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- | dimethyl fumarate / Generic mfg.
Journal: Activation of Nrf2 Pathway by Dimethyl Fumarate Attenuates Renal Ischemia-Reperfusion Injury. (Pubmed Central) - Nov 29, 2021
DMF attenuates renal IRI by reducing inflammation and upregulating the antioxidant capacity, which may be through Nrf2/HO-1and NQO1 signaling pathway.
- | dimethyl fumarate / Generic mfg.
Journal: 4-Octyl-Itaconate and Dimethyl Fumarate Inhibit COX2 Expression and Prostaglandin Production in Macrophages. (Pubmed Central) - Nov 29, 2021
We also demonstrate that the decrease in COX2 expression and inhibition of downstream PG production occurs in an NRF2-independent manner. Our findings provide a new insight into the potential of 4-OI as an anti-inflammatory agent and also identifies a novel anti-inflammatory function of dimethyl fumarate.
- || dimethyl fumarate / Generic mfg., fingolimod / Generic mfg.
Clinical, Journal: Assessment of fingolimod versus dimethyl fumarate for the treatment of multiple sclerosis; a 24-month follow-up study. (Pubmed Central) - Nov 29, 2021
According to our findings, within 24-month follow-up, DMF was neither superior nor inferior to FTY comparing MRI lesions, EDSS scores, and adverse effects. Although, further evaluations with larger sample size are recommended.
- ||| dimethyl fumarate / Generic mfg.
I was successfully managing my MS with exercise and diet, and no DMT’s for 9 years. Then last Oct, I stopped exercising, pigged out at Christmas and let it all go. Then relapsed in May for first time in all that time with my first spinal lesion. Back on the regime, and Tecfidera (Twitter) - Nov 23, 2021
- | dimethyl fumarate / Generic mfg.
Journal, IO biomarker: Switch off inflammation in spleen cells with CD40-targeted PLGA nanoparticles containing dimethyl fumarate. (Pubmed Central) - Nov 21, 2021
The decrease in expression was markedly higher in the antibody-targeted nanoparticles group relative to other treatment groups. Our results in this area are promising and provide a good basis for further future studies in this regard.
- | dimethyl fumarate / Generic mfg.
Journal, IO biomarker: Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2/HO-1 Pathway in Intervertebral Disc Degeneration. (Pubmed Central) - Nov 21, 2021
However, Nrf2 knockdown abolished these protective effects of DMF. Our data suggested that treatment with DMF mitigated LPS-induced oxidative stress, inflammation, and ER stress-associated apoptosis in NPCs via the Nrf2/HO-1 signaling pathway, thus reliving LPS-induced dysfunction of NPCs, which offered a novel potential pharmacological treatment strategy for IVDD.
- Tysabri (natalizumab) / Biogen, Ocrevus (ocrelizumab) / Roche, Biogen
[VIRTUAL] Temporal Trends in Humoral and Cellular Immune Responses to Sars-Cov-2 mRNA Vaccines Among Multiple Sclerosis Patients Treated with Natalizumab, Ocrelizumab or Fumarates () - Nov 20, 2021 - Abstract #CMSC2021CMSC_693;
T-cell responses were comparable among all three treatment cohorts. Antibody titers decreased by 44-72% two months after the second vaccine dose.
- Fumaderm (dimethyl fumarate) / Biogen, Ocrevus (ocrelizumab) / Roche, Biogen
[VIRTUAL] Dimethyl Fumarate Is Associated with Lower Rates of Infection and Lower Infection-Related Healthcare Costs When Compared with Ocrelizumab () - Nov 20, 2021 - Abstract #CMSC2021CMSC_681;
DMF-treated patients matched with OCR patients experienced lower annualized rates of infection encounters and lower infection-related healthcare costs. Study Support: Biogen
- glatiramer acetate / Generic mfg., dimethyl fumarate / Generic mfg.
