- |||||||||| A case of bilateral paraneoplastic trigeminal neuralgia associated with renal cell carcinoma () - Jun 18, 2024 - Abstract #AHS2024AHS_187;
Of these three patients, two had detectable anti-Hu antibodies (one with lung cancer and one with intestinal-type mucinous ovarian carcinoma), whereas the remaining patient with serous-type ovarian carcinoma did not have any paraneoplastic antibodies detected. Our patient represents one of only a small subset of reported cases of paraneoplastic trigeminal neuralgia and the first documented case of paraneoplastic trigeminal neuralgia associated with renal cell carcinoma.
- |||||||||| Zavzpret (zavegepant nasal spray) / Pfizer, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Review, Journal: An update on pharmacotherapy for trigeminal neuralgia. (Pubmed Central) - Jun 13, 2024 Third-generation anticonvulsants, new calcitonin gene-related peptide blockers for migraine, and older drugs such as ketamine and cannabinoids may be promising adjuvants or monotherapeutic options...Combination therapy might allow for lower doses of carbamazepine or oxcarbazepine, thus reducing the number and severity of potential adverse events but the potential for pharmacokinetic drug-drug interactions must be considered. Drug therapy for trigeminal neuralgia involves acute or abortive treatments, often administered in hospital versus long-term preventive therapy, usually involving oral agents.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Observational data, Journal: The cenobamate KORK study-A prospective monocenter observational study investigating cenobamate as an adjunctive therapy in refractory epilepsy, with comparisons to historical cohorts treated with add-on lacosamide, perampanel, and brivaracetam. (Pubmed Central) - Jun 11, 2024 The rate of PWE continuing cenobamate was 80%. In our hands, cenobamate showed promising efficacy and tolerability even when compared to other recently introduced antiseizure medications.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma, Diacomit (stiripentol) / Biocodex, Meiji Seika, Aptiom (eslicarbazepine) / Sumitomo Pharma, BIAL
Journal, Adverse events: An analysis of suicidal and self-injurious behavior reports with antiseizure medications in the FDA adverse event database. (Pubmed Central) - Jun 6, 2024 These drugs included diazepam, brivaracetam, gabapenetin, and pregabalin. Although several limitations are present with the FAERS database, it is imperative to closely monitor patient comorbidities for increased risk of suicidality with the use of several ASMs.
- |||||||||| lacosamide / Generic mfg.
Preclinical, Journal: Inhibition of ERK1/2 or CRMP2 Disrupts Alcohol Memory Reconsolidation and Prevents Relapse in Rats. (Pubmed Central) - May 25, 2024 Attenuation of relapse was also induced by post-retrieval administration of lacosamide, an inhibitor of collapsin response mediator protein-2 (CRMP2)-a translational product of mTORC1. Together, our findings indicate the crucial role of ERK1/2 and CRMP2 in the reconsolidation of alcohol memories, with their inhibition as potential treatment targets for relapse prevention.
- |||||||||| Review, Journal: Clinical approaches for poststroke seizure: a review. (Pubmed Central) - Apr 25, 2024
Antiseizure drugs such as lamotrigine, carbamazepine, lacosamide, levetiracetam, phenytoin, and valproate may be administered. Poststroke seizures should be diagnosed systematically through history with differential diagnosis; in addition, classifying them as early or late seizures can help to determine treatment strategies.
