- |||||||||| Seizalam (midazolam intramuscular) / Pfizer
Review, Journal: Optimal Management of Status Epilepticus in Children in the Emergency Setting: A Review of Recent Advances. (Pubmed Central) - Sep 29, 2022
Up until 2019, phenobarbital and phenytoin (or fosphenytoin) were the preferred second-line treatments but with no good supporting RCT evidence...Lacosamide is an alternative second-line treatment but with no supporting RCT evidence...Pragmatically, levetiracetam or sodium valproate are preferred to phenytoin (or fosphenytoin) because of their ease of administration and lack of serious adverse side-effects, including potentially fatal cardiac arrhythmias. Sodium valproate must be used with caution in children aged three and under because of the rare risk of hepatotoxicity and particularly if there is an underlying mitochondrial disorder.
- |||||||||| lacosamide / Generic mfg.
Journal: Lacosamide decreases neonatal seizures without increasing apoptosis. (Pubmed Central) - Sep 29, 2022
Lacosamide reduces neocortical seizure-like activity in neonatal mice in vitro and in vivo without an acute increase in apoptosis. Our results support the use of lacosamide to treat neonatal seizures, with the advantage of not increasing apoptosis acutely.
- |||||||||| lacosamide / Generic mfg.
Retrospective data, Journal: Status epilepticus management and mortality risk factors: a retrospective study. (Pubmed Central) - Sep 10, 2022
Patients with these two factors should be carefully checked for skin rashes. To improve SE management and reduce mortality rates, training activities targeting emergency department physicians should be implemented, together with elective intensive care admission for patients with multiple mortality risk factors (eg, absence of history of epilepsy, acute stroke, or cardiovascular complications).
- |||||||||| Nucynta (tapentadol) / Collegium Pharma, Grunenthal
Biomarker, Clinical, Journal: IMI2-PainCare-BioPain-RCT2 protocol: a randomized, double-blind, placebo-controlled, crossover, multicenter trial in healthy subjects to investigate the effects of lacosamide, pregabalin, and tapentadol on biomarkers of pain processing observed by non-invasive neurophysiological measurements of human spinal cord and brainstem activity. (Pubmed Central) - Sep 7, 2022
P2
For these reasons, IMI2-PainCare-BioPain-RCT2 hypothesizes that spinal and brainstem neurophysiological measures can serve as biomarkers of target engagement of analgesic drugs for future Phase 1 clinical trials. Phase 2 and 3 clinical trials could also benefit from these tools for patient stratification.
- |||||||||| Fycompa (perampanel) / Eisai, Xcopri (cenobamate) / SK Bio, Angelini Group, Endo, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Efficiency of Third-Generation Antiseizure Medications in Spain for Drug-Resistant Epilepsy: A Cost-per-Number Needed to Treat Analysis (In-person; Virtual) - Sep 1, 2022 - Abstract #ISPOREU2022ISPOR_EU_1623;
The findings show a clear link between the efficacy of third-generation ASMs available in Spain for the treatment of FOS in patients with DRE and their efficiency, facilitating determination of drug’s value contribution and decision-making in Spain. Cenobamate presents the lowest cost per NNT relative to seizure freedom, proving to be the most efficient option compared to third-generation alternatives.
- |||||||||| Review, Journal: Neurosyphilis presenting as autoimmune limbic encephalitis: A case report and literature review. (Pubmed Central) - Aug 28, 2022
The present case was diagnosed with neurosyphilis presenting as ALE, but meanwhile, in most case, neurosyphilis presenting as LE developed at a slower progressive rate, and it had a broader or restricted involvement on brain MRI than ALE based on the literature review. Therefore, an appropriate differential diagnosis of LE can be obtained by identifying clinical differences between the 2 conditions.