[VIRTUAL] Bad Lettuce? Frozen Vegetables? Undercooked Steak? Case Report of Systemic Listeria Monocytogenes Infection in a Patient on Dimethyl Fumarate () - Nov 20, 2021 - Abstract #CMSC2021CMSC_678;
Common side effects of dimethyl fumarate are well described, but ongoing vigilance is required to identify less common, potentially life-threating side effects. Systemic symptoms of unknown origin in a patient on dimethyl fumarate need to be extensively worked up, including obtaining blood cultures and spinal fluid analyses to rule out rare opportunistic infections.
- | Bafiertam (monomethyl fumarate) / Thermo Fisher Scientific
Enrollment change, Trial withdrawal: PERSIST: Observational Study in Patients With Relapsing-Remitting Multiple Sclerosis Switched to Bafiertam® From Dimethyl Fumarate (clinicaltrials.gov) - Nov 18, 2021
P=N/A, N=0, Withdrawn, Sponsor: Banner Life Sciences LLC
Systemic symptoms of unknown origin in a patient on dimethyl fumarate need to be extensively worked up, including obtaining blood cultures and spinal fluid analyses to rule out rare opportunistic infections. N=50 --> 0 | Not yet recruiting --> Withdrawn
- | dimethyl fumarate / Generic mfg.
Journal: Dimethyl fumarate prevents acute lung injury related cognitive impairment potentially via reducing inflammation. (Pubmed Central) - Nov 17, 2021
In conclusion, DME had the ability to alleviate the lung injury and cerebral cognitive impairment in ALI model mice. This protective effect partly associated with the suppression of inflammation by DMF.
- | dimethyl fumarate / Generic mfg.
Journal: Selective Ammonolysis of Bioderived Esters for Biobased Amide Synthesis. (Pubmed Central) - Nov 17, 2021
To improve the selectivity to unsaturated amides rather than byproducts, the effects of thermal conditions and additives in dimethyl fumarate ammonolysis were examined. Lower temperature and decreasing methoxide ion concentration in the solution relative to the base case conditions increased the fumaramide selectivity from 67.1 to 90.6%.
- || dimethyl fumarate / Generic mfg., Arzerra (ofatumumab) / Novartis, Genmab, Ocrevus (ocrelizumab) / Roche, Biogen
How does ocrelizumab compare to ofatumumab? I am belong taken off tecfidera because of a new lesion and the latter has been recommended. Was keen to know your thoughts. (Twitter) - Nov 10, 2021
- || dimethyl fumarate / Generic mfg., Ocrevus (ocrelizumab) / Roche, Biogen
Switched from Tecfidera to Ocrevus in 2018. Completely stable since then. No disease activity, no MRI activity. All fine for me! (Twitter) - Nov 10, 2021
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal: Dimethyl fumarate attenuates 2-VO-induced vascular dementia via activating the Nrf2 signaling pathway in rats. (Pubmed Central) - Nov 7, 2021
Lower temperature and decreasing methoxide ion concentration in the solution relative to the base case conditions increased the fumaramide selectivity from 67.1 to 90.6%. Taken together, the results demonstrate that DMF could serve as a promising neuroprotective agent for treating vascular dementia.
- | Lemtrada (alemtuzumab) / Sanofi
Journal: Interferon-β Is Less Effective Than Other Drugs in Controlling the Rate of Retinal Ganglion Cell Loss in MS. (Pubmed Central) - Nov 4, 2021
Progressive loss of RGCs in patients with MS is more pronounced in patients treated with interferon-β than other DMTs. This finding may have implications for DMT selection in MS.
- | dimethyl fumarate / Generic mfg.
Journal: Pivotal Trials in Multiple Sclerosis: Similarities Prove Not to Be Useful. (Pubmed Central) - Nov 2, 2021
The objective is to stimulate a discussion about the need to improve research strategies. The discovery of new drugs studied without personalized criteria does not allow for useful advances in knowledge.
