- |||||||||| lacosamide / Generic mfg.
Outcomes of Patients on Lacosamide Medication During Pregnancy (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1102;
Additionally, DNCs exhibited a decreasing trend during pregnancy, confirming that regular, optimized LCM dosage changes may be necessary to achieve the best possible maternal and fetal outcomes. Future analyses in larger cohort sizes are needed.
- |||||||||| lacosamide / Generic mfg.
Discontinuation Characteristics in Older Adults with Epilepsy Taking Lacosamide (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1074;
Death within 3 months of LCM initiation excluded 79 OAWE and 7 YAWE. Initial daily LCM dose at the start of the study was similar between YAWE and OAWE reflecting different dosing starting points (already taking LCM at study start, titrating, and emergent escalation dosing).
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Retention of Cenobamate in the Real World (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1065;
Cenobamate was associated with significantly better retention vs. a pooling of four branded ASMs in this analysis of real-world use. A limitation of this analysis is the potential for unmeasured differences across the two groups that impact differential retention outcomes such as patient severity, drug load, and use of monotherapy.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
The Pharmacokinetics of Cenobamate When Used as Monotherapy (Hall B, Level 3) - Nov 29, 2022 - Abstract #AES2022AES_1009;
The following antiseizure medications (ASMs) were tested as covariates for statistically significant effects on the apparent clearance (CL/F) of cenobamate based on their use in the clinical studies of patients with focal seizures: carbamazepine, clobazam, lacosamide, lamotrigine, levetiracetam, oxcarbazepine, topiramate, and valproate. Based on these findings, cenobamate monotherapy should result in plasma exposures comparable to those that have been demonstrated to be safe and effective when used as adjunctive therapy for the treatment of focal seizures.
- |||||||||| Profile of Neuronal Apoptosis After Exposure to Voltage Gated Sodium Channel Blockers: Comparison Between Phenytoin, Lacosamide, Zonisamide, and Rufinamide () - Nov 29, 2022 - Abstract #AES2022AES_757;
Consistent with prior studies, we found that both phenobarbital and phenytoin significantly increased the number of degenerating cells in the hippocampus, nucleus accumbens, and lateral thalamus (P < 0.05). By contrast, rufinamide, zonisamide, and lacosamide were all without effect in all brain regions examined.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Seizure Control with Cenobamate in an Outpatient Setting () - Nov 29, 2022 - Abstract #AES2022AES_695;
However, drug-drug interactions and frequent AEs limit its use. Clinicians need to anticipate possible interactions between cenobamate and other ASMs.
- |||||||||| Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Real World Evaluation of Serum Sodium Levels in Patients With Focal Seizures Treated With Eslicarbazepine Acetate () - Nov 29, 2022 - Abstract #AES2022AES_658;
The most common concomitant baseline ASMs were levetiracetam and lacosamide, and the most common comorbidities were bipolar disorder and chronic pulmonary disease. In both epilepsy and focal epilepsy groups, mean serum sodium values in patients treated with ESL aged ≥ 4 years did not change from baseline in a real-world clinical setting over a period of 12 months.
- |||||||||| lacosamide / Generic mfg., zonisamide / Generic mfg., carbamazepine / Generic mfg.
Clinical, Journal: Supply problems of antiseizure medication are common among epilepsy patients in Germany. (Pubmed Central) - Nov 25, 2022
Supply problems with ASM are frequent among PWE in Germany and are reported for older and newer ASMs. Supply problems contribute to ASM nonadherence and are positively correlated with the number of ASM taken and adverse events.
- |||||||||| lacosamide / Generic mfg., aspirin / Generic mfg., levetiracetam / Generic mfg.
JUMPING MOUSTACHES IN A CASE OF STROKE (GALLERY) - Nov 7, 2022 - Abstract #WSC2022WSC_1473;
In this case, right facial EPC were the presenting features of stoke and they lasted for over 3-4 days. In our patient, the left precentral gyral ischemic lesion may be the possible culprit cortical generator leading to facial EPC.
- |||||||||| lacosamide / Generic mfg., phenytoin / Generic mfg., levetiracetam / Generic mfg.
Preclinical, Journal: Evaluation of an ex-vivo neonatal extracorporeal membrane oxygenation circuit on antiepileptic drug sequestration. (Pubmed Central) - Nov 1, 2022
Percent drug sequestrations for levetiracetam and lacosamide were less than 20% and for phenytoin were as high as 30% based on the sampling following single bolus dose administration into a neonatal ECMO circuit. Careful consideration of patient clinical status should be taken in consideration when optimizing antiepileptic therapy in neonates receiving ECMO.
