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- Fumaderm (dimethyl fumarate) / Biogen
[VIRTUAL] q -Space myelin map imaging for longitudinal analysis of remyelination in multiple sclerosis patients treated with dimethyl fumarate, follow-up results (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_2021;
The updated report implies that DMF has the efficacy of remyelination not only in the early phase of DMF treatment. We continue this study to investigate the association between q MM-supported remyelination and disease progression.
- glatiramer acetate / Generic mfg., dimethyl fumarate / Generic mfg.
[VIRTUAL] Evaluating DMT escalation based on isolated MRI activity (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1992;
Methods : From the Vienna Innsbruck MS database (VIMSD), we included RMS patients (18-65 years) with a) newly initiated moderately effective DMT (interferon-beta, glatiramer acetate, dimethyl fumarate, or teriflunomide) continued for 12 months, b) clinical stability (no relapses or disability progression) on DMT for 12 months, c) MRI at baseline (MRI-0) and after 12 months of DMT (MRI-1), and d) available clinical follow-up for ≥3 years... In our real-world cohort of clinically stable patients, DMT escalation based on isolated MRI activity only changed outcome when MRI activity fulfilled at least MAGNIMS criteria (exceeding 3 new/enlarged T2 lesions).
- Kesimpta (ofatumumab subcutaneous) / Novartis, Genmab, Mavenclad (cladribine) / EMD Serono
[VIRTUAL] Cost-effectiveness of ofatumumab in comparison with other disease modifying therapies and best supportive care for the treatment of relapsing-remitting multiple sclerosis in Canada (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1871;
Considering first-line therapies, ofatumumab was dominant (more efficacy, lower costs) over teriflunomide, interferons, dimethyl fumarate, and ocrelizumab, and resulted in incremental cost-utility ratios (ICURs) of $24,177 Canadian dollars per quality-adjusted life-years (QALYs) gained versus glatiramer acetate and $28,034 versus BSC... In Canada, ofatumumab is cost effective against all comparators and dominant compared to all currently approved and reimbursed first-line DMTs for the treatment of patients with RRMS, except glatiramer acetate.
- Fumaderm (dimethyl fumarate) / Biogen
[VIRTUAL] Disease activity and patient-reported outcomes in patients with multiple sclerosis switching from first-line platform therapies to dimethyl fumarate (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1847;
P=N/A
Overall, results suggest that DMF is an effective treatment option for patients with RRMS previously treated with injectable therapies or teriflunomide, regardless of the reasons that led to the switch from the previous first-line treatment. Supported by: Biogen
- Lemtrada (alemtuzumab) / Sanofi
[VIRTUAL] Real-world patient-reported outcomes in RRMS patients transitioning to alemtuzumab: results from the PRO-ACT study (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1834;
Significant improvements in employment and household productivity were seen after switching, which may reflect a reduction in the burden that MS imposes on patients with employment and household responsibilities. Alemtuzumab safety was consistent with the pivotal studies.
- Mavenclad (cladribine) / EMD Serono, Lemtrada (alemtuzumab) / Sanofi
[VIRTUAL] COVID-19 in a neuroimmunology and multiple sclerosis referral unit (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1804;
Los datos de nuestra serie estan en concordancia con otros estudios, mostrando que la esclerosis múltiple per se y los diferentes tratamientos immunomoduladors no son un factor de riesgo para el COVID19. Es importante acelerar la vacunación de los pacientes con esclerosis múltiple para reducir la posibilidad de infección por SARS-CoV-2.
- dimethyl fumarate / Generic mfg.
[VIRTUAL] Impact of cancer immunotherapy on multiple sclerosis course and management (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1797;
These results highlight that MS should not be a contraindication to ICI treatment. However, a concerted care between neurologists and oncologists is a crucial point.
- Mavenclad (cladribine) / EMD Serono
[VIRTUAL] Disease modifying therapy and pregnancy outcomes in multiple sclerosis: a systematic review and meta-analysis (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1742;
Live birth with birth defects in Multiple Sclerosis patients treated with Natalizumab were statistically significant in comparison to Glatiramer Acetate. Whereas Live birth with birth defects in MS patients treated with Fingolimod, Dimethyl Fumarate, Teriflunomide and all Interferons were not significant compare to Glatiramer Acetate.
- Fumaderm (dimethyl fumarate) / Biogen
[VIRTUAL] Pregnancy outcomes following exposure to dimethyl fumarate: interim analysis of a prospective international registry (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1739;
P=N/A
Outcomes are consistent with previous smaller reports and with the general population. Supported by: Biogen
- Actemra IV (tocilizumab) / Roche, JW Pharma, Lemtrada (alemtuzumab) / Sanofi
[VIRTUAL] COVID-19 in patients with multiple sclerosis and neuromyelitis optica spectrum disorder in Colombia (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1711;
No significant differences were observed by sex and treatment type in prognosis and mortality from COVID-19. However, we suggested to carry out robust sample studies to identify the main complicating factors and severity.