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal: Neuroprotection by dimethyl fumarate following ventral root crush in C57BL/6 J mice. (Pubmed Central) - Oct 31, 2021
The results indicated that treatment with DMF, at a dose of 90 mg/kg, promoted neuroprotection and immunomodulation towards an anti-inflammatory response. It also resulted in greater preservation of inhibitory synapses and reduced astroglial reactivity, providing a more favorable environment for sensorimotor recovery.
- | dimethyl fumarate / Generic mfg.
Journal: Fluorescent thermal shift-based method for detection of NF-κB binding to double-stranded DNA. (Pubmed Central) - Oct 31, 2021
In addition, the assay can be used to analyse the direct binding of inhibitors and their effects on structural stability of the protein probe. This may facilitate the identification and rational design of new drug candidates interfering with NF-κB functions.
- | Fumaderm (dimethyl fumarate) / Biogen
Journal: Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses. (Pubmed Central) - Oct 30, 2021
Fumaric acid esters exhibit different biodistribution and may elicit different biological responses; furthermore, pharmacodynamic effects of combinations differ unpredictably from monotherapy. The strong potential to induce lymphopenia in patients with MS may be a result of activation of apoptosis pathways by MEF compared with DMF.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal: Do dimethyl fumarate and nicotinic acid elicit common, potentially HCA -mediated adverse reactions? A combined epidemiological-experimental approach. (Pubmed Central) - Oct 29, 2021
The gastrointestinal ADRs common to both substances may be mediated by HCA . Other ADRs not common to both substances are compound or indication-specific reactions and likely do not involve HCA .
- | dimethyl fumarate / Generic mfg.
Journal, IO biomarker: Dimethyl Fumarate Exerts Neuroprotection by Modulating Calcineurin/NFAT1 and NFκB Dependent BACE1 Activity in a Neuronal Model of Alzheimer's Disease. (Pubmed Central) - Oct 28, 2021
DMF does not alter either beta amyloid precursor protein (βAPP) or its mRNA levels in SH-SY5Y cells, confirming that it does not possess amyloidogenic effect. Inhibiting molecular events related to Aβ-induced calcineurin activity by DMF, may be an approach towards finding suitable treatment for Alzheimer's disease.
- | dimethyl fumarate / Generic mfg.
Journal: Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia-reperfusion injury. (Pubmed Central) - Oct 27, 2021
These results suggest that DMF treatment might prevent the formation of PUs induced by cutaneous I/R injury via suppressing oxidative stress and subsequent inflammation. DMF treatment during the early phase of decubitus ulcers might protect against the further progression.
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal: Development and validation of a stability-indicating RP-HPLC method for the identification, determination of related substances and assay of dimethyl fumarate in drug substance. (Pubmed Central) - Oct 27, 2021
Based on literature survey it was evident that many methods were published for determination of DMF individually or its related substances, however short run time methods were not available for simultaneous estimation of DMF and its related substances. The intended method would support to industries for quick quantitation of DMF and its related substances without compromising quality parameters like precision and accuracy.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal: Safety and persistence of dimethyl fumarate as a treatment for relapsing-remitting multiple-sclerosis. (Pubmed Central) - Oct 27, 2021
The persistence of the medication was similar to that found in pivotal trials. The significant association found between a decreased lymphocyte count over the first 6 months of treatment and the development of severe lymphopenia by the end of the study suggests a connection between both variables, which could be instrumental in being able to predict and even prevent the occurrence of such lymphopenias.
- || Fumaderm (dimethyl fumarate) / Biogen
Clinical, Journal, Heterogeneity: A two-stage prediction model for heterogeneous effects of treatments. (Pubmed Central) - Oct 27, 2021
We apply the approach to a network meta-analysis of three randomized clinical trials comparing the relapses in Natalizumab, Glatiramer Acetate, and Dimethyl Fumarate, including 3590 patients diagnosed with relapsing-remitting multiple sclerosis...For high-risk patients, the treatment that minimizes the risk of relapse in 2 years is Natalizumab, whereas Dimethyl Fumarate might be a better option for low-risk patients. Our approach can be easily extended to all outcomes of interest and has the potential to inform a personalized treatment approach.
