Lucentis (ranibizumab) / Roche, Novartis 
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 172 Diseases   135 Trials   135 Trials   7089 News 


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  • ||||||||||  Axpaxli (intravitreal axitinib implant) / Ocular Therap
    Enrollment open, Trial initiation date:  CLN-0046: Treatment of AMD Subjects With OTX-TKI (clinicaltrials.gov) -  Mar 22, 2019   
    P1,  N=18, Recruiting, 
    Importantly, Ranibizumab showed better effect than the standard anti-rheumatic drugs Methotrexate (MTX) or Tocilizumab (TCZ) in bone protection and cartilage health; hence proves to be a promising new therapeutic agent for RA. Not yet recruiting --> Recruiting | Initiation date: Aug 2018 --> Feb 2019
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Trial completion, Trial completion date, Trial primary completion date:  SMILE: Dosing Strategy of Intravitreal Ranibizumab for Pathological Myopia Choroidal Neovascularization (clinicaltrials.gov) -  Mar 11, 2019   
    P4,  N=54, Completed, 
    Not yet recruiting --> Recruiting | Initiation date: Aug 2018 --> Feb 2019 Recruiting --> Completed | Trial completion date: Apr 2020 --> Jul 2018 | Trial primary completion date: Apr 2020 --> Jul 2018
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Enrollment open, Trial completion date, Trial primary completion date:  CyPov: Intraocular Cytokine in Recurrence of Polypoidal Choroidal Vasculopathy (clinicaltrials.gov) -  Mar 4, 2019   
    P4,  N=28, Recruiting, 
    Recruiting --> Completed | Trial completion date: Apr 2020 --> Jul 2018 | Trial primary completion date: Apr 2020 --> Jul 2018 Not yet recruiting --> Recruiting | Trial completion date: Aug 2018 --> Dec 2019 | Trial primary completion date: Mar 2018 --> Sep 2019
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Trial completion date:  Retrospective Review of Proliferative Diabetic Retinopathy Patients (clinicaltrials.gov) -  Feb 7, 2019   
    P=N/A,  N=100, Active, not recruiting, 
    Active, not recruiting --> Completed Trial completion date: Dec 2018 --> Dec 2019
  • ||||||||||  carotuximab ophthalmic (DE-122) / Tracon Pharma, Santen
    Enrollment change, Trial completion date, Trial primary completion date, Combination therapy, Monotherapy:  Study Assessing the Efficacy and Safety of Intravitreal Injections of DE-122 in Combination With Lucentis (clinicaltrials.gov) -  Feb 6, 2019   
    P2,  N=76, Recruiting, 
    Trial completion date: Dec 2018 --> Dec 2019 N=56 --> 76 | Trial completion date: Jul 2019 --> Jan 2020 | Trial primary completion date: Jun 2019 --> Dec 2019
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Enrollment change, Trial completion date, Trial termination, Trial primary completion date:  Enhancing the Lucentis (Ranibizumab) Management of Choroidal Neovascular Membranes With Hyperspectral Imaging (clinicaltrials.gov) -  Feb 5, 2019   
    P=N/A,  N=4, Terminated, 
    Recruiting --> Completed | Trial primary completion date: Sep 2015 --> Jul 2018 N=100 --> 4 | Trial completion date: Dec 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Dec 2020 --> Dec 2018; The delay between diagnosis and initiation of treatment was no longer consistent with standard of care
  • ||||||||||  Eylea (aflibercept intravitreal) / Regeneron, Lucentis (ranibizumab) / Roche, Novartis
    Trial completion date, Trial primary completion date:  OPHTH-010915: Aflibercept in Recurrent or Persistent CNV (clinicaltrials.gov) -  Jan 31, 2019   
    P=N/A,  N=80, Recruiting, 
    N=100 --> 4 | Trial completion date: Dec 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Dec 2020 --> Dec 2018; The delay between diagnosis and initiation of treatment was no longer consistent with standard of care Trial completion date: Mar 2019 --> Mar 2020 | Trial primary completion date: Dec 2018 --> Dec 2019
  • ||||||||||  Xipere (triamcinolone acetonide) / Clearside Biomedical, Bausch Health, Arctic Vision
    Trial completion date, Trial termination, Trial primary completion date, Combination therapy:  TOPAZ: Suprachoroidal Injection of Triamcinolone Acetonide With IVT Anti-VEGF in Subjects With Macular Edema Following RVO (clinicaltrials.gov) -  Jan 9, 2019   
    P3,  N=323, Terminated, 
    Not yet recruiting --> Enrolling by invitation Trial completion date: Jun 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2019 --> Dec 2018; The early termination is due to the results obtained from the sister study, SAPPHIRE (CLS1003-301), which did not meet the 8-week primary efficacy endpoint.
