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58 Diseases |  |
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27 Trials |  |
1449 News |  |
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- | oxycodone controlled release / Generic mfg.
How much is spent on pharmaceuticals TOTAL? How much is spent on SSRI's? The numbers are astounding - 100s of B and 10s of B are the approximate answers. Shall we talk about Oxycontin and the like...since you're interested in wasteful/harmful prescription drugs? (Twitter) - Jan 18, 2022
- ||| oxycodone controlled release / Generic mfg.
When used as directed/OxyContin/Chemotherapy & Anesthesia R safe medications 2 achieve the stated goal. All medical interventions have trade-offs. Opting against the intervention is usually the wrong choice. If u have a tumor the risk of surgery outweighs the risk of the tumor. (Twitter) - Jan 14, 2022
- || oxycodone controlled release / Generic mfg.
I know right?! That’s why I waited until the FDA and doctors said OxyContin was totally safe before I started using it (Twitter) - Jan 14, 2022
- | risperidone / Generic mfg., oxycodone controlled release / Generic mfg., ziprasidone / Generic mfg.
Enrollment closed, Trial completion date: Reducing the Abuse of Opioids in Drug Users (clinicaltrials.gov) - Jan 11, 2022
P1, N=25, Active, not recruiting, Sponsor: The University of Texas Health Science Center at San Antonio
Recruiting --> Active, not recruiting | Trial completion date: Mar 2023 --> Aug 2022
- ||| oxycodone controlled release / Generic mfg.
The Sackler Family just go fined for creating d OxyContin, crisis & addictions, they got d FDA that is funded by Pharma to say an opioid isn't addicting. (Twitter) - Jan 9, 2022
- |||| oxycodone controlled release / Generic mfg.
These people gave u d OxyContin, crisis & addictions, they got d FDA that is funded by Pharma to say an opioid isn't addicting. U trust those crooks. The Sackler Family just go fined, Pfizer had some of the biggest fines for lying in Pharma history. u trust these thieves. (Twitter) - Jan 9, 2022
- |||| oxycodone controlled release / Generic mfg.
These people gave u d OxyContin, crisis & addictions, they got d FDA that is funded by Pharma to say an opioid isn't addicting. U trust those crooks. The Sackler Family just go fined, Pfizer had some of the biggest fines for lying in Pharma history. u trust these thieves. (Twitter) - Jan 9, 2022
- |||| oxycodone controlled release / Generic mfg.
Clinical, Adverse events: Not just shift to addiction. They focused on pts falling Asleep midsentence (clearly overprescribed). They focused on pts reporting negative side effects (not felt by all pts). They made it seem like that was the ONLY outcome of OxyContin. It is not, but they don't acknowledge it (Twitter) - Jan 4, 2022
- || oxycodone controlled release / Generic mfg.
PK/PD data, Journal: Effect of Roux-en-Y gastric bypass on the pharmacokinetic-pharmacodynamic relationships of liquid and controlled-release formulations of oxycodone. (Pubmed Central) - Jan 4, 2022
However, baseline pupil diameter was inversely correlated with age (P<0.001) and plasma concentrations of oxycodone at half-maximum effect was 31% lower in males compared to females (P<0.05). Generic substitution of monophasic lipid-based and water-swellable controlled-release oxycodone tablets may be considered safe in RYGB patients.
- ||| fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg.
La heroina mata, pero no tanto como fentanyl y oxycontin. (Twitter) - Jan 2, 2022
- || oxycodone controlled release / Generic mfg.
No veo Oxycontin..... (Twitter) - Jan 2, 2022
- | fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg.
Journal: Opioid Prescribing in United States Health Systems, 2015 to 2019. (Pubmed Central) - Jan 1, 2022
Opioid use and expenditures in health systems have been decreasing following national trends from retail pharmacies. Nevertheless, fentanyl use increased in clinics and was prescribed at higher proportions in nonfederal hospitals than other opioids, which warrants further investigation.
- | oxycodone controlled release / Generic mfg.
How many billion doses of OxyContin did you distribute? (Twitter) - Jan 1, 2022
- ||| oxycodone controlled release / Generic mfg.
Prescription opioid pain medicines such as OxyContin and Vicodin are just that: medicines. It takes a very low class imbecile to compare it to a street drug. You, sir, are the problem. (Twitter) - Dec 31, 2021
- || oxycodone controlled release / Generic mfg.
@JNJNews is a company known 4 killing people. Talcum powder caused ovarian cancer: $550M compensatory & $1.4B punitive damages; luring Tanzanian farmers w/cars, $$, & a competition 2 grow most potent poppy plants used in Oxycontin/@purdueoharma, resulting in 100,00 ODs a year 1/2 (Twitter) - Dec 29, 2021
- ||| oxycodone controlled release / Generic mfg.