- | dimethyl fumarate / Generic mfg.
Journal: Interventions to Increase Leukocyte Testing during Treatment with Dimethyl Fumarate. (Pubmed Central) - Oct 27, 2021
The WBC monitoring rate increased by 3.8% for each additional intervention used (95% CI 1.2-6.4%, p = 0.005). Interventions focused on the physician, including academic detailing, were associated with improved WBC monitoring for patients at risk for leukopenia from DMF treatment.
- | dimethyl fumarate / Generic mfg.
Journal: Wdr1 and cofilin are necessary mediators of immune-cell-specific apoptosis triggered by Tecfidera. (Pubmed Central) - Oct 25, 2021
On-target Keap1-ligand-engagement is accompanied by dissociation of Wdr1 from Keap1 and subsequent coordination with cofilin, intercepting Bax. This phagocytic-specific cell-killing program is recapitulated by whole-animal administration of dimethyl fumarate, where individual depletions of the players identified above robustly suppress apoptosis.
- ||| dimethyl fumarate / Generic mfg., teriflunomide / Generic mfg.
دراسة تحليلية تقارن مخرجات علاج مرضى #التصلب_اللويحي بعلاج Dimethyl Fumarate و Teriflunomide (الأول لدينا ماركة تيكفيديرا و الثاني أوباجيو). وجدت الدراسة أن الأول فعال أكثر في التحكم بالمرض (Twitter) - Oct 24, 2021
- ||| dimethyl fumarate / Generic mfg.
Adverse events: At first I thought maybe it was a Tecfidera side effect but I left over 4 hours between doses and I haven't had any side effects since about Week 3, and none involving cramping. (Twitter) - Oct 22, 2021
- | Tysabri (natalizumab) / Biogen, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Journal: Rituximab versus natalizumab, fingolimod, and dimethyl fumarate in multiple sclerosis treatment. (Pubmed Central) - Oct 22, 2021
Although RTX demonstrated similar effectiveness and discontinuation compared to NTZ, RTX had superior effectiveness during months 6-24 and fewer discontinuations when excluding discontinuations due to insurance issues. Results suggest superiority of RTX in reducing disease activity and maintaining long-term treatment in a real-world MS cohort.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal, Real-world evidence: Three-Year Effectiveness of Dimethyl Fumarate in Multiple Sclerosis: A Prospective Multicenter Real-World Study. (Pubmed Central) - Oct 22, 2021
Results suggest superiority of RTX in reducing disease activity and maintaining long-term treatment in a real-world MS cohort. Our findings confirm the sustained effectiveness of DMF on the clinical and radiological activity of multiple sclerosis in a real-world setting, both in naïve patients and in those switching from other multiple sclerosis therapies.
- | Mavenclad (cladribine) / EMD Serono
Observational data, Journal: Therapeutic inertia in relapsing-remitting multiple sclerosis. (Pubmed Central) - Oct 22, 2021
TI is a topic rarely addressed in MS and this work highlights the importance of therapeutic optimization in these patients. Further studies should be held to explore the factors that influence TI once they have a great impact on therapeutic decisions.
- | glatiramer acetate / Generic mfg., dimethyl fumarate / Generic mfg.
Retrospective data, Journal: Radiologically isolated syndrome: A single-center, retrospective cohort study. (Pubmed Central) - Oct 22, 2021
We characterize a new cohort of RIS patients, demonstrating time to clinically evident demyelinating disease from RIS diagnosis of approximately 3.4 years. Our data suggest that early use of a DMT in RIS may mitigate the impact of recognized risk factors on the occurrence of clinically evident disease and reduce the likelihood of conversion to clinically definite CNS demyelinating disease in high-risk individuals.
