- |||||||||| Prolia (denosumab) / Amgen
Journal: Giant Cell Tumor of Mandible : A Case Report. (Pubmed Central) - Apr 3, 2024 After exclusion of distant metastasis by F-18 FDG PET scan, she underwent en-bloc resection of the tumor with free fibula flap reconstruction. During 6 months of follow up visit patient had no recurrence.
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Journal: Recurrent Giant Cell Tumor of Sphenoid Bone: A Rare Finding. (Pubmed Central) - Apr 3, 2024 Here, we describe a case of recurrent giant cell tumor of sphenoid bone in a young male, who underwent surgical resection twice, after which he was advised adjuvant radiotherapy and denosumab. The patient did not take radiotherapy.
- |||||||||| Prolia (denosumab) / Amgen, Tagrisso (osimertinib) / AstraZeneca
Retrospective data, Journal: Assessing EGFR-mutated NSCLC with bone metastasis: Clinical features and optimal treatment strategy. (Pubmed Central) - Apr 2, 2024 The presence of BoM is a negative prognostic factor for NSCLC patients with an EGFR mutation, possibly due to the presence of extrathoracic metastases. However, adding AAT and denosumab, along with sequential osimertinib, to the treatment regimen for patients with BoM can improve survival outcomes.
- |||||||||| Prolia (denosumab) / Amgen, Evenity (romosozumab-aqqg) / Astellas, Amgen, UCB
Review, Journal: Anti-osteoporotic treatments in the era of non-alcoholic fatty liver disease: friend or foe. (Pubmed Central) - Mar 29, 2024 Since these two chronic diseases frequently co-exist, there are data suggesting that anti-osteoporosis treatments may affect NAFLD progression by impacting on its pathogenetic mechanisms. In the present review, we present on overview of the current understanding of the liver-bone cross talk and summarize the experimental and clinical evidence correlating NAFLD and osteoporosis, focusing on the possible effects of anti-osteoporotic drugs on NAFLD.
- |||||||||| Prolia (denosumab) / Amgen, Kadcyla (ado-trastuzumab emtansine) / Roche
Journal, Metastases: Recurrent severe hypocalcemia following chemotherapy regimen changes in advanced breast cancer: two case reports. (Pubmed Central) - Mar 29, 2024 It is possible that antitumor drugs affect calcium and bone metabolism associated with bone metastases. While these cases are rare, it is crucial for oncologists to be aware of hypocalcemia not only at the initiation of bone-modifying agents but also throughout the entire antitumor therapy, as hypocalcemia can lead to fatal outcomes.
- |||||||||| methotrexate / Generic mfg.
INSUFFICIENCY FRACTURES IN INFLAMMATORY ARTHRITIS PATIENTS (Poster View) - Mar 29, 2024 - Abstract #EULAR2024EULAR_2578; Methotrexate was stopped and she had Pamidronate...He was initially treated with Alendronate, then zoledronate and later teriparatide...She was treated with teriparatide, denosumab and then zoledronate...Stopping Methotrexate is helpful, but some patients may require anabolic and/or anti-resorptive drugs. Figure 1.
- |||||||||| Prolia (denosumab) / Amgen
COMPARATIVE EFFECTIVENESS OF DENOSUMAB VERSUS ZOLEDRONIC ACID AMONG POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS IN THE U.S. MEDICARE PROGRAM (Poster View) - Mar 29, 2024 - Abstract #EULAR2024EULAR_1171; Physicians should consider the evaluation and treatment of secondary osteoporosis in the management of AAV to decrease the risk of osteoporotic fracture, a severe comorbidity. In a cohort of over 125,000 treatment-naive women with PMO, we observed robust, clinically meaningful reductions in the risk of MOP, hip, NV, and NHNV fractures for patients on Dmab compared to ZA, with greater reductions in fracture risk with longer duration of exposure.
- |||||||||| Prolia (denosumab) / Amgen
STUDY OF BONE METABOLISM IN PATIENTS DIAGNOSED WITH OSTEOGENESIS IMPERFECTA (Poster View) - Mar 29, 2024 - Abstract #EULAR2024EULAR_1166; Nearly all have a history of previous fractures and demonstrate bone mineral density (BMD) within the range of osteoporosis. The most commonly used treatments are bisphosphonates, with pamidronate in pediatric cases and zoledronic acid in adults being the predominant choices.
- |||||||||| Prolia (denosumab) / Amgen
COMPARATIVE EFFECTIVENESS OF DENOSUMAB VERSUS BISPHOSPHONATES AMONG TREATMENT-EXPERIENCED POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS IN THE U.S. MEDICARE PROGRAM (Poster Tour 3) - Mar 29, 2024 - Abstract #EULAR2024EULAR_1144; 66 years of age with prior history of treatment with an oral BP, who newly initiated Dmab (n~108,000), a different oral BP (alendronate, ibandronate, or risedronate; n=100,649), alendronate (Aln; n=53,165), or zoledronic acid (ZA; n=35,100) between Jan 1, 2012 to Dec 31, 2018 were followed from treatment initiation (index date) until the first instance of a fracture, treatment discontinuation (defined as the end of exposure + 60-day gap) or switch, Medicare disenrollment, death, end of available data (Dec 31, 2019), or 5 years post-index date. In a large cohort of treatment-experienced women with PMO, we observed robust, clinically meaningful reductions in the risk of hip, NV, NHNV, HV, and MOP fractures for patients on Dmab compared to oral BP, Aln, and ZA; greater reductions in fracture risk were observed with longer duration of exposure.
