- |||||||||| lacosamide / Generic mfg.
Journal, Adverse events: Investigation of the efficacy and adverse effects of lacosamide over 36 (Pubmed Central) - Jun 19, 2023 The literature suggests that Lacosamide is a promising candidate antiseizure medication for patients with poststroke seizures and epilepsy. Our response rate was lower and our retention rate was higher in comparison to a previous study that observed patients over 36
- |||||||||| phenytoin / Generic mfg.
Journal: Phenytoin Toxicity with High Dose, Concomitant Ascorbic Acid Dosing. (Pubmed Central) - Jun 12, 2023 Subsequent initiation of phenytoin and later addition of high dose AA resulted in truncal ataxia and falls with bilateral wrist and finger extension weakness. Phenytoin and AA were discontinued, and the patient returned to baseline on a new medication regimen of lacosamide and gabapentin without any other major seizures one year later.
- |||||||||| vixotrigine (BIIB074) / Biogen, GSK
Journal: Structural mapping of Na1.7 antagonists. (Pubmed Central) - Jun 8, 2023 We show that vinpocetine, a synthetic derivative of a vinca alkaloid, and hardwickiic acid, a natural product with antinociceptive effect, bind to the III-IV fenestration, while vixotrigine, an analgesic candidate, penetrates the IV-I fenestration of the pore domain. Our results permit building a 3D structural map for known drug-binding sites on Na channels summarized from the present and previous structures.
- |||||||||| lacosamide / Generic mfg.
Journal: Synthesis of Antiepileptic Drug (R)-Lacosamide and Chronic Pain Reliever (S)-Lacosamide from Chiral Glycine Enolate Equivalent. (Pubmed Central) - Jun 5, 2023 Our results permit building a 3D structural map for known drug-binding sites on Na channels summarized from the present and previous structures. Evans' asymmetric alkylation using N-(N-Boc-glycinyl) oxazolidinone was standardized to ensure the stereoselective formation of (Z)-enolate for a diastereofacial selection in the C-alkylation process of chiral glycine enolate equivalent with different alkyl halides such as methyl iodide, methoxymethyl chloride, benzyl bromide, p-NOCHCHBr, allyl bromide, and p-OCHCHCHBr in the presence of lithium diisopropyl amide at -78
- |||||||||| FASTKD2 gene mutation presenting with status epilepticus evolving to super-refractory status in dizygotic twins (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_749;
Based on our treatment experience, a universal maintenance dose of LCM would be needed in Chinese patients. Mitochondrial status epilepticus is reported rarely and challenging in terms of management and prognosis.Other than a lateralization difference, this dizygotic twins had identical clinical and radiological findings which further expands the phenotype of FASTKD2 gene mutation.
- |||||||||| lacosamide / Generic mfg., verapamil / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Hemiplegic migraine with fever, impaired consciousness and cognitive dysfunction: a case report (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_589; In addition to calcium channel blockers, antiepileptic drugs or betablockers are used in the treatment. The monoclonal antibodies seem to be the promise for the future of migraine therapy in children.
- |||||||||| Report of life threatening ictal apnoeas responsive to Ketogenic Diet (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_511;
Ketogenic diet was effective in this patient and despite she does not remain seizure free, the features of the seizures have changed being now safe for the patient being out of hospital. The ketogenic diet should be considered earlier as treatment in patients with these type of seizures.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., clobazam / Generic mfg.
Long-term effect of early ketogenic diet on PNKP mutation-associated epileptic encephalopathy (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_507; The good response to the ketogenic diet marked a before and after in the clinical evolution of this patient. Probably, the early establishment of the ketogenic diet in this and other genetic syndromes that occur with refractory epilepsy can help to better control seizures, even partially improve their psychomotor development.
- |||||||||| Kineret (anakinra) / SOBI
Febrile infection-related epilepsy syndrome - case report (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_498; A ketogenic diet and various antiepileptic drugs (levetiracetam, clobazam, lacosamide, topiramate, phenobarbital) were introduced... FIRES is rare but diagnostically and therapeutically challenging disorder which must be considered in the differential diagnosis of refractory status epilepticus.
- |||||||||| lacosamide / Generic mfg.
