- |||||||||| Journal, Real-world evidence: Real-world prescription patterns for reproductive assistance patients in China: A trend analysis from 2016 to 2020. (Pubmed Central) - Dec 6, 2022
Different progesterone preparations (47472, 21.08%), chorionic gonadotrophin gondotrophin for injection (38932, 17.29%), dydrogesterone tables (33591, 14.91%), and triptorelin for injection (26959, 11.97%) rounded out the top five...Goserelin, leuprorelin, triptorelin, growth hormone, and didroxyprogesterone are among the top five most expensive medications per capita...In addition, the price of certain medicines is high, which will increase the patients' financial burden. Future research will focus on enhancing the degree of rational drug use among outpatients and realizing the economical, safe, and effective use of pharmaceuticals to lessen the economic burden of patients.
- |||||||||| Yselty (linzagolix) / Kissei, Theramex, Syneos Health
Enrollment open: A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia (clinicaltrials.gov) - Nov 30, 2022 P3, N=264, Recruiting, Future research will focus on enhancing the degree of rational drug use among outpatients and realizing the economical, safe, and effective use of pharmaceuticals to lessen the economic burden of patients. Not yet recruiting --> Recruiting
- |||||||||| goserelin acetate / Generic mfg., leuprolide acetate for depot suspension / Generic mfg., tamoxifen / Generic mfg.
Ovarian function suppression in early & locally advanced breast cancer: an audit of practice (Exhibition Hall) - Nov 23, 2022 - Abstract #EBCC2022EBCC_371; Compliance against national guidance has been demonstrated with regards to patient selection for OFS but further work is advised to improve the monitoring and holistic care of these patients, including liaison with primary care. An updated clinical protocol should provide more consistency in the local approach to patients requiring OFS.
- |||||||||| fentanyl citrate / Generic mfg.
Journal: Case Reports of Transdermal Fentanyl Patch Administration Difficulties in Cancer Patients with Excess Sweating. (Pubmed Central) - Nov 17, 2022 Treatment was administered using bicalutamide and leuprorelin acetate, while a transdermal fentanyl (TDF) was applied for pain relief...For analgesic control, etodolac tablets, carbamazepine tablets, and TDF were administered...When using a TDF, it is necessary to monitor patients for any sweating during treatment, while also considering changes in medication in some cases. This should promote the maintenance and improvement of the quality of life of the affected patients.
- |||||||||| leuprolide acetate for depot suspension / Generic mfg.
Stress and Hyperprolactinemia: Can a Stimulation Test be Used to Evaluate? (Rome, Italy) - Nov 13, 2022 - Abstract #ESPE2022ESPE_1430; Medications used during the stimulation testing and circadian rhythm effects could also be implicated, but will need to be examined further. This study demonstrates that a hormone stimulation test may be a good way to examine the cause of hyperprolactinemia in patients.
- |||||||||| leuprolide acetate for depot suspension / Generic mfg.
Biomarker, Trial completion, Enrollment change: Menopausal Sleep Fragmentation and Body Fat Gain (clinicaltrials.gov) - Nov 10, 2022 P4, N=125, Completed, This study demonstrates that a hormone stimulation test may be a good way to examine the cause of hyperprolactinemia in patients. Active, not recruiting --> Completed | N=58 --> 125
- |||||||||| Orgovyx (relugolix) / Intas, Gedeon Richter, Takeda, ASKA Pharma, Sumitomo Pharma, Pfizer
New P3 trial, Adverse events: REPLACE-CV: Randomized Study to Evaluate MACE in Patients With Prostate Cancer Treated With Relugolix or Leuprolide Acetate (clinicaltrials.gov) - Nov 4, 2022 P3, N=2250, Not yet recruiting,
- |||||||||| leuprolide acetate for depot suspension / Generic mfg.
Trial completion date, Trial primary completion date: Brown Adipose Tissue Activity in Pre- and Postmenopausal Women (clinicaltrials.gov) - Nov 1, 2022 P=N/A, N=72, Recruiting, This fact may support a direct relation with leuprorelin, whose serum levels remain high for months because of its long-acting depot formulation. Trial completion date: Aug 2022 --> Aug 2023 | Trial primary completion date: Aug 2022 --> Aug 2023
- |||||||||| leuprolide acetate for depot suspension / Generic mfg.
Journal: Non-aqueous bonding of leuprorelin to ochratoxin A for peptide-based solid-phase extraction. (Pubmed Central) - Oct 29, 2022 Binding between the surface-bound leuprorelin and mycotoxin was corroborated with DFT calculations, and it was extended to the extraction of OTA from the heavily fatty matrices of coffee, achieving 95% recovery with improved cyclability as compared with immunoaffinity. This work presents the potential of peptide-mycotoxin interactions for durable non-aqueous extraction.
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