- |||||||||| Xatmep (methotrexate oral solution) / Azurity Pharma, Nexlizet (bempedoic acid/ezetimibe) / Esperion Therap, Otsuka, Daiichi Sankyo
Trial completion, Enrollment change: Drug Concentrations in Breast Milk and Prediction of Blood Levels of the Breastfed Infants (clinicaltrials.gov) - Apr 9, 2024 P=N/A, N=39, Completed, The PBPK model of LCM can be utilized to optimize dosage regimens for special populations. Recruiting --> Completed | N=304 --> 39
- |||||||||| Journal: Prenatal exposure to antiseizure medications and fetal growth: a population-based cohort study from the Nordic countries. (Pubmed Central) - Mar 13, 2024
Prenatal exposure to carbamazepine, oxcarbazepine, clonazepam, and topiramate was associated with increased risk of being born small for gestational age in both the overall population and in children of women with epilepsy suggesting that prenatal exposure to these drugs is associated with fetal growth restriction. The NordForsk Nordic Program on Health and Welfare (83539), the Independent Research Fund Denmark (1133-00026B), the Danish Epilepsy Association, the Central Denmark Region, the Novo Nordisk Foundation (NNF16OC0019126 and NNF22OC0075033), and the Lundbeck Foundation (R400-2022-1205).
- |||||||||| lacosamide / Generic mfg., pregabalin / Generic mfg.
Trial completion: POLO: Combined Effect of Pregabalin and Oxycodone, and Lacosamide and Oxycodone, on Breathing (clinicaltrials.gov) - Mar 12, 2024 P4, N=24, Completed, The NordForsk Nordic Program on Health and Welfare (83539), the Independent Research Fund Denmark (1133-00026B), the Danish Epilepsy Association, the Central Denmark Region, the Novo Nordisk Foundation (NNF16OC0019126 and NNF22OC0075033), and the Lundbeck Foundation (R400-2022-1205). Recruiting --> Completed
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Cenobamate Use as Monotherapy: A Retrospective Claims-based Analysis (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3961; Among 244 patients who switched to cenobamate monotherapy, the most common previous ASMs included lacosamide (n=35), lamotrigine (n=26), and gabapentin (n=24). Patients taking cenobamate monotherapy, inclusive of the titration period, experienced nominally fewer inpatient days and ER visits and lower rates of status epilepticus vs previous LOT.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Effectiveness of Cenobamate in Postsurgical Patients: A Retrospective Claims-based Analysis (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3952; We compared LOT adding cenobamate with those adding brivaracetam, clobazam, eslicarbazepine, lacosamide, lamotrigine, levetiracetam, or perampanel.7835 patients (52.4% female, mean age=39.3 years) were exposed to 11,771 LOT. Following surgery, cenobamate was associated with lower ER rates than 7 leading ASMs, and with lower inpatient days than all comparators except eslicarbazepine, suggesting that improved seizure control with cenobamate may provide significant cost savings and reductions in seizure-related morbidity and mortality.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
Safety and Efficacy of Neuro-responsive Stimulator (RNS) in Bilateral Temporal Lobe GAD65 Antibody Positive Autoimmune Epilepsy in Patients on Immunosuppression (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3666; Design/NAWe present a young female patient diagnosed with GAD65 antibody positive AE on multiple ASMs including Levetiracetam, Lamotrigine, Zonisamide, Phenobarbital, Clobazam, Lacosamide, and Ativan. Her immunomodulating therapies include IVIG maintenance therapy, mycophenolate, and daily prednisone...RNS has a role in tracking disease treatment in patients with AE on immunosuppression and provides a safe therapeutic option for these commonly immunosuppressed groups, as demonstrated with our patient with GAD65 positive AE.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., midazolam hydrochloride / Generic mfg.
Bi-allelic POLG2 mutation leading to epilepsy in an infant: a case report (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3655; Her immunomodulating therapies include IVIG maintenance therapy, mycophenolate, and daily prednisone...RNS has a role in tracking disease treatment in patients with AE on immunosuppression and provides a safe therapeutic option for these commonly immunosuppressed groups, as demonstrated with our patient with GAD65 positive AE. Seizures responded to levetiracetam, and the patient was weaned off midazolam and discharged home without complication while metabolic investigation was pending...Over the following 48 hours, she developed epilepsia partialis continua (EPC) which responded well to lacosamide administration...Although POLG1 is widely known, here we present a case of bi-allelic POLG2 mutation that led to epilepsy, liver failure, and eventually death.