Most know too many people dead from Vioxx or OxyContin. Followed our health agencies to type 2 diabetes and chronic illness. Our health agencies have spent 30 years (not 2) destroying and all credibility. This is where we are at (Twitter) - Dec 27, 2021
- ||| oxycodone controlled release / Generic mfg.
FDA event: The FDA also approved oxycontin and it's product label. More recently: https://t.co/3nWkyWw8wN There's genuine risk of regulatory capture by industry and political interests. Must be hard to combat from within. (Twitter) - Dec 24, 2021
- || oxycodone controlled release / Generic mfg.
P1 data, PK/PD data, Journal: Urinary Pharmacokinetics of Immediate and Controlled Release Oxycodone and its Phase I and II Metabolites using LC-MS/MS. (Pubmed Central) - Dec 21, 2021
The metabolite ratios showed a general increase over time. Four metabolite to parent ratios were used to predict the time of intake showing that predictions were best at the early time points.
- morphine sulphate / Generic mfg., oxycodone controlled release / Generic mfg.
Engagement of Beta-Arrestin 2 at the µ-opioid receptor reduces the abuse liability of opioids in mice during operant self-administration (Virtual Only) - Dec 20, 2021 - Abstract #Neuroscience2021Neuroscience_6710;
At the end of 16 weeks, operant self-administration was extinguished and reinstatement was assessed to model OUDs. Our results suggest that βAR2 recruitment influences OUDs and that drugs that recruit βAR2 will have a reduced abuse liability.; Grant Support: R01 DA 019958; R21 A 049565
- || oxycodone controlled release / Generic mfg.
Review, Journal: Oxycodone in the Opioid Epidemic: High 'Liking', 'Wanting', and Abuse Liability. (Pubmed Central) - Dec 16, 2021
The false-claimed non-addictive formulation of oxycodone, OxyContin, further contributed to the opioid crisis...We will discuss various mechanisms that likely contribute to the high abuse rate of oxycodone including clinical drug likability, pharmacokinetics, pharmacodynamics, differences in its actions within mesolimbic reward circuity compared to other opioids, and the possibility of differential molecular and cellular receptor interactions that contribute to its selective effects. We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction.
- || oxycodone controlled release / Generic mfg.
Drug supply was at its safest when OxyContin was being diverted. Not sure what to make of that but it’s true (Twitter) - Dec 16, 2021
- ||| oxycodone controlled release / Generic mfg.
FDA event: Was it a mistake for FDA to approve OxyContin in 1995, @SenatorHassan asks @califf001. Califf: "I think, if we look back, approving OxyContin with no long-term studies and no assessment of the addictive capabilities is something that could have been done differently." (Twitter) - Dec 14, 2021
- || oxycodone controlled release / Generic mfg.
Clinical: Yes, @US_FDA corruption plus #BigPhama greed had been going on for decades. The Vaxxes are the new OxyContin. And ivermectin is Vicodin! And millions dead for profit in both cases. (Twitter) - Dec 12, 2021
- | oxycodone controlled release / Generic mfg.
Journal: Abuse-Deterrent Opioids: A Survey of Physician Beliefs, Behaviors, and Psychology. (Pubmed Central) - Dec 7, 2021
We will also discuss marketing strategies and drug difference that likely contributes to the oxycodone opioid use disorders and addiction. The primary motivator for prescribing ADFs was preventing diversion by family members, not patient-level abuse concerns.
- | oxycodone controlled release / Generic mfg.
Suosittelen kattomaan disney+ palvelusta dopesick sarjan jossei jenkkien opioidikriisi ja oxycontin ole tuttu tapaus. Tämän tapauksen ja monien muiden jälkeen ei voi kyllä yllättyä big pharman suhteen juuri mistään. (Twitter) - Dec 5, 2021
- | fentanyl citrate / Generic mfg., oxycodone controlled release / Generic mfg.
Journal: Is the rise in illicit opioids affecting labor supply and disability claiming rates? (Pubmed Central) - Nov 29, 2021
We observe meaningful reductions in labor supply measured in terms of employment-to-population ratios, hours worked, and earnings in states more exposed to reformulation relative to those less exposed. We also find evidence of increases in disability applications and beneficiaries.
- | oxycodone controlled release / Generic mfg.
Retrospective data, Journal: The effect of perioperative sustained-release opioid use on long-term opioid dispensing following total knee arthroplasty: a retrospective cohort study. (Pubmed Central) - Nov 29, 2021
The postoperative use of SR opioids is not routinely recommended following TKA. Their use is associated with greater overall inpatient opioid use, sustained opioid dispensing during and after the expected recovery period, and the potential for significant harm.
- oxycodone controlled release / Generic mfg.
