leuprolide acetate for depot suspension / Generic mfg. 
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  • ||||||||||  leuprorelin depot / Generic mfg., norethindrone / Generic mfg.
    Clinical, Journal:  A Case of Hemothorax as Manifestation of Thoracic Endometrial Syndrome. (Pubmed Central) -  Dec 22, 2021   
    Patient improved on leuprolide acetate and norethindrone. This case illustrates an important consideration in the differential of a reproductive-age female with new onset shortness of breath and anemia.
  • ||||||||||  leuprorelin depot / Generic mfg., abiraterone acetate / Generic mfg., bicalutamide / Generic mfg.
    Journal:  Patterns of Care and Outcomes for Non-Metastatic Prostate Cancer in the United States: Results of the CancerMPact Survey 2018. (Pubmed Central) -  Dec 21, 2021   
    Only 16.5% of non-metastatic castration-resistant PCa (nmCRPC) patients did not relapse within five years of initial therapy for nmCRPC. While PCa treatment recommendations are rapidly changing due to advances in treatment, we observed great concordance between their most current versions and real-world data treatment patterns reported by US physicians.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Journal:  C-Reactive Protein Is a Poor Marker of Baseline Inflammation in Prostate Cancer and Response to Radiotherapy or Androgen Ablation. (Pubmed Central) -  Dec 21, 2021   
    Labs were performed up to one week prior to androgen ablation via leuprolide injection (pre-AA), up to one week prior to radiotherapy (RT) (pre-RT), within one week of RT completion (post-RT), and three months following RT completion (FU [follow-up])...CRP did not significantly change during any of these periods and was not significantly related to changes in PSA, WBCs, or lymphocytes. Conclusion CRP is not a sensitive marker of the acute inflammatory effects of non-metastatic prostate cancer and treatment response with androgen ablation or radiation therapy.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Clinical, Clinical data, Journal:  Dual Trigger Compared with Human Chorionic Gonadotropin Alone and Effects on Clinical Outcome of Intracytoplasmic Sperm Injection. (Pubmed Central) -  Dec 17, 2021   
    This study compared outcomes of the standard 6000 IU human chorionic gonadotropin (hCG) trigger with a dual trigger comprised of 6000 IU hCG and 1 mg leuprolide acetate for final oocyte maturation in an intracytoplasmic sperm injection (ICSI) cycle...The median number of oocytes (8 vs. 7), metaphase-two oocytes (6 vs. 5.5), blastocysts (1 vs. 1), clinical pregnancy rates (CPR) (28% vs. 22%), ongoing pregnancy rates (OPR) (22% vs. 20%) and pregnancy rate per transfer (53.3% vs 53.8%) were similar between the dual trigger and hCG only groups, respectively. Dual trigger for oocyte maturation stimulation failed to improve the ICSI outcome.
  • ||||||||||  leuprorelin depot / Generic mfg., bicalutamide / Generic mfg.
    Journal:  Decreased testosterone recovery after androgen deprivation therapy for prostate cancer. (Pubmed Central) -  Dec 16, 2021   
    Increasing age and duration of ADT therapy are associated with decreased likelihood to recover normal testosterone levels after cessation of therapy. The use of the ADT agent goserelin was also associated with decreased testosterone recovery for unclear reasons.
  • ||||||||||  leuprorelin depot / Generic mfg., azacitidine / Generic mfg., docetaxel / Generic mfg.
    Clinical, Journal:  Patient Safety and Satisfaction in Home Chemotherapy. (Pubmed Central) -  Nov 29, 2021   
    All patients reported feeling just as safe as in the hospital. Our results contribute to the feasibility and safety of home chemotherapy.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Journal:  Transgender Youth Referred to Clinics for Gender-Affirming Medical Care in Canada. (Pubmed Central) -  Nov 29, 2021   
    Our results contribute to the feasibility and safety of home chemotherapy. Trans youth in Canada attending clinics for hormonal suppression or gender-affirming hormones were generally healthy but with depression, anxiety, and support needs.
