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- | Cilcane (cilengitide) / Iceni Pharma, LY294002 / Eli Lilly, Ex-Rad (recilisib) / Onconova
Journal: FNDC5 inhibits malignant growth of human cervical cancer cells via restraining PI3K/AKT pathway. (Pubmed Central) - Apr 1, 2024
The effects of FNDC5 were prevented by inhibiting integrin with cilengitide, activating PI3K with recilisib or activating Akt with SC79...PI3K inhibitor LY294002 showed similar effects to FNDC5 in HeLa and SiHa cells...These results indicate that FNDC5 inhibits the malignant phenotype of CxCa cells through restraining PI3K/Akt signaling. Upregulation of FNDC5 may play a beneficial role in retarding the tumor growth of CxCa.
- | LY294002 / Eli Lilly, Ex-Rad (recilisib) / Onconova
Preclinical, Journal: Effects of the PI3K/Akt/HO-1 pathway on autophagy in a sepsis-induced acute lung injury mouse model. (Pubmed Central) - Nov 3, 2023
Upregulation of FNDC5 may play a beneficial role in retarding the tumor growth of CxCa. Furthermore, when PI3K inhibitors LY294002, PI3K activators Recilisib and hemin were administered before the surgery, Akt, p-Akt, HO-1, and LC3-II levels were measured 24
- | LY294002 / Eli Lilly, Ex-Rad (recilisib) / Onconova
Preclinical, Journal: Inhibiting PI3K/Akt-Signaling Pathway Improves Neurobehavior Changes in Anti-NMDAR Encephalitis Mice by Ameliorating Blood-Brain Barrier Disruption and Neuronal Damage. (Pubmed Central) - Sep 7, 2023
Furthermore, when PI3K inhibitors LY294002, PI3K activators Recilisib and hemin were administered before the surgery, Akt, p-Akt, HO-1, and LC3-II levels were measured 24 To study its potential mechanism, LY294002 (PI3K inhibitor, 8
- | Ex-Rad (recilisib) / Onconova
Journal: Analysis of the Proteomic Profile in Serum of Irradiated Nonhuman Primates Treated with Ex-Rad, a Radiation Medical Countermeasure. (Pubmed Central) - Apr 10, 2023
We observed that administration of Ex-Rad post-irradiation is capable of mitigating radiation-induced perturbations in protein abundance, particularly in restoring protein homeostasis, immune response, and mitigating hematopoietic damage, at least in part after acute exposure. Taken together, restoration of functionally significant pathway perturbations may serve to protect damage to vital organs and provide long-term survival benefits to the afflicted population.
- | sevoflurane / Generic mfg.
Journal: Inhibiting specificity protein 1 attenuated sevoflurane-induced mitochondrial stress and promoted autophagy in hippocampal neurons through PI3K/Akt/mTOR and α7-nAChR signaling. (Pubmed Central) - Dec 5, 2022
In conclusions, our research indicated that SP1 regulated sevoflurane-induced oxidative stress dysregulation, mitochondrial function and cell autophagy in hippocampus via mediating the PI3K/Akt/mTOR and α7-nAChR pathways. Therefore, it might provide a novel sight for sevoflurane-induced hippocampus injury and POCD therapy.
- | Ex-Rad (recilisib) / Onconova
Journal: Autophagy participates in germline cyst breakdown and follicular formation by modulating glycolysis switch via Akt signaling in newly-hatched chicken ovaries. (Pubmed Central) - May 31, 2022
Furthermore, the glycolysis level was downregulated in ovaries treated with 3-MA, while Recilisib (a specific activator of Akt) reversed this inhibiting effect of 3-MA on primordial folliculogenesis. Collectively, these data indicate that autophagy functions to maintain germ cell cyst breakdown and primordial follicle assembly by regulating ovarian glycolysis involving Akt signaling in the ovaries of newly-hatched chickens.