- Fumaderm (dimethyl fumarate) / Biogen
[VIRTUAL] CONNECT: an open-label, active-controlled dimethyl fumarate study in pediatric patients with relapsing-remitting multiple sclerosis (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1646;
P3
Adjusted ARR also was lower for DMF vs IFNβ-1a at W96. Overall safety and tolerability in pediatric patients were consistent with the adult population.
- glatiramer acetate / Generic mfg., dimethyl fumarate / Generic mfg.
[VIRTUAL] Is there a multiple sclerosis (MS) personality? Personality characteristics in persons with recently diagnosed MS at a single Canadian centre (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1628;
Extraversion is less prominent. Females are significantly more likely to be Agreeable and Conscientious than males.
- dimethyl fumarate / Generic mfg., teriflunomide / Generic mfg.
[VIRTUAL] Comparative analysis of dimethyl fumarate and teriflunomide in relapsing-remitting multiple sclerosis (Stream 7 Therapy / Global views) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1539;
Objective: To compare the clinical outcomes in patients on DMF and TFL in a real-world setting, where both drugs are licensed as a first-line disease modifying therapy (DMT) for RRMS... Analysis of real-world data showed that in RRMS, DMF treatment was associated with more favorable clinical outcomes compared to TFL.
- Mavenclad (cladribine) / EMD Serono
[VIRTUAL] Disease-modifying therapy effect on COVID-19 vaccine response in multiple sclerosis patients: data from two New York State Multiple Sclerosis Consortium centers (Stream 7 Therapy / Global views) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1535;
MS patients treated with B-cell depleting medications and S1P modulators have significantly lower seroconversion after COVID-19 vaccination when compared to DMT-naïve patients and other DMT groups. Future studies should determine the risk of severe clinical outcomes in vaccinated patients with no evidence of seroconversion.
- Mavenclad (cladribine) / EMD Serono
[VIRTUAL] COVID-19 vaccination and humoral immune response in people with multiple sclerosis (Stream 5 Therapy / Global views) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1507;
Some patients treated with anti-CD20 and fingolimod failed to develop a post-vaccination humoral response. Adverse events were similar to the general population.
- Mavenclad (cladribine) / EMD Serono
[VIRTUAL] Comparing humoral immune response to SARS-CoV2 vaccines in multiple sclerosis and healthy controls: an Austrian multi-center study (Stream 1 Clinical) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1472;
Humoral response to SARS-CoV2 vaccines in MS patients is generally excellent. While reduced by immunosuppressive DMT, most importantly by B-cell depleting CD20mAb, protective humoral response is still expected in the majority of patients.
- dimethyl fumarate / Generic mfg.
[VIRTUAL] A real-world study to assess the economic burden and clinical outcome in patients with relapsing-remitting multiple sclerosis treated with dimethyl fumarate in Greece (ePoster Library) - Sep 23, 2021 - Abstract #ECTRIMS2021ECTRIMS_1452;
While reduced by immunosuppressive DMT, most importantly by B-cell depleting CD20mAb, protective humoral response is still expected in the majority of patients. In real-life settings in Greece, DMF displayed cost-effectiveness and beneficial effects on disease activity and QoL with no new safety signals emerging.
- | Fumaderm (dimethyl fumarate) / Biogen
Journal: A proof-of-concept application of a novel scoring approach for personalized medicine in multiple sclerosis. (Pubmed Central) - Sep 22, 2021
The strongest treatment effect modifiers were the Short Form-36 Physical Component Summary, age, Visual Function Test 2.5%, prior MS treatment and Expanded Disability Status Scale. Our modelling strategy detects and validates an ITR score and opens up avenues for building treatment response calculators that are also applicable in routine clinical practice.
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal: Non invasive in vivo monitoring of dimethyl fumarate treatment in EAE by assessing the glucose metabolism in secondary lymphoid organs. (Pubmed Central) - Sep 22, 2021
[ F]FDG-PET/CT is a high sensitive functional diagnostic imaging modality to monitor tumor but also immune cell activation by determination of the glucose metabolism. Our results show that the anti-inflammatory effects of immunotherapeutics like DMF can be assessed non invasively in vivo during Th1/Th17 cell-mediated encephalomyelitis (EAE) by [ F]FDG-PET/CT imaging of the draining lymph nodes.
