leuprolide acetate for depot suspension / Generic mfg. 
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 138 Diseases   94 Trials   94 Trials   2090 News 


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  • ||||||||||  Ovidrel (choriogonadotropin alfa) / EMD Serono, Choriomon (human choriomon gonadotropin (hCG)) / IBSA Institute Biochemical SA
    CAN THE DUAL TRIGGER PROTOCOL IMPACT EMBRYO PLOIDIA? (Anaheim Convention Center - Poster Hall in Expo Hall) -  Aug 21, 2022 - Abstract #ASRM2022ASRM_1125;    
    IMPACT STATEMENT: The results of this study may assist in the selection of patients who may benefit from the dual trigger protocol. In addition, the study will contribute to the development of new studies to better understand the processes of ovulation induction and its effect on embryonic aneuploidies.
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg.
    GONADOTROPIN BOOST ADMINISTRATION WITH OVULATORY TRIGGER IMPROVES IN VITRO FERTILIZATION CYCLE OUTCOMES IN THE SETTING OF ESTRADIOL PLATEAU (Anaheim Convention Center - Poster Hall in Expo Hall) -  Aug 21, 2022 - Abstract #ASRM2022ASRM_848;    
    The role of the FSH surge has been presumed to promote an optimal environment for nuclear and cytoplasmic maturation of the oocyte. An estradiol plateau or decline during ovarian stimulation suggests insufficient gonadotropin levels to stimulate the developing follicles and thus this patient cohort may be the most vulnerable to insufficient FSH levels at the time of hCG-only ovulatory trigger.
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg.
    ANTAGONIST OR PROTAGONIST: ASSESSING STIMULATION PROTOCOLS THROUGH THE LENS OF ARTIFICIAL INTELLIGENCE (Anaheim Convention Center - Poster Hall in Expo Hall) -  Aug 21, 2022 - Abstract #ASRM2022ASRM_255;    
    IMPACT STATEMENT: Given the subjectivity of image evaluation and processing among clinicians and embryologists, this AI system allows for objective review of embryo morphology to assess for oocyte and embryo quality amongst these cycles. Future directions include prospective use of AI algorithms to assess patient outcomes between protocols and regimens, not only focusing on protocol type but also degree of gonadotropin stimulation such as conventional IVF, minimal stimulation IVF, and natural cycle IVF.
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg.
    Journal:  Virtual drug repurposing study for the CGRPR identifies pentagastrin and leuprorelin as putative candidates. (Pubmed Central) -  Aug 17, 2022   
    Moreover, it is found that the crucial interactions for receptor signaling and heterodimerization occurred between CLR and RAMP1 interface are disrupted more with the ligands bound to ectodomain site, rather than the transmembrane domain. These findings of pentagastrin and leuprorelin molecules are recommended to be considered in further de novo drug development and/or experimental studies related to CGRPR signaling blockade and antagonism.
  • ||||||||||  Avastin (bevacizumab) / Roche
    A CASE OF PULMONARY TUMOR THROMBOEMBOLIC MICROANGIOPATHY FROM PROSTATE CARCINOMA (Convention Center 101DE) -  Aug 16, 2022 - Abstract #CHEST2022CHEST_2409;    
    His prostate cancer is being treated with leuprolide and abiraterone... PTTM requires a high clinical suspicion for diagnosis with promising therapies using PDGF and VEGF inhibitors that require further clinical trials.
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg.
    Journal:  Nationwide Industry-Led Community Exercise Program for Men With Locally Advanced, Relapsed, or Metastatic Prostate Cancer on Androgen-Deprivation Therapy. (Pubmed Central) -  Aug 14, 2022   
    PCa patients with locally advanced, relapsed, or metastatic disease receiving leuprorelin acetate were enrolled across multiple sites in Australia and assigned supervised group exercise undertaken weekly or biweekly (ie, 16 exercise sessions in total) for 10-18 weeks, consisting of aerobic and resistance training performed at moderate-to-vigorous intensity...For most of the investigated outcomes, participants with poorer initial measures had the greatest benefit from participating in the program. The community exercise program was feasible and effective in preventing weight gain, reducing blood pressure, and improving physical function in patients with PCa on androgen-deprivation therapy.