  • ||||||||||  Keytruda (pembrolizumab) / Merck (MSD), nelitolimod (SD-101) / TriSalus Life Sci, UT MD Anderson Cancer Center
    Trial completion date, Trial primary completion date, Combination therapy, Metastases:  Pembrolizumab +/- SD-101 in Hormone-Na (clinicaltrials.gov) -  Nov 24, 2021   
    P2,  N=42, Recruiting, 
    Trans youth in Canada attending clinics for hormonal suppression or gender-affirming hormones were generally healthy but with depression, anxiety, and support needs. Trial completion date: Oct 2023 --> Mar 2023 | Trial primary completion date: Oct 2021 --> Mar 2023
  • ||||||||||  goserelin acetate / Generic mfg., leuprolide acetate for depot suspension / Generic mfg.
    New trial, Real-world evidence, Compliance, Real-world:  RWE About QOL and Compliance of Patients With OFS in China (clinicaltrials.gov) -  Nov 15, 2021   
    P=N/A,  N=500, Not yet recruiting, 
  • ||||||||||  leuprorelin depot / Generic mfg., dydrogesterone / Generic mfg.
    Retrospective data, Journal:  Dydrogesterone in the treatment of endometriosis: evidence mapping and meta-analysis. (Pubmed Central) -  Nov 12, 2021   
    Limited evidence suggests that dydrogesterone may have some advantages over gestrinone, GnRH agonists, and other therapeutic interventions in treating endometriosis. However, this conclusion should be interpreted with caution.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Preclinical, Journal:  An in vitro gel-based system for characterizing and predicting the long-term performance of PLGA in situ forming implants. (Pubmed Central) -  Nov 11, 2021   
    Poly(D,L-lactide-co-glycolide) in situ forming implants containing leuprolide acetate as the model peptide and N-methyl-2-pyrrolidone (NMP), dimethyl sulfoxide (DMSO) or triacetin as co-solvent were investigated...A pH drop (from pH 7.4 to 6.7 for the NMP and DMSO implants, to pH 5.5 for the triacetin implants) within the first day was observed, followed by an increase to pH ∼7.4. The gel-based system coupled with UV imaging offered opportunity for detailed evaluation and prediction of the in vitro performance of long-acting injectables, facilitating future development of in situ depot forming delivery systems.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Journal:  Biphasic electrochemical peptide synthesis. (Pubmed Central) -  Nov 10, 2021   
    Given that methods to reduce PhP[double bond, length as m-dash]O to PhP have been reported, PhP[double bond, length as m-dash]O could be a recyclable byproduct unlike byproducts from typical coupling reagents. Moreover, a commercial peptide active pharmaceutical ingredient (API), leuprorelin, was successfully synthesized without the use of traditional coupling reagents.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Preclinical, Journal:  Daily GnRH agonist treatment delays the development of reproductive physiology and behavior in male rats. (Pubmed Central) -  Nov 4, 2021   
    By the last test, the leuprolide-treated subjects showed signs of catching up, however, many continued to be delayed. Estradiol and progesterone mildly feminized male physiology (e.g., decreased testes weight and serum testosterone) and behavior (e.g., increased lordosis), but did not interact with leuprolide treatment.
  • ||||||||||  leuprorelin depot / Generic mfg.
    Journal:  Leuprolide acetate (Fensolvi) for central precocious puberty. (Pubmed Central) -  Oct 28, 2021   
    The changes of ovarian volume and the major axes of the ovary, uterus, cervix can be used as sensitive observation indexes. No abstract available
  • ||||||||||  leuprorelin depot / Generic mfg.
    Journal:  Effects of Estradiol on Immunoglobulin G Glycosylation: Mapping of the Downstream Signaling Mechanism. (Pubmed Central) -  Oct 27, 2021   
    Aiming to investigate the effect of estrogen on IgG glycosylation, we analysed IgG and total serum glycomes in 36 healthy premenopausal women enrolled in a randomized controlled trial of the gonadotropin-releasing hormone analogue (GnRH) leuprolide acetate to lower gonadal steroids to postmenopausal levels and then randomized to transdermal placebo or estradiol (E) patch...To determine whether previously identified IgG GWAS hits RUNX1, RUNX3, SPINK4, and ELL2 are involved in downstream signaling mechanisms, linking E with IgG glycosylation, we used the FreeStyle 293-F transient system expressing IgG antibodies with stably integrated CRISPR/dCas9 expression cassettes for gene up- and downregulation. RUNX3 and SPINK4 upregulation using dCas9-VPR resulted in a decreased IgG galactosylation and, in the case of RUNX3, a concomitant increase in IgG agalactosylation.