- | dimethyl fumarate / Generic mfg.
Journal: Survey of diagnostic and treatment practices for multiple sclerosis in Russian Federation in comparison to European data. (Pubmed Central) - Oct 22, 2021
The products without indication to be used in SPMS are rarely prescribed in RF in comparison to EU. Most cases of PPMS in RF would be treated with ocrelizumab.
- || dimethyl fumarate / Generic mfg.
Review, Journal: The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections. (Pubmed Central) - Oct 22, 2021
The TCA cycle is at the core of viral infection and replication as well as viral pathogenesis and anti-viral immunity. This review highlights the role of the TCA cycle in viral infections and explores recent advances in the fast-moving field of virometabolism.
- dimethyl fumarate / Generic mfg.
[VIRTUAL] NOVEL FUMARATE SMALL MOLECULE PROTECTS MICE FROM ALCOHOLIC LIVER INJURY () - Oct 21, 2021 - Abstract #AASLD2021AASLD_605;
Novel small molecule NMF significantly ameliorates alcoholic liver injury in mice and is superior to DMF. 2.
- dimethyl fumarate / Generic mfg.
[VIRTUAL] Isolated Cranial Nerve Palsies in Multiple Sclerosis () - Oct 21, 2021 - Abstract #ANA2021ANA_477;
Isolated cranial nerve palsies are rare presentations of MS and even rarer symptoms of relapse as compared to new onset internulcear ophthalmoplegia and optic neuritis which are more common ophthalmic presen tations of MS. Zadro et al.
- dimethyl fumarate / Generic mfg.
[VIRTUAL] Response to COVID-19 mRNA Vaccination in Patients with Multiple Sclerosis on anti-CD20 Disease Modifying Therapies () - Oct 21, 2021 - Abstract #ANA2021ANA_364;
Patients with MS on anti-CD20 DMT are less likely to develop antibodies to SARS-CoV-2 RBD and had lower titers after mRNA vaccination. This highlights the importance of better understanding vaccine responsiveness with larger studies and developing better strategies for effec tive vaccination in MS patients on B-cell depleting therapies
- || dimethyl fumarate / Generic mfg.
Clinical, P2 data, Journal: Dimethyl fumarate (DMF) therapy in CTCL: results from a clinical phase II study. (Pubmed Central) - Oct 20, 2021
This highlights the importance of better understanding vaccine responsiveness with larger studies and developing better strategies for effec tive vaccination in MS patients on B-cell depleting therapies No abstract available
- | dimethyl fumarate / Generic mfg.
Journal: Low serum neurofilament light chain values identify optimal responders to dimethyl fumarate in multiple sclerosis treatment. (Pubmed Central) - Oct 20, 2021
Consequently, low baseline sNfL values (≤ 12 pg/ml) increased the probability of NEDA (OR 5.8; CI 1.82-15.6; p = 0.002, after correcting by disease activity in the previous year), and associated with significant reductions of central memory CD4+ T lymphocytes, interferon-gamma+ CD8+ T lymphocytes, Natural Killer T cells, and memory B cells upon DMF treatment, being the highest differences in memory B cells (p < 0.0001). This shows that low baseline sNfL values identify MS patients with higher probability of optimal response to DMF and of a reduction in effector immune cells.
- || dimethyl fumarate / Generic mfg.
Clinical, Journal, Lymphopenia: CMV meningitis associated with dimethyl fumarate therapy-induced lymphopenia in a multiple sclerosis patient. (Pubmed Central) - Oct 16, 2021
This shows that low baseline sNfL values identify MS patients with higher probability of optimal response to DMF and of a reduction in effector immune cells. No abstract available
- | dimethyl fumarate / Generic mfg.
