- |||||||||| Journal: Gut microbiota-driven drug metabolism in inflammatory bowel disease. (Pubmed Central) - Jul 12, 2020
The human intestinal microbiota can have a major impact on drug metabolism and efficacy of medication prescribed in inflammatory bowel disease practice. A better understanding of these interactions between microbiota and drugs is needed and should be an integral part of the drug development pathway of new inflammatory bowel disease medication.
- |||||||||| allopurinol / Generic mfg.
Could CD45 have a role in the development of myeloid malignancies? () - May 14, 2020 - Abstract #BSH2020BSH_118;
The combination of these drugs with Cytarabine has indicated some degree of synergy. In conclusion, CD45 is highly expressed in AML cell lines and the inhibition of the gene, by siRNA or novel repurposed agents targeting CD45, have given an insight into the molecular pathways and potential therapeutic options associated with this gene.
- |||||||||| balsalazide / Generic mfg., Giazo (balsalazide disodium tablet) / Bausch Health
Clinical, Journal: Outcomes of a drug shortage requiring switching in patients with ulcerative colitis. (Pubmed Central) - Apr 23, 2020
In conclusion, CD45 is highly expressed in AML cell lines and the inhibition of the gene, by siRNA or novel repurposed agents targeting CD45, have given an insight into the molecular pathways and potential therapeutic options associated with this gene. This study of a balsalazide shortage in UC patients exemplifies the detrimental impact of a drug shortage on long term patient, disease and commercial outcomes.
- |||||||||| Colazal (balsalazide) / Bausch Health, Giazo (balsalazide disodium tablet) / Bausch Health
Journal: Development of an effective fluorescence probe for discovery of aminopeptidase inhibitors to suppress biofilm formation. (Pubmed Central) - Nov 6, 2019
Through screening of an in-house chemical library, a commercially available drug, balsalazide, has been identified as a novel PaAP inhibitor, which exhibited remarkable anti-biofilm effect. Our study indicated that the newly developed fluorescence probe is applicable in exploring new aminopeptidase inhibitors, and it also warrants further investigation of balsalazide as a new anti-biofilm agent to treat P. aeruginosa infection in combination with known antibiotics.
- |||||||||| Remicade (infliximab) / Mitsubishi Tanabe, J&J, Entyvio (vedolizumab) / Takeda
Management of Severe Ulcerative Colitis in a Patient With Familial Dysautonomia (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_2818;
She had been maintained on balsalazide...Infliximab and cyclosporine were opposed due to infection risk and later exhibiting possible nephrotoxicity...Due to the gut-specificity of vedolizumab, infection risk is considerably reduced compared to that of other biologics and is the most favorable option in the setting of underlying FD. This case highlights the difficulty encountered when treating IBD in the setting of systemic illness and underscores the need to carefully consider management options to enhance patient outcomes.
- |||||||||| Colazal (balsalazide) / Bausch Health, Giazo (balsalazide disodium tablet) / Bausch Health, Azulfidine (sulfasalazine) / Generic Mfg.
A Rare Cause of Dyspnea in a Patient With Inflammatory Bowel Disease (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1918;
Diagnosis of pneumonitis is difficult in the setting of IBD due to extensive pulmonary manifestations in IBD ranging from bronchitis to pulmonary fibrosis even when IBD activity is quiessent.1 These pulmonary complications typically respond well to steroids alone while DIP responds well to removal of the inciting agent.1 Our patient had an extensive work-up that was negative while the combination of the HRCT and BAL made BIP the leading diagnosis, meeting diagnostic criteria.2 The time frame of the patient’s symptoms in relation to starting Balsalazide supported the diagnosis of BIP and strengthened when Balsalazide was discontinued and prednisone started leading to improvement in symptoms. This patient illustrates the need to consider a broad differential when evaluation a patient with IBD with pulmonary complications.
- |||||||||| Colazal (balsalazide) / Bausch Health, budesonide / Generic Mfg., Giazo (balsalazide disodium tablet) / Bausch Health
Coexistence of Lymphocytic Colitis in a Patient With Ulcerative Colitis (Exhibit Halls 3 and 4 (Street Level)) - Aug 8, 2019 - Abstract #ACG2019ACG_1915;
Here we describe a case of active UC further complicated by lymphocytic colitis which was successfully managed with a combination of a 5-aminosalicyclic-acid derivative and glucocorticoids. This case emphasizes the importance of looking for alternative causes of symptoms in patients with mild colonoscopic findings.
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