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- | Journal: Efficacy and safety of Adrenaline-augmented subconjunctival anesthesia in phacoemulsification: A randomized controlled trial. (Pubmed Central) - Feb 24, 2025
While immediate postoperative effects exist, subconjunctival anesthesia holds promise for enhanced patient comfort and procedural efficiency. Further research is needed to validate its long-term benefits and broader implications in evolving ophthalmic surgical practices.
- | lignocaine / Generic mfg.
Journal: Efficacy of Articaine versus Lignocaine as Local Anesthetic Agents Using Buccal Infiltration Technique for Extraction of Mandibular Premolars. (Pubmed Central) - Feb 10, 2025
No severe pain was recorded in the Articaine group. Articaine demonstrated superior pain control, making it a more effective choice over Lignocaine for mandibular premolar extractions using the buccal infiltration technique.
- || tramadol hydrochloride / Generic mfg., lignocaine / Generic mfg.
Clinical, Journal: Assessing Tramadol Hydrochloride as an Alternative to Lignocaine Hydrochloride in Dental Implant Procedures: A Randomized Trial. (Pubmed Central) - Nov 14, 2024
Assessing Tramadol Hydrochloride as an Alternative to Lignocaine Hydrochloride in Dental Implant Procedures: A Randomized Trial. J Contemp Dent Pract 2024;25(7):639-644.
- | lignocaine / Generic mfg.
Journal: Dataset on characterisation and stability of gingival retraction cord lignocaine-adrenaline nanogel optimised using central composite design. (Pubmed Central) - Nov 14, 2024
The optimised NBG remained stable in stress-induced environments. CCD enabled optimisation of a stable NBG formulation.
- | ibuprofen / Generic mfg.
Journal: Photobiomodulation by soft laser irradiation with and without ibuprofen improves success rate of inferior alveolar nerve block using 2% lignocaine with adrenaline in symptomatic irreversible pulpitis of mandibular molar teeth: a double-blind, randomized placebo-controlled trial. (Pubmed Central) - Oct 15, 2024
There was no significant difference between ibuprofen and laser groups (P = 0.24). For teeth with irreversible pulpitis, preoperative ibuprofen treatment combined with soft laser irradiation greatly improved the success rates of inferior alveolar nerve block anesthesia.
- | lignocaine / Generic mfg.
Journal, Surgery: Comparative Evaluation of the Anesthetic Efficacy of 1% Chloroprocaine Vis-a-vis 2% Lignocaine with Adrenaline (1:80,000) in Third Molar Surgery. (Pubmed Central) - Oct 8, 2024
Chloroprocaine has a rapid onset of action and short duration of action with minimal effects on the hemodynamic changes than lignocaine. Considering the fact that it is a safe drug with no effects of the cardiovascular system it can be advocated that Chloroprocaine can be used as an effective local anesthetic agent for performing oral and maxillofacial surgical interventions of short duration.
- | dexmedetomidine / Generic mfg.
Journal: Efficacy of Pre-emptive Infiltration of Dexmedetomidine with a Local Anaesthetic on Postoperative Pain in Maxillofacial Trauma Management under General Anaesthesia: A Prospective Study. (Pubmed Central) - Aug 26, 2024
Post-operative VAS scores were lower in the DL group at 6 and 12 h, with a median score of 1 at 16 and 24 h. Pre-emptive DEX infiltration is effective in reducing post-operative pain and opioid consumption in maxillofacial trauma cases undergoing open reduction and internal fixation. This approach can enhance patient comfort and improve surgical outcomes without significant risks.
- Efficacy and Safety of Adrenaline-Augmented Shubconjunctival Anestesia in Phacoemulsification: A Randomized Controlled Trial (154_Upper Mezzanine_South; In Person Only) - Aug 9, 2024 - Abstract #ACSCLINCON2024ACS_CLINCON_3271;
The addition of adrenaline extends anesthesia duration. While immediate postoperative effects exist, subconjunctival anesthesia holds promise for enhanced patient comfort and procedural efficiency.