- |||||||||| Prolia (denosumab) / Amgen, Evenity (romosozumab-aqqg) / Astellas, Amgen, UCB
ROMOSOZUMAB AND DENOSUMAB COMBINATION THERAPY IN POSTMENOPAUSAL OSTEOPOROSIS (Poster Tour 3) - Mar 29, 2024 - Abstract #EULAR2024EULAR_1142; Romosozumab added to ongoing denosumab resulted in an increase in P1nP and lumbar spine BMD, but not in femoral neck BMD. For patients on denosumab, using romosozumab as an additional treatment appeared to be useful in terms of bone formation markers and spine BMD versus denosumab alone.
- |||||||||| Prolia (denosumab) / Amgen
Review, Journal: A narrative review of the pharmaceutical management of osteoporosis. (Pubmed Central) - Mar 26, 2024 Hormonal therapies are used if patients cannot tolerate bisphosphonates or denosumab or are refractory to these medications. Preventative measures for osteoporosis include tailored exercise and sufficient intake of calcium and vitamin D via diet or supplementation.
- |||||||||| CMAB807 (denosumab biosimilar) / 3SBio
Trial completion date, Trial primary completion date: Clinical Efficacy and Safety Comparative Study Between CMAB807 Injection and Prolia (clinicaltrials.gov) - Mar 26, 2024 P3, N=278, Recruiting, Preventative measures for osteoporosis include tailored exercise and sufficient intake of calcium and vitamin D via diet or supplementation. Trial completion date: Nov 2023 --> Nov 2024 | Trial primary completion date: Oct 2023 --> Oct 2024
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Journal: Management of Vertebral Fragility Fracture in Older People: Recommendations from a Spanish Consensus of Experts. (Pubmed Central) - Mar 25, 2024 Participants agreed on the administration of teriparatide for 24 months and then a switch to denosumab or bisphosphonates in patients at high risk of fracture...Although there was multidisciplinary agreement on diagnostic tests and non-pharmacological and pharmacological treatment in frail older people, therapeutic objectives should be individualized for every patient. In addition to the specific recommendations, close collaboration between the geriatrician and the primary care physician is essential for the optimal chronic management of frail patients with fragility fractures.
- |||||||||| cinacalcet HCl / Generic mfg.
Nephrogenic Diabetes Insipidus secondary to Hypercalcemia of Malignancy responsive to Cinacalcet () - Mar 23, 2024 - Abstract #NKFSCM2024NKF_SCM_541; Ionized calcium remained the same despite Zometa, calcitonin, denosumab, and aggressive IVF with NS...Desmopressin was then initiated but did not sufficiently concentrate the urine... This case exhibits the potential use of cinacalcet for the treatment of nephrogenic DI secondary to hypercalcemia of malignancy.
- |||||||||| abiraterone acetate / Generic mfg.
Clinical, Journal, Metastases: Bone-Modifying Agents in Patients With High-Risk Metastatic Castration-Sensitive Prostate Cancer Treated With Abiraterone Acetate. (Pubmed Central) - Mar 19, 2024 The association between the use of bone-modifying agents (BMAs) and the outcomes among patients with metastatic castration-sensitive prostate cancer (mCSPC) treated with abiraterone acetate plus prednisone (AAP) remains unclear...Use of BMAs was defined as the administration of bisphosphonates and denosumab within 90 days before and after randomization...Zoledronic acid was the most frequently administered BMA in both the AAP (93 [70.5%]) and the ADT (88 [67.2%]) cohorts...No evidence was found that the outcomes of BMA varied by AAP or ADT (hazard ratio for time to SRE, 0.99 [95% CI, 0.48-2.08]; P?=?.99 for interaction; hazard ratio for OS, 1.31 [95% CI, 0.88-1.96]; P?=?.18 for interaction). The findings of this cohort study suggest that use of BMAs was associated with a longer time to SRE in patients with high-risk mCSPC treated with ADT, with or without AAP, suggesting that BMA use might provide benefits to this population.
- |||||||||| Prolia (denosumab) / Amgen
Review, Journal: Evidence-Based Guideline for the management of osteoporosis in men. (Pubmed Central) - Mar 15, 2024 This suggests that MRI examination and whole exome sequencing should be considered when MCTO is suspected, and Denosumab might be an option in the treatment of MCTO. The recommendations are based on a comprehensive review of the latest research related to diagnostic and screening approaches for osteoporosis and its
- |||||||||| Prolia (denosumab) / Amgen
Enrollment change, Trial termination: The Efficacy of Denosumab in Incomplete Patients Spinal Cord Injury (clinicaltrials.gov) - Mar 15, 2024 P4, N=5, Terminated, The recommendations are based on a comprehensive review of the latest research related to diagnostic and screening approaches for osteoporosis and its N=32 --> 5 | Recruiting --> Terminated; Study ended early due to COVID-19
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