A Reduced Complexity Cross Between BALB/c Substrains Identifies Zhx2 as a Candidate Gene Underlying Brain Concentration of the Oxycodone Metabolite Oxymorphone and State-Dependent Oxycodone Reward ([VIRTUAL]) - Nov 28, 2021 - Abstract #ACNP2021ACNP_1195;
We hypothesize that decreased Zhx2 expression leads to altered liver expression of one or more key pharmacokinetic enzymes that regulate liver and brain [OMOR] (e.g., CYPs and/or UGTs). Future studies will use CRISPR/Cas9 gene editing to validate the Zhx2 MERV as the quantitative trait variant and determine the quantitative trait mechanism linking the Zhx2 MERV with brain [OMOR] and OXY behaviors.
- oxycodone controlled release / Generic mfg.
A Reduced Complexity Cross Between BALB/c Substrains Identifies Zhx2 as a Candidate Gene Underlying Brain Concentration of the Oxycodone Metabolite Oxymorphone and State-Dependent Oxycodone Reward (Exhibit Hall C) - Nov 28, 2021 - Abstract #ACNP2021ACNP_484;
We hypothesize that decreased Zhx2 expression leads to altered liver expression of one or more key pharmacokinetic enzymes that regulate liver and brain [OMOR] (e.g., CYPs and/or UGTs). Future studies will use CRISPR/Cas9 gene editing to validate the Zhx2 MERV as the quantitative trait variant and determine the quantitative trait mechanism linking the Zhx2 MERV with brain [OMOR] and OXY behaviors.
- ||| oxycodone controlled release / Generic mfg.
Clinical: Big pharma has not been known in the past to necessarily have the interests of patients at heart. Worries that the FDA might not be correct also is of concern. “Dopesick” on Hulu illustrates this, and it is all true concerning OxyContin. (Twitter) - Nov 24, 2021
- ||| Clinical: You mean the physicians who prescribed Vioxx, Oxycontin, Risperdal, Paxil, Depakotem, Zyprexa, Aranesp, Seroquel, racleer, Ventavis, Veletri, Opsumit..please, doctors are no more ethical than the rest of the population....maybe less so. (Twitter) - Nov 21, 2021
- ||| oxycodone controlled release / Generic mfg.
Scholars, researchers, PWUD, and others on the frontlines of this crisis express frustration to me. That so much of the focus remains on Rx opioids like OxyContin. Even in ~2006, the majority of ODs in places like WV resulted from what's called "non-medical use." h/t @adfoxMD (Twitter) - Nov 18, 2021
- | Hysingla ER (hydrocodone bitartrate) / Purdue
Journal: Abuse-Deterrent Opioid Formulations and the Opioid Crisis: A Pharmacist's Perspective. (Pubmed Central) - Nov 17, 2021
However, cost, loopholes in deterrence mechanism, and possible diversion to other substances hinder their role in the opioid crisis. Multiple approaches must be employed to improve opioid safety, and further post-marketing and real-world analyses should be performed on available opioid formulations to assess their impact on abuse-related adverse events.
- || oxycodone controlled release / Generic mfg.
Totally down with @califf001 for #FDA commish! We wouldn’t be viewing #Dopesick right now if #Oxycontin had shown up on his radar. (Twitter) - Nov 12, 2021
- | risperidone / Generic mfg., oxycodone controlled release / Generic mfg., ziprasidone / Generic mfg.
Trial completion date, Trial primary completion date: Reducing the Abuse of Opioids in Drug Users (clinicaltrials.gov) - Oct 25, 2021
P1, N=25, Recruiting, Sponsor: The University of Texas Health Science Center at San Antonio
Multiple approaches must be employed to improve opioid safety, and further post-marketing and real-world analyses should be performed on available opioid formulations to assess their impact on abuse-related adverse events. Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Sep 2021 --> Sep 2022
- || oxycodone controlled release / Generic mfg.
Because there is too much money to be had. I remember when big pharma told MDs to push OxyContin because it “wasn’t addictive.” It’s hard to “trust the science” when many people are bought off. (Twitter) - Oct 18, 2021
- || oxycodone controlled release / Generic mfg.
What a powerful show. Dopesick explains the problems with OxyContin so clearly. (Twitter) - Oct 15, 2021
- | Palexia RP (tapentadol extended release) / Assertio, J&J, Grunenthal, Collegium Pharma
Retrospective data, Journal, HEOR: Quality of life and functional outcomes with tapentadol prolonged release in chronic musculoskeletal pain: post hoc analysis. (Pubmed Central) - Oct 10, 2021
QOL and functionality improvements were consistently greater with tapentadol PR than oxycodone controlled release. Tapentadol PR provides consistent, clinically relevant improvements in QOL and functionality in chronic pain.
- | oxycodone controlled release / Generic mfg.