A case of two sisters with DEPDC5-related epileptic encephalopathy successfully treated with lacosamide add-on therapy (Foyer 3B, 3rd Floor) - May 29, 2023 - Abstract #EPNS2023EPNS_419; Although, there is currently no evidence that seizures respond better to one particular anti-seizure medication, one case series reported some positive effects from SCB anti-seizure drugs, with 5 out of 8 patients seizure free on monotherapy. While DEPDC5 is not a commonly associated gene with infantile spasms, 10% of probands were reported to have infantile spasms, and DEPDC5-related infantile spasms may have favorable responses to LCM.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Journal: Affordability of newer anti-seizure medications in Asian resource-limited countries. (Pubmed Central) - May 27, 2023 While DEPDC5 is not a commonly associated gene with infantile spasms, 10% of probands were reported to have infantile spasms, and DEPDC5-related infantile spasms may have favorable responses to LCM. All new generation ASMs, either original or generic brands, were not affordable in most Asian LMICs.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., hydroxyurea / Generic mfg.
Journal: Newly diagnosed PRES in a sickle cell diseased patient: a case report. (Pubmed Central) - May 25, 2023 However, the addition of other medications like anticonvulsants (levetiracetam and lacosamide) to prevent seizures as a consequence of PRES still remains debatable. Considering the case reported below, the addition of Hydroxyurea to the treatment can be another cause of the recurrence of PRES and needs to be weighed for its risks and benefits.
- |||||||||| lacosamide / Generic mfg.
Journal: CRMP2 Participates in Regulating Mitochondrial Morphology and Motility in Alzheimer's Disease. (Pubmed Central) - May 17, 2023 (S)-lacosamide ((S)-LCM), a small molecule that binds to CRMP2, decreased its phosphorylation at Ser 522 and Thr 509/514, and restored CRMP2's interaction with Miro 2, Drp1, and Mitofusin 2...Additionally, (S)-LCM-protected cultured cortical AD neurons from cell death. Thus, our data suggest that CRMP2, in a phosphorylation-dependent manner, participates in the regulation of mitochondrial morphology and motility, and modulates neuronal survival in AD.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Journal, HEOR, Cost-effectiveness, Cost effectiveness: Cost-effectiveness of cenobamate for focal seizures in people with drug-resistant epilepsy. (Pubmed Central) - Apr 14, 2023 Cenobamate improved QALYs and was less costly than brivaracetam, eslicarbazepine, lacosamide, and perampanel. Therefore, cenobamate may be considered as a cost-effective adjunctive antiseizure medication for people with drug-resistant focal seizures.
- |||||||||| lacosamide / Generic mfg.
Journal: Tolerability and Safety of Lacosamide in Neonatal Population. (Pubmed Central) - Mar 28, 2023 Otherwise, lacosamide was generally well tolerated with sleepiness being the most common symptom noted. This case series reports data on the tolerability of lacosamide and emphasizes the importance of monitoring key cardiac intervals with ECG before and after the use of lacosamide in this population.
- |||||||||| New Onset Refractory Status Epilepticus Shaking Up the Intensive Care Unit (Walter E. Washington Convention Center, Area C, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5039;
The patient was intubated and treated with Propofol, Dexmedetomidine, Fosphenytoin, and Levetiracetam. Due to persistent generalized seizures, she was transferred to a tertiary hospital, where Brivaracetam, Cenobamate, Lacosamide, Levocarnitine, Perampanel, and Zonisamide, and Ketamine and Pentobarbital drips were tried, but did not fully control the patient
- |||||||||| Status Epilepticus in Myxedema Coma, A Rare Entity (Walter E. Washington Convention Center, Area C, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5038;
Patient was treated with IV antibiotics, epinephrine, atropine and levothyroxine...Her seizure activity worsened despite increasing doses of Propofol, Phenytoin, Midazolam, Lacosamide and Levetiracetam...In Hashimoto's thyroiditis, cerebral angitis of autoimmune origin has been postulated as the most likely etiology. Prognosis remains guarded even after early diagnosis and treatment.
- |||||||||| Herpes Simplex Virus 1 Meningitis Presenting as Status Epilepticus (Walter E. Washington Convention Center, Area C, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_5033;
A CT scan of the head was non-suggestive of hemorrhage or increased pressure, and he was started empirically on intravenous ampicillin, vancomycin, and acyclovir...His antiepileptic drug (AED) regimen was uptitrated to infusions of propofol, midazolam and ketamine, along with which he received lacosamide, levetiracetam, and phenytoin...Studies suggest there is also an incidence of cerebral vasculitis associated with HSV-1 supporting short-term use of steroids along with AEDs, which may help improve cerebral edema associated with viral meningitis. Status epilepticus should be treated promptly due to high mortality and it is important to evaluate and treat patients with an established protocol including AEDs, alternate therapies and antibiotics/antivirals.