- |||||||||| TBC1D24 Mutation Presenting as Post-partum New Onset Refractory Status Epilepticus (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3654;
This variant has been reported in one other non-related heterozygous carrier who presented in infanthood with prolonged tonic-clonic seizures during febrile episodes. While this individual showed a dramatic improvement in seizure control associated with less frequent febrile episodes, no prior response to immunomodulatory therapies have been previously described in TBC1D24 variants.
- |||||||||| Rituxan (rituximab) / Roche
Late-onset Anti-NMDAr Encephalitis After HSV Encephalitis in Pregnancy (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3559; Although post-infectious anti-NMDAr encephalitis typically presents within a few weeks following HSVE, delayed presentation is still a possibility and must be considered. Furthermore, HSV infection may trigger in these patients a persistent autoimmune activation, as opposed to classic anti-NMDAr encephalitis which is more often monophasic.
- |||||||||| lacosamide / Generic mfg., levetiracetam / Generic mfg., oxcarbazepine / Generic mfg.
Seizures in the Leukodystrophies (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3442; Abnormal MRI brain and generalized slowing on EEG are widespread in this cohort and do not confer increased seizure risk. Patients with generalized discharges have higher risk of seizures compared with focal discharges.
- |||||||||| Xcopri (cenobamate) / SK Bio, Angelini Group, Endo
Leukemoid Reaction in the Setting of Status Epilepticus: A Case Report (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3257; The patient was treated with midazolam by EMS and loaded with levetiracetam on arrival to the hospital...Presenting lacosamide and cenobamate levels were subtherapeutic...Status epilepticus is an emergent condition that yields considerable physiologic stress as evidenced by this patient's severe lactic acidosis and CPK elevations. It should be recognized as an etiology for leukemoid reaction due to inflammatory leukocyte margination.
- |||||||||| lacosamide / Generic mfg., aspirin / Generic mfg.
Misdiagnosis in a Case of Pediatric Stroke (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3162; 60% of patients will end up with disability and half will have a decreased quality of life. Collaborative approaches could avoid significant delays in diagnosis and treatment in pediatric patients.
- |||||||||| Fycompa (perampanel) / Eisai, Catalyst Pharma
Stridor of Epileptic Origin (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_3047; Lacosamide, Perampanel and Phenytoin were added sequentially...Stridor due to paradoxical vocal cord movement is a possible semiology of seizures originating from fronto-central lesions. Clinicians should be vigilant to such rare forms of semiology in the proper clinical settings.
- |||||||||| lacosamide / Generic mfg.
Occipital Lobe Epilepsy Presenting with Alice in Wonderland Syndrome (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_2625; With supportive evidence for left occipital lobe epilepsy, patient was started on daily lacosamide and there was marked reduction in his symptoms...This is the first case in literature to report an occipital lobe epilepsy presenting with pediatric AIWS. Identification and localization of the focal epilepsy using magnetoencephalography was critical in this case to start appropriate treatment.
- |||||||||| lamotrigine liquid oral suspension / OWP Pharma
That Tickles!: A New Type of Reflex Epilepsy (Colorado Convention Center | Exhibit Hall B-E) - Mar 8, 2024 - Abstract #AAN2024AAN_2502; The pathophysiology of "tickling" epilepsy is unknown. Behavior modification may be a necessary intervention to avoid seizures.
- |||||||||| Journal: Lettre to editor: Case report of an ictal asystole as debut in new onset epilepsy. (Pubmed Central) - Mar 6, 2024
Anti-seizures drugs must be initiated in all patients, and there is a recommendation to avoid those with negative inotropic and arrhythmogenic effects (such as phenytoin, carbamazepine, and lacosamide). There is a discussion about pacemaker indication, however, it is highly recommended in non-controlled epilepsy and in ictal asystoles that last for more than 6
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