- | ibuprofen / Generic mfg., lignocaine / Generic mfg.
Journal: Comparison of Effectiveness of Lignocaine and Lignocaine with Pre-Operative Oral Ibuprofen for Pulpectomy in 5 to 9-Year-Old Children: A Randomized Controlled Trial. (Pubmed Central) - Aug 9, 2024
Oral medication with ibuprofen is effective in increasing the success rate of IANB with lignocaine for the treatment of irreversible pulpitis of 5 to 9-year-old children. (EEJ-2023-09-122).
- || Clinical, Journal: Efficacy for Lidocaine and Articaine in Inferior Alveolar Nerve Block - A Comparative Study. (Pubmed Central) - Jun 27, 2024
4% Articaine with adrenaline (1:100,000) onset of action is faster and depth of anaesthesia is better compared to 2% lignocaine with adrenaline (1:200,000). Many previous studies reported onset of anaesthesia, but this study evaluates onset and depth of both the anaesthetic agent quantitatively and qualitatively.
- | dexamethasone / Generic mfg., lignocaine/adrenaline / Generic mfg., lignocaine / Generic mfg.
Journal, Surgery: A comparative evaluation of the effect of addition of 8?mg dexamethasone to 2% lignocaine with adrenaline in mandibular third molar surgery: a split mouth randomised double blind study. (Pubmed Central) - Feb 26, 2024
The addition of dexamethasone to lignocaine in the nerve block reduces the time of onset and significantly prolongs the duration of anaesthesia with decreased pain, swelling and trismus. Steroids mixed directly with the local anaesthetic agent can minimise the post-operative sequelae associated with third molar surgery with a single needle prick.
- lignocaine/adrenaline / Generic mfg.
Use of ablative Carbon Dioxide Laser for surgical removal of Xanthelasma Palpebrarum (e-Poster Hall) - Aug 30, 2023 - Abstract #EADV2023EADV_2903;
Complications like persistent periorbital edema, secondary bacterial infection, and post-inflammatory hyperpigmentation were not seen. Suturing of wounds helped in minimizing this complication in our study.
- fentanyl citrate / Generic mfg., lignocaine/adrenaline / Generic mfg.
Anesthetic Management of Cesarean Section in a Parturient with Ebstein's Anomaly (Exhibit Hall) - Aug 23, 2023 - Abstract #ASA2023ASA_4680;
Spinal anesthesia (23G needle, L3-L4 space) provided with 1.2 ml of 0.5% BUPIVACAINE with 20 mcg of FENTANYL. Delivery was uneventful; hemodynamic stability was maintained throughout.
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Trial primary completion date: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - Aug 9, 2023
P4, N=40, Not yet recruiting, Sponsor: Chinese University of Hong Kong
Delivery was uneventful; hemodynamic stability was maintained throughout. Trial primary completion date: Jun 2024 --> Sep 2024
- | lignocaine/adrenaline / Generic mfg.
Journal: Increasing the Safety Profile of Follicular Unit Extraction by Eliminating the Use of Bupivacaine and Nerve Block: Experience from a Tertiary Care Center of North India. (Pubmed Central) - Jun 29, 2023
We found lignocaine with adrenaline to be a very safe and effective anesthetic agent for field block anesthesia in FUE. The exclusion of bupivacaine and nerve blocks from the procedure of FUE can further increase the safety of the procedure, particularly for beginners and in cases where the area to be covered is not extensive (Norwood-Hamilton grades 3, 4, and 5).