- || Mavenclad (cladribine) / EMD Serono, Lemtrada (alemtuzumab) / Sanofi
Clinical, Review, Journal: Risk of invasive fungal infections among patients treated with disease modifying treatments for multiple sclerosis: a comprehensive review. (Pubmed Central) - Sep 22, 2021
Papers evaluating the following drugs were reviewed: rituximab, ocrelizumab, alemtuzumab, fingolimod, natalizumab, dimethyl fumarate, interferon, glatiramer acetate, cladribine, teriflunomide.Expert opinion: Overall, the occurrence of invasive fungal infections was low, with most infective events reported among patients treated with monoclonal antibodies and fingolimod...Although not common, these infections may be difficult to diagnose and their fatality rate is often high. For this reason, screening protocols for fungal infections must be implemented in the clinical practice when managing patients with MS.
- | dimethyl fumarate / Generic mfg.
Journal: Mechanism of action of dimethyl fumarate: a small molecule with big effects. (Pubmed Central) - Sep 22, 2021
For this reason, screening protocols for fungal infections must be implemented in the clinical practice when managing patients with MS. No abstract available
- || Mavenclad (cladribine) / EMD Serono
Review, Journal: Reviewing the Significance of Blood-Brain Barrier Disruption in Multiple Sclerosis Pathology and Treatment. (Pubmed Central) - Sep 22, 2021
Detailed mechanisms of action of these DMTs are described and also illustrated in dedicated images. With increasing knowledge about the involvement of BBB in MS pathology, BBB might become a therapeutic target in MS not only to make it impenetrable against activated immune cells but also to allow molecules that have a neuroprotective effect in reaching the cell target inside the CNS.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal: Tetravalent Influenza Vaccine Is Not Associated With Neuroaxonal Damage in Multiple Sclerosis Patients. (Pubmed Central) - Sep 22, 2021
DMF-treated patients mount an adequate humoral immune response to influenza vaccines. Within the limits of the small cohort investigated, our data suggest that influenza immunization is not associated with clinical or subclinical disease reactivation.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal: The Dimethyl Fumarate Experience: A Handy Drug With Broad Clinical Utility. (Pubmed Central) - Sep 21, 2021
Our findings confirm DMF as a handy drug with broad clinical utility, with greater benefits for naive patients and horizontal switchers. Additionally, an increase in the flow of DMF prescriptions in these two groups of patients was also observed in our cohort.
- | dimethyl fumarate / Generic mfg.
Journal: Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential. (Pubmed Central) - Sep 16, 2021
Treatment of RRMS subjects with dimethyl fumarate (DMF) rescued SLC7A11 induction and fully recovered Treg cell expansion. These results suggest a previously unrecognized mechanism that may account for the progressive loss of Treg cells in autoimmunity and unveil SLC7A11 as major target for the rescue of Treg cell proliferation.
- | dimethyl fumarate / Generic mfg.
Journal: Dimethyl fumarate suppresses granulocyte macrophage colony-stimulating factor-producing Th1 cells in CNS neuroinflammation. (Pubmed Central) - Sep 15, 2021
These findings indicate that DF has a better therapeutic effect on patients with Th1-dominant immunophenotype. However, future longitudinal study to validate this finding in MS is needed.
- | dimethyl fumarate / Generic mfg.
Journal: Dimethyl Fumarate Promotes the Survival of Retinal Ganglion Cells after Optic Nerve Injury, Possibly through the Nrf2/HO-1 Pathway. (Pubmed Central) - Sep 15, 2021
Immunoblotting analysis revealed an increase in the nuclear expression of Nrf2 and marked upregulation of HO-1 after DMF administration. These results suggest that DMF has survival-promoting effects in RGC after ONC, possibly via the Nrf2/HO-1 pathway.
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal: Dimethyl fumarate reduces oxidative stress, inflammation and fat deposition by modulation of Nrf2, SREBP-1c and NF-κB signaling in HFD fed mice. (Pubmed Central) - Sep 15, 2021
DMF reduces the development of NAFLD induced by HFD in mice through the modulation of transcription factors Nrf2, SREBP-1c and NF-κB. Thus, DMF can be considered as an effective candidate in the treatment of human NAFLD.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal: Intestinal Permeability and Circulating CD161+CCR6+CD8+T Cells in Patients With Relapsing-Remitting Multiple Sclerosis Treated With Dimethylfumarate. (Pubmed Central) - Sep 14, 2021
The effects of DMF on gut barrier alterations was variable, without a clear longitudinal pattern, while we found significant relationships between IP changes and drop of MRI activity (p = 0.04) and circulating CD161+CCr6+CD8+ T cells (p = 0.023). The gut barrier is frequently altered in MS, and the CD161+ CCR6+CD8+ T cell-subset shows dynamics which correlate with disease course and therapy.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal: Anti-N-methyl-D-aspartate receptor encephalitis in a patient with multiple sclerosis on dimethyl fumarate: a case report. (Pubmed Central) - Sep 12, 2021
The gut barrier is frequently altered in MS, and the CD161+ CCR6+CD8+ T cell-subset shows dynamics which correlate with disease course and therapy. No abstract available
- | dimethyl fumarate / Generic mfg.