- || Estybon (rigosertib) / Onconova, SymBio Pharma, Knight Therap, Ex-Rad (recilisib) / Onconova
Review, Journal: Recent applications of vinyl sulfone motif in drug design and discovery. (Pubmed Central) - Apr 13, 2022
The vinyl sulfone motif has been especially used in the design of chemotherapeutics and neuroprotective as well as radioprotective agents. In this review, we have described design, chemical structures, biological properties and related mechanism of actions, and structure activity relationship (SAR) study of vinyl sulfone-based compounds.
- | Ex-Rad (recilisib) / Onconova
Journal: Analysis of the metabolomic profile in serum of irradiated nonhuman primates treated with Ex-Rad, a radiation countermeasure. (Pubmed Central) - Nov 7, 2021
We observed alterations in biochemical pathways relating to inflammation and oxidative stress after radiation exposure that were alleviated in animals that received Ex-Rad I or Ex-Rad II. The results from this study lend credence to the possible radiomitigative effects of this drug possibly via a dampening of metabolism-based tissue injury, thus aiding in recovery of vital, radiation-injured organ systems.
- | Ex-Rad (recilisib) / Onconova
Journal: Overexpression of microRNA-23a-5p induces myocardial infarction by promoting cardiomyocyte apoptosis through inhibited of PI3K/AKT signalling pathway. (Pubmed Central) - May 27, 2021
Recilisib-activated PI3K/Akt singling pathway could restrain apoptosis from inducing miR-23a-5p overexpression, and Miltefosine-blocked PI3K/Akt singling pathway could restrict apoptosis from inhibiting miR-23a-5p reduction. In conclusion, these findings revealed the pivotal role of miR-23a-5p-PI3K/Akt axis in regulating apoptosis during MI, introducing this novel axis as a potential indicator to detect ischemic heart disease and it could be used for therapeutic intervention.
- | Ex-Rad (recilisib) / Onconova
Journal: KRAS gene silencing inhibits the activation of PI3K-Akt-mTOR signaling pathway to regulate breast cancer cell epithelial-mesenchymal transition, proliferation and apoptosis. (Pubmed Central) - Mar 16, 2021
Silencing of KRAS gene expression may inhibit the activation of PI3K-Akt-mTOR signaling pathway, and thus inhibit EMT, proliferation and apoptosis of breast cancer cells. By contrast, activation of the studied signaling pathway can reverse the positive effect of KRAS gene silencing.
- | Ex-Rad (recilisib) / Onconova
Biomarker, Journal: miR-15b, a diagnostic biomarker and therapeutic target, inhibits oesophageal cancer progression by regulating the PI3K/AKT signalling pathway. (Pubmed Central) - Dec 29, 2020
Treatment of EC cells with the PI3K/AKT pathway agonist recilisib displayed the opposite effects, blocking the inhibitory function of miR-15b mimic on EC cell viability, migration and invasion. In summary, the results indicated that miR-15b suppressed EC cell viability, migration and invasion, and promoted EC cell apoptosis by inhibiting the PI3K/AKT signalling pathway.
- | Ex-Rad (recilisib) / Onconova
Journal: A cadaveric study of radial and ulnar bowing in the sagittal and coronal planes. (Pubmed Central) - Oct 24, 2020
Ulnar lateral bow was found to be more distal than in previously published works, which analyzed only the proximal ulna, and this study describes a reverse ulnar bow in 19% of specimens. This demonstrates lateral ulnar morphology to be more variable than previously defined with minimal side-to-side variability, which are important considerations for fracture fixation and elbow arthroplasty.
- || Ex-Rad (recilisib) / Onconova
Review, Journal: Radiation protection by Ex-RAD: a systematic review. (Pubmed Central) - Aug 20, 2020
Furthermore, the inhibition of apoptosis through p53 signaling pathway was the main mechanism of radioprotection by Ex-RAD. However, its radioprotective effect would need to be investigated for more organs in future studies.