- |||||||||| Review, Journal: Polycystic ovary syndrome and the new antiepileptic drugs: A systematic review. (Pubmed Central) - Aug 24, 2022
Therefore, an appropriate differential diagnosis of LE can be obtained by identifying clinical differences between the 2 conditions. The anticonvulsants are probably safer, but the risk of developing PCOS associated with the antiepileptics cannot be established, since there are insufficient studies.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Journal: Reponse of second-line treatment in focal status epilepticus: A tertiary hospital experience. (Pubmed Central) - Aug 24, 2022
Our findings further support the notion that early termination of SE with a first or second ASM confers a better functional outcome. The large difference in response between the first ASM and consecutive ones suggests that the sum of different ASMs might be the key to resolving focal SE.
- |||||||||| Review, Journal: Mini Review on Forced Degradation Studies on Anti-Epileptic Drugs and Beyond. (Pubmed Central) - Aug 22, 2022
A systematic method for the forced degradation studies on anti-epileptic drugs such as "Topiramate, Vigabatrin, Lacosamide, Tiagabine, Levetiracetam and Zonisamide" is discussed. This review helps researchers to get an idea about stability-indicating methods of development and validation for newer antiepileptic drugs and the characteristics of drug products that degrade under specific degradation conditions.
- |||||||||| Successful Use Of Electroconvulsive Therapy For Severe Medically Refractory Status Epilepticus (Hall C) - Aug 15, 2022 - Abstract #ASA2022ASA_4910;
Intubated for airway protection and transferred to our hospital for further management and admitted to Neuro ICU. She was burst suppressed with Phenytoin, Pentobarbital, Valproate, Propofol, Ketamine, and underwent multiple sessions of electroconvulsive therapy with multidisciplinary input from Anesthesia Critical Care, Neurology, and Psychiatry, with success in aborting status epilepticus.
- |||||||||| Review, Journal: Antiseizure Drugs and Movement Disorders. (Pubmed Central) - Aug 6, 2022
Although little information is available on the adverse effects or benefits on movement disorders of newer antiseizure drugs (such as brivaracetam, cenobamate, eslicarbazepine, lacosamide, and rufinamide), the evidence collected in this review should guide the choice of antiseizure drugs in patients with concomitant epilepsy and movement disorders. Finally, these notions can lead to a better understanding of the mechanisms involved in the pathophysiology and treatments of movement disorders.
- |||||||||| Ospolot (sultiam) / AOP Orphan Pharma
Preclinical, Journal: An Investigation of the Effects of Chronic Zonisamide, Sultiam, Lacosamide, Clobazam, and Rufinamide Antiseizure Drugs on Foliculogenesis in Ovarian Tissue in Prepubertal Non-Epileptic Rats. (Pubmed Central) - Aug 5, 2022
HSCORE, immunohistochemical EGF, IGF-1 and GDF-9 staining, a very strong immunoreaction was observed in the ovarian multilaminar primary follicle granulosa cells and oocytes in the control group (p<0.001), and an immunoreaction ranging from weak to medium was observed in the antiseizure drug groups. Long-term anti-seizure drug therapy with zonisamide, sultiam, lacosamide, clobazam, and rufinamide from prepubertal to adulthood causes apoptosis and disruption of folliculogenesis in the ovarian follicles of nonepileptic rats.
- |||||||||| Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Observational data, Journal: Efficacy and safety of antiseizure medication in post-stroke epilepsy. (Pubmed Central) - Aug 5, 2022
Long-term anti-seizure drug therapy with zonisamide, sultiam, lacosamide, clobazam, and rufinamide from prepubertal to adulthood causes apoptosis and disruption of folliculogenesis in the ovarian follicles of nonepileptic rats. Our data show that antiseizure medications acting via the slow inactivation of sodium channels, such as lacosamide and eslicarbazepine, are well tolerated and might be associated with better seizure control in PSE.
- |||||||||| lacosamide / Generic mfg.
Journal: Evaluation of Cardiovascular Concerns of Intravenous Lacosamide Therapy in Epilepsy Patients. (Pubmed Central) - Jul 23, 2022
Intravenous LCM does have some effects on the ECG parameters and blood pressure but without clinical relevance. Despite the theoretical concern of cardiac adverse effects of LCM, the benefit of seizure control outweighed the risk in patients with status epilepticus or seizure clusters, such as hyperthermia, pulmonary edema, cardiac arrhythmias, or cardiovascular collapse.