Journal: Dynamics and Inhibition of MLL1 CXXC Domain on DNA Revealed by Single-Molecule Quantification. (Pubmed Central) - Sep 12, 2021
Finally, in a proof of concept we demonstrate the inhibiting effect of dimethyl fumarate on the CXXC-DNA complexes by measuring the dose-response curve of the unfolding time. This demonstrates the potential feasibility of using single-molecule strand separation as a label-free detector in drug discovery and chemical biology.
- ||| Clinical: My friend on O is likely being switched to Tecfidera or Vumerity bc she was hospitalized. For me, I don’t know what I’m to do. I was dx with MS 23 years ago. Been on two interferons, Tysabri, Gilenya, Ocrevus, now Kesimpta to avoid infusion centers during the pandemic. (Twitter) - Sep 11, 2021
- || dimethyl fumarate / Generic mfg.
Clinical, Journal, Lymphopenia: Persisting lymphopenia and dimethyl fumarate: A clinical commentary. (Pubmed Central) - Sep 11, 2021
We discuss several clinical implications. Safe withdrawal of disease modifying therapies in terms of reoccurrence of disease activity and drug related adverse events need further attention as our treatment armamentarium continues to grow.
- ||| dimethyl fumarate / Generic mfg.
Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL https://t.co/XFWYswMULK (Twitter) - Sep 10, 2021
- | dimethyl fumarate / Generic mfg.
Journal, HEOR: Economic impact of the new oral treatments for multiple sclerosis. (Pubmed Central) - Sep 10, 2021
Safe withdrawal of disease modifying therapies in terms of reoccurrence of disease activity and drug related adverse events need further attention as our treatment armamentarium continues to grow. In addition to contributing new therapeutic alternatives, dimethyl fumarate and teriflunomide produced an economic saving in MS treatment at our hospital.
- ||| dimethyl fumarate / Generic mfg.
Clinical: Delay in getting diagnosed, “wait and see” approach then slow to get on low efficacy DMT. Further relapses, now on Tecfidera, EDSS 6, lost my home and my career. I feel I was ignored for years and have paid a heavy price. No one seems to care now. (Twitter) - Sep 9, 2021
- ||| dimethyl fumarate / Generic mfg.
Enrollment open: Effectiveness and Safety of Generic Delayed-Release Dimethyl Fumarate (Sclera® or Marovarex ®, Hikma) in Routine Medical Practice in the Treatment of Relapsing-Remitting Multiple Sclerosis in MENA Region (clinicaltrials.gov) - Sep 9, 2021
P=N/A, N=155, Recruiting, Sponsor: Hikma Pharmaceuticals LLC
In addition to contributing new therapeutic alternatives, dimethyl fumarate and teriflunomide produced an economic saving in MS treatment at our hospital. Not yet recruiting --> Recruiting
- | dimethyl fumarate / Generic mfg.
Journal: The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury. (Pubmed Central) - Sep 7, 2021
It was found that dimethyl fumarate significantly decreased hepatic and renal injury in cholestatic animals (P < 0.05). Based on these data, the activation of the cellular antioxidant response could serve as an efficient therapeutic option for managing cholestasis-induced organ injury.
- ||||| dimethyl fumarate / Generic mfg., Mayzent (siponimod) / Novartis
Clinical: In this #MS_Selfie_Case_Study for subscribers, the patient is NEDA-2 (no relapses or MRI activity) but is getting worse on DMF (Tecfidera). She has smouldering MS. Do I label her as having SPMS and switch her to siponimod (Mayzent), or not? Have your say? https://t.co/0GHYmqe3mF (Twitter) - Sep 6, 2021
- | dimethyl fumarate / Generic mfg.
Journal: PDSS2-Del2, a new variant of PDSS2, promotes tumor cell metastasis and angiogenesis in hepatocellular carcinoma via activating NF-κB. (Pubmed Central) - Sep 5, 2021
Considering that DMF is a prescribed oral therapy for multiple sclerosis, it might be a potential treatment for metastasis of patients with HCC. Early clinical trials are needed to validate its potential in this context.