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Trial completion date, Trial primary completion date: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - Apr 19, 2023
P4, N=40, Not yet recruiting, Sponsor: Chinese University of Hong Kong
The exclusion of bupivacaine and nerve blocks from the procedure of FUE can further increase the safety of the procedure, particularly for beginners and in cases where the area to be covered is not extensive (Norwood-Hamilton grades 3, 4, and 5). Trial completion date: Jan 2024 --> Jul 2024 | Trial primary completion date: Dec 2023 --> Jun 2024
- Intraprostatic delivery of local anesthetics via transurethral catheter (Schelin catheter) in Rez?m Water vapor therapy (Video Abstract Theater) - Mar 30, 2023 - Abstract #AUA2023AUA_2341;
Schelin catheter allow transurethral intraprostatic delivery of local anaesthetics. It is a possible alternative to transperineal block or regional anesthesia for the
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Trial completion date, Trial primary completion date: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - Jul 20, 2022
P4, N=40, Not yet recruiting, Sponsor: Chinese University of Hong Kong
It is a possible alternative to transperineal block or regional anesthesia for the Trial completion date: Jan 2023 --> Jan 2024 | Trial primary completion date: Dec 2022 --> Dec 2023
- | lignocaine/adrenaline / Generic mfg., lignocaine / Generic mfg., dexmedetomidine / Generic mfg.
Journal: A Comparative Study Evaluating the Efficacy of Lignocaine and Dexmedetomidine with Lignocaine and Adrenaline in Third Molar Surgery. (Pubmed Central) - Jun 22, 2022
There were no significant changes in the systolic blood pressure, diastolic blood pressure, and heart rate from the baseline following the injection of dexmedetomidine. The study demonstrated that the combination of dexmedetomidine with lignocaine enhances the local anesthetic potency of lignocaine without significant systemic effects when locally injected into oral mucosa.
- | tramadol hydrochloride / Generic mfg., lignocaine / Generic mfg.
Journal: Comparative study of local anesthetic efficacy of 5% tramadol versus 2 %Lignocaine with 1:100,000 adrenaline for extraction of fully erupted maxillary 3rd molars using infiltration anesthesia. (Pubmed Central) - Jun 14, 2022
It was found that 5% tramadol has a local anesthetic efficacy similar to 2% lignocaine with adrenaline but was found to be a comparatively weaker agent. tramadol is a valid alternative for performing extractions in normal patients or patients allergic to lidocaine.
- | tranexamic acid oral / Generic mfg.
Journal: Use of Tumescent Anesthesia in Surgical Excision of Gynecomastia. (Pubmed Central) - Mar 26, 2022
Tumescent anaesthesia for surgical excision of gynecomastia using a periareolar incision is a minimally invasive bloodless and painless technique in which ductal and stromal tissue can be removed resulting in a high level of patient satisfaction. In todays covid era it avoids the use of general anesthesia and electrocautery.
- | lignocaine/adrenaline / Generic mfg., lignocaine / Generic mfg.
Journal: To evaluate the Efficacy of Buprenorphine and 2% lignocaine with adrenaline as postoperative analgesia following mandibular third molar surgery: A Comparative Study. (Pubmed Central) - Mar 11, 2022
Buprenorphine when added to local anaesthesia can prolong postoperative analgesia with minimum or no side effects. Hence, buprenorphine can be safely used for lower third molar surgery.
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Enrollment open: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - Mar 8, 2022
P4, N=40, Recruiting, Sponsor: Chinese University of Hong Kong
Hence, buprenorphine can be safely used for lower third molar surgery. Not yet recruiting --> Recruiting
- | lignocaine/adrenaline / Generic mfg., lignocaine / Generic mfg.
Journal: Effectiveness of dexamethasone or adrenaline with lignocaine 2% for prolonging inferior alveolar nerve block: a randomized controlled trial. (Pubmed Central) - Mar 1, 2022
A single injection of dexamethasone prolongs the duration of action of lignocaine 2% IANB. Additionally, it can be used in cases where adrenaline is contraindicated.
- || Emla-cream / Akorn, AstraZeneca
Clinical, Journal: 2.5% EMLA Versus 2% Lignocaine with Adrenaline Injection in Small Oral Mucosal Biopsies: A Parallel Group Randomized Controlled Trial. (Pubmed Central) - Nov 17, 2021
We recommend the use of EMLA as a sole anaesthetic in small mucosal biopsies and shavings in all patients. We suggest it as a higher and first line recommendation for anaesthesia in needle phobic patients and children.