  • ||||||||||  Avastin (bevacizumab) / Roche, Lucentis (ranibizumab) / Roche, Novartis
    Trial completion:  VEGF Concentrations After Intravitreal Bevacizumab vs Ranibizumab as a Treatment for Type 1 ROP (clinicaltrials.gov) -  Jan 9, 2019   
    P4,  N=16, Completed, 
    Trial completion date: Jun 2020 --> Dec 2018 | Recruiting --> Terminated | Trial primary completion date: Aug 2019 --> Dec 2018; The early termination is due to the results obtained from the sister study, SAPPHIRE (CLS1003-301), which did not meet the 8-week primary efficacy endpoint. Recruiting --> Completed
  • ||||||||||  JNJ-1887 / J&J
    Enrollment change:  AAVCAGsCD59 for the Treatment of Wet AMD (clinicaltrials.gov) -  Jan 8, 2019   
    P1,  N=25, Recruiting, 
    Recruiting --> Completed N=10 --> 25
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    New P2 trial:  Intravitreal Ranibizumab (Lucentis (clinicaltrials.gov) -  Dec 4, 2018   
    P2,  N=10, Active, not recruiting, 
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Trial completion date, Trial primary completion date:  RabOCT: Proof of Concept Study of Re-treatment in BRVO With Ranibizumab Guided by OCT (clinicaltrials.gov) -  Dec 3, 2018   
    P2b,  N=27, Completed, 
    Phase classification: P2/3 --> P4 Trial completion date: Dec 2015 --> Dec 2016 | Trial primary completion date: Apr 2015 --> Jun 2016
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Enrollment closed, Trial completion date, Trial primary completion date, Combination therapy, Monotherapy:  RANTA: Intravitreal Ranibizumab and TA Combination Therapy vs. Ranibizumab Monotherapy in Polypoidal Choroidal Vasculopathy (clinicaltrials.gov) -  Nov 30, 2018   
    P4,  N=120, Active, not recruiting, 
    Trial completion date: Dec 2015 --> Dec 2016 | Trial primary completion date: Apr 2015 --> Jun 2016 Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Jun 2018 --> Dec 2018
  • ||||||||||  OPT-302 / Opthea
    Enrollment closed, Combination therapy:  A Dose Ranging Study of OPT-302 With Ranibizumab in Neovascular (Wet) AMD (clinicaltrials.gov) -  Nov 28, 2018   
    P2,  N=366, Active, not recruiting, 
    Recruiting --> Active, not recruiting | Trial completion date: Dec 2018 --> Dec 2019 | Trial primary completion date: Jun 2018 --> Dec 2018 Recruiting --> Active, not recruiting
  • ||||||||||  Eylea (aflibercept intravitreal) / Regeneron, Lucentis (ranibizumab) / Roche, Novartis
    Enrollment change, Trial primary completion date:  VITCLEAR: A Pharmacokinetic Study: Ranibizumab, Aflibercept and the Effect of Vitrectomy. (clinicaltrials.gov) -  Nov 9, 2018   
    P=N/A,  N=62, Recruiting, 
    Recruiting --> Completed N=120 --> 62 | Trial primary completion date: Dec 2016 --> Jun 2019
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Trial completion date, Trial primary completion date:  Retrospective Review of Proliferative Diabetic Retinopathy Patients (clinicaltrials.gov) -  Oct 29, 2018   
    P=N/A,  N=100, Active, not recruiting, 
    N=120 --> 62 | Trial primary completion date: Dec 2016 --> Jun 2019 Trial completion date: Sep 2018 --> Dec 2018 | Trial primary completion date: Aug 2018 --> Dec 2018
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Trial completion, Enrollment change:  Serum Vascular Endothelial Growth Factor in Infants With Intravitreal Ranibizumab (clinicaltrials.gov) -  Oct 12, 2018   
    P=N/A,  N=17, Completed, 
    Trial completion date: Dec 2019 --> Dec 2020 | Trial primary completion date: May 2019 --> May 2020 Recruiting --> Completed | N=30 --> 17
  • ||||||||||  JNJ-1887 / J&J
    Enrollment open:  AAVCAGsCD59 for the Treatment of Wet AMD (clinicaltrials.gov) -  Sep 14, 2018   
    P1,  N=10, Recruiting, 
    Active, not recruiting --> Completed Not yet recruiting --> Recruiting
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Trial completion, Enrollment change, Trial completion date, Trial primary completion date:  Acute Pseudophakic Cystoid Macular Edema Treatment Trial: Intravitreal Ranibizumab Versus Triamcinolone Acetonide (clinicaltrials.gov) -  Sep 11, 2018   
    P1,  N=4, Completed, 
    Trial completion date: Aug 2018 --> Apr 2019 | Trial primary completion date: Aug 2018 --> Apr 2019 Recruiting --> Completed | N=20 --> 4 | Trial completion date: Nov 2020 --> Sep 2018 | Trial primary completion date: Nov 2019 --> Sep 2018
  • ||||||||||  Lucentis (ranibizumab) / Roche, Novartis
    Trial completion, Trial completion date, Trial primary completion date:  PROTECT: Prophylactic Ranibizumab for Exudative Age-Related Macular Degeneration (clinicaltrials.gov) -  Aug 28, 2018   
    P1/2,  N=4, Completed, 
    Trial completion date: Mar 2019 --> Jul 2019 | Trial primary completion date: Feb 2019 --> Jun 2019 Active, not recruiting --> Completed | Trial completion date: Jul 2017 --> Jul 2018 | Trial primary completion date: Jul 2017 --> Jul 2018
  • ||||||||||  Axpaxli (intravitreal axitinib implant) / Ocular Therap
    New P1 trial:  CLN-0046: Treatment of AMD Subjects With OTX-TKI (clinicaltrials.gov) -  Aug 13, 2018   
    P1,  N=25, Not yet recruiting,