- || Targretin oral (bexarotene oral) / ReXceptor
Clinical, P2a data, Journal: Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study. (Pubmed Central) - Sep 4, 2021
We do not recommend the use of bexarotene to treat patients with multiple sclerosis because of its poor tolerability and negative primary efficacy outcome. However, statistically significant effects were seen in some exploratory MRI and electrophysiological analyses, suggesting that other retinoid X receptor agonists might have small biological effects that could be investigated in further studies.
- ||||| Ocrevus (ocrelizumab) / Roche, Biogen
Clinical: Do you know how to time the switch from ocrelizumab to dimethyl fumarate to maximise the chances of an antibody response to the COVID-19 booster vaccine? A highly topical #MS_Selfie_Newsletter case study. #ClinicSpeak https://t.co/WSElvbKhdu (Twitter) - Sep 3, 2021
- | dimethyl fumarate / Generic mfg.
Journal: Characterization of More Selective Central Nervous System Nrf2-Activating Novel Vinyl Sulfoximine Compounds Compared to Dimethyl Fumarate. (Pubmed Central) - Sep 3, 2021
While both CH-3 and DMF activated Nrf2, CH-3 showed less off-target effects and displayed more selective OL associated effects. Further studies with Nrf2-acting compounds are promising candidates to explore potential myelin protective or regenerative effects in demyelinating disorders.
- | Vumerity (diroximel fumarate) / Biogen
Journal: Diroximel fumarate in the treatment of multiple sclerosis. (Pubmed Central) - Sep 3, 2021
DRF seems a promising alternative to DMF and other first-line therapies for multiple sclerosis. The current review is based on the two existing Phase III trials of DRF: the interim analysis of the EVOLVE-MS-1 trial and the completed EVOLVE-MS-2 trial.
- ||||| Ocrevus (ocrelizumab) / Roche, Biogen
Clinical: #MS_Selfie_Newsletter case study: ocrelizumab to dimethyl fumarate switch. Will the adoption of an induction-maintenance treatment paradigm be the legacy that COVID-19 leaves behind in the MS treatment landscape? I suspect so. #ClinicSpeak https://t.co/vjtskNIVlU (Twitter) - Sep 3, 2021
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal: Immunomodulation by dimethyl fumarate treatment improves mouse sciatic nerve regeneration. (Pubmed Central) - Sep 2, 2021
Better motor recovery was observed in the DMF-treated group, as verified by an automated walking track test. Overall, our data reinforce the pro-regenerative capacity of DMF after traumatic nerve injury based on downmodulation of the proinflammatory immune response.
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal, IO biomarker: Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse. (Pubmed Central) - Aug 31, 2021
Overall, our data reinforce the pro-regenerative capacity of DMF after traumatic nerve injury based on downmodulation of the proinflammatory immune response. In conclusion, DMF prevents antibody-mediated platelet destruction in ITP mice possibly through promoting apoptosis, indicating that it might be used as a new approach for the treatment of ITP.
- || glatiramer acetate / Generic mfg., dimethyl fumarate / Generic mfg., fingolimod / Generic mfg.
Clinical, Journal, PD(L)-1 Biomarker, IO biomarker: Regulation of CTLA-4 and PD-L1 Expression in Relapsing-Remitting Multiple Sclerosis Patients after Treatment with Fingolimod, IFNβ-1α, Glatiramer Acetate, and Dimethyl Fumarate Drugs. (Pubmed Central) - Aug 28, 2021
Additionally, this study outlines how CTLA-4 and PD-L1 expression was altered in the PBMC samples of relapsing-remitting multiple sclerosis (RRMS) patients compared to the healthy group. Finally, it investigates the impact of various MS-related treatments in the CTLA-4 and PD-L1 expression to restrain autoreactive T cells and stop the development of MS autoimmunity.
- | dimethyl fumarate / Generic mfg.
Journal: Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. (Pubmed Central) - Aug 28, 2021
However, compared with the model group, the expression levels were markedly downregulated in the DMF, succinic acid and DMF + succinic acid groups. In conclusion, fumaric acid and succinic acid may treat gestational hypertension by downregulating the expression of KCNMB1 and TET1.
- ||| dimethyl fumarate / Generic mfg.
Trial completion, Real-world evidence, Lymphopenia, Real-world: Lympho-TEC: Real World Analysis on Lymphocyte Reconstitution After Lymphopenia in Participants Treated by Tecfidera (clinicaltrials.gov) - Aug 23, 2021
P=N/A, N=1575, Completed, Sponsor: Biogen
In conclusion, fumaric acid and succinic acid may treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Recruiting --> Completed