- |||||||||| lacosamide / Generic mfg., pregabalin / Generic mfg.
Back Translation of Functional, Pharmacodynamic Pain Biomarkers into Rodents (715 B) - Jul 19, 2022 - Abstract #IASP2022IASP_511;
The compounds also modulate concurrently recorded resting state spectral power and auditory evoked potential amplitude, providing additional insights into non-specific effects of the compounds on CNS function (e.g. sedation). With the aid of extensive PK and PD profiles generated for each compound (including within-subject PK & PD), we will present the PK-PD relationships describing these pharmacological effects.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Implications of anaesthetics' utilization in NCSE prognosis (A6) - Jul 18, 2022 - Abstract #EAN2022EAN_2583;
Anesthetics' utilization might be associated with worse outcomes, but a causal relationship is unclear. Larger prospective studies are needed to clarify which situations might benefit from a more aggressive strategy.
- |||||||||| lacosamide / Generic mfg.
Journal: Blood-brain barrier targeted delivery of lacosamide-conjugated gold nanoparticles: Improving outcomes in absence seizures. (Pubmed Central) - Jul 15, 2022
Larger prospective studies are needed to clarify which situations might benefit from a more aggressive strategy. We suggest that the conjugation of LCM to GNPs may provide a novel approach for efficient brain drug delivery in light of the effectiveness of our strategy not only in suppressing the seizure activity but also in decreasing the need to use high dosages of the antiepileptics to reduce the frequently encountered side effects in drug-resistant epilepsy.
- |||||||||| Fycompa (perampanel) / Eisai
Review, Journal: Effects of antiepileptic drugs on sleep architecture parameters in adults. (Pubmed Central) - Jun 28, 2022
Studies found used different methodologies not always addressing the analysis on the same parameters. In spite of these, newer AEDs have less effects on sleep structure when compared with classic AEDs but furthermore robust evidence is needed.
- |||||||||| Fycompa (perampanel) / Eisai
The Efficacy of Anti-epileptic Drugs in the Animal Model of Autism Spectrum Disorder () - Jun 26, 2022 - Abstract #CINP2022CINP_261;
Hyperactivity of glutamatergic system represented by the up-regulation of NR2B and phosphorylation of ERK in the prefrontal cortex. The ameliorating effects of anti-epileptic drugs on the ASD-like behaviors suggested that modulation of glutamatergic nervous system is therapeutic target for ASD, which should be subjected for further investigation to verify the clinical relevance.
- |||||||||| Journal: Individualizing doses of antiepileptic drugs. (Pubmed Central) - Jun 22, 2022
We used Pubmed, Google Scholar and EMBASE database's to support our article. To ensure that the patient with seizure receives the best treatment in relation to their comorbidities, careful clinical-laboratory monitoring is necessary to maximize effectiveness while maintaining safety, especially in the case of polytherapy.
- |||||||||| Review, Journal: Impact of Antiseizure Medications on Appetite and Weight in Children. (Pubmed Central) - Jun 22, 2022
The ASM most robustly associated with increased appetite and/or weight gain is valproic acid; however, both pregabalin and perampanel may also lead to modest weight gain or increased appetite in children. Certain ASMs may impact both appetite and weight, which may lead to increased morbidity of the underlying disease and impaired adherence to the treatment regimen.
- |||||||||| 19 Year Old Wrestler With Altered Mental Status (31A) - Jun 2, 2022 - Abstract #ACSM2022ACSM_1323;
CT 11/3: Interval development of increased sulcal crowding of the bilateral cerebral convexities concerning for mild diffuse cerebral edema. MRI 10/18: Subtle cortical edema is suggested diffusely that can be seen with encephalitis versus seizure activity.
- |||||||||| Fycompa (perampanel) / Eisai
Review, Journal: Movement disorders associated with antiseizure medications: A systematic review. (Pubmed Central) - May 25, 2022
The majority of attempted interventions for all agents were discontinuation of the offending drug or dose reduction which led to the resolution of symptoms in most patients. Familiarity with the movement disorder phenomenology previously encountered in relation with specific ASMs facilitates early recognition of adverse effects and timely institution of targeted interventions.
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