- |||||||||| Fycompa (perampanel) / Eisai
Review, Journal: Paediatric status epilepticus (Pubmed Central) - Oct 18, 2022
Early identification and treatment of a prolonged crisis are essential to prevent progression to status. Although with fewer sequelae than in adults, status epilepticus in children represents a cause of mortality of up to 3-5%, while 25% of them will develop subsequent epilepsy, as well as a considerable percentage of neurological sequelae.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Actigraphic Correlates of Psychiatric Disability in Patients with Focal Epilepsy () - Oct 17, 2022 - Abstract #ANA2022ANA_419;
Can we achieve similar therapeutic effects by instituting behavioral modifications that reshape a subject’s RAR? In ongoing stud ies, we are characterizing RAR structure in PWE with broader comorbidities, including intellectual disability, lim ited/no verbal abilities and/or static motor impairments (e.g., quadriparesis).
- |||||||||| Octreosphere (octreotide extended release) / Xbrane, Seizalam (midazolam intramuscular) / Pfizer
Severe Hypoglycemic encephalopathy () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1341;
27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in death or in several neurological damage without further improving. The initial management with the specific treatment and airway and hemodynamical support is a key point in the survival rate of these patients.
- |||||||||| Octreosphere (octreotide extended release) / Xbrane, Seizalam (midazolam intramuscular) / Pfizer
Severe Hypoglycemic encephalopathy () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1340;
27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in death or in several neurological damage without further improving. The initial management with the specific treatment and airway and hemodynamical support is a key point in the survival rate of these patients.
- |||||||||| Octreosphere (octreotide extended release) / Xbrane, Seizalam (midazolam intramuscular) / Pfizer
Severe Hypoglycemic encephalopathy () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1339;
27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in death or in several neurological damage without further improving. The initial management with the specific treatment and airway and hemodynamical support is a key point in the survival rate of these patients.
- |||||||||| Octreosphere (octreotide extended release) / Xbrane, Seizalam (midazolam intramuscular) / Pfizer
Severe Hypoglycemic encephalopathy () - Oct 17, 2022 - Abstract #EUSEM2022EUSEM_1338;
27-years-old male with a history of depression, previous suicide attempt and a recent diagnosis of insulin-dependent diabetes mellitus found unconsciousness surrounded by a diazepam blister and lots of rapid-acting (1800 UI) and slow-acting (600 UI) insulin-pens...Tracheal intubation was performed using midazolam, etomidate and rocuronium and fluid management with three units of 50%glucose, 500ml of 10%glucose and 500 ml of 5%glucose was started with a capillary glycemic of 130mg/dL prior the transfer to the emergency room (ER)...The electroencephalography showed periodic 1 Hz activity that during the ICU stay progressed to a pattern of cortical damage and epileptics crisis that were controlled with the use of antiepileptic drugs (levetiracetam, lacosamide and clonazepam)...Besides it, we can use iv or im glucagon, iv octreotide, iv hydrocortisone and support with complex carbohydrates...Half of the patients will have good outcomes while the other half will end-up in death or in several neurological damage without further improving. The initial management with the specific treatment and airway and hemodynamical support is a key point in the survival rate of these patients.
- |||||||||| Fycompa (perampanel) / Eisai
Journal: Management of epilepsy in brain tumor patients. (Pubmed Central) - Oct 15, 2022
Management of seizures in BTRE is complex and with currently available evidence levetiracetam seems the preferred choice. Comparative efficacy RCTs in BTRE are warranted.
- |||||||||| Tenofovir Associated Hyaline Arteriosclerosis (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_2440;
Introduction Tenofovir Disoproxil Fumarate (TDF) is associated with various patterns of kidney injury...Case Description A 40-year-old Caucasian male with a history of epilepsy on Lacosamide and Brivaracetam, hepatitis C (HCV) treated with Sofosbuvir/Velpatasvir (SV), cutaneous sarcoid on Hydroxychloroquine, pre-exposure prophylaxis on Emtricitabine and TDF for seven years presented to nephrology clinic with asymptomatic elevation in creatinine (CR)...Blood pressures were normal and the only known potential nephrotoxic agents were TDF and Omeprazole...Moreover, the twelve weeks of increased TDF exposure may have led to microvascular changes that ultimately resulted in HA. To our knowledge, this is the first case of HA associated with TDF in a young patient without any known risk factors.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg.