Journal: Expanding the MECP2 network using comparative genomics reveals potential therapeutic targets for Rett syndrome. (Pubmed Central) - Oct 14, 2021
The drugs targeting these three proteins (Pacritinib, DMF, and EPO) were able to rescue different phenotypes of MECP2 inactivation in cultured human neural cell types, and appeared to converge on Nuclear Factor Kappa B (NF-κB) signaling in inflammation. This study highlights the potential of comparative genomics to accelerate drug discovery, and yields potential new avenues for the treatment of RTT.
- | Rituxan (rituximab) / Roche
Trial completion: RIFUND-MS: RItuximab Versus FUmarate in Newly Diagnosed Multiple Sclerosis. (clinicaltrials.gov) - Oct 12, 2021
P3, N=200, Completed, Sponsor: Anders Svenningsson
This study highlights the potential of comparative genomics to accelerate drug discovery, and yields potential new avenues for the treatment of RTT. Active, not recruiting --> Completed
- | dimethyl fumarate / Generic mfg.
Journal: Differential effects of dimethylfumarate and monomethylfumarate on neutrophil granulocyte and peripheral blood mononuclear cell apoptosis. (Pubmed Central) - Oct 10, 2021
Active, not recruiting --> Completed No abstract available
- Vumerity (diroximel fumarate) / Biogen, Fumaderm (dimethyl fumarate) / Biogen
[VIRTUAL] Treatment Persistence, Safety, Tolerability, and Effectiveness of Diroximel Fumarate in the Real-World: Design of the Phase 4 ExperienceUS Study () - Oct 8, 2021 - Abstract #CMSC2021CMSC_664;
The DRF EXPERIENCEUS Phase 4 study will characterize treatment persistence, safety, and clinical effectiveness of DRF in routine clinical practice. Study Support: Biogen
- Ocrevus (ocrelizumab) / Roche, Biogen
[VIRTUAL] Safety of Ocrelizumab in Patients with Relapsing-Remitting Multiple Sclerosis with Suboptimal Response to Prior Disease-Modifying Therapies: Data from the CASTING Study () - Oct 8, 2021 - Abstract #CMSC2021CMSC_643;
P3
The safety profile was comparable between subgroups, including age and number/type of prior DMTs. No new safety signals were identified.
- Fumaderm (dimethyl fumarate) / Biogen
[VIRTUAL] Real-World Safety and Effectiveness of Delayed-Release Dimethyl Fumarate in Relapsing Multiple Sclerosis Patients: Interim Results from Esteem () - Oct 8, 2021 - Abstract #CMSC2021CMSC_629;
P=N/A
Results from the 5-year analysis reveal no new safety concerns emerging from the use of DMF in MS patients treated with DMF in the real-world setting. ARR at 5 years was significantly reduced vs. the year prior to DMF initiation.
- Fumaderm (dimethyl fumarate) / Biogen
[VIRTUAL] Opportunities and Pitfalls in the Assessment of Brain Atrophy in Dimethyl Fumarate-Treated Relapsing Multiple Sclerosis Patients Using Real-World Data () - Oct 8, 2021 - Abstract #CMSC2021CMSC_607;
In particular, quantitative image analysis may be hampered by suboptimal protocols in terms of slice thickness and inconsistency in terms of imaging protocols over time. Despite these challenges, the study shows that atrophy values as detected from DMF-treated subjects in the real world follow those of randomized controlled trials.
- Mavenclad (cladribine) / EMD Serono
[VIRTUAL] Online Medical Education Increases Knowledge Among Neurologists of Safety Considerations for Disease Modifying Therapies in Multiple Sclerosis () - Oct 8, 2021 - Abstract #CMSC2021CMSC_606;
The results indicated that a CME-certified 30-minute expert panel discussion was effective at improving knowledge among neurologists regarding the risks associated with DMTs in MS. Future education should address both the associated risks, and approaches to monitoring adverse events, in patients receiving DMTs for the management of MS.