Journal: Abuse-deterrent extended-release oxycodone and risk of opioid-related harm. (Pubmed Central) - Oct 2, 2021
Tapentadol PR provides consistent, clinically relevant improvements in QOL and functionality in chronic pain. Patients with a new prescription of abuse-deterrent formulation oxycodone may be at increased risk of opioid-related harm.
- | oxycodone controlled release / Generic mfg.
Journal, HEOR: Understanding Government Decisions to De-fund Medical Services Analyzing the Impact of Problem Frames on Resource Allocation Policies. (Pubmed Central) - Sep 29, 2021
The two cases selected were the Ontario government's decisions to de-fund the drug Oxycontin and blood glucose test strips used by patients with diabetes...In the framework, government decision-making is a partial reflection of the visibility of the policy issue and complexity of the causal story told within a problem frame. By applying this framework and considering these two key characteristics of problem frames, we can better understand, and possibly predict, the shape and timing of government policy decisions to withdraw resources from medical services.
- | oxycodone controlled release / Generic mfg.
Journal: THE EVOLVING CONSEQUENCES OF OXYCONTIN REFORMULATION ON DRUG OVERDOSES. (Pubmed Central) - Sep 28, 2021
More exposed areas experienced disproportionate increases in fatal overdoses involving synthetic opioids (fentanyl) and nonopioid substances like cocaine, suggesting that these new epidemics are related to the same factors driving the rise in heroin deaths. Instead of just short-term substitution from prescription opioid to heroin overdoses, the transition to illicit markets spurred by reformulation led to growth in the overall overdose rate to unprecedented levels.
- | OxiFast (oxycodone immediate release) / Purdue, Shionogi, Mundipharma
Enrollment change, Trial withdrawal: Multimodal Analgesia in Shoulder Arthroplasty (clinicaltrials.gov) - Sep 28, 2021
P3, N=0, Withdrawn, Sponsor: Rush University Medical Center
Instead of just short-term substitution from prescription opioid to heroin overdoses, the transition to illicit markets spurred by reformulation led to growth in the overall overdose rate to unprecedented levels. N=18 --> 0 | Terminated --> Withdrawn
- ketamine / Generic mfg.
Postoperative Bilateral Quadratus Lumborum Continuous Block For Lumber Spine Surgery In An Opioid Dependent Patient (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_5019;
Two days later the patient and the surgeon requested the QLB following an exploration of his wound due to a dural leak. Bilateral QLB catheters were placed after surgery with good pain control for 7 days.
- Successful Non-operative Management Of Symptomatic Intradural Catheter Tip Granuloma In A Patient With Intrathecal Drug Delivery System (Exhibit Hall) - Sep 25, 2021 - Abstract #ASA2021ASA_4994;
She was rapidly weaned off of her intrathecal medications within 10 days of her inpatient stay and her pump was filled with normal saline. Her lower extremity numbness completely resolved and pain well controlled with OxyContin 30 mg bid and oxycodone 15 mg tid.
- | Trial completion, Trial completion date: Transversus Abdominis Plane Block in Microsurgical Breast Recon w/Abdominal Free Flap in Breast CA (clinicaltrials.gov) - Sep 23, 2021
P3, N=120, Completed, Sponsor: Stanford University
Her lower extremity numbness completely resolved and pain well controlled with OxyContin 30 mg bid and oxycodone 15 mg tid. Recruiting --> Completed | Trial completion date: Mar 2020 --> Jun 2021
- || oxycodone controlled release / Generic mfg.
You mean the same pharmaceutical companies that got thousands hooked on OxyContin? That’s where you’re putting your trust 😂😂😂 (Twitter) - Sep 17, 2021
- oxycodone/acetaminophen / Generic mfg.
Opioid Prescribing Patterns in an Emergency Department at a Veterans Affairs Hospital () - Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_54;
Literature review suggests our ED opioid prescribing rates may be lower than other healthcare facilities, although there exists continued opportunities to reduce the rate of long-acting and injectable opioid use within the ED. Further conclusions will be made as data regarding trends continues to be analyzed.
- Hysingla ER (hydrocodone bitartrate) / Purdue, Xtampza ER (oxycodone) / Collegium Pharma
Non-Medical Use and Diversion of XTAMPZA ER in the General Population () - Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_52;
XTAMPZA ER was rarely non-medically used independently of these two comparators. While NMU of XTAMPZA ER was less prevalent than comparators, the motivations and behaviors among those who non-medically used were similar.
- Hysingla ER (hydrocodone bitartrate) / Purdue
Diversion and street price of XTAMPZA® ER relative to other prescription opioids () - Sep 15, 2021 - Abstract #PAINWeek2021PAINWeek_27;
One appropriate comparator is IR oxycodone because it contains the same active ingredient in an easy to manipulate form. IR oxycodone had the highest number of cases.