- || clonidine / Generic mfg., lignocaine / Generic mfg.
Clinical, Journal: Comparative Evaluation of Effectiveness of 2% Lignocaine Hydrochloride with Clonidine Hydrochloride versus 2% Lignocaine Hydrochloride with Adrenaline Bitartrate as Local Anesthetic for Adult Patients Undergoing Surgical Extraction of Impacted Mandibular Third Molars: A Randomized Controlled Clinical Study. (Pubmed Central) - Nov 16, 2021
Clonidine as an additive to lignocaine has proved to have the onset of action, vasoconstrictive properties, and pain control, equivalent to adrenaline. However, with better stability of hemodynamic variables and prolonged duration of action of LA with clonidine, it can be considered as a better, safer, and more effective additive to lignocaine than adrenaline.
- || ropivacaine / Generic mfg., lignocaine / Generic mfg.
Clinical, Journal: Clinical efficacy of 0.75% ropivacaine vs. 2% lignocaine hydrochloride with adrenaline (1:80,000) in patients undergoing removal of bilateral maxillary third molars: a randomized controlled trial. (Pubmed Central) - Oct 28, 2021
Lignocaine with adrenaline is routinely used as a local anesthetic for dental procedures...However, epinephrine containing a local anesthetic solution is not recommended in conditions such as advanced cardiovascular diseases and hyperthyroidism...No significant difference was observed in the perioperative variation in blood pressure and heart rate. Ropivacaine (0.75%) is a safe and an adrenaline-free local anesthetic option for posterior superior alveolar nerve block, which provides adequate intraoperative anesthesia and a stable hemodynamic profile for the removal of the maxillary third molar.
- || lignocaine/adrenaline / Generic mfg., lignocaine / Generic mfg.
Clinical, Journal: Comparison of clinical efficacy of ropivacaine and lignocaine with adrenaline for implant surgery anesthesia: a split-mouth randomized controlled clinical trial. (Pubmed Central) - Aug 17, 2021
Ropivacaine 0.75% decreased intraoperative and postoperative analgesia compared to lignocaine 2% with adrenaline. Hence, ropivacaine 0.75% can be used as an alternative to lignocaine in implant surgeries and other intraoral surgical procedures that require a longer duration of anesthesia and analgesia.
- | lignocaine/adrenaline / Generic mfg.
Journal: Local Infiltration Anaesthesia with a Bloodless Operative Field (WALANT). Presentation of the Technique and its Use in Hand Surgery. (Pubmed Central) - Jun 8, 2021
This effect is obtained through an injection of greater than standard volume of the anaesthetic solution composed of lignocaine and adrenaline...Data from the literature are presented showing that this technique is attracting increasing popularity worldwide. Our centre was the first in Poland to introduce the WALANT method to hand surgery.
- | ketorolac / Generic mfg.
Journal: Surgical Locker room Environment: Understanding the Hazards (SLEUTH) study. (Pubmed Central) - Apr 30, 2021
The burden of available medical supplies found in the theatre changing room is high and worrisome. Strategies for appropriate disposal and safe storage of medical equipment are required.
- || lignocaine / Generic mfg.
Clinical, Journal: Comparison of 0.5% Centbucridine and 2% Lignocaine as Local Anesthetic Agents for Dental Procedures in Children: A Randomised Controlled Trial. (Pubmed Central) - Apr 28, 2021
Strategies for appropriate disposal and safe storage of medical equipment are required. There was no significant difference between 0.5% centbucridine and 2% lignocaine with respect to onset, duration and depth of anesthesia.
- | dexamethasone / Generic mfg.
New P3 trial: Efficacy of Dexamethasone or Adrenaline in Inferior Alveolar Nerve Block (clinicaltrials.gov) - Apr 19, 2021
P3, N=83, Completed, Sponsor: Tribhuvan University, Nepal
- || fentanyl citrate / Generic mfg.
