- |||||||||| Axpaxli (intravitreal axitinib implant) / Ocular Therap
Enrollment open, Trial initiation date: CLN-0046: Treatment of AMD Subjects With OTX-TKI (clinicaltrials.gov) - Mar 22, 2019 P1, N=18, Recruiting, Importantly, Ranibizumab showed better effect than the standard anti-rheumatic drugs Methotrexate (MTX) or Tocilizumab (TCZ) in bone protection and cartilage health; hence proves to be a promising new therapeutic agent for RA. Not yet recruiting --> Recruiting | Initiation date: Aug 2018 --> Feb 2019
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis
Enrollment open, Trial completion date, Trial primary completion date: CyPov: Intraocular Cytokine in Recurrence of Polypoidal Choroidal Vasculopathy (clinicaltrials.gov) - Mar 4, 2019 P4, N=28, Recruiting, Recruiting --> Completed | Trial completion date: Apr 2020 --> Jul 2018 | Trial primary completion date: Apr 2020 --> Jul 2018 Not yet recruiting --> Recruiting | Trial completion date: Aug 2018 --> Dec 2019 | Trial primary completion date: Mar 2018 --> Sep 2019
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis
Enrollment change, Trial completion date, Trial termination, Trial primary completion date: Enhancing the Lucentis (Ranibizumab) Management of Choroidal Neovascular Membranes With Hyperspectral Imaging (clinicaltrials.gov) - Feb 5, 2019 P=N/A, N=4, Terminated, Recruiting --> Completed | Trial primary completion date: Sep 2015 --> Jul 2018 N=100 --> 4 | Trial completion date: Dec 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Dec 2020 --> Dec 2018; The delay between diagnosis and initiation of treatment was no longer consistent with standard of care
- |||||||||| Eylea (aflibercept intravitreal) / Regeneron, Lucentis (ranibizumab) / Roche, Novartis
Trial completion date, Trial primary completion date: OPHTH-010915: Aflibercept in Recurrent or Persistent CNV (clinicaltrials.gov) - Jan 31, 2019 P=N/A, N=80, Recruiting, N=100 --> 4 | Trial completion date: Dec 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Dec 2020 --> Dec 2018; The delay between diagnosis and initiation of treatment was no longer consistent with standard of care Trial completion date: Mar 2019 --> Mar 2020 | Trial primary completion date: Dec 2018 --> Dec 2019
- |||||||||| Xipere (triamcinolone acetonide) / Clearside Biomedical, Bausch Health, Arctic Vision
Trial completion date, Trial termination, Trial primary completion date, Combination therapy: TOPAZ: Suprachoroidal Injection of Triamcinolone Acetonide With IVT Anti-VEGF in Subjects With Macular Edema Following RVO (clinicaltrials.gov) - Jan 9, 2019 P3, N=323, Terminated, Not yet recruiting --> Enrolling by invitation Trial completion date: Jun 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2019 --> Dec 2018; The early termination is due to the results obtained from the sister study, SAPPHIRE (CLS1003-301), which did not meet the 8-week primary efficacy endpoint.
- |||||||||| Avastin (bevacizumab) / Roche, Lucentis (ranibizumab) / Roche, Novartis
Trial completion: VEGF Concentrations After Intravitreal Bevacizumab vs Ranibizumab as a Treatment for Type 1 ROP (clinicaltrials.gov) - Jan 9, 2019 P4, N=16, Completed, Trial completion date: Jun 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2019 --> Dec 2018; The early termination is due to the results obtained from the sister study, SAPPHIRE (CLS1003-301), which did not meet the 8-week primary efficacy endpoint. Recruiting --> Completed
- |||||||||| Byooviz (ranibizumab-nuna) / Samsung, AffaMed Therap, Biogen
Enrollment closed, Trial completion date, Trial primary completion date: A Study to Compare SB11 (Proposed Ranibizumab Biosimilar) to Lucentis in Subjects With Neovascular Age-related Macular Degeneration (AMD) (clinicaltrials.gov) - Jan 3, 2019 P3, N=705, Active, not recruiting, N=10 --> 25 Recruiting --> Active, not recruiting | Trial completion date: Jul 2020 --> Nov 2019 | Trial primary completion date: Dec 2019 --> Jan 2019
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis, Fovista (pegpleranib) / Roche, Astellas
Trial completion date, Trial primary completion date: A Phase I/II Trial for Intravitreous Treatment of Severe Ocular Von Hippel-Lindau Disease Using a Combination of the PDGF Antagonist E10030 and the VEGF Antagonist Ranibizumab (clinicaltrials.gov) - Dec 24, 2018 P1/2, N=3, Active, not recruiting, Recruiting --> Active, not recruiting | Trial completion date: Jul 2020 --> Nov 2019 | Trial primary completion date: Dec 2019 --> Jan 2019 Trial completion date: Apr 2019 --> May 2020 | Trial primary completion date: Apr 2019 --> May 2020
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis
Enrollment closed, Trial completion date, Trial primary completion date, Combination therapy, Monotherapy: RANTA: Intravitreal Ranibizumab and TA Combination Therapy vs. Ranibizumab Monotherapy in Polypoidal Choroidal Vasculopathy (clinicaltrials.gov) - Nov 30, 2018 P4, N=120, Active, not recruiting, Trial completion date: Dec 2015 --> Dec 2016 | Trial primary completion date: Apr 2015 --> Jun 2016 Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Jun 2018 --> Dec 2018
- |||||||||| OPT-302 / Opthea
Enrollment closed, Combination therapy: A Dose Ranging Study of OPT-302 With Ranibizumab in Neovascular (Wet) AMD (clinicaltrials.gov) - Nov 28, 2018 P2, N=366, Active, not recruiting, Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Jun 2018 --> Dec 2018 Recruiting --> Active, not recruiting
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis
Trial completion date, Trial primary completion date: Retrospective Review of Proliferative Diabetic Retinopathy Patients (clinicaltrials.gov) - Oct 29, 2018 P=N/A, N=100, Active, not recruiting, N=120 --> 62 | Trial primary completion date: Dec 2016 --> Jun 2019 Trial completion date: Sep 2018 --> Dec 2018 | Trial primary completion date: Aug 2018 --> Dec 2018
- |||||||||| JNJ-1887 / J&J
Enrollment open: AAVCAGsCD59 for the Treatment of Wet AMD (clinicaltrials.gov) - Sep 14, 2018 P1, N=10, Recruiting, Active, not recruiting --> Completed Not yet recruiting --> Recruiting
- |||||||||| Lucentis (ranibizumab) / Roche, Novartis
Trial completion, Trial completion date, Trial primary completion date: PROTECT: Prophylactic Ranibizumab for Exudative Age-Related Macular Degeneration (clinicaltrials.gov) - Aug 28, 2018 P1/2, N=4, Completed, Trial completion date: Mar 2019 --> Jul 2019 | Trial primary completion date: Feb 2019 --> Jun 2019 Active, not recruiting --> Completed | Trial completion date: Jul 2017 --> Jul 2018 | Trial primary completion date: Jul 2017 --> Jul 2018
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