Pharmacologic Treatments and Improving Clinical Outcomes. (Pubmed Central) -  Dec 16, 2021   
    Ornithine phenylacetate, an ammonia-reducing agent currently in development, is also being investigated in hospitalized patients with hepatic encephalopathy. Overall, data support that prophylaxis for the prevention of hepatic encephalopathy recurrence improves outcomes in patients with cirrhosis and a history of hepatic encephalopathy.
  • ||||||||||  lactulose / Generic mfg.
    Journal:  Impact of alkaline electro-activation treatment on physicochemical and functional properties of sweet whey. (Pubmed Central) -  Dec 16, 2021   
    At low electric current and holding time, proteins aggregation through disulfide bonds was observed, whereas increasing currents and holding times caused proteins to conjugate with sugars such as lactose, lactulose and galactose...EA-treated whey tended to generate foams with significantly higher overrun and stability. The present study demonstrated that EA can enhance the functionality of whey.
  • ||||||||||  lactulose / Generic mfg.
    Biomarker, Journal, IO biomarker:  The Dietary Inflammatory Index Is Not Associated With Gut Permeability or Biomarkers of Systemic Inflammation in HIV Immunologic Non-responders. (Pubmed Central) -  Dec 13, 2021   
    Plasma inflammatory markers (IFNγ, TNF, IL-6, sVCAM, D-dimer, sCD14 and CRP) were assayed by ELISA, cellular immune activation (HLA-DR and CD38 on CD4+ and CD8+ T cells) was quantified using flow cytometry, and small bowel permeability assessed by calculation of the urine LacMan ratio after drinking a mix of lactulose and mannitol...Self-reported alcohol intake, a potential confounder of the relationship between diet and inflammatory biomarkers, was also not associated with systemic inflammation or gut permeability. Our findings suggest that other mechanisms, rather than diet, are likely to be the major driver of systemic inflammation in INR individuals.