Clinical, Journal: Fentanyl and clonidine as adjuncts to a mixture of local anesthetics in potentiating postoperative analgesia in supraclavicular block: A randomized controlled study. (Pubmed Central) - Apr 17, 2021
In clonidine (C) group, patients received 10 ml of 0.5% bupivacaine + 20 ml of 2% lignocaine with adrenaline (1:200,000) and 1 μg/kg clonidine diluted till 35 cc with normal saline...Two patients of Group F complained of nausea and vomiting once in the early hours of surgery for which ondansetron i.v. was given...Both clonidine and fentanyl establish a good safety profile. Fentanyl ensures a faster onset of sensory and motor blockade, while clonidine ensures a longer duration of sensory and motor blockade as well as prolonged analgesia.
- || lignocaine/adrenaline / Generic mfg., lignocaine / Generic mfg.
Clinical, Journal: Comparison of anaesthetic efficacy of ropivacaine (0.75% & 0.5%) with 2% lignocaine with adrenaline (1:200000) in surgical extraction of bilateral mandibular 3 molars using IANB:a prospective, randomized, single blind study. (Pubmed Central) - Mar 16, 2021
Else mean heart rate lower in other time interval. Ropivacaine (0.75%,0.5%) was more efficacious than 2% lignocaine with adrenaline (1:200000) it terms of all measured parameters in study.
- | lignocaine/adrenaline / Generic mfg., epinephrine / Generic mfg.
Journal: Plating of clavicle fracture using the wide-awake technique. (Pubmed Central) - Mar 10, 2021
Ropivacaine (0.75%,0.5%) was more efficacious than 2% lignocaine with adrenaline (1:200000) it terms of all measured parameters in study. We conclude that clavicle plating under WALANT is a good alternative option of anesthesia.
- || piroxicam / Generic mfg.
Clinical, Journal: Efficacy of buccal piroxicam infiltration and inferior alveolar nerve block in patients with irreversible pulpitis: a prospective, double-blind, randomized clinical trial. (Pubmed Central) - Mar 9, 2021
The piroxicam group presented a significantly lower (p < 0.05) mean pain score than the saline group during AOP. Buccal infiltration with piroxicam enhanced the efficacy of anesthesia with IANB and buccal infiltration with lignocaine in patients with irreversible pulpitis.
- || lignocaine/adrenaline / Generic mfg.
Clinical, Journal: A Randomized Controlled Trial Comparing Wide-Awake Local Anesthesia With No Tourniquet (WALANT) to General Anesthesia in Plating of Distal Radius Fractures With Pain and Anxiety Level Perception. (Pubmed Central) - Feb 27, 2021
We conclude that distal radius plating under WALANT has similar outcomes to GA. In centres with limited resources, WALANT offers a safe, reliable and cheaper option, reserving GA time for head, abdominal and thoracic surgery.
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Trial completion date, Trial initiation date, Trial primary completion date: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - Jan 27, 2021
P4, N=40, Not yet recruiting, Sponsor: Chinese University of Hong Kong
In centres with limited resources, WALANT offers a safe, reliable and cheaper option, reserving GA time for head, abdominal and thoracic surgery. Trial completion date: Jul 2022 --> Jan 2023 | Initiation date: Dec 2020 --> Jun 2021 | Trial primary completion date: Jun 2022 --> Dec 2022
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
Trial initiation date: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - Aug 7, 2020
P4, N=40, Not yet recruiting, Sponsor: Chinese University of Hong Kong
Trial completion date: Jul 2022 --> Jan 2023 | Initiation date: Dec 2020 --> Jun 2021 | Trial primary completion date: Jun 2022 --> Dec 2022 Initiation date: Jul 2020 --> Dec 2020
- | Chirocaine (levobupivacaine) / Purdue, AbbVie
New P4 trial: Prospective RCT Lidocaine & Levobupivacaine on Block Dynamics After Subparaneural Popliteal Sciatic Nerve Block (clinicaltrials.gov) - May 21, 2020
P4, N=40, Not yet recruiting, Sponsor: Chinese University of Hong Kong