Investigation of recurrent deja vu attacks: a case with mesial temporal lobe epilepsy (Poster area [ONLINE]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1321;
It may point some conditions like epilepsy, migraine and vestibular disease. Epileptic deja vu occurs more frequently than physiological deja vu, and epilepsy patients report some associative features like derealisation, olfactory/gustatory hallucinations, headaches, abdominal sensations, prior fatigue and fear more often[3].
- |||||||||| Fycompa (perampanel) / Eisai, Diacomit (stiripentol) / Biocodex, Meiji Seika, Fintepla (low-dose fenfluramine) / UCB
Review, Journal, Adverse events: Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies. (Pubmed Central) - Oct 13, 2022
Bromide, felbamate and other sodium channel ASMs are discussed briefly...Cannabidiol, PER and pregabalin may be associated with improvements in sleep, LTG is associated with insomnia, while VPA, TPM, LEV, ZNS and LCM do not appear to have detrimental effects...Finally, we discuss how a variety of factors can affect mood, behaviour and cognition, and untangling the associations between the effects of the underlying syndrome and those of the ASMs can be challenging. In particular, there is enormous heterogeneity in cognitive, behavioural and developmental impairments that is complex and can change naturally over time; there is a lack of standardised instruments for evaluating these outcomes in developmental and epileptic encephalopathies, with a reliance on subjective evaluations by proxy (caregivers); and treatment regimes are complex involving multiple ASMs as well as other drugs.
- |||||||||| Review, Journal: Breastfeeding while on treatment with antiseizure medications: a systematic review from the ILAE Women Task Force (Pubmed Central) - Oct 11, 2022
High infant levels (30% up to 100% of maternal serum concentrations) have been reported with ethosuximide, phenobarbital and zonisamide...It is concluded that breastfeeding should in general be encouraged in women taking ASMs, given the well-established benefits of breastfeeding with regard to both short- and long-term infant health in the general population. Counselling needs to be individualized including information on the current knowledge regarding the woman's specific ASM treatment.
- |||||||||| lacosamide / Generic mfg.
Lacosamide decreases neonatal seizures without increasing apoptosis in mice (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_12335;
Phenobarbital, a GABAA receptor allosteric modulator, has low efficacy in treating neonatal seizures and causes neuronal apoptosis...In vitro, we measured the effect of different lacosamide concentrations on seizure-like activity induced by the pro-convulsant drug 4-aminopyridine in neonatal (postnatal day P8-11, both sexes) and adult (1-1.6-month-old, male) neocortical brain slices (layer IV/V; C57BL/6J mice)...In conclusion, lacosamide reduces neocortical seizure-like activity in neonatal mice in vitro and in vivo, with no increase in apoptosis. Our results support the use of lacosamide to treat neonatal seizures, with the advantage of not increasing apoptosis.
- |||||||||| lacosamide / Generic mfg.
The tripeptide arginine-glutamate-arginine (RER), an active region of secreted amyloid precursor protein-alpha, upregulates LTP in a CamKII- and CRMP-dependent manner (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_9538;
Taken together, and considering previous work, these data suggest that Ac-rER enhances synaptic plasticity by activating CaMKII, CRMP2, and protein synthesis, and by promoting intracellular trafficking of critical proteins to the hippocampal pyramidal cell surface. Given the similarity of these mechanisms to those of sAPPα, and the ability of Ac-rER to enhance memory in other vertebrates, this tripeptide may have notable therapeutic benefits.
- |||||||||| vixotrigine (BIIB074) / Biogen, GSK
Spontaneous activity in organotypic cultures of human spinal cord slices: potential for use in the drug discovery process (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_3993;
Conversely, the SA IC50 for vixotrigine was right-shifted relative to its FTPC range, in agreement with prior studies indicating that it is a well-tolerated drug. In conclusion, these initial data indicate that SA can be reliably measured in adult human CNS tissue up to 3 weeks in vitro and that organotypic hSC slice cultures can provide a valuable translational tool for the evaluation of the safety and possible efficacy of novel CNS drug candidates.
- |||||||||| Fycompa (perampanel) / Eisai, Diacomit (stiripentol) / Biocodex, Meiji Seika, Aptiom (eslicarbazepine) / Sumitomo Dainippon, BIAL
Journal: Stability Indicating Methods for Determination of Third Generation Antiepileptic Drugs and Their Related Substances. (Pubmed Central) - Oct 7, 2022
A number of these antiepileptic drugs were found to have had a small number of studies related to their stability and for the detection of impurities. The presentation of the current level of research on third generation antiepileptic drugs highlights the need for new stability and safety studies that are necessary to develop new pharmaceutical products containing these drugs.
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