- |||||||||| lacosamide / Generic mfg.
Trial completion date, Trial primary completion date: The Lacosamide's Effect on Calcitonin Gene-related Peptide in Migraine Patients (clinicaltrials.gov) - Mar 21, 2023 P3, N=50, Recruiting, Status epilepticus should be treated promptly due to high mortality and it is important to evaluate and treat patients with an established protocol including AEDs, alternate therapies and antibiotics/antivirals. Trial completion date: Dec 2022 --> Apr 2023 | Trial primary completion date: Dec 2022 --> Mar 2023
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma
Journal: Palliative care and end-of-life care in adults with malignant brain tumors. (Pubmed Central) - Mar 16, 2023 Early palliative care interventions are essential to define goals of care and minimize symptom burden in a timely fashion. Interventional studies that address pain, fatigue, and psychiatric symptoms as well as (the timing of) early palliative care are urgently needed.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma
Journal: Frontline Sodium Channel-Blocking Antiseizure Medicine Use Promotes Future Onset of Drug-Resistant Chronic Seizures. (Pubmed Central) - Mar 16, 2023 Therefore, this study assessed whether lacosamide (LCM) monotherapy during corneal kindling would promote future development of drug-resistant focal seizures in mice...The dose-related antiseizure efficacy of distinct ASMs, including LTG, LCM, carbamazepine, levetiracetam, gabapentin, perampanel, valproic acid, phenobarbital, and topiramate, was then assessed in the remaining kindled mice...This study indicates that early, repeated administration of sodium channel-blocking ASMs, regardless of inactivation state preference, promotes pharmacoresistant chronic seizures. Inappropriate ASM monotherapy in newly diagnosed epilepsy may thus be one driver of future drug resistance, with resistance being highly ASM class specific.
- |||||||||| carbamazepine / Generic mfg.
Imperfect Pitch: a Cellist (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3972; Additionally, this case highlights a rare side effect of carbamazepine, alteration of pitch, which is likely only appreciated by patients with absolute pitch. Finally, it raises the possibility of an association between PKD and stuttering since there is a strong family history of stuttering in this patient.
- |||||||||| Actemra IV (tocilizumab) / Roche, JW Pharma, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
A Tale of Two Cases: When to Use PLEX That is The Question (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3403; Data on timely administration of Plasmapheresis (PLEX) vs IVIG/Solumedrol therapy is lacking...Various agents were used for seizure control such as Vimpat, Keppra, Depakote and Ketamine...Day 11, started on 5 sessions of PLEX followed by chemotherapy (Actemra and Rituxan) with significant improvement. Conclusions NORSE is a diagnosis with high rate of refractoriness to treatment and severe outcome.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., methylprednisolone sodium succinate / Generic mfg.
Refractory Seizures in the Setting of Lupus (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_3222; Lacosamide and valproic acid were added with some improvement...The patient was started on plasmapheresis concurrently with a 5-day course of IV methylprednisolone with steroid taper...Conclusions Antibody-mediated diseases can occur anywhere in the body where the immune system is able to gain access to a target antigen. We believe that CNS involvement of lupus may represent an under-recognized entity in the general category of NPSLE with features of autoimmune encephalitis, which include a similar therapeutic response to early plasmapheresis.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
The Pharmacokinetics of Cenobamate When Used as Monotherapy (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1890; Therefore, plasma cenobamate exposures with adjunctive therapy were comparable to monotherapy. Conclusions Based on these findings, cenobamate monotherapy should result in plasma exposures comparable to those that have been demonstrated to be safe and effective when used as adjunctive therapy for the treatment of focal seizures.
- |||||||||| lacosamide / Generic mfg.
Characterization of lacosamide pharmacokinetics in older adults with epilepsy (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1888; Conclusions Creatinine clearance was a significant predictor of lacosamide DNCs in older patients with epilepsy. Thus, as CLCR changes are more pronounced as one ages, modification in dosing regimens may be required to maintain lacosamide concentrations in the tolerable and effective range.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Long-term Cenobamate for Uncontrolled Focal Seizures in Patients Living in a Group Home or With Developmental Disability (Both in-person and online) - Mar 12, 2023 - Abstract #AAN2023AAN_1887; Dose reductions were most common with lacosamide (n=12; median reduction, 50%), brivaracetam (n=4, 50%), clobazam (n=4; 80%), lamotrigine (n=3; 50%), and perampanel (n=3; all 100%). Conclusions Patients living in a group home or with developmental disability achieved substantial reduction in seizure frequency at 12 months with adjunctive cenobamate.
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