  • ||||||||||  Firmagon (degarelix) / Astellas, Ferring
    P4 data, Journal, HEOR, Real-world evidence:  Real-World Evidence Prediction of a Phase IV Oncology Trial: Comparative Degarelix vs Leuprolide Safety. (Pubmed Central) -  Aug 11, 2022   
    This study successfully predicted the result of a comparative cardiovascular safety trial in the oncology setting. Although the findings are encouraging, limitations of measuring cancer stage and tumor progression are representative of challenges in attempting to generalize whether claims-based RWE can be used as actionable evidence.
  • ||||||||||  docetaxel / Generic mfg.
    Trial completion date, Metastases:  Docetaxel, Radiation Therapy, and Hormone Therapy in Treating Patients With Locally Advanced Prostate Cancer (clinicaltrials.gov) -  Aug 11, 2022   
    P1,  N=20, Active, not recruiting, 
    Although the findings are encouraging, limitations of measuring cancer stage and tumor progression are representative of challenges in attempting to generalize whether claims-based RWE can be used as actionable evidence. Trial completion date: Jun 2022 --> Dec 2022
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg., docetaxel / Generic mfg., naproxen / Generic mfg.
    Journal:  Fever as a first presentation of castration-resistant prostate cancer: A case report. (Pubmed Central) -  Aug 6, 2022   
    Differentiating cancer-related fever from infection-related fever is important for appropriate patient management. In this case, fever appeared as the first symptom of castration-resistant prostate cancer and was managed by naproxen and resolved with systemic chemotherapy.
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg., bicalutamide / Generic mfg., docetaxel / Generic mfg.
    Trial completion, Trial completion date, Metastases:  oligo-mets: A Study of Definitive Therapy to Treat Prostate Cancer (clinicaltrials.gov) -  Aug 4, 2022   
    P2,  N=26, Completed, 
    Together with our findings in male rats, these results add to our understanding of the developmental effects of chemically suppressing puberty in rats. Active, not recruiting --> Completed | Trial completion date: Apr 2024 --> Apr 2022
  • ||||||||||  Herceptin (trastuzumab) / Roche, Kisqali (ribociclib) / Novartis, Perjeta (pertuzumab) / Roche
    Trial completion date, Trial primary completion date, Combination therapy, Metastases:  Detect V / CHEVENDO (Chemo vs. Endo) (clinicaltrials.gov) -  Jul 28, 2022   
    P3,  N=270, Recruiting, 
    Trial primary completion date: Jun 2022 --> Dec 2022 Trial completion date: Jun 2023 --> Nov 2024 | Trial primary completion date: Sep 2021 --> Sep 2024
  • ||||||||||  leuprolide acetate for depot suspension / Generic mfg.
    Journal:  Accuracy of various tests alone and in combination to differentiate IHH from CDGP. (Pubmed Central) -  Jul 27, 2022   
    Basal LH, basal inhibin-B, 3 hours post leuprolide LH and 72 hours post hCG testosterone were significantly higher in CDGP than IHH...Differentiating IHH from CDGP is a challenging task due to considerable overlap in their clinical as well as hormonal profiles. Therefore we suggest that a combination of basal LH and basal inhibin-B may be considered as a useful screening tool to differentiate IHH from CDGP rather than the cumbersome and invasive stimulation tests.
  • ||||||||||  Estrace (estradiol) / AbbVie
    Trial completion, Enrollment change:  Neurobiology of Bulimia Nervosa (clinicaltrials.gov) -  Jul 26, 2022   
    P2,  N=10, Completed, 
    Therefore we suggest that a combination of basal LH and basal inhibin-B may be considered as a useful screening tool to differentiate IHH from CDGP rather than the cumbersome and invasive stimulation tests. Recruiting